Review
Medicine, General & Internal
Ianthe Piscaer, Rob Janssen, Frits M. E. Franssen, Leon J. Schurgers, Emiel F. M. Wouters
Summary: Patients with chronic obstructive pulmonary disease (COPD) often have multiple co-occurring conditions and systemic manifestations. Vitamin A, vitamin D, and vitamin K are all potentially involved in COPD pathogenesis. In this review, the potential role of vitamin K in the systemic manifestations of COPD is discussed, including its effects on prevalent co-occurring chronic conditions such as cardiovascular disorders, chronic kidney disease, osteoporosis, and sarcopenia. Recommendations for future clinical studies are also provided.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Marija Gredic, Isabel Blanco, Gabor Kovacs, Zsuzsanna Helyes, Peter Ferdinandy, Horst Olschewski, Joan Albert Barbera, Norbert Weissmann
Summary: This article summarizes the pathophysiology and treatment options for PH in COPD patients, pointing out that current research still does not fully understand its underlying mechanisms, and some of the treatment methods tested in clinical settings have not been effective. Preclinical studies have proposed some treatment approaches.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Michael C. Ferrera, Wassim W. Labaki, MeiLan K. Han
Summary: COPD is a common respiratory disorder with high morbidity and mortality, often underdiagnosed until clinical advancement. Research focuses on early changes for better diagnosis and identifying patients for early intervention. Treatment options have significantly expanded in the past 20 years with new medications and procedures.
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021
(2021)
Article
Nutrition & Dietetics
Rachida Rafiq, Floor E. Aleva, Jasmijn A. Schrumpf, Johannes M. Daniels, Pierre M. Bet, Wim G. Boersma, Paul Bresser, Michiel Spanbroek, Paul Lips, Tim J. van den Broek, Bart J. F. Keijser, Andre J. A. M. van der Ven, Pieter S. Hiemstra, Martin den Heijer, Renate T. de Jongh
Summary: This study assessed the effect of vitamin D supplementation on exacerbation rate in vitamin D-deficient patients with COPD. The results showed that vitamin D supplementation did not affect the exacerbation rate in COPD patients.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Physiology
Xia Xu, Ke Huang, Fen Dong, Shiwei Qumu, Qichao Zhao, Hongtao Niu, Xiaoxia Ren, Xiaoying Gu, Tao Yu, Lin Pan, Ting Yang, Chen Wang
Summary: COPD is a heterogeneous disease with eosinophils potentially associated with emphysema, different from neutrophilic inflammation-related emphysema in small airway disease. The characterization of heterogeneity in COPD-associated inflammation may pave the way for personalized medicine and new therapeutic approaches.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Respiratory System
Vasiliy V. Polosukhin, Sergey S. Gutor, Rui-Hong Du, Bradley W. Richmond, Pierre P. Massion, Pingsheng Wu, Justin M. Cates, Kim L. Sandler, Stephen Rennard, Timothy S. Blackwell
Summary: In patients with COPD, thickening of epithelial and subepithelial tissue, mucus plugging, reduced collagen density in the airway wall, and loss of radial alveolar attachments were associated with airflow limitation. The major determinant of airflow limitation related to small airways was found to be the loss of alveolar attachments, which may be mediated by neutrophilic inflammation. Additionally, quantitative analysis of CT scans found an association between the extent of emphysema and loss of alveolar attachments.
Article
Hematology
Peter G. Miller, Dandi Qiao, Joselyn Rojas-Quintero, Michael C. Honigberg, Adam S. Sperling, Christopher J. Gibson, Alexander G. Bick, Abhishek Niroula, Marie E. McConkey, Brittany Sandoval, Brian C. Miller, Weiwei Shi, Kaushik Viswanathan, Matthew Leventhal, Lillian Werner, Matthew Moll, Brian E. Cade, R. Graham Barr, Adolfo Correa, L. Adrienne Cupples, Sina A. Gharib, Deepti Jain, Stephanie M. Gogarten, Leslie A. Lange, Stephanie J. London, Ani Manichaikul, George T. O'Connor, Elizabeth C. Oelsner, Susan Redline, Stephen S. Rich, Jerome I. Rotter, Vasan Ramachandran, Bing Yu, Lynette Sholl, Donna Neuberg, Siddhartha Jaiswal, Bruce D. Levy, Caroline A. Owen, Pradeep Natarajan, Edwin K. Silverman, Peter van Galen, Yohannes Tesfaigzi, Michael H. Cho, Benjamin L. Ebert
Summary: Somatic mutations in blood cells are associated with the development and severity of chronic obstructive pulmonary disease (COPD), independent of age and smoking.
Review
Respiratory System
Monica L. L. Mullin, Stephen Milne
Summary: This review summarizes recent findings regarding the role of vitamin D in chronic obstructive pulmonary disease (COPD). Although there are many known associations between vitamin D and COPD outcomes, the causal nature of these associations and the precise benefits of vitamin D supplementation remain unclear. High-quality randomized controlled trials are necessary.
CURRENT OPINION IN PULMONARY MEDICINE
(2023)
Review
Respiratory System
Mairi MacLeod, Alberto Papi, Marco Contoli, Bianca Beghe, Bartolome R. Celli, Jadwiga A. Wedzicha, Leonardo M. Fabbri
Summary: Exacerbations in COPD significantly impact disease progression, comorbidities, wellbeing, and mortality. They represent a major socioeconomic burden. Current definitions of exacerbations focus on worsening respiratory symptoms, but other factors can also contribute. Objective measurements like blood counts and C-reactive protein should be used to improve accuracy in diagnosis. Acute management includes interventions like corticosteroids, antibiotics, and non-invasive ventilation. Long-term prevention strategies, such as inhaled therapy and tailored approaches based on clinical phenotypes, are needed to better manage exacerbations.
Article
Immunology
Charlotte de Fays, Vincent Geudens, Iwein Gyselinck, Pieterjan Kerckhof, Astrid Vermaut, Tinne Goos, Marie Vermant, Hanne Beeckmans, Janne Kaes, Jan Van Slambrouck, Yousry Mohamady, Lynn Willems, Lucia Aversa, Emanuela E. Cortesi, Charlotte Hooft, Gitte Aerts, Celine Aelbrecht, Stephanie Everaerts, John E. McDonough, Laurens J. De Sadeleer, Sophie Gohy, Jerome Ambroise, Wim Janssens, Laurens J. Ceulemans, Dirk Van Raemdonck, Robin Vos, Tillie L. Hackett, James C. Hogg, Naftali Kaminski, Ghislaine Gayan-Ramirez, Charles Pilette, Bart M. Vanaudenaerde
Summary: This study investigated the mucosal immune defense in control and end-stage COPD lungs, and found dysregulation in mucosal defense, with decreased defensins and increased mucus and IgA responses. The study also observed CD8+ T-cell accumulation in mild emphysema zones and adaptive Th and B cell activation in areas with more advanced tissue destruction. The study suggests that innate immune alterations in COPD occur early in the tissue destruction process, affecting both the alveoli and the terminal bronchioles, before the onset of an adaptive immune response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Humairat H. Rahman, Danielle Niemann, Stuart H. Munson-McGee
Summary: This study investigated the correlation between asthma, emphysema, chronic bronchitis, chronic obstructive lung disease (COPD) and lung cancer in the US adult population. The study found a significant correlation between emphysema, chronic bronchitis, COPD and lung cancer. However, no correlation was established between asthma and lung cancer.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Praneeth Reddy Amudala Puchakayala, Venkata L. Sthanam, Arie Nakhmani, Muhammad F. A. Chaudhary, Abhilash Kizhakke Puliyakote, Joseph M. Reinhardt, Chengcui Zhang, Surya P. Bhatt, Sandeep Bodduluri
Summary: This study evaluated the performance of radiomics features in the diagnosis of COPD and found that a combination of features representing parenchymal texture and lung and airway shape on inspiratory CT scans can accurately detect COPD.
Article
Nutrition & Dietetics
Maria Minter, Hanna Augustin, Jenny van Odijk, Lowie E. G. W. Vanfleteren
Summary: This study aimed to assess vitamin D status and determinants of vitamin D insufficiency in patients with COPD in Southwestern Sweden. The results showed that vitamin D insufficiency is common in patients with COPD and is related to male gender, smoking habits, lack of supplements containing vitamin D, and the winter season for blood sampling.
Article
Biochemistry & Molecular Biology
Sheng-Ming Wu, Wei-Lun Sun, Kang-Yun Lee, Cheng-Wei Lin, Po-Hao Feng, Hsiao-Chi Chuang, Shu-Chuan Ho, Kuan-Yuan Chen, Tzu-Tao Chen, Wen-Te Liu, Chien-Hua Tseng, Oluwaseun Adebayo Bamodu
Summary: This study in Taiwanese patients with COPD emphysema identified BMI, lnc-IL7R, PM2.5, PM10, and SO2 as predictors of disease severity and progression. Geospatial analysis showed that areas with high BMI and lnc-IL7R but low air pollutant levels had fewer COPD cases, while areas with high air pollutant levels but low BMI and lnc-IL7R had more cases and exacerbated conditions. The prediction model effectively differentiated patients with mild/no COPD from moderate/severe cases, with high precision.
Article
Public, Environmental & Occupational Health
Peter J. Castaldi, Zhonghui Xu, Kendra A. Young, John E. Hokanson, David A. Lynch, Stephen M. Humphries, James C. Ross, Michael H. Cho, Craig P. Hersh, James D. Crapo, Matthew Strand, Edwin K. Silverman
Summary: This study found that there is significant variation in the severity of emphysema in patients with COPD. By analyzing a large cohort of COPD patients, the study demonstrated that patients with emphysema-predominant disease (EPD) have a greater decline in lung function and a higher risk of mortality compared to patients with non-emphysema-predominant disease (NEPD).
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Letter
Allergy
Hyun Lee, Jiin Ryu, Sung Jun Chung, Dong Won Park, Tai Sun Park, Ji-Yong Moon, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon, Sang-Heon Kim
Article
Allergy
Paul E. Pfeffer, Nasloon Ali, Ruth Murray, Charlotte Ulrik., Trung N. Tran, Jorge Maspero, Matthew Peters, George C. Christoff, Mohsen Sadatsafavi, Carlos A. Torres-Duque, Alan Altraja, Lauri Lehtimaki, Nikolaos G. Papadopoulos, Sundeep Salvi, Richard W. Costello, Breda Cushen, Enrico Heffler, Takashi Iwanaga, Mona Al-Ahmad, Desiree Larenas-Linnemann, Piotr Kuna, Joao A. Fonseca, Riyad Al-Lehebi, Chin Kook Rhee, Luis Perez-de-Llano, Diahn-Warng Perng Steve, Bassam Mahboub, Eileen Wang, Celine Goh, Juntao Lyu, Anthony Newell, Marianna Alacqua, Andrey S. Belevskiy, Mohit Bhutani, Leif Bjermer, Unnur Bjornsdottir, Arnaud Bourdin, Anna von Boulow, John Busby, Giorgio Walter Canonica, Borja G. Cosio, Delbert R. Dorscheid, Mariana Munoz-Esquerre, J. Mark FitzGerald, Esther Garcia Gil, Peter G. Gibson, Liam G. Heaney, Mark Hew, Ole Hilberg, Flavia Hoyte, David J. Jackson, Mariko Siyue Koh, Hsin-Kuo Bruce Ko, Jae Ha Lee, Sverre Lehmann, Claudia Chaves Loureiro, Dora Ludviksdottir, Andrew N. Menzies-Gow, Patrick Mitchell, Andriana I. Papaioannou, Todor A. Popov, Celeste M. Porsbjerg, Laila Salameh, Concetta Sirena, Camille Taille, Christian Taube, Yuji Tohda, Michael E. Wechsler, David B. Price
Summary: This study aimed to describe the profile of severe asthma patients eligible for both anti-IgE and anti-IL5/5R and compare the effectiveness of these two treatments in real-life settings. The results showed that anti-IL5/5R was superior to anti-IgE in reducing asthma exacerbations and long-term oral corticosteroid use, while there was some evidence suggesting a decrease in asthma-related hospitalizations with anti-IL5/5R treatment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyunjung Park, Jihye Yun, Sang Min Lee, Hye Jeon Hwang, Joon Beom Seo, Young Ju Jung, Jeongeun Hwang, Se Hee Lee, Sei Won Lee, Namkug Kim
Summary: In this study, a deep learning algorithm was developed to predict pulmonary function using low-dose CT images in participants undergoing health screening. The algorithm showed relatively good performance in predicting pulmonary function.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sohee Park, Sang Min Lee, Jooae Choe, Sehoon Choi, Kyung-Hyun Do, Joon Beom Seo
Summary: This retrospective study investigates the recurrence patterns and outcomes in patients with resected lung adenocarcinoma, comparing those with and without ground-glass opacity (GGO) at CT.
Article
Public, Environmental & Occupational Health
YouHyun Park, Jun Hyuk Koo, Hoyeon Jeong, Ji Ye Jung, Changsoo Kim, Dae Ryong Kang
Summary: This study investigates the effects of an air quality warning system (AQWS) implemented in Korea in 2015 on the incidence and exacerbation rates of environmental diseases. The results show that the AQWS has led to a gradual decrease in asthma incidence, as well as significant decreases in cardiovascular disease and stroke incidence. However, there was no immediate or gradual decrease in the exacerbation rate of any environmental disease. The findings suggest that tailoring the AQWS to demographic and sociological characteristics and providing enhanced education can effectively reduce air pollution-related health risks.
EPIDEMIOLOGY AND HEALTH
(2023)
Letter
Respiratory System
Changhwan Kim, Yousang Ko, Jae Seung Lee, Chin Kook Rhee, Jin Hwa Lee, Ji-Yong Moon, Seong Yong Lim, Kwang Ha Yoo, Joon Beom Seo, Yeon-Mok Oh, Sang-Do Lee, Yong Bum Park
Article
Computer Science, Artificial Intelligence
Kyungjin Cho, Jeeyoung Kim, Ki Duk Kim, Seungju Park, Junsik Kim, Jihye Yun, Yura Ahn, Sang Young Oh, Sang Min Lee, Joon Beom Seo, Namkug Kim
Summary: A major responsibility of radiologists is to read follow-up chest radiographs and differentiate meaningful changes from natural or benign variations. This study proposes the use of a multi-task Siamese convolutional vision transformer with an anatomy-matching module to mimic the radiologist's cognitive process.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Medicine, General & Internal
Jieun Kang, Ji-Yong Moon, Deog Kyeom Kim, Jin Woo Kim, Seung Hun Jang, Hyeon-Kyoung Koo
Summary: Although cough is a common symptom, determining its cause is challenging. This study explored how cough severity and characteristics vary with different etiologies, and their associations with demographic features. Demographic features such as age and sex showed complex associations with cough characteristics and severity, with different patterns based on the etiology.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Juwhan Choi, Jae Jeong Shim, Myung Goo Lee, Chin Kook Rhee, Hyonsoo Joo, Jin Hwa Lee, Hye Yun Park, Woo Jin Kim, Soo-Jung Um, Deog Kyeom Kim, Kyung Hoon Min
Summary: This study investigated the correlation between air pollution and respiratory pathogens in severe AECOPD. It found that air pollution may increase the risk of respiratory viral infections in COPD patients, especially influenza virus A. Therefore, COPD patients need to be more cautious about respiratory infections on days with poor air quality.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Sang Hyuk Kim, Hyun Lee, Youlim Kim, Chin Kook Rhee, Kyung Hoon Min, Yong Il Hwang, Deog Kyeom Kim, Yong Bum Park, Kwang Ha Yoo, Ji-Yong Moon
Summary: The prevalence of COPD in South Korea remains stable, with a relatively high rate among individuals aged 70 years and older. Aging is a significant risk factor for COPD, along with male sex, asthma, and current smoking. Conversely, a higher body mass index is inversely associated with COPD.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Respiratory System
Joon Young Choi, Chin Kook Rhee, Kwang Ha Yoo, Ki-Suck Jung, Jae Ha Lee, Hyoung Kyu Yoon, Seung Won Ra, Myung Goo Lee, Yong Suk Jo
Summary: This study identified the heterogeneity of asthma-COPD overlap (ACO) from patients with severe asthma and COPD using the same diagnostic criteria. The prevalence of ACO was similar in severe asthma and COPD cohorts, and ACO from both cohorts had similar lung function and exacerbation risk.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2023)
Article
Medicine, General & Internal
Tai Joon An, Ji Hye Kim, Jung Hur, Chan Kwon Park, Jeong Uk Lim, Seohyun Kim, Chin Kook Rhee, Hyoung Kyu Yoon
Summary: This study found that tiotropium bromide (TIO) plays a significant role in neutrophilic asthma by recovering histone deacetylase 2 (HDAC2) activity and regulating the transcription of inflammatory cytokines. Experimental results from mouse models and asthma patients' cells showed that TIO can improve NF-KB activity, CXCL1 levels, and HDAC2 activity. These findings suggest that TIO modulates inflammation by restoring HDAC2 activity, possibly through the PLC gamma-1-IP3-IP3R-mediated intracellular calcium ion pathway.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Gil -Sun Hong, Miso Jang, Sunggu Kyung, Kyungjin Cho, Jiheon Jeong, Grace Yoojin Lee, Keewon Shin, Ki Duk Kim, Seung Min Ryu, Joon Beom Seo, Sang Min Lee, Namkug Kim
Summary: Artificial intelligence in radiology is rapidly advancing, but there are several challenges to its successful implementation, such as limited data, privacy concerns, and data heterogeneity. This review discusses potential solutions to these challenges, including training with diverse datasets, using generative models for image modification and synthesis, and explainable AI.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Medicine, General & Internal
Bo-Guen Kim, Hyun Lee, Min Gu Kang, Jong Seung Kim, Ji-Yong Moon
Summary: This study used a longitudinal database to investigate the risk of ischemic heart disease (IHD) in patients with chronic obstructive pulmonary disease (COPD) and found that COPD patients had a higher risk of developing IHD, independent of demographic characteristics and health-related behaviors.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)