Article
Food Science & Technology
Erica Pontonio, Marco Montemurro, Gina Valeria De Gennaro, Valerio Miceli, Carlo Giuseppe Rizzello
Summary: A biotechnological protocol was developed to obtain bioactive peptides with ACE-inhibitory activity from the ricotta cheese exhausted whey (RCEW) by combining membrane filtration and fermentation. The fermented protein-rich retentate showed high anti-ACE activity, with identified peptides overlapping with previously reported antihypertensive fragments. The fortified ricotta cheese with fermented retentate exhibited significantly higher anti-ACE activity and improved sensory properties compared to the control and unfermented samples.
Article
Food Science & Technology
Emilio Francesco Ricciardi, Matteo Alessandro Del Nobile, Amalia Conte, Francesco Fracassi, Eloisa Sardella
Summary: This study tested two innovative plasma assisted approaches to prolong the shelf life of ricotta cheese. The results showed that both treatments were effective in controlling microbial proliferation and preserving sensory quality, leading to a significant shelf life extension.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2022)
Article
Food Science & Technology
Franks Kamgang Nzekoue, Alessandro Alesi, Sauro Vittori, Gianni Sagratini, Giovanni Caprioli
Summary: This study evaluated the stability of phytosterols in whey cheese during processing and storage, developing an innovative analytical method for sterol determination. The results showed good heat-stability of phytosterols in the cheese matrix and maintained bioactivity during shelf-life.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Review
Agriculture, Dairy & Animal Science
G. Mangione, M. Caccamo, A. Natalello, G. Licitra
Summary: This review focused on the historical, technological, and analytical characteristics of ricotta cheese. It highlighted the biodiversity in production and the factors influencing the final product. The review also discussed the development of new trends in ricotta cheese production and the challenges faced in bringing these developments to market.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Nahuel E. Casa, Julieta Lois-Milevicich, Paola Alvarez, Ricardo Mateucci, Marina de Escalada Pla
Summary: The batch production of Chlorella vulgaris using ricotta cheese whey as a growth media was evaluated. Different pre-treatment methods were tested, and tangential flow microfiltration showed the best performance. Macronutrient supplementation did not enhance the biomass production.
JOURNAL OF APPLIED PHYCOLOGY
(2022)
Article
Food Science & Technology
Azis Boing Sitanggang, Julius Sumitra, Slamet Budijanto
Summary: This study used a combination of fermentation and in vitro enzymatic hydrolysis to produce bioactive peptides with antioxidant and AICE inhibitory properties. The automated membrane reactor system developed in this study allowed for continuous hydrolysis of tempe flour under optimal conditions, resulting in increased functionality of the peptides. This innovative approach is expected to enhance the commercialization of tempe-based food products.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2021)
Article
Chemistry, Multidisciplinary
Marian Rofeal, Fady Abdelmalek
Summary: In order to enhance the reliability and performance of active biodegradable and sustainable biomaterials for food preservation, physically stable layer by layer (LBL) and multilayer films were developed. These films, made from gelatin, xanthan and crosslinked by Echinacea purpurea extract, showed improved mechanical properties, oxygen and water vapor barriers, as well as antioxidant capacities. The films also demonstrated controlled release of the active ingredient in acidic environments and exhibited strong antimicrobial properties. The use of these films in packaging can help maintain food quality and microbiological safety.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Microbiology
Roberta Coronas, Giacomo Zara, Antonio Gallo, Gabriele Rocchetti, Marco Lapris, Giacomo Luigi Petretto, Severino Zara, Francesco Fancello, Ilaria Mannazzu
Summary: In this study, 47 strains of propionibacteria and acidopropionibacteria were isolated from goat cheese, milk, and ewe rumen liquor. These strains were characterized and evaluated for their potential in the production of novel pro-bioactive food. Four strains showed high resistance and were selected for further investigation. These strains exhibited capability in producing vitamins B9 and B12.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Francesca Bosco, Simona Cirrincione, Riccardo Carletto, Luca Marmo, Francesco Chiesa, Roberto Mazzoli, Enrica Pessione
Summary: The urgent need to expand the market of biodegradable alternatives to oil-derived plastics is highlighted due to limited oil availability and the negative impact of traditional plastics on ecosystems. Polyhydroxyalkanoates (PHAs) show promise as biodegradable polymers produced through microbial fermentation of agro-industrial byproducts. Isolation of PHA-producing strains from a mixed microbial culture (MMC), including Citrobacter freundii and Leuconostoc spp., revealed their potential for PHA accumulation in synthetic media. Further validation of Leuconostoc mesenteroides' ability to produce PHA from agro-industrial byproducts is needed, marking the first study reporting PHA production with the Leuconostoc genus.
Article
Food Science & Technology
Aysun Altinyuzuk Akilli, Ozgur Cem Erkin, Levent Yurdaer Aydemir, Zafer Erbay
Summary: This study aimed to explore the bioactive potentials of enzyme-modified cheese (EMC) during production stages and after digestion. The results showed that EMC has antioxidant, antihypertensive, antidiabetic, antimicrobial, and antiproliferative potentials. Further research is needed to investigate the components formed during production stages in detail.
INTERNATIONAL DAIRY JOURNAL
(2023)
Article
Chemistry, Medicinal
Bruno Inarra, Carlos Bald, Monica Gutierrez, David San Martin, Jaime Zufia, Jone Ibarruri
Summary: This study utilized fish by-catch to produce bioactive protein hydrolysates and successfully scaled up the process based on optimized conditions. The results confirmed the technical feasibility of this proposed method.
Article
Biotechnology & Applied Microbiology
Qi Liu, Yushan Yao, Mahmoud A. A. Ibrahim, Ali Mahmoud El Halawany, Li Yang, Xuewu Zhang
Summary: Squid processing by-product was hydrolyzed using 6 proteases, with neutral protease producing the most promising ACE inhibitory activity. The optimal hydrolysis conditions were determined, and the hydrolysate showed high ACE and renin inhibitory activities. However, these activities decreased after digestion by simulated gastrointestinal juice.
MARINE BIOTECHNOLOGY
(2022)
Review
Chemistry, Applied
Ildephonse Habinshuti, Daniel Nsengumuremyi, Bertrand Muhoza, Falade Ebenezer, Afusat Yinka Aregbe, Marc Antoine Ndisanze
Summary: Antioxidant peptides obtained from enzymatic hydrolysis of food proteins have a wide range of bioactivities against reactive oxygen species and pro-oxidative substances. Increasing the yield of antioxidant peptides and reducing enzyme quantity and reaction time are the main challenges. Various food processing technologies such as thermal, ultrasound, microwave, high hydrostatic pressure, and pulsed electric field have been developed to enhance enzymatic hydrolysis and production of antioxidant peptides. These technologies induce protein denaturation/unfolding and enzymatic activation without altering their functional and nutritional properties.
Review
Food Science & Technology
Tolulope Joshua Ashaolu, Chi Ching Lee, Joseph Opeolu Ashaolu, Ozgur Tarhan, Hadi Pourjafar, Seid Mahdi Jafari
Summary: This review focuses on the use of pepsin as a unique protease for generating bioactive peptides (BPs). The properties of BPs and proteases are described, followed by the discussion on pepsin's characteristics and immobilization for BP production. Peptic hydrolysis of unconventional protein sources such as vegetables, fish, seafood, whey, casein, blood plasma, and egg proteins is discussed, highlighting the generation of BPs with various biological activities. The review concludes with the application of BPs in developing food products for their techno-functional properties.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Agriculture, Multidisciplinary
Meng Gui, Liang Gao, Lei Rao, Pinglan Li, Ying Zhang, Jia-Wei Han, Jun Li
Summary: The study demonstrated that sturgeon skin protein extract hydrolyzed by flavourzyme generated bioactive peptides with antioxidant, DPP-IV inhibitory, and ACE inhibitory activities. Peptides such as P1, P6, P11, and P12 showed strong bioactive properties and potential for use in the health food industry. The molecular docking analysis revealed the mechanisms of action for the bioactive peptides in inhibiting DPP-IV and ACE activities.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Polymer Science
Claudio Russo, Jose Luis Ramirez, Xavier Fernandez-Francos, Silvia De la Flor
Summary: In this study, electro-responsive shape-memory actuators were developed by incorporating a conductive heater in a dual-curing thiol-acrylate-epoxy shape-memory polymer. The addition of boron nitride agglomerates increased thermal conductivity and achieved faster shape-recovery. The results demonstrated that the electro-responsive actuators were faster in shape recovery compared to the conventional SMPs based on external heating.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
F. Settepani, A. Cappai, A. Cannata, B. Merlanti, M. Carrozzini, G. Olivieri, A. Costetti, C. Russo
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2022)
Review
Biochemistry & Molecular Biology
Daniela Passarella, Silvia Ciampi, Valentina Di Liberto, Mariachiara Zuccarini, Maurizio Ronci, Alessandro Medoro, Emanuele Fodera, Monica Frinchi, Donatella Mignogna, Claudio Russo, Carola Porcile
Summary: The low-density-lipoprotein receptors, including LRP8, play a crucial role in lipid homeostasis, cell migration, proliferation, and differentiation, and are involved in both cancer and neurodegenerative diseases. LRP8 is overexpressed in various types of cancer and also has potential roles in neurodegeneration, acting as a receptor for ApoE and reelin, and a substrate for gamma-secretase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Daniela Passarella, Maurizio Ronci, Valentina Di Liberto, Mariachiara Zuccarini, Giuseppa Mudo, Carola Porcile, Monica Frinchi, Patrizia Di Iorio, Henning Ulrich, Claudio Russo
Summary: Recent studies have found that cerebral cholesterol formation is primarily controlled by astrocytes, which synthesize cholesterol and deliver it to neurons and oligodendrocytes through specific lipoprotein receptors. Various proteins and carbohydrates modulate the cholesterol shuttle, affecting lipoprotein receptor activity, function, and signaling. Purine receptors, particularly subtypes P2Y(2), P2X(7), and A(2A), play a role in neurodegenerative diseases such as Alzheimer's and Niemann-Pick C diseases by regulating brain cholesterol homeostasis. The precise mechanisms of these interactions are not well understood, but further research in the cholesterol-purine reciprocal control is warranted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Oncology
G. Finocchiaro, M. Eoli, F. Farina, B. Gentner, A. Capotondo, E. Anghileri, M. Bruzzone, Q. G. D'Alessandris, A. Franzin, P. Ferroli, F. Gagliardi, F. Legnani, S. Mazzoleni, A. Olivi, R. Pallini, M. Saini, A. Zambanini, L. Naldini, C. Russo, F. Ciceri
ANNALS OF ONCOLOGY
(2022)
Meeting Abstract
Oncology
G. Finocchiaro, M. Eoli, B. Gentner, M. Bruzzone, F. Di Meco, P. Mortini, A. Olivi, L. Naldini, C. Russo, F. Ciceri
Article
Polymer Science
Stefano Bianchi, Paola Marchese, Micaela Vannini, Laura Sisti, Annalisa Tassoni, Maura Ferri, Norma Mallegni, Patrizia Cinelli, Annamaria Celli
Summary: In this study, the antioxidant activity of natural phenolic compounds extracted from coffee residues was evaluated. The addition of these compounds to a poly(1,4-butylene succinate) matrix was found to increase the activation energy of thermo-oxidative degradation. The results were consistent with the ABTS radical scavenging assay, highlighting the potential of using active molecules from agri-food waste to enhance the antioxidant capacity of biopolymers.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Food Science & Technology
Monica Bergamaschi, Nicoletta Simoncini, Vincenzo Maria Spezzano, Maura Ferri, Annalisa Tassoni
Summary: This study assessed the effects of polyphenol-rich extract from non-compliant defatted green coffee beans on the properties and sensory profile of vacuum-packed pork burgers. The results suggest that 0.15% coffee extract is a promising alternative to improve the quality of refrigerated pork burgers.
Article
Food Science & Technology
Maura Ferri, Vasco Lima, Alessandro Zappi, Ana Luisa Fernando, Dora Melucci, Annalisa Tassoni
Summary: In the past 20 years, researchers have shown increased interest in using different types and combinations of enzymes to extract phenolic compounds from grape pomace. This study aimed to improve the recovery of phenolic compounds from Merlot and Garganega pomace using five commercial cellulolytic enzymes. The results showed that the enzyme/substrate ratio and incubation time had significant effects on the extraction yield, and the use of different enzymes resulted in different compositions of the extracts. The enzymatic and acetone extracts were found to be complex mixtures of compounds.
Article
Psychology, Multidisciplinary
Luna Carpinelli, Giulia Savarese, Claudio Russo, Giovanna Stornaiuolo, Ettore Luisi, Francesca Pellegrino, Monica Mollo, Maria Teresa Pellecchia
Summary: Parkinson's disease (PD) is a chronic progressive neurological disease that affects both patients and caregivers. In our study, we found that female caregivers who cohabited with PD patients experienced higher burden compared to non-cohabiting caregivers. The burden was particularly severe in 7.7% of the participants according to the PQoL. The findings emphasize the importance of investigating the burden on PD caregivers and addressing their physical and psychological health to improve their quality of life.
Article
Plant Sciences
Antony van der Ent, Mirko Salinitro, Dennis Brueckner, Kathryn M. Spiers, Sofia Montanari, Annalisa Tassoni, Michela Schiavon
Summary: This study investigates the distribution of selenium in three hyperaccumulator species and reveals significant differences among them, suggesting different physiological mechanisms for selenium handling and storage. The findings imply that selenium hyperaccumulation may have evolved multiple times under similar environmental pressures.
Article
Cardiac & Cardiovascular Systems
Maurizio Bottiroli, Angelo Calini, Nuccia Morici, Guido Tavazzi, Luca Galimberti, Clorinda Facciorusso, Enrico Ammirati, Claudio Russo, Alberto Montoli, Michele Mondino
Summary: AKI is a common and early complication in patients with acute decompensated heart failure complicated by cardiogenic shock. Central venous pressure and serum lactate level are independently associated with AKI. Age and AKI stage are independent predictors of 90-day mortality.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Plant Sciences
Stefania Monari, Maura Ferri, Mirko Salinitro, Annalisa Tassoni
Summary: This study compares the levels of primary and secondary metabolites in different plant organs of seven wild plant species and finds that flower and leaf extracts contain higher levels of polyphenols, reducing sugars, proteins, and antioxidant capacity. The results also validate the traditional healing effects of these species on human health.