Article
Biochemistry & Molecular Biology
Yuhua Zhu, Ziyan Wang, Shuxuan Yu, Chong Zhao, Baofeng Xu, Rui Liu, Li Xu, Yi Guo
Summary: This study investigated the neuroprotective effects of ginseng fibrous root against oxidative stress in Alzheimer's disease (AD). The results showed that ginseng fibrous root enzymatic hydrolysate exhibited antioxidant activities, protected cells from oxidative damage, and improved the survival rate of Caenorhabditis elegans under oxidative stress.
Article
Engineering, Environmental
Xiaoyu Yuan, Ran Tang, Zhi Jia, Yutong Chen, Jie Liu, Yanan Liu
Summary: A novel Zn2+-responsive nano-drug delivery platform has been developed for the treatment of Alzheimer's disease. It effectively alleviates oxidative stress and modulates the microenvironment to provide therapeutic effects.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Neurosciences
Shalini Mani, Rajni Dubey, I-Chun Lai, M. Arockia Babu, Sakshi Tyagi, Geeta Swargiary, Deepansh Mody, Manisha Singh, Shriya Agarwal, Danish Iqbal, Sanjay Kumar, Munerah Hamed, Punya Sachdeva, Abdulmajeed G. Almutary, Hind Muteb Albadrani, Shreesh Ojha, Sandeep Kumar Singh, Niraj Kumar Jha
Summary: Alzheimer's disease is a neurodegenerative disease caused by aging, neuroinflammation, and oxidative stress. Compounds from natural sources have shown potential for treating AD due to their antioxidant, anti-inflammatory, and biological activities.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biotechnology & Applied Microbiology
Asmaa K. Abdelghany, El-Shymaa El-Nahass, Marwa A. Ibrahim, Akram. M. El-Kashlan, H. H. Emeash, Fatma Khalil
Summary: The study found that four medicinal plant extracts (Nigella sativa, rosemary, sage, and ginseng) were effective in mitigating neurobehavioral damage induced by scopolamine, indicating neuroprotective action.
Review
Biochemistry & Molecular Biology
Nickolay K. Isaev, Elizaveta E. Genrikhs, Elena V. Stelmashook
Summary: Oxidative stress is a main factor in neuron damage, making it a therapeutic target for neuroprotectors. Thymoquinone, a drug with wide pharmacological activity, including neuroprotective effects, has shown promise in experimental modeling of neurodegenerative diseases. Its neuroprotective effect is attributed to its antioxidant ability. Thymoquinone has been found to effectively reduce the negative consequences of cerebral pathology and normalize antioxidant enzyme levels, making it a promising candidate for treating degenerative diseases of the central nervous system.
Review
Nutrition & Dietetics
Nitu L. Wankhede, Mayur B. Kale, Ashwini K. Bawankule, Manish M. Aglawe, Brijesh G. Taksande, Rashmi V. Trivedi, Milind J. Umekar, Ankush Jamadagni, Prathamesh Walse, Sushruta Koppula, Spandana Rajendra Kopalli
Summary: Avenanthramides (Avns) and their derivatives, polyphenolic compounds found in oats, show potential as neuroprotective agents due to their antioxidant, anti-inflammatory, and anti-apoptotic properties. The dysregulation of the PI3K signaling pathway, which is involved in cell survival and growth, has been implicated in neurodegenerative diseases. Avns have been shown to modulate the PI3K/AKT signaling pathway, leading to increased neuronal survival and improved cognitive function. This review highlights the therapeutic potential of Avns for neurodegenerative diseases and calls for further investigation and clinical exploration.
Review
Neurosciences
Rong Yang, Xinxing Yang, Feng Zhang
Summary: Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, cerebral amyloid angiopathy, and Huntington's disease, are characterized by cognitive and motor dysfunctions and neurodegeneration. These diseases have become more severe over time and cannot be cured currently. Taxifolin, a compound derived from Douglas fir and Larix gemelini, has been confirmed to exhibit various pharmacological activities and has shown potential in the treatment of neurodegenerative diseases.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nikolaos Pavlidis, Aristeidis Kofinas, Michael G. Papanikolaou, Haralampos N. Miras, Chryssoula Drouza, Angelos G. Kalampounias, Themistoklis A. Kabanos, Maria Konstandi, George Leondaritis
Summary: This study investigated the synthesis and characterization of four quinoline-based metal chelators and their copper(II) complexes, showing potential neuroprotective effects against Alzheimer's disease. The metal chelator H(2)dqpyca demonstrated significant neuroprotection and interaction with acetylcholinesterase, suggesting its potential as a multifunctional lead compound for AD treatment.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Amir Rostami, Fatemeh Taleahmad, Narges Haddadzadeh-Niri, Ensiye Joneidi, Siamak Afshin-Majd, Tourandokht Baluchnejadmojarad, Mehrdad Roghani
Summary: Sinomenine could alleviate TMT-induced cognitive dysfunction by attenuating hippocampal oxidative stress and neuroinflammation.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Review
Endocrinology & Metabolism
Grammatiki Alexandra Sidiropoulou, Athanasios Metaxas, Malamati Kourti
Summary: Alzheimer's disease (AD) is a neurodegenerative disease that causes dementia in older adults. Oxidative stress is a contributing factor to AD, and natural antioxidants have potential therapeutic effects. The transcription factor NRF2 plays a key role in the antioxidant response, and recent research has focused on the NRF2-modulating activity of natural antioxidants in AD models.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tatiani Bellettini-Santos, Hemily Batista-Silva, Clairton Marcolongo-Pereira, Fernanda Cristina de Abreu Quintela-Castro, Rafael Mazioli Barcelos, Kelly Cristina Mota Braga Chiepe, Joamyr Victor Rossoni, Roberta Passamani-Ambrosio, Bruno Spalenza da Silva, Orlando Chiarelli-Neto, Michelle Lima Garcez
Summary: Alzheimer's disease (AD) is the leading cause of dementia worldwide, and current treatments only provide symptomatic relief. Physical activity has been studied as a potential preventive measure, and the hormone irisin, produced during exercise, has shown promising effects on cognitive function. Irisin enhances neuroprotection, metabolism, and autophagy, and protects against cell death, oxidative stress, and neuroinflammation, which are all implicated in AD. However, further research is needed to understand the mechanisms and therapeutic potential of irisin in AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marika Cordaro, Angela Trovato Salinaro, Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Maria Scuto, Maria Laura Ontario, Salvatore Cuzzocrea, Rosanna Di Paola, Roberta Fusco, Vittorio Calabrese
Summary: Alzheimer's disease is the principal cause of dementia and is associated with neurodegenerative disorders. Hericium erinaceus, a nutritional mushroom with important antioxidant effects, has shown significant therapeutic effects in a rat model of AD, reducing behavioral changes and hippocampal neuronal degeneration.
Review
Biochemistry & Molecular Biology
Laura Gomez-Virgilio, Alejandro Luarte, Daniela P. Ponce, Barbara A. Bruna, Maria Behrens
Summary: Among the proposed pathogenic mechanisms for Alzheimer's disease, increased oxidative stress appears to be a robust and early feature. Utilizing patient-derived peripheral cells may provide a more biologically relevant model for studying the disease. Analyzing olfactory neuronal precursors isolated non-invasively through NADH FLIM has the potential to reveal AD-related oxidative stress and accelerate the discovery of effective antioxidant therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Mohd. Akram, Mohd Neha, Mohd Pinky, Mohd Saqib, Mohd Salman, Suhel Parvez
Summary: This study investigated the protective effects of ropinirole (ROP) medication in a Wistar rat model of cognitive decline induced by A beta(1-42). ROP was found to attenuate cognitive deficits, improve spatial learning and memory, and exhibit antioxidant benefits. Additionally, ROP reduced neuronal loss and potentially modulated the pathogenesis of Alzheimer's disease (AD) through its protective effects on oxidative stress and mitochondrial function.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Giuseppe Caruso, Margherita Grasso, Annamaria Fidilio, Sebastiano Alfio Torrisi, Nicolo Musso, Federica Geraci, Maria Rosaria Tropea, Anna Privitera, Fabio Tascedda, Daniela Puzzo, Salvatore Salomone, Filippo Drago, Gian Marco Leggio, Filippo Caraci
Summary: The study shows that depression is a risk factor for Alzheimer's disease. Antidepressants can reverse memory deficits and depressive-like phenotype induced by Aβ oligomers, as well as prevent Aβ-induced oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Bhagteshwar Singh, Suzannah Lant, Sofia Cividini, Jonathan W. S. Cattrall, Lynsey C. Goodwin, Laura Benjamin, Benedict D. Michael, Ayaz Khawaja, Aline de Moura Brasil Matos, Walid Alkeridy, Andrea Pilotto, Durjoy Lahiri, Rebecca Rawlinson, Sithembinkosi Mhlanga, Evelyn C. Lopez, Brendan F. Sargent, Anushri Somasundaran, Arina Tamborska, Glynn Webb, Komal Younas, Yaqub Al Sami, Heavenna Babu, Tristan Banks, Francesco Cavallieri, Matthew Cohen, Emma Davies, Shalley Dhar, Anna Fajardo Modol, Hamzah Farooq, Jeffrey Harte, Samuel Hey, Albert Joseph, Dileep Karthikappallil, Daniel Kassahun, Gareth Lipunga, Rachel Mason, Thomas Minton, Gabrielle Mond, Joseph Poxon, Sophie Rabas, Germander Soothill, Marialuisa Zedde, Konstantin Yenkoyan, Bruce Brew, Erika Contini, Lucette Cysique, Xin Zhang, Pietro Maggi, Vincent van Pesch, Jerome Lechien, Sven Saussez, Alex Heyse, Maria Lucia Brito Ferreira, Cristiane N. Soares, Isabel Elicer, Laura Eugenin-von Bernhardi, Waleng Nancupil Reyes, Rong Yin, Mohammed A. Azab, Foad Abd-Allah, Ahmed Elkady, Simon Escalard, Jean-Christophe Corvol, Cecile Delorme, Pierre Tattevin, Kevin Bigaut, Norbert Lorenz, Daniel Hornuss, Jonas Hosp, Siegbert Rieg, Dirk Wagner, Benjamin Knier, Paul Lingor, Andrea Sylvia Winkler, Athena Sharifi-Razavi, Shima T. Moein, SeyedAhmad SeyedAlinaghi, Saeidreza JamaliMoghadamSiahkali, Mauro Morassi, Alessandro Padovani, Marcello Giunta, Ilenia Libri, Simone Beretta, Sabrina Ravaglia, Matteo Foschi, Paolo Calabresi, Guido Primiano, Serenella Servidei, Nicola Biagio Mercuri, Claudio Liguori, Mariangela Pierantozzi, Loredana Sarmati, Federica Boso, Silvia Garazzino, Sara Mariotto, Kimani N. Patrick, Oana Costache, Alexander Pincherle, Frederikus A. Klok, Roger Meza, Veronica Cabreira, Sofia R. Valdoleiros, Vanessa Oliveira, Igor Kaimovsky, Alla Guekht, Jasmine Koh, Eva Fernandez Diaz, Jose Maria Barrios-Lopez, Cristina Guijarro-Castro, Alvaro Beltran-Corbellini, Javier Martinez-Poles, Alba Maria Diezma-Martin, Maria Isabel Morales-Casado, Sergio Garcia Garcia, Gautier Breville, Matteo Coen, Marjolaine Uginet, Raphael Bernard-Valnet, Renaud Du Pasquier, Yildiz Kaya, Loay H. Abdelnour, Claire Rice, Hamish Morrison, Sylviane Defres, Saif Huda, Noelle Enright, Jane Hassell, Lucio D'Anna, Matthew Benger, Laszlo Sztriha, Eamon Raith, Krishna Chinthapalli, Ross Nortley, Ross Paterson, Arvind Chandratheva, David J. Werring, Samir Dervisevic, Kirsty Harkness, Ashwin Pinto, Dinesh Jillella, Scott Beach, Kulothungan Gunasekaran, Ivan Rocha Ferreira Da Silva, Krishna Nalleballe, Jonathan Santoro, Tyler Scullen, Lora Kahn, Carla Y. Kim, Kiran T. Thakur, Rajan Jain, Thirugnanam Umapathi, Timothy R. Nicholson, James J. Sejvar, Eva Maria Hodel, Catrin Tudur Smith, Tom Solomon
Summary: This study investigated the spectrum of neurological disease in hospitalized COVID-19 patients and analyzed the clinical outcomes and factors associated with poor outcomes. The study found that encephalopathy and cerebrovascular events were the most common diagnoses, with cerebrovascular event patients more likely to have poor outcomes. Specific risk factors for poor outcomes included breathlessness on admission and elevated D-dimer. Overall, neurological COVID-19 disease poses a considerable burden in terms of disease outcomes and use of hospital resources.
Article
Biochemistry & Molecular Biology
Konstantin A. Demin, Olga Kupriyanova, Vadim A. Shevyrin, Ksenia A. Derzhavina, Nataliya A. Krotova, Nikita P. Ilyin, Tatiana O. Kolesnikova, David S. Galstyan, Yurii M. Kositsyn, Abubakar-Askhab S. Khaybaev, Maria Seredinskaya, Yaroslav Dubrovskii, Raziya G. Sadykova, Maria O. Nerush, Mikael S. Mor, Elena Petersen, Tatyana Strekalova, Evgeniya Efimova, Savelii R. Kuvarzin, Konstantin B. Yenkoyan, Dmitrii Bozhko, Vladislav O. Myrov, Sofia M. Kolchanova, Aleksander Polovian, Georgii K. Galumov, Allan Kalueff
Summary: This passage introduces the zebrafish as a powerful animal model for studying neuroactive drugs, including hallucinogens. A battery of novel NBPEA derivatives were tested on adult zebrafish, showing significant acute behavioral and neurochemical effects. Computational analyses identified distinct clusters for these agents and revealed the phenotypic similarities between NBPEAs and conventional hallucinogens.
ACS CHEMICAL NEUROSCIENCE
(2022)
Review
Behavioral Sciences
Alim A. Bashirzade, Konstantin N. Zabegalov, Andrey D. Volgin, Alisa S. Belova, Konstantin A. Demin, Murilo S. de Abreu, Vladislav Ya. Babchenko, Kseniya A. Bashirzade, Konstantin B. Yenkoyan, Maria A. Tikhonova, Tamara G. Amstislavskaya, Allan V. Kalueff
Summary: Neurodegenerative diseases, such as Alzheimer's and Parkinson's, have a complex pathogenesis involving genetic and neurochemical deficits, misfolded protein toxicity, and mitochondrial dysfunctions. Zebrafish models have been proven to be highly relevant in studying these diseases and can provide insights into the underlying mechanisms.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Multidisciplinary Sciences
Mariam Movsisyan, Armine Chopikyan, Irina Kasparova, Gohar Hakobjanyan, Fabrice Carrat, Meline Sukiasyan, Marieta Rushanyan, Mariam Chalabyan, Sanobar Shariff, Burhan Kantawala, Anna Keshishyan, Alvard Hovhannisyan, Armine Hakobyan, Gayane Petrosyan, Armen Minasyan, Armen Muradyan, Arsene Mekinian, Konstantin Yenkoyan
Summary: The comprehension of long-term humoral immune response against SARS-CoV-2 is crucial for the treatment and vaccination strategies of COVID-19. In this study, we found that the majority of convalescent patients had durable antibodies lasting more than a year, and the antibody levels were correlated with disease severity and age.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Karine Melkumyan, Darshan Shingala, Syuzanna Simonyan, Hrag Torossian, Karen Mkrtumyan, Karen Dilbaryan, Garri Davtyan, Erik Vardumyan, Konstantin Yenkoyan
Summary: This study aimed to evaluate the degree of smell and taste disturbances caused by COVID-19 among the Armenian population. The results showed that the trigeminal nerve was more affected and taste disturbances did not improve over time.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Anatomy & Morphology
S. H. Sarkisyan, M. H. Danielyan, L. Darbinyan, K. Simonyan, V. A. Chavushyan
Summary: This study investigated the characteristics of impulse activity in the neurons of the lateral vestibular nucleus of unilaterally labyrinthectomized rats during different periods of vibration exposure. The results showed that the mean impulse frequency of neurons on the injured side was lower than that on the uninjured side after vibration exposure.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Endocrinology & Metabolism
V. A. Chavushyan, K. Simonyan, M. H. Danielyan, L. G. Avetisyan, L. Darbinyan, A. S. Isoyan, A. G. Lorikyan, L. E. Hovhannisyan, M. A. Babakhanyan, L. M. Sukiasyan
Summary: A high-fructose diet causes microvascular and neuronal disorders in the brain of rats, but pharmacological treatments can modulate these disorders and delay cognitive decline.
METABOLIC BRAIN DISEASE
(2023)
Article
Multidisciplinary Sciences
Gohar Karapetyan, Katarine Fereshetyan, Hayk Harutyunyan, Konstantin Yenkoyan
Summary: Alzheimer's disease is a type of dementia that affects memory, thinking, and behavior. The combination of A beta and oxidative stress plays a critical role in the development of Alzheimer's disease.
SCIENTIFIC REPORTS
(2022)
Article
Parasitology
Amandine Pisoni, Elisa Reynaud, Maylis Douine, Louise Hureau, Carmen Alcocer Cordellat, Roxane Schaub, Dennis Poland, Richard Monkel, Joan Lommen, Konstantin Yenkoyan, Stephen Vreden, Mathieu Nacher, Edouard Tuaillon
Summary: A standardized blood collection device combined with an automated elution system was used to test illegal gold miners in French Guiana for HIV, HBV, HCV, and syphilis. The results showed that the Ser-Col method allows automated dried blood testing with performances comparable to dried blood spot sampling. This method facilitates large-scale surveys and improves testing in remote areas.
Review
Biochemistry & Molecular Biology
Fabiano V. Costa, Tatiana O. Kolesnikova, David S. Galstyan, Nikita P. Ilyin, Murilo S. de Abreu, Elena V. Petersen, Konstantin A. Demin, Konstantin B. Yenkoyan, Allan V. Kalueff
Summary: Psychiatric disorders are prevalent brain pathologies. Reliable animal models are needed for effective treatment. Zebrafish show complex behaviors similar to rodents and humans, making them suitable for modeling psychiatric disorders. However, there are challenges and the field needs further discussion and consideration of clinical prevalence and pathological complexity. Recent developments in molecular biology might pave the way for wider use of zebrafish in CNS disease modeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yuriy M. Kositsyn, Murilo S. de Abreu, Tatiana O. Kolesnikova, Alexey A. Lagunin, Vladimir V. Poroikov, Hasmik S. Harutyunyan, Konstantin B. Yenkoyan, Allan V. Kalueff
Summary: Depression and schizophrenia are common and debilitating neuropsychiatric disorders, for which current pharmacotherapies have limited efficacy and significant side effects. This highlights the need for novel drug targets. Recent advancements in translational research, research tools, and approaches have provided potential avenues for innovative drug discovery. This article provides a comprehensive overview of current treatments and outlines potential molecular targets for these disorders, while also addressing translational challenges and unanswered questions to encourage further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Anton D. D. Shevlyakov, Tatiana O. O. Kolesnikova, Murilo S. S. de Abreu, Elena V. V. Petersen, Konstantin B. B. Yenkoyan, Konstantin A. A. Demin, Allan V. V. Kalueff
Summary: Epilepsy is a neurological disorder characterized by seizures and neuronal hyperactivity. The exact pathogenesis is not fully understood, but genetic factors are known to play a key role. In this study, a computational approach was used to generate a comprehensive network of molecular pathways associated with epilepsy. The study identified potential key interactors and revealed functional molecular pathways, highlighting the importance of targeting downstream pathways for more effective treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Senik Matinyan, Burak Demir, Pavel Filipcik, Jan Pieter Abrahams, Eric van Genderen
Summary: As an alternative to traditional methods, single-molecule electron diffraction offers better resolution and signal-to-noise ratio for protein models. However, collecting the vast amount of diffraction patterns can lead to data congestion. To address this, machine learning algorithms were used for data classification, effectively distinguishing between different materials. While limited in its current application, this approach has the potential for protein data classification and feature extraction.
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES
(2023)
Review
Clinical Neurology
L. Hovhannisyan, S. Khachatryan, A. Khamperyan, S. Matinyan
Summary: The purpose of this study was to systematically review and meta-analyze the safety, effectiveness, and limitations of stem cell therapies in stroke patients. The findings showed that while stem cell therapy was reasonably safe, the effectiveness evidence varied greatly due to the heterogeneity of clinical trials and the lack of a systematic approach. The sources of stem cells and the timing of administration were not strongly associated with clinical outcomes. Further research is needed to understand the differences between preclinical and clinical trials and to conduct phase 3 clinical trials with robust control of study characteristics and outcomes.
NEUROLOGICAL SCIENCES
(2023)
Review
Veterinary Sciences
Maria M. Kotova, David S. Galstyan, Tatiana O. Kolesnikova, Murilo S. de Abreu, Tamara G. Amstislavskaya, Tatyana Strekalova, Elena V. Petersen, Konstantin B. Yenkoyan, Konstantin A. Demin, Allan V. Kalueff
Summary: Antimicrobial drugs can influence the central nervous system and gut microbiota, leading to changes in brain and behavior. Zebrafish models are useful for studying the effects of these drugs on the central nervous system. Recent research has revealed the impacts of a wide range of antimicrobial drugs on brain and behavior in zebrafish.
VETERINARY SCIENCES
(2023)