Melatonin Protects Intervertebral Disc from Degeneration by Improving Cell Survival and Function via Activation of the ERK1/2 Signaling Pathway

Melatonin ameliorates intervertebral disc degeneration via the potential mechanisms of mitophagy induction and apoptosis inhibition

(2019) Yu Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

PMMA bone cement acts on the Hippo/YAP pathway to regulate CTGF and induce intervertebral disc degeneration

(2019) Jun Ge et al.   ACS Biomaterials-Science & Engineering

Melatonin resists oxidative stress-induced apoptosis in nucleus pulposus cells

(2018) Ruijun He et al.   LIFE SCIENCES

Melatonin: A Review of Its Potential Functions and Effects on Dental Diseases

(2017) Maria Permuy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin inhibits nucleus pulposus (NP) cell proliferation and extracellular matrix (ECM) remodeling via the melatonin membrane receptors mediated PI3K-Akt pathway

(2017) Zheng Li et al.   JOURNAL OF PINEAL RESEARCH

Long non‑coding RNA FAF1 promotes intervertebral disc degeneration by targeting the Erk signaling pathway

(2017) Daguo Mi et al.   Molecular Medicine Reports

miR-155 Inhibits Nucleus Pulposus Cells’ Degeneration through Targeting ERK 1/2

(2016) Dongping Ye et al.   DISEASE MARKERS

The role of TGF-β1/Smad2/3 pathway in platelet-rich plasma in retarding intervertebral disc degeneration

(2016) Huilin Yang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Melatonin modifies basal and stimulated insulin secretion via NADPH oxidase

(2016) Daniel Simões et al.   JOURNAL OF ENDOCRINOLOGY

Management of Symptomatic Lumbar Degenerative Disk Disease

(2016) Luke Madigan et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

Inhibition of MEK/ERK activation attenuates autophagy and potentiates pemetrexed-induced activity against HepG2 hepatocellular carcinoma cells

(2015) Yongxi Tong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ginsenoside Rh2 Mitigates Pediatric Leukemia Through Suppression of Bcl-2 in Leukemia Cells

(2015) Xiaoru Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

TGF-β1 antagonizes TNF-αinduced up-regulation of matrix metalloproteinase 3 in nucleus pulposus cells: role of the ERK1/2 pathway

(2015) Hao Yang et al.   CONNECTIVE TISSUE RESEARCH

Bone marrow mesenchymal stem cells slow intervertebral disc degeneration through the NF-κB pathway

(2015) Cheng Cao et al.   Spine Journal

TGF-βl Suppresses Inflammation in Cell Therapy for Intervertebral Disc Degeneration

(2015) Huilin Yang et al.   Scientific Reports

Melatonin enhances adult rat hippocampal progenitor cell proliferation via ERK signaling pathway through melatonin receptor

(2014) C. Tocharus et al.   NEUROSCIENCE

Apoptosis, senescence, and autophagy in rat nucleus pulposus cells: Implications for diabetic intervertebral disc degeneration

(2012) Libo Jiang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Cytoprotective and anti-inflammatory effects of melatonin in hydrogen peroxide-stimulated CHON-001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway

(2012) Hyun-Dae Lim et al.   JOURNAL OF PINEAL RESEARCH

Exogenous and autocrine growth factors stimulate human intervertebral disc cell proliferation via the ERK and Akt pathways

(2011) Harris Pratsinis et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Melatonin synergistically enhances cisplatin-induced apoptosis via the dephosphorylation of ERK/p90 ribosomal S6 kinase/heat shock protein 27 in SK-OV-3 cells

(2011) Ji-Hyun Kim et al.   JOURNAL OF PINEAL RESEARCH

Melatonin promotes osteoblastic differentiation through the BMP/ERK/Wnt signaling pathways

(2011) Ki-Ho Park et al.   JOURNAL OF PINEAL RESEARCH

The Red Wine Polyphenol Resveratrol Shows Promising Potential for the Treatment of Nucleus Pulposus–Mediated Pain In Vitro and In Vivo

(2011) Karin Wuertz et al.   SPINE

TNF-α Induces MMP2 Gelatinase Activity and MT1-MMP Expression in an In Vitro Model of Nucleus Pulposus Tissue Degeneration

(2009) Cheryle A. Séguin et al.   SPINE

Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes

(2008) Ming Pei et al.   JOURNAL OF PINEAL RESEARCH

Melatonin Attenuates the Cerebral Ischemic Injury via the MEK/ERK/p90RSK/Bad Signaling Cascade

(2008) Phil-Ok KOH   JOURNAL OF VETERINARY MEDICAL SCIENCE