Merging chemoenzymatic and radical-based retrosynthetic logic for rapid and modular synthesis of oxidized meroterpenoids

Intermolecular C(sp3 )−H Amination of Complex Molecules

(2018) Nicholas D. Chiappini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total synthesis of complex terpenoids employing radical cascade processes

(2018) Kevin Hung et al.   NATURAL PRODUCT REPORTS

Radical Retrosynthesis

(2018) Joel M. Smith et al.   ACCOUNTS OF CHEMICAL RESEARCH

The High Chemofidelity of Metal-Catalyzed Hydrogen Atom Transfer

(2018) Samantha A. Green et al.   ACCOUNTS OF CHEMICAL RESEARCH

Scalable, Electrochemical Oxidation of Unactivated C–H Bonds

(2017) Yu Kawamata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C—H Functionalization

(2017) Andrew N. Lowell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Total Synthesis of Nigelladine A via Late-Stage C–H Oxidation Enabled by an Engineered P450 Enzyme

(2017) Steven A. Loskot et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fe-Catalyzed C–C Bond Construction from Olefins via Radicals

(2017) Julian C. Lo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mn-, Fe-, and Co-Catalyzed Radical Hydrofunctionalizations of Olefins

(2016) Steven W. M. Crossley et al.   CHEMICAL REVIEWS

Site-Selective Aliphatic C–H Chlorination Using N-Chloroamides Enables a Synthesis of Chlorolissoclimide

(2016) Ryan K. Quinn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of fungal meroterpenoids

(2016) Yudai Matsuda et al.   NATURAL PRODUCT REPORTS

Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation

(2016) Jonathan Latham et al.   Nature Communications

Late-Stage Diversification of Biologically Active Molecules via Chemoenzymatic C–H Functionalization

(2016) Landon J. Durak et al.   ACS Catalysis

Improving the Monooxygenase Activity and the Regio- and Stereoselectivity of Terpenoid Hydroxylation Using Ester Directing Groups

(2016) Emma A. Hall et al.   ACS Catalysis

Simple, Chemoselective Hydrogenation with Thermodynamic Stereocontrol

(2014) Kotaro Iwasaki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Method for the Selective Hydrogenation of Alkenyl Halides to Alkyl Halides

(2014) Sandra M. King et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unusual cyclic terpenoids with terminal pendant prenyl moieties: from occurrence to synthesis

(2014) Veaceslav Kulcitki et al.   NATURAL PRODUCT REPORTS

Brevianes Revisited

(2013) Francisco A. Macías et al.   CHEMICAL REVIEWS

Biocatalytic retrosynthesis

(2013) Nicholas J Turner et al.   Nature Chemical Biology

Scalable, Divergent Synthesis of Meroterpenoids via “Borono-sclareolide”

(2012) Darryl D. Dixon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Isolation, Chemical, and Biotransformation Routes of Labdane-type Diterpenes

(2011) Luís M. T. Frija et al.   CHEMICAL REVIEWS

P450 Fingerprinting Method for Rapid Discovery of Terpene Hydroxylating P450 Catalysts with Diversified Regioselectivity

(2011) Kaidong Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantiocontrolled Total Syntheses of Breviones A, B, and C

(2011) Hiromasa Yokoe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Combinatorial Alanine Substitution Enables Rapid Optimization of Cytochrome P450BM3 for Selective Hydroxylation of Large Substrates

(2010) Jared C. Lewis et al.   CHEMBIOCHEM

Nickel-Catalyzed Reductive Cross-Coupling of Aryl Halides with Alkyl Halides

(2010) Daniel A. Everson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases

(2010) Takayuki Itoh et al.   Nature Chemistry

Combined Effects on Selectivity in Fe-Catalyzed Methylene Oxidation

(2010) M. S. Chen et al.   SCIENCE

Synthesis of (+)-makassaric acid, a protein kinase MK2 inhibitor

(2010) P. Basabe et al.   TETRAHEDRON

Scalable synthesis of methyl ent-isocopalate and its derivatives

(2010) Si-Kai Hua et al.   TETRAHEDRON

Directed evolution drives the next generation of biocatalysts

(2009) Nicholas J Turner   Nature Chemical Biology

Unusually cyclized triterpenes: occurrence, biosynthesis and chemical synthesis

(2008) Victoriano Domingo et al.   NATURAL PRODUCT REPORTS

Brønsted Acid-Catalyzed Synthesis of Pyransvia a Formal [3+3] Cycloaddition

(2007) Claudie Hubert et al.   ADVANCED SYNTHESIS & CATALYSIS