Surfaces Affect Screening Reliability in Formulation Development of Biologics

Characterisation of protein aggregation with the Smoluchowski coagulation approach for use in biopharmaceuticals

(2018) Mitja Zidar et al.   Soft Matter

Stabilizing two IgG1 monoclonal antibodies by surfactants: Balance between aggregation prevention and structure perturbation

(2017) Shujing Wang et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The film tells the story: Physical-chemical characteristics of IgG at the liquid-air interface

(2017) Ellen Koepf et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Synergistic Effect of Cavitation and Agitation on Protein Aggregation

(2017) Tetsuo Torisu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Identifying protein aggregation mechanisms and quantifying aggregation rates from combined monomer depletion and continuous scattering

(2016) Gregory V. Barnett et al.   ANALYTICAL BIOCHEMISTRY

No Touching! Abrasion of Adsorbed Protein Is the Root Cause of Subvisible Particle Formation During Stirring

(2016) Ahmad S. Sediq et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Evaluating the Role of the Air-Solution Interface on the Mechanism of Subvisible Particle Formation Caused by Mechanical Agitation for an IgG1 mAb

(2016) Saba Ghazvini et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Kinetics of Antibody Aggregation at Neutral pH and Ambient Temperatures Triggered by Temporal Exposure to Acid

(2016) Hiroshi Imamura et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Predicting the Agitation-Induced Aggregation of Monoclonal Antibodies Using Surface Tensiometry

(2015) Ian C. Shieh et al.   MOLECULAR PHARMACEUTICS

Conformational and Colloidal Stabilities of Isolated Constant Domains of Human Immunoglobulin G and Their Impact on Antibody Aggregation under Acidic Conditions

(2015) Seiki Yageta et al.   MOLECULAR PHARMACEUTICS

Kinetic Analysis of the Multistep Aggregation Mechanism of Monoclonal Antibodies

(2014) Lucrèce Nicoud et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Population Balance Modeling of Aggregation and Coalescence in Colloidal Systems

(2014) Ivan Kryven et al.   MACROMOLECULAR THEORY AND SIMULATIONS

Immunogenicity of therapeutic proteins: Influence of aggregation

(2013) Kirsty D. Ratanji et al.   Journal of Immunotoxicology

Challenges and approaches for the development of safer immunomodulatory biologics

(2013) Jean G. Sathish et al.   NATURE REVIEWS DRUG DISCOVERY

Aggregation of anti-streptavidin immunoglobulin gamma‐1 involves Fab unfolding and competing growth pathways mediated by pH and salt concentration

(2012) Nayoung Kim et al.   BIOPHYSICAL CHEMISTRY

From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation

(2012) Samuel I.A. Cohen et al.   JOURNAL OF MOLECULAR BIOLOGY

Aggregation Mechanism of an IgG2 and two IgG1 Monoclonal Antibodies at low pH: From Oligomers to Larger Aggregates

(2012) Paolo Arosio et al.   PHARMACEUTICAL RESEARCH

Aggregates in monoclonal antibody manufacturing processes

(2011) María Vázquez-Rey et al.   BIOTECHNOLOGY AND BIOENGINEERING

Nonnative Aggregation of an IgG1 Antibody in Acidic Conditions: Part 1. Unfolding, Colloidal Interactions, and Formation of High-Molecular-Weight Aggregates

(2011) Rebecca K. Brummitt et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Antibody Adsorption and Orientation on Hydrophobic Surfaces

(2011) Meredith E. Wiseman et al.   LANGMUIR

Potential aggregation prone regions in biotherapeutics

(2010) Xiaoling Wang et al.   mAbs

Effects of Solution Conditions, Processing Parameters, and Container Materials on Aggregation of a Monoclonal Antibody during Freeze-Thawing

(2007) Lisa A. Kueltzo et al.   JOURNAL OF PHARMACEUTICAL SCIENCES