The KRAS-BCAA-BCAT2 axis in PDAC development

BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma

(2020) Jin-Tao Li et al.   NATURE CELL BIOLOGY

Acetyl-CoA metabolism supports multi-step pancreatic tumorigenesis

(2019) Alessandro Carrer et al.   Cancer Discovery

Branched-chain amino acid metabolism in cancer

(2018) Elitsa A. Ananieva et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer

(2018) Marcus D. Goncalves et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

(2017) Prasenjit Dey et al.   NATURE

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

(2017) Simon Raffel et al.   NATURE

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

(2017) Oliver D. K. Maddocks et al.   NATURE

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

(2016) J. R. Mayers et al.   SCIENCE

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1

(2013) Martje Tönjes et al.   NATURE MEDICINE