Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

(2018) Jennifer R. Molina et al.   NATURE MEDICINE

The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation

(2018) Fabienne Lampert et al.   eLife

Global interactomics uncovers extensive organellar targeting by Zika virus

(2018) Etienne Coyaud et al.   MOLECULAR & CELLULAR PROTEOMICS

The thymidine dideoxynucleoside analogue, alovudine, inhibits the mitochondrial DNA polymerase γ, impairs oxidative phosphorylation and promotes monocytic differentiation in acute myeloid leukemia

(2018) Dana Yehudai et al.   HAEMATOLOGICA

Ovarian serous carcinomas acquire cisplatin resistance and increased invasion through downregulation of the high-temperature-required protein A2 (HtrA2), following repeated treatment with cisplatin

(2017) Hiroaki Soyama et al.   MEDICAL ONCOLOGY

LACTB is a tumour suppressor that modulates lipid metabolism and cell state

(2017) Zuzana Keckesova et al.   NATURE

Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

(2017) Thomas Farge et al.   Cancer Discovery

A New Function of Human HtrA2 as an Amyloid-β Oligomerization Inhibitor

(2017) Joel Kooistra et al.   JOURNAL OF ALZHEIMERS DISEASE

Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex

(2016) Martijn A. Huynen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The MICOS complex of human mitochondria

(2016) Vera Kozjak-Pavlovic   CELL AND TISSUE RESEARCH

Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone

(2016) Victor S. Van Laar et al.   NEUROBIOLOGY OF DISEASE

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

(2015) S. Sriskanthadevan et al.   BLOOD

Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2015) Alicia Cole et al.   CANCER CELL

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface

(2015) Gagan D. Gupta et al.   CELL

BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2E3 Ligase Substrates

(2015) Etienne Coyaud et al.   MOLECULAR & CELLULAR PROTEOMICS

New roles for mitochondrial proteases in health, ageing and disease

(2015) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins

(2015) Sarah E. Calvo et al.   NUCLEIC ACIDS RESEARCH

QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology

(2015) Virginia Guarani et al.   eLife

The Protein Import Machinery of Mitochondria—A Regulatory Hub in Metabolism, Stress, and Disease

(2014) Angelika B. Harbauer et al.   Cell Metabolism

p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion

(2014) Shota Yamauchi et al.   JOURNAL OF CELL BIOLOGY

Thei-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

(2014) Ruchika Anand et al.   JOURNAL OF CELL BIOLOGY

Proteomic Mapping of the Human Mitochondrial Intermembrane Space in Live Cells via Ratiometric APEX Tagging

(2014) Victoria Hung et al.   MOLECULAR CELL

Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease

(2014) Hilal Unal Gulsuner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing nuclear pore complex architecture with proximity-dependent biotinylation

(2014) D. I. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

SAINTexpress: Improvements and additional features in Significance Analysis of INTeractome software

(2013) Guoci Teo et al.   Journal of Proteomics

Mitochondrial protein import: Common principles and physiological networks

(2012) Jan Dudek et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging

(2012) S Kang et al.   CELL DEATH AND DIFFERENTIATION

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

(2012) Kyle J. Roux et al.   JOURNAL OF CELL BIOLOGY

Role of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria

(2012) Bernadette Schreiner et al.   MOLECULAR BIOLOGY OF THE CELL

Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2011) Marko Škrtić et al.   CANCER CELL

The Intermembrane Space of Mitochondria

(2010) Johannes M. Herrmann et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial proteases and cancer

(2010) Anne-Laure Bulteau et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1

(2010) Nicole Kieper et al.   EXPERIMENTAL CELL RESEARCH

ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function

(2010) Manjula Darshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deregulation of Mitochondrial Membrane Potential by Mitochondrial Insertion of Granzyme B and Direct Hax-1 Cleavage

(2010) Jie Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Wilms' Tumor Suppressor Protein WT1 Is Processed by the Serine Protease HtrA2/Omi

(2010) Jörg Hartkamp et al.   MOLECULAR CELL

SAINT: probabilistic scoring of affinity purification–mass spectrometry data

(2010) Hyungwon Choi et al.   NATURE METHODS

The Role of Mitochondria in Apoptosis

(2009) Chunxin Wang et al.   Annual Review of Genetics

Emerging roles of mitochondrial proteases in neurodegeneration

(2009) Paola Martinelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Recognition of misfolded proteins by Lon, a AAA+ protease

(2008) E. Gur et al.   GENES & DEVELOPMENT