Review
Clinical Neurology
James F. Meschia, Bradford B. Worrall, Fanny M. Elahi, Owen A. Ross, Michael M. Wang, Eric D. Goldstein, Natalia S. Rost, Jennifer J. Majersik, Jose Gutierrez
Summary: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, which is characterized by lacunar infarcts and vascular dementia, is a common inherited small vessel disease. Early recognition and molecular diagnosis are important, although there is currently no proven disease-modifying treatment. This scientific statement aims to review the clinical, genetic, and imaging aspects of the disease, and provide key considerations for prevention, management, and therapy to reduce practice variability.
Article
Clinical Neurology
Alvin S. Das, Robert W. Regenhardt, Elif Gokcal, Mitchell J. Horn, Nader Daoud, Kristin M. Schwab, Natalia S. Rost, Anand Viswanathan, W. Taylor Kimberly, Joshua N. Goldstein, Alessandro Biffi, Lee H. Schwamm, Jonathan Rosand, Steven M. Greenberg, M. Edip Gurol
Summary: The study found that approximately one-third of IP-IVH patients had cerebral amyloid angiopathy, and 23% had hypertensive small vessel disease. This suggests that both types of small vessel diseases may be associated with IP-IVH.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Neurosciences
Mengke Zhang, Ruiwen Che, Wenbo Zhao, Hailiang Sun, Changhong Ren, Jin Ma, Wenbo Hu, Milan Jia, Chuanjie Wu, Xin Liu, Xunming Ji
Summary: This study aimed to explore the relationship between computed tomography (CT)-based cerebral small vessel disease (SVD) markers and the clinical outcomes in patients with cerebral amyloid angiopathy (CAA)-related intracerebral hemorrhage (ICH). The results showed that the SVD markers based on CT could predict the short-term outcome more effectively in patients with CAA-ICH. Further studies are needed to validate these findings and identify modifiable factors for preventing CAA-ICH development.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Peter Kang, Chunwei Ying, Yasheng Chen, Andria L. Ford, Hongyu An, Jin-Moo Lee
Summary: Chronic hypoxia-ischemia in the watershed region may play a significant role in the pathogenesis of cerebral small vessel disease. Watershed OEF holds promise as an imaging biomarker to identify individuals at risk for cerebral small vessel disease progression.
Article
Clinical Neurology
Robin B. Brown, Daniel J. Tozer, Marco Egle, Anil M. Tuladhar, Frank-Erik de Leeuw, Hugh S. Markus
Summary: This study investigated the regression of white matter hyperintensity lesions (WMHs) in patients with cerebral small vessel disease (SVD). It found that only a small proportion of patients showed regression, and this regression was associated with smaller initial lesion volume and better white matter microstructural integrity.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Stephanie Guey, Saskia A. J. Lesnik Oberstein, Elisabeth Tournier-Lasserve, Hugues Chabriat
Summary: This article summarizes the key features for diagnosing hereditary cerebral small vessel diseases in adult stroke patients, describes the main clinical and imaging characteristics of major hereditary cerebral small vessel diseases that can present as stroke, and provides general recommendations for clinical management of affected patients and their relatives.
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Morotti, Giorgio Busto, Gregoire Boulouis, Elisa Scola, Alessandro Padovani, Ilaria Casetta, Enrico Fainardi
Summary: The combined analysis of non-contrast CT and CT perfusion markers improves the prediction of hematoma expansion and outcome in intracerebral hemorrhage.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jawed Nawabi, Frieder Schlunk, Andrea Dell Orco, Sarah Elsayed, Federico Mazzacane, Dmitriy Desser, Ly Vu, Estelle Vogt, Haoyin Cao, Maik F. H. Boehmer, Burak Han Akkurt, Peter B. Sporns, Marco Pasi, Ulf Jensen-Kondering, Gabriel Broocks, Tobias Penzkofer, Jens Fiehler, Alessandro Padovani, Uta Hanning, Andrea Morotti
Summary: Non-contrast computed tomography (NCCT) markers are reliable predictors for predicting parenchymal hematoma expansion in intracerebral hemorrhage (ICH). This study investigates whether NCCT features can also identify patients at risk of intraventricular hemorrhage (IVH) growth.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Stefania Nannoni, Laura Ohlmeier, Robin B. Brown, Robin G. Morris, Andrew D. MacKinnon, Hugh S. Markus
Summary: In patients with symptomatic cerebral small vessel disease, cerebral microbleeds are significantly associated with cognitive dysfunction, especially affecting executive function and processing speed. The presence and number of microbleeds also independently predict vascular cognitive impairment.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Neurosciences
Zi-Jie Wang, Rui Zhao, Xiao Hu, Wen-Song Yang, Lan Deng, Xin-Ni Lv, Zuo-Qiao Li, Jing Cheng, Ming-Jun Pu, Zhou-Ping Tang, Guo-Feng Wu, Li-Bo Zhao, Peng Xie, Qi Li
Summary: The global SVD score is associated with small ICH and is inversely correlated with hematoma volume, especially in non-lobar ICH.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Clinical Neurology
Riwaj Bhagat, Sandro Marini, Jose R. Romero
Summary: Cerebral small vessel disease (CSVD) encompasses a broad clinical spectrum united by pathology of the small vessels of the brain. Recent research has identified novel genetic factors involved in CSVD, promoting understanding of the disease and suggesting effective treatments and preventive measures at the individual level. The knowledge gained has advanced understanding of the pathophysiology of CSVD, improved subtype identification of small vessel strokes, and is getting closer to influencing clinical care through pharmacogenetic studies.
FRONTIERS IN NEUROLOGY
(2023)
Article
Critical Care Medicine
Mengying Yu, Dongqin Zhu, Zhixian Luo, Zhifang Pan, Yunjun Yang, Haoli Xu
Summary: This study aimed to investigate the correlation between white matter lesion (WML) severity and delayed intraventricular hemorrhage (IVH) in patients with intracerebral hemorrhage (ICH), as well as the association between WML and baseline IVH. The results showed that moderate-severe WML was an independent risk factor for both delayed IVH and baseline IVH.
NEUROCRITICAL CARE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jin-hao Lyu, Sen-hao Zhang, Xue-yang Wang, Zhi-hua Meng, Xiao-yan Wu, Wen Chen, Guo-hua Wang, Qing-liang Niu, Xin Li, Yi-tong Bian, Dan Han, Wei-ting Guo, Shuai Yang, Meng-ting Wei, Ting-yang Zhang, Qi Duan, Cao-hui Duan, Xiang-bing Bian, Cheng-lin Tian, Xin Lou
Summary: This study aimed to investigate the prognostic value of fluid-attenuated inversion recovery vessel hyperintensity (FVH) in patients with acute ischemic stroke (AIS) receiving medical therapy. The presence of FVH, along with larger infarct volume and higher FVH grade, was found to predict poor long-term functional outcomes in patients with large vessel stenosis (LVS).
EUROPEAN RADIOLOGY
(2022)
Review
Clinical Neurology
Jonathan G. Best, Aaron Jesuthasan, David J. Werring
Summary: Balancing the risks of recurrent ischemia and antithrombotic-associated bleeding, particularly intracranial hemorrhage (ICH), is a key challenge in secondary prevention of ischemic stroke and transient ischemic attack. This review explores the connection between neuroimaging markers of cerebral small vessel disease (CSVD) and antithrombotic and thrombolytic-associated ICH, focusing on cerebral microbleeds (CMB). The presence of CMB has the potential to enhance ICH risk prediction and guide clinical decision making.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Apostolos Safouris, Lina Palaiodimou, Sandor Nardai, Odysseas Kargiotis, George Magoufis, Klearchos Psychogios, Marius Matusevicius, Katharina Feil, Niaz Ahmed, Lars Kellert, Stavros Spiliopoulos, Elias Brountzos, Istvan Szikora, Amrou Sarraj, Nitin Goyal, Diana Aguiar de Sousa, Daniel Strbian, Valeria Caso, Andrei V. Alexandrov, Georgios Tsivgoulis
Summary: For anterior circulation large-vessel occlusion ischemic stroke patients with low baseline National Institutes of Health Stroke Scale score, EVT appears to be equivalent to BMT in terms of excellent functional outcome, but it carries an increased risk of symptomatic intracranial hemorrhage.
Article
Clinical Neurology
Sean P. Polster, Julian Carrion-Penagos, Sean B. Lyne, Barbara A. Gregson, Ying Cao, Richard E. Thompson, Agnieszka Stadnik, Romuald Girard, Patricia Lynn Money, Karen Lane, Nichol McBee, Wendy Ziai, W. Andrew Mould, Ahmed Iqbal, Stephen Metcalfe, Yi Hao, Robert Dodd, Andrew P. Carlson, Paul J. Camarata, Jean-Louis Caron, Mark R. Harrigan, Mario Zuccarello, A. David Mendelow, Daniel F. Hanley, Issam A. Awad
Summary: The extent of intracerebral hemorrhage removal has a similar impact on outcomes with both minimally invasive and open surgery, showing a likelihood of achieving a good outcome within a broad therapeutic time window for both procedures. Timing of surgery did not significantly affect mortality up to 47 hours with either procedure.
Article
Clinical Neurology
Sean P. Polster, Julian Carrion-Penagos, Sean B. Lyne, Fernando D. Goldenberg, Ali Mansour, Wendy Ziai, Andrew P. Carlson, Paul J. Camarata, Jean-Louis Caron, Mark R. Harrigan, Barbara Gregson, A. David Mendelow, Mario Zuccarello, Daniel F. Hanley, Robert Dodd, Issam A. Awad
Summary: This study protocolized steps in the MISTIE and CLEAR procedures to maximize hematoma evacuation and minimize complications. Modifiable factors for efficiency include optimizing catheter placement and dosing, while nonmodifiable factors include initial hemorrhage volume and potential new bleeding during dosing, despite protocol adherence. Surgeon education is key to maximizing benefits of these procedures.
OPERATIVE NEUROSURGERY
(2021)
Article
Neurosciences
Sarah T. Menacho, Ramesh Grandhi, Alen Delic, Mohammad Anadani, Wendy C. Ziai, Issam A. Awad, Daniel F. Hanley, Adam de Havenon
Summary: The study assessed the impact of ICP monitor placement on neurologic outcome in patients with spontaneous intracranial hemorrhage and found that ICP monitor placement was associated with higher rates of poor outcome and death. Further research is needed to identify patients who might benefit from invasive ICP monitoring.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Clinical Neurology
Santosh B. Murthy, Cenai Zhang, Ajay Gupta, Sung-Min Cho, Lucia Rivera-Lara, Radhika Avadhani, Joshua Gruber, Costantino Iadecola, Guido J. Falcone, Kevin N. Sheth, Adnan Qureshi, Joshua N. Goldstein, Daniel F. Hanley, Hooman Kamel, Wendy C. Ziai
Summary: Presence of DWI lesions in patients with ICH is associated with a heightened risk of stroke, particularly ischemic stroke. The increased risk persists for ischemic stroke but not for recurrent ICH.
Article
Geriatrics & Gerontology
Johannes Boltze, Jaroslaw A. Aronowski, Jerome Badaut, Marion S. Buckwalter, Mateo Caleo, Michael Chopp, Kunjan R. Dave, Nadine Didwischus, Rick M. Dijkhuizen, Thorsten R. Doeppner, Jens P. Dreier, Karim Fouad, Mathias Gelderblom, Karen Gertz, Dominika Golubczyk, Barbara A. Gregson, Edith Hamel, Daniel F. Hanley, Wolfgang Haertig, Friedhelm C. Hummel, Maulana Ikhsan, Miroslaw Janowski, Jukka Jolkkonen, Saravanan S. Karuppagounder, Richard F. Keep, Inga K. Koerte, Zaal Kokaia, Peiying Li, Fudong Liu, Ignacio Lizasoain, Peter Ludewig, Gerlinde A. S. Metz, Axel Montagne, Andre Obenaus, Alex Palumbo, Monica Pearl, Miguel Perez-Pinzon, Anna M. Planas, Nikolaus Plesnila, Ami P. Raval, Maria A. Rueger, Lauren H. Sansing, Farida Sohrabji, Charlotte J. Stagg, R. Anne Stetler, Ann M. Stowe, Dandan Sun, Akihiko Taguchi, Mickael Tanter, Sabine U. Vay, Raghu Vemuganti, Denis Vivien, Piotr Walczak, Jian Wang, Ye Xiong, Marietta Zille
Summary: The past decade has witnessed significant advancements in both diagnosis and treatment of cerebrovascular diseases, with the introduction of thrombectomy in ischemic stroke and the identification of new therapeutic targets based on deeper understanding of pathomechanisms. Additionally, translational aspects are increasingly recognized in basic science studies, enhancing their predictive value for clinical application.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Immunology
Michael H. Askenase, Brittany A. Goods, Hannah E. Beatty, Arthur F. Steinschneider, Sofia E. Velazquez, Artem Osherov, Margaret J. Landreneau, Shaina L. Carroll, Tho B. Tran, Victor S. Avram, Riley S. Drake, G. James Gatter, Jordan A. Massey, Saravanan S. Karuppagounder, Rajiv R. Ratan, Charles C. Matouk, Kevin N. Sheth, Wendy C. Ziai, Adrian R. Parry-Jones, Issam A. Awad, Mario Zuccarello, Richard E. Thompson, Jesse Dawson, Daniel F. Hanley, J. Christopher Love, Alex K. Shalek, Lauren H. Sansing
Summary: By analyzing longitudinal transcriptional profiles in the hematomas of patients with ICH, it was found that the myeloid response to ICH displays a conserved progression from proinflammatory to proresolution states over time. These findings provide insights into the time course of immune responses in the human brain after injury and identify transcriptional programs associated with neurological recovery.
SCIENCE IMMUNOLOGY
(2021)
Correction
Immunology
Wei Zhu, Yufeng Gao, Jieru Wan, Xi Lan, Xiaoning Han, Shanshan Zhu, Weidong Zang, Xuemei Chen, Wendy Ziai, Daniel F. Hanley, Scott J. Russo, Ricardo E. Jorge, Jian Wang
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Neurosciences
Radhika Avadhani, Richard E. Thompson, Lourdes Carhuapoma, Gayane Yenokyan, Nichol McBee, Karen Lane, Noeleen Ostapkovich, Agnieszka Stadnik, Issam A. Awad, Daniel F. Hanley, Wendy C. Ziai
Summary: The study found a high burden of post-stroke depression (PSD) in patients with spontaneous intracerebral hemorrhage (ICH). Impaired cognition and not living at home may be more important than physical limitations in predicting PSD. Therefore, increased screening of high-risk post-stroke patients for depression, especially females and Hispanics, may be warranted.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Clinical Neurology
David J. Roh, Ifeyinwa S. Asonye, Fernanda Carvalho Poyraz, Jessica R. Magid-Bernstein, Evan F. Joiner, Radhika Avadhani, Issam Awad, Daniel F. Hanley, Wendy C. Ziai, Santosh B. Murthy
Summary: This study aimed to evaluate factors associated with intraventricular hemorrhage expansion and its impact on long-term outcomes. The authors found that acute hematoma characteristics, such as larger parenchymal volume, hematoma expansion, and thalamic intracerebral hemorrhage location, were associated with intraventricular hemorrhage expansion. Additionally, intraventricular hemorrhage expansion was associated with poor clinical outcomes. This study highlights the importance of optimizing hemostasis and preventing intraventricular hemorrhage expansion.
Review
Clinical Neurology
Adnan Qureshi, Abdullah Lodhi, Iqra N. Akhtar, Xiaoyu Ma, Danish Kherani, Chun Shing Kwok, Daniel E. Ford, Daniel F. Hanley, Ameer E. Hassan, Thanh N. Nguyen, Alejandro M. Spiotta, Syed F. Zaidi
Summary: This systematic review found conflicting evidence on the benefit of intra-arterial thrombolysis (IAT) in patients with acute stroke undergoing mechanical thrombectomy (MT). Statistical analysis showed no significant difference in functional independence, mortality, or angiographic recanalization between IAT and MT alone. Furthermore, the study design and quality had a significant impact on the association between IAT and functional independence at 90 days.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Editorial Material
Critical Care Medicine
Lourdes R. Carhuapoma, Radhika Avadhani, Daniel F. Hanley
NEUROCRITICAL CARE
(2023)
Article
Clinical Neurology
Abdulaziz T. Bako, Thomas Potter, Alan P. Pan, Jonika Tannous, Gavin Britz, Wendy C. Ziai, Issam Awad, Daniel Hanley, Farhaan S. Vahidy
Summary: The study examined the relationship between corticostriatal A beta-amyloid deposition and cognitive dysfunction in patients with Parkinson disease at risk for dementia. PET imaging and neuropsychological assessments were conducted on 40 PD patients, revealing a significant correlation between cortical PiB binding and global cognitive function.
Letter
Clinical Neurology
Vishank A. Shah, Lourdes Carhuapoma, Daniel F. Hanley, Wendy C. Ziai
Article
Medicine, Research & Experimental
Daniel F. F. Hanley Jr, Gordon R. Bernard, Consuelo H. Wilkins, Harry P. Selker, Jamie P. Dwyer, J. Michael Dean, Daniel Kelly Benjamin Jr, Sarah E. Dunsmore, Salina P. Waddy, Kenneth L. L. Wiley Jr, Marisha E. Palm, W. Andrew Mould, Daniel F. Ford, Jeri S. Burr, Jacqueline Huvane, Karen Lane, Lori Poole, Terri L. Edwards, Nan Kennedy, Leslie R. Boone, Jasmine Bell, Emily Serdoz, Loretta M. Byrne, Paul A. Harris
Summary: New technologies and disruptions caused by COVID-19 have led to the expansion of decentralized clinical trials, which hold promise for increasing efficiency and reducing barriers. The Trial Innovation Network has provided recommendations for decentralized approaches and has consulted on numerous research proposals. While some elements of decentralized trials have worked well, others require further refinement and assessment. Efforts are needed to build trust and ensure access to remote technology for inclusive participation in decentralized clinical trials.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Review
Medicine, Research & Experimental
Michael E. Singer, Dallas C. Hack, Daniel F. Hanley
Summary: This article explores the integration of the long development path of medical devices with the necessity for diagnostic capabilities for mild traumatic brain injury (mTBI/concussion), demonstrating the effective role of public-private partnerships (PPPs). Through PPP collaborations, multiple FDA clearances and product introductions have been achieved, meeting urgent military and public needs.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2022)