Review
Biochemistry & Molecular Biology
Hongkun Xue, Yumei Sang, Yuchao Gao, Yuan Zeng, Jianqing Liao, Jiaqi Tan
Summary: Berries are rich in anthocyanins, vitamins, fiber, polyphenols, essential amino acids, and other ingredients, making them highly nutritious and medicinal. Anthocyanins, the bioactive components in berries, exhibit various biological activities such as vision protection, antioxidant and anti-inflammatory properties, inhibition of lipid peroxidation, anti-cardiovascular disease effects, control of hypoglycemic conditions, etc. Therefore, it is necessary to systematically review the research progress and future prospects of anthocyanins to enhance understanding of their absorption, metabolism, and biological activities.
Article
Biochemistry & Molecular Biology
Mei-Kuang Lu, Chia- Jen, Chi-Hsein Chao, Yu-Chi Hsu, Lean-Teik Ng
Summary: Laetiporus sulphureus is an edible and medicinal mushroom. A sulfated galactoglucan (SPS) and polysaccharides (PS) were isolated from it. SPS inhibited TNF-alpha release, reversed I kappa B degradation, and suppressed the phosphorylation of AKT/ERK, p38, and JNK. PS suppressed the secretion of IL-6 and TGF beta by inhibiting the phosphorylation of p-38 and TGFRII signaling pathways. These findings demonstrate the potential anti-inflammatory activity of SPS and PS for dietary supplements and functional food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Liuwei Qin, Hui Xie, Nan Xiang, Min Wang, Shouan Han, Mingqi Pan, Xinbo Guo, Wen Zhang
Summary: This study investigated the influences of different climatic conditions on grape coloring and quality formation. Two common varieties of grapes were grown in Urumqi and Turpan, China, and the results showed that grapes grown in Urumqi had lower brightness value and higher red-green value compared to those grown in Turpan. The higher transcription of key genes related to anthocyanin biosynthesis in Urumqi grapes resulted in more abundant phenolic substances, especially anthocyanins. The maximum antioxidant activity was also observed in Urumqi grapes. These findings provide insights into the impact of climate on grape quality formation and contribute to the cultivation of grapes with higher nutritional value.
Article
Clinical Neurology
Nayara Rampazzo Morelli, Michael Maes, Kamila Landucci Bonifacio, Heber Odebrecht Vargas, Sandra Odebrecht Vargas Nunes, Decio Sabbatini Barbosa
Summary: This study found that MetS shares partially common RONS/NOSTOX pathways with mood disorders, GAD, and TUD. MetS is characterized by increased lipid peroxidation, chlorinative stress, and strong mediation of atherogenicity and insulin resistance by RONS/NOSTOX.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Food Science & Technology
Vanessa Magalhaes, Bruna Silva, Xiaoying Zhang, Ana Rita Silva, Alberto C. P. Dias
Summary: This study compared the anti-inflammatory and antioxidant activities of methanolic extracts from red and black goji berries. The results showed that black goji berries extract exhibited significantly higher anti-inflammatory and antioxidant activities compared to the red goji berries extract, suggesting that black goji berries may serve as a potential source of pharmacologically active compounds for diseases with inflammation and oxidative stress.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Polymer Science
H. Shashidharagowda, Shridhar Mathad, Shridhar Malladi, Vinod Gubbiveeranna, C. G. Kusuma, S. Nagaraju, Arun Y. Patil, Anish Khan, Abdul Rub Malik, Abdullah M. Asiri, Naved Azum
Summary: Copper-substituted nickel manganites were successfully synthesized using a co-precipitation method. Characterization through XRD and SEM revealed the structural properties of the samples, while Raman spectroscopy confirmed the presence of copper doping. Anticoagulant assays demonstrated the biomedical potential of the materials.
Article
Agriculture, Multidisciplinary
Lanlan Du, Han Lu, Yan Chen, Xiaohua Yu, Tunyu Jian, Huifang Zhao, Wenlong Wu, Xiaoqin Ding, Jian Chen, Weilin Li
Summary: This study found that blueberry and blackberry anthocyanins have beneficial effects on metabolic syndrome by modulating the gut microbiota and production of short-chain fatty acids.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Infectious Diseases
Rana A. Elmesseri, Sarra E. Saleh, Sarah A. Ghobish, Taghreed A. Majrashi, Heba M. Elsherif, Khaled M. Aboshanab
Summary: This study aimed to explore the inhibitory effect of the anti-inflammatory drugs meloxicam and diclofenac on the production of staphyloxanthin by Staphylococcus aureus. The results showed that meloxicam and diclofenac effectively inhibited the synthesis of staphyloxanthin and downregulated the expression of genes associated with its synthesis, highlighting the potential role of these drugs in combating MRSA infections.
Article
Chemistry, Applied
Xiao Li, Zeliang Wei, Xingyue Wang, Feixia Duan, Lidan Xiong, Jingwen Li, Jing Tian, Lirong Jia, Hong Gao
Summary: Premna microphylla turcz leaf juice with polysaccharides (PMPs) extracted under alkaline conditions showed remarkable radical scavenging capability, especially in inhibiting the production of inflammatory cytokines, making them a promising non-toxic natural dietary supplement.
Article
Plant Sciences
Shou-Kai Wang, Ting-Xiao Chen, Wei Wang, Ling-Ling Xu, Yu-Qing Zhang, Zhen Jin, You -Bin Liu, You-Zhi Tang
Summary: Aesculetin exhibits potent anti-inflammatory effect both in vitro and in vivo by inhibiting the production of inflammatory mediators and the activation of NF-Kappa B and MAPKs signaling pathways. In a DSS-induced colitis model, aesculetin can alleviate clinical symptoms and reduce the secretion of inflammatory mediators.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Agata Rolnik, Anna Stochmal, Beata Olas
Summary: Extracts from plants of the Asteraceae family, such as dandelion, have been found to possess antioxidant and anti-platelet activity. However, little is known about the effects of extracts from other Asteraceae plants, such as chicory leaves, lettuce leaves, and Jerusalem artichoke roots, on the hemostatic system. The study found that dandelion root extract and fruit extracts have the strongest anti-platelet potential in whole blood, while red lettuce leaves and Jerusalem artichoke roots showed the strongest anti-platelet activity in washed blood platelets.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Plant Sciences
Maria Sulli, Lorenzo Barchi, Laura Toppino, Gianfranco Diretto, Tea Sala, Sergio Lanteri, Giuseppe Leonardo Rotino, Giovanni Giuliano
Summary: The study utilized metabolomics methods to investigate metabolites in eggplants, identifying differential accumulations of metabolites and related quantitative trait loci. Each metabolic trait was controlled by one or more quantitative trait loci, with most traits having a major mQTL.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Food Science & Technology
James Coleman Miller, Adhini Kuppuswamy Satheesh Babu, Chrissa Petersen, Umesh D. Wankhade, Michael S. I. I. I. I. Robeson, Madison Nicole Putich, Jennifer Ellen Mueller, Aubrey Sarah O'Farrell, Jae Min Cho, Sree Chintapalli, Thunder Jalili, John David Symons, Pon Velayutham Anandh Babu
Summary: This study found that dietary strawberry consumption can reduce the risk of vascular complications in an animal model of MetS, and this effect is associated with changes in the composition of gut microbes.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Chemistry, Medicinal
Weiying Liu, Fangyang Shao, Xinyue You, Yiyi Cao, Jing Xi, Jiaying Wu, Jingjing Wan, Xinyu Zhang, Jian Fei, Yang Luan
Summary: This study demonstrates the anti-inflammatory effects of AAIVa, a compound found in Aristolochic acid (AA)-containing herbs. Both in vitro and in vivo experiments confirm its ability to decrease pro-inflammatory cytokines and inhibit inflammation. Online pharmacological databases suggest that AAIVa may target T cell activation-related proteins to exert its anti-inflammatory effects.
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Chemistry, Multidisciplinary
Hina Rasheed, Maham Shehzad, Roshina Rabail, Przemyslaw Lukasz Kowalczewski, Marcin Kidon, Pawel Jezowski, Muhammad Modassar Ali Nawaz Ranjha, Allah Rakha, Ahmad Din, Rana Muhammad Aadil
Summary: This review explores the role of purple carrot's main bioactive compounds in the prevention of MetS and cancer. Phenolic compounds, such as anthocyanin, present in purple carrot roots, are effective in reducing metabolic changes and inflammation, thereby preventing the onset of cardiovascular disease, obesity, diabetes, and cancer. While researchers have made efforts to use purple carrot in the prevention and treatment of MetS and cancer, more advanced studies are needed to determine its detailed role and suitable intake for these diseases.
APPLIED SCIENCES-BASEL
(2022)
Article
Food Science & Technology
Lada Vugic, Natalie Colson, Elham Nikbakht, Almottesembellah Gaiz, Olivia J. Holland, Avinash Reddy Kundur, Indu Singh
JOURNAL OF FUNCTIONAL FOODS
(2020)
Article
Biochemistry & Molecular Biology
Anahita Aboonabi, Arta Aboonabi
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Sport Sciences
Emma K. Zadow, Kate H. Edwards, Cecilia M. Kitic, James W. Fell, Murray J. Adams, Indu Singh, Avinash Kundur, Amy N. B. Johnston, Julia Crilly, Andrew C. Bulmer, Shona L. Halson, Sam S. X. Wu
Summary: Compression socks reduce exercise-induced intestinal damage, which is advantageous for recovery and performance.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2022)
Article
Cell Biology
Elham Nikbakht, Indu Singh, Jelena Vider, Lauren T. Williams, Lada Vugic, Almottesembellah Gaiz, Avinash Reddy Kundur, Natalie Colson
Summary: The study found a significant decrease in pro-inflammatory biomarkers in the T2D group, as well as improvements in some biochemical parameters in the T2D-at-risk group. There was also a significant difference in DII scores between the healthy and T2D groups, with the T2D group's score indicative of an anti-inflammatory diet.
INFLAMMATION RESEARCH
(2021)
Article
Dermatology
Ruchi Roy, Janet Zayas, F. Mohamed Mohamed, Anahita Aboonabi, Kaylee Delgado, Jennillee Wallace, Mohammad Bayat, Timothy M. Kuzel, Jochen Reiser, Sasha H. Shafikhani
Summary: Persistent inflammation is a major hindrance to healing in diabetic chronic wounds. However, the diabetic wound environment during the acute healing phase exhibits reduced macrophage response due to inadequate expression of CCL2 proinflammatory cytokine. In this study, it was found that short-term exposure to high glucose leads to rapid monocyte reprogramming through increased expression and secretion of IL-10, which transforms monocytes into an anti-inflammatory phenotype. Increased IL-10 expression in diabetic wounds during the acute healing phase inhibits toll-like receptor signaling and proinflammatory cytokine production, delaying macrophage and leukocyte responses and impairing healing. Blocking IL-10 signaling during the acute healing phase can improve toll-like receptor signaling, increase proinflammatory cytokine production, enhance macrophage and leukocyte responses, and stimulate healing in diabetic wounds.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Emiri Tarbit, Indu Singh, Jason Nigel Peart, Svetlana Bivol, Roselyn Barbara Rose'Meyer
Summary: Elevated blood serotonin levels have been observed in heart failure patients, and the presence of serotonin receptors and increased serotonin metabolism in myofibroblasts compared to fibroblasts suggest a potential role of serotonin in the pathogenesis of heart failure. The study provides insights into the involvement of the serotonin system in cardiac fibroblast and myofibroblast cells, highlighting the importance of serotonin receptors in cardiac function and potential therapeutic targets for heart failure.
SCIENTIFIC REPORTS
(2021)
Review
Nutrition & Dietetics
Elza Bevilacqua, Vinicius Cruzat, Indu Singh, Roselyn B. Rose'Meyer, Sunil K. Panchal, Lindsay Brown
Summary: Coffee is a popular and widely consumed beverage worldwide, with potential health benefits such as reduced risks of cardiovascular disease, cancers, and liver disease. This study focuses on investigating the health effects and potential applications of spent coffee grounds (SCG), which contain bioactive compounds similar to coffee and have shown positive effects on metabolic parameters, gut microbiome, and energy consumption. SCG utilization could also contribute to reducing global waste from coffee production. Overall, SCG shows promise in moderating chronic human diseases and decreasing environmental impact.
Article
Cardiac & Cardiovascular Systems
Anahita Aboonabi, Mark D. McCauley
Summary: Diastolic heart failure (DHF), which accounts for over 50% of heart failure cases, is associated with risk factors such as metabolic syndrome, hypertension, diabetes, and aging. Many patients with DHF have normal left ventricular ejection fraction. The molecular mechanisms of diastolic dysfunction are poorly understood, hindering the development of effective therapeutic agents.
HEART FAILURE REVIEWS
(2023)
Review
Integrative & Complementary Medicine
Almottesembellah Gaiz, Avinash Reddy Kundur, Elham Nikbakht, Lada Vugic, Natalie Colson, Sapha Shibeeb, Indu Singh
Summary: This study demonstrates that anthocyanins have a positive impact on inhibiting platelet aggregation and activation, as well as reducing mean platelet volume, which may be beneficial for reducing the risk of thrombosis.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2022)
Article
Integrative & Complementary Medicine
Almottesembellah Gaiz, Avinash R. Kundur, Natalie Colson, Sapha Shibeeb, Indu Singh
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2020)