Review
Oncology
Xavier Roussel, Francine Garnache Ottou, Florian Renosi
Summary: Plasmacytoid dendritic cells (pDC) are the main type I interferon-producing cells in humans and are capable of regulating innate and adaptive immune responses. Tumor infiltration by pDC is well-documented in various cancers and is associated with unfavorable clinical outcomes. While Blastic Plasmacytoid Dendritic Cells Neoplasm (BPDCN) is a well-described aggressive leukemia derived from pDCs, the understanding of tumor infiltration by mature pDCs in Myeloid Neoplasms (MN) is limited. This review aims to provide a comprehensive overview of pDC biology in MN, emphasizing the need for further research into pDC oncogenesis and immune responses for better therapeutic strategies.
Review
Oncology
Juan Peng, Shaolong He, Xingcheng Yang, Liang Huang, Jia Wei
Summary: This review discusses the classification and expansion of plasmacytoid dendritic cells (pDCs) in neoplasms and explores their relationship with mature plasmacytoid dendritic myeloid neoplasm (MPDMN).
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Giulio Verna, Marina Liso, Elisabetta Cavalcanti, Giusy Bianco, Veronica Di Sarno, Angelo Santino, Pietro Campiglia, Marcello Chieppa
Summary: Dendritic cells can be divided into myeloid dendritic cells and plasmacytoid dendritic cells, which play important roles in regulating immune responses. Inflammatory bowel diseases are characterized by leaky intestinal barrier and translocation of bacterial lipopolysaccharide. It was found that quercetin can modulate dendritic cell responses through a specific molecular pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Wei Wang, Jie Xu, Joseph D. Khoury, Naveen Pemmaraju, Hong Fang, Roberto N. Miranda, C. Cameron Yin, Siba El Hussein, Fuli Jia, Zhenya Tang, Shimin Hu, Marina Konopleva, L. Jeffrey Medeiros, Sa A. Wang
Summary: This study investigated the immunophenotypic and molecular profiles of pDC-AML and BPDCN and found that they have different phenotypes and mutation profiles, indicating that they are two distinct entities.
Article
Multidisciplinary Sciences
Meiling Zheng, Zhi Hu, Xiaole Mei, Lianlian Ouyang, Yang Song, Wenhui Zhou, Yi Kong, Ruifang Wu, Shijia Rao, Hai Long, Wei Shi, Hui Jing, Shuang Lu, Haijing Wu, Sujie Jia, Qianjin Lu, Ming Zhao
Summary: This study compares the differences between cutaneous lesions from DLE and SLE patients and healthy controls using single-cell RNA sequencing data. The findings reveal differential immune cell recruitment, cell type, and gene expression, highlighting potential therapeutic targets for lupus erythematosus.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Huiguo Chen, Jianfeng Tan, Xiaojun Li, Hui Li, Weibin Wu, Yonghui Wu, Jian Zhang, Lijia Gu
Summary: The study demonstrated that a combined vaccine of myeloid dendritic cells and plasmacytoid dendritic cells loaded with heat-treated cancer cell lysates can enhance T lymphocyte proliferation and increase CTL-mediated cytotoxicity against lung cancer cells, leading to significant inhibition of tumor growth.
Review
Cell Biology
Meng Feng, Shuping Zhou, Yong Yu, Qinghong Su, Xiaofan Li, Wei Lin
Summary: Dendritic cells (DCs) are a class of antigen-presenting cells with crucial roles in immune activation and tolerance. Understanding the migration mechanisms and regulatory factors of different DC subgroups provides new insights for disease treatment, such as infection, tumors, and vaccine preparation. Various factors, including chemokines, membrane molecules, and microenvironments, influence DC migration and immunological functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Ya-Qi Peng, De-Hua Chen, Zhi-Bin Xu, Shu-Bing Fang, Bi-Xin He, Xiao-Qing Liu, Cezmi A. Akdis, Qing-Ling Fu
Summary: This study examined the levels of ST2+mDCs and ST2+pDCs in the blood of patients with allergic rhinitis (AR) and healthy subjects, revealing higher levels of these cells in AR patients, especially after allergen inhalation. Additionally, the study found that IL-33 treatment increased the expression of ST2 on mDCs, suggesting a potential role of the IL-33/ST2 axis in the pathogenesis of allergic rhinitis by dendritic cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Hematology
Siba El Hussein, Wei Wang
Summary: In this article, three pathologic presentations of plasmacytoid dendritic cells (pDCs) associated with myeloid neoplasms are described. These include mature pDC expansion in myeloid neoplasms such as chronic myelomonocytic leukaemia (CMML), pDC differentiation in myeloid neoplasms such as acute myeloid leukaemia (AML), and myeloid neoplasms associated with blastic plasmacytoid dendritic cell neoplasm (BPDCN). A diagnostic algorithm for pathologic classification and clarification of nomenclatures pertaining to pDC biological states is provided.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Immunology
Marianna Halasi, Aviv Talmon, Yuval Tal, Gil Yosipovitch, Irit Adini
Summary: According to epidemiological research, skin autoimmune diseases are more common among black Americans. This study investigates the role of pigment production in immune responses mediated by dendritic cell activation. It is found that darkly pigmented melanocytes produce more IL-3, IL-6, and TNF-alpha, leading to plasmacytoid DC maturation. Additionally, low pigment-associated fibromodulin interferes with cytokine secretion and pDC maturation.
CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Wei Zhang, Eun-Koung An, Juyoung Hwang, Jun-O Jin
Summary: The study found that LPS can directly stimulate pDCs via the TLR4/MD2 pathway and promote the activation of pDCs and cDCs. cDCs may contribute to the enhancement of IFN-alpha production in pDCs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medical Laboratory Technology
Xiaofang Zhang, Yiping Wu, Chen Li, Keming Shen, Ruimin Li
Summary: The aim of this study was to investigate the clinical characteristics and diagnosis of acute myeloid leukemia with CD56- blastic plasmacytoid dendritic cell neoplasm. Three cases of elderly men with acute myeloid leukemia were analyzed retrospectively, and their bone marrow features suggested the diagnosis of acute myeloid leukemia with blastic plasmacytoid dendritic cell neoplasm. Flow cytometry and second generation sequencing were performed to detect abnormalities in myeloid cells and abnormal plasmacytoid dendritic cells, as well as gene mutations in RUNX1 and DNMT3A.
CLINICAL LABORATORY
(2023)
Article
Geriatrics & Gerontology
Yan Li, Pei Chen, Hao Huang, Huiyu Feng, Hao Ran, Weibin Liu
Summary: This study found that all common DC subsets are present in the human thymus of various ages, with the density of pDCs gradually increasing with age, suggesting an additional role of pDCs in the thymus beyond central tolerance. The ratio of medulla to cortex area in the human thymus increases with age, while the densities of different DC subsets also show changes.
Article
Immunology
Xiaodan Xiang, Yaping Wu, Hongwei Li, Cun Li, Lu Yan, Qian Li
Summary: Helicobacter pylori infection promotes SLFN4(+) MDSC differentiation by inducing secretion of IFN-alpha from pDCs, through activating the TLR9-MyD88-IRF7 pathway. IFN-alpha induces SLFN4 transcription by binding to the Slfn4 promoter.
INFECTION AND IMMUNITY
(2021)
Article
Medicine, General & Internal
Eleni Chouri, Maojie Wang, Maarten R. Hillen, Chiara Angiolilli, Sandra C. Silva-Cardoso, Catharina G. K. Wichers, Maarten van der Kroef, Cornelis P. J. Bekker, Marta Cossu, Lenny van Bon, Alsya J. Affandi, Tiago Carvalheiro, Aridaman Pandit, Joel A. G. van Roon, Lorenzo Beretta, Boudewijn M. T. Burgering, Timothy R. D. J. Radstake, Marzia Rossato
Summary: The study found that miRNA expression levels are altered in pDCs of early-stage SSc patients and may contribute to the observed pDC activation in patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Tomasz P. Wypych, Celine Pattaroni, Olaf Perdijk, Carmen Yap, Aurelien Trompette, Dovile Anderson, Darren J. Creek, Nicola L. Harris, Benjamin J. Marsland
Summary: The composition of the gut microbiome is influenced by the local habitat and immunological pressures, which can shape a community of bacteria with enhanced metabolism capabilities. By using a mouse model, researchers found that a gut microbe-derived metabolite, p-cresol sulfate, can protect against allergic airway inflammation by reducing production of CCL20 in airway epithelial cells. This suggests that the microbiome can have a distal effect on the airway epithelium and help in reducing allergic airway responses such as asthma.
Article
Biochemistry & Molecular Biology
Dorianne van Heerden, Robert S. van Binnendijk, Samantha A. M. Tromp, Huub F. J. Savelkoul, R. J. Joost van Neerven, Gerco den Hartog
Summary: The study shows that asthma-associated loTSLP can inhibit the secretion of IgA, while IL-4 and the vitamin A metabolite retinoic acid can promote IgA production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Joelle J. E. Janssen, Bart Lagerwaard, Mojtaba Porbahaie, Arie G. Nieuwenhuizen, Huub F. J. Savelkoul, R. J. Joost van Neerven, Jaap Keijer, Vincent C. J. de Boer
Summary: The mitochondrial metabolism in PBMCs from high-fit females is significantly higher than that in low-fit females, and this is not affected by PBMC composition or a recent exercise bout. Therefore, PBMC metabolism can be used as a marker to study the impact of lifestyle factors on human health.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Food Science & Technology
Bartijn C. H. Pieters, Onno J. Arntz, Joyce Aarts, Anouk L. Feitsma, R. J. Joost van Neerven, Peter M. van der Kraan, Marina C. Oliveira, Fons A. J. van de Loo
Summary: Regular milk consumption in females has been found to be associated with reduced joint cartilage loss and osteoarthritis progression. This study suggests that milk-derived extracellular vesicles (EVs) have the potential to protect cartilage by affecting chondrocytes. The EVs from cow's milk were found to reduce the release of sulfated glycosaminoglycan and inhibit the expression of cartilage destructive enzymes. The presence of TGF beta and miR-148a on these vesicles may contribute to these protective effects.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Nutrition & Dietetics
Daniela Briceno Noriega, Hannah E. Zenker, Cresci-Anne Croes, Arifa Ewaz, Janneke Ruinemans-Koerts, Huub F. J. Savelkoul, R. J. Joost van Neerven, Malgorzata Teodorowicz
Summary: Recent evidence has shown that the Maillard reaction affects the structure and function of food proteins. The modified proteins resulting from the Maillard reaction can interact with immune cells and affect their biological properties, including digestibility, bioavailability, immunogenicity, and allergenicity. Receptors on immune cells recognize these modified proteins, leading to enhanced cytokine production and immune responses. This review discusses the immunogenicity of advanced glycation end products (AGEs) in food, their interactions with immune cell receptors, and their clinical relevance in food allergies.
Article
Nutrition & Dietetics
Nicolette W. de Jong, Marloes E. van Splunter, Joyce A. M. Emons, Kasper A. Hettinga, Roy Gerth van Wijk, Harry J. Wichers, Huub F. J. Savelkoul, Aline B. Sprikkelman, R. J. Joost van Neerven, Liu Liu, Gerbrich van der Meulen, Irene Herpertz, Yvonne C. M. Duijvestijn, Mijke Breukels, Marianne I. Brouwer, Jaap Schilperoord, Olga van Doorn, Berber Vlieg-Boerstra, Jochum van den Berg, Linette Pellis, Severina Terlouw, Astrid I. Hendriks, Marco W. J. Schreurs, Frank E. van Boven, Nicolette J. T. Arends
Summary: The aim of this study was to evaluate the safety and tolerability of a new heated cow's milk protein product in cow's milk allergic children. The results showed that 72% of the children tolerated the product, while some experienced adverse events. Skin prick tests and specific IgE levels may predict the tolerability of the product.
Article
Immunology
Mati Moyat, Luc Lebon, Olaf Perdijk, Lakshanie C. Wickramasinghe, Mario M. Zaiss, Ilaria Mosconi, Beatrice Volpe, Nadine Guenat, Kathleen Shah, Gillian Coakley, Tiffany Bouchery, Nicola L. Harris
Summary: The study suggests that the complex bacterial microbiota plays a crucial role in host resistance against intestinal helminths, as the lack of a diverse bacterial microbiota reduces the host's ability to resist worm infections.
MUCOSAL IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Laurien H. Ulfman, Joyce E. L. Schloesser, Guus A. M. Kortman, Maartje van den Belt, Elly Lucas-van De Bos, Joris Roggekamp, R. J. Joost van Neerven, Mojtaba Porbahaie, Els van Hoffen, Alwine F. M. Kardinaal
Summary: Consumption of whey protein concentrate did not reduce diarrhea symptoms in an E. coli infection model.
Review
Immunology
Coen Govers, Philip C. Calder, Huub F. J. Savelkoul, Ruud Albers, R. J. Joost van Neerven
Summary: Respiratory infections, especially in vulnerable groups, place a heavy burden on the health care system. Nutrition plays a role in optimizing immune responsiveness and preventing infections. Micronutrients act as regulators of immune cells' molecular responses, while undernutrition and specific micronutrient deficiencies impair immune response and increase susceptibility to respiratory and gastrointestinal infections. Dietary components such as proteins, pre-, pro- and synbiotics, as well as animal- and plant-derived bioactive components, can support the immune system. Both innate and adaptive defense systems contribute to respiratory tract immunity, and this review aims to describe the effects of different dietary components on these immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Jerry M. Wells, Yifan Gao, Nanda de Groot, Marlotte M. Vonk, Laurien Ulfman, R. J. Joost van Neerven
Summary: The intestinal barrier is crucial for preventing infection, inflammation, and food allergies in early life. Exclusive breastfeeding or milk-based infant formulas can support gut health and immune system development.
ANNUAL REVIEW OF NUTRITION
(2022)
Article
Immunology
Aurelien Trompette, Julie Pernot, Olaf Perdijk, Rayed Ali A. Alqahtani, Jaime Santo Domingo, Dolores Camacho-Munoz, Nicholas C. Wong, Alexandra C. Kendall, Andreas Wiederkehr, Laurent P. Nicod, Anna Nicolaou, Christophe von Garnier, Niki D. J. Ubags, Benjamin J. Marsland
Summary: Barrier integrity is crucial for maintaining immune balance. A diet rich in fermentable fiber improves skin barrier function and reduces allergen sensitization and disease severity. This is achieved through the production of short-chain fatty acids, particularly butyrate, which enhances mitochondrial metabolism and structural components in epidermal keratinocytes.
MUCOSAL IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Laurien Ulfman, Angela Tsuang, Aline B. Sprikkelman, Anne Goh, R. J. Joost van Neerven
Summary: The incidence of food allergies has increased worldwide in the past 20 years. Early introduction of allergenic foods has been shown to reduce the risk of allergies, but less is known about the introduction of cow's milk. Recent studies suggest that early introduction of cow's-milk-based formulas with intact milk proteins can reduce the risk of cow's milk allergy, while very early introduction followed by discontinuation may increase the risk.
Article
Nutrition & Dietetics
Prokopis Konstanti, Marloes van Splunter, Erik van den Brink, Clara Belzer, Arjen Nauta, R. J. Joost van Neerven, Hauke Smidt
Summary: Supplementation of bLF increased the relative abundance of Holdemanella in the fecal microbiota of healthy elderly women, while the addition of GOS further increased the relative abundance of Bifidobacterium.
Editorial Material
Nutrition & Dietetics
R. J. Joost van Neerven, Janneke Ruinemans-Koerts
Article
Nutrition & Dietetics
Frank E. E. van Boven, Nicolette J. T. Arends, Aline B. B. Sprikkelman, Joyce A. M. Emons, Astrid I. I. Hendriks, Marloes van Splunter, Marco W. J. Schreurs, Severina Terlouw, Roy Gerth van Wijk, Harry J. J. Wichers, Huub F. J. Savelkoul, R. J. Joost van Neerven, Kasper A. Hettinga, Nicolette W. W. de Jong
Summary: Accelerating tolerance induction to cow's milk can reduce the burden of cow's milk allergy. This study aimed to investigate the tolerance induction of a novel heated cow milk protein in children with cow's milk allergy. Results showed that 73% of children in the treatment group had a negative food challenge test, compared to 57% in the control group.
