Doxorubicin‐induced normal breast epithelial cellular aging and its related breast cancer growth through mitochondrial autophagy and oxidative stress mitigated by ginsenoside Rh2

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Ginsenoside Rh2 Ameliorates Doxorubicin-Induced Senescence Bystander Effect in Breast Carcinoma Cell MDA-MB-231 and Normal Epithelial Cell MCF-10A

(2019) Jin-Gang Hou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Toxicity of Doxorubicin (Dox) to different experimental organ systems

(2018) Arivalagan Pugazhendhi et al.   LIFE SCIENCES

Ginsenoside Rh2 Improves Cardiac Fibrosis via PPARδ–STAT3 Signaling in Type 1-Like Diabetic Rats

(2017) Shih-Hsiang Lo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1

(2017) Xiaoli Cai et al.   Oncotarget

Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

(2017) Viktor I. Korolchuk et al.   EBioMedicine

How autophagy both activates and inhibits cellular senescence

(2016) Chanhee Kang et al.   Autophagy

Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans

(2016) Judith E. Carroll et al.   BRAIN BEHAVIOR AND IMMUNITY

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy

(2016) Tongmei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-Inflammatory Effects of Ginsenoside-Rh2 Inhibits LPS-Induced Activation of Microglia and Overproduction of Inflammatory Mediators Via Modulation of TGF-β1/Smad Pathway

(2016) R Vinoth Kumar et al.   NEUROCHEMICAL RESEARCH

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

TNF-α promotes breast cancer cell migration and enhances the concentration of membrane-associated proteases in lipid rafts

(2016) Dominika Wolczyk et al.   CELLULAR ONCOLOGY

MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8

(2016) Dipa Bhaumik et al.   Aging-US

Deciphering the role of Nuclear Factor-κB in cellular senescence

(2016) Simon Vaughan et al.   Aging-US

Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence

(2015) Christelle Lenain et al.   CARCINOGENESIS

Ginsenoside Rh2 attenuates allergic airway inflammation by modulating nuclear factor-κB activation in a murine model of asthma

(2015) LIANG CHANG LI et al.   Molecular Medicine Reports

MEK-dependent IL-8 induction regulates the invasiveness of triple-negative breast cancer cells

(2015) Sangmin Kim et al.   TUMOR BIOLOGY

Oxidative stress triggered by naturally occurring flavone apigenin results in senescence and chemotherapeutic effect in human colorectal cancer cells

(2015) Kacoli Banerjee et al.   Redox Biology

Curcumin Triggers p16-Dependent Senescence in Active Breast Cancer-Associated Fibroblasts and Suppresses Their Paracrine Procarcinogenic Effects

(2015) Siti-Fauziah Hendrayani et al.   NEOPLASIA

Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence

(2014) Izumi Horikawa et al.   Nature Communications

Doxorubicin, DNA torsion, and chromatin dynamics

(2013) Fan Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Atg9 Interacts with dTRAF2/TRAF6 to Regulate Oxidative Stress-Induced JNK Activation and Autophagy Induction

(2013) Hong-Wen Tang et al.   DEVELOPMENTAL CELL

Relaxation Response Induces Temporal Transcriptome Changes in Energy Metabolism, Insulin Secretion and Inflammatory Pathways

(2013) Manoj K. Bhasin et al.   PLoS One

Characterization of the ginsenoside-transforming recombinant β-glucosidase from Actinosynnema mirum and bioconversion of major ginsenosides into minor ginsenosides

(2012) Chang-Hao Cui et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases

(2012) R M Naylor et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Reactive oxygen species mediated ginsenoside Rg3- and Rh2-induced apoptosis in hepatoma cells through mitochondrial signaling pathways

(2012) Hye-Min Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson’s disease

(2011) Anna Pilsl et al.   ACTA NEUROPATHOLOGICA

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Antihyperglycemic Effect of Ginsenoside Rh2 by Inducing Islet β-cell Regeneration in Mice

(2011) Y. Wang et al.   HORMONE AND METABOLIC RESEARCH

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

A Cytoplasmic ATM-TRAF6-cIAP1 Module Links Nuclear DNA Damage Signaling to Ubiquitin-Mediated NF-κB Activation

(2010) Michael Hinz et al.   MOLECULAR CELL

Helicobacter pylori CagA activates NF-κB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination

(2009) Acacia Lamb et al.   EMBO REPORTS

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

(2007) Antero Salminen et al.   AGEING RESEARCH REVIEWS