Implications of the Gut Microbiome in Parkinson's Disease

Microbiome, Parkinson’s Disease and Molecular Mimicry

(2019) Fabiana Miraglia et al.   Cells

Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers

(2019) Nielson T. Baxter et al.   mBio

Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

(2019) Serena Sanna et al.   NATURE GENETICS

Selected serum cytokines and nitric oxide as potential multi-marker biosignature panels for Parkinson disease of varying durations: a case-control study

(2019) Dilini Rathnayake et al.   BMC Neurology

The combination of sport and sport-specific diet is associated with characteristics of gut microbiota: an observational study

(2019) Lae-Guen Jang et al.   Journal of the International Society of Sports Nutrition

Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats

(2019) Nathalie Van Den Berge et al.   ACTA NEUROPATHOLOGICA

Altered gut microbiota and inflammatory cytokine responses in patients with Parkinson’s disease

(2019) Chin-Hsien Lin et al.   Journal of Neuroinflammation

Potential roles of gut microbiome and metabolites in modulating ALS in mice

(2019) Eran Blacher et al.   NATURE

Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice

(2019) Diana Matheoud et al.   NATURE

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

(2019) Sangjune Kim et al.   NEURON

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

Potential Role of the Gut Microbiome in ALS: A Systematic Review

(2018) Michelle L. Wright et al.   Biological Research for Nursing

Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson’s disease mice: Gut microbiota, glial reaction and TLR4/TNF-α signaling pathway

(2018) Meng-Fei Sun et al.   BRAIN BEHAVIOR AND IMMUNITY

Alteration of the fecal microbiota in Chinese patients with Parkinson’s disease

(2018) Yiwei Qian et al.   BRAIN BEHAVIOR AND IMMUNITY

Clinical and metabolic response to probiotic administration in people with Parkinson's disease: A randomized, double-blind, placebo-controlled trial

(2018) Omid Reza Tamtaji et al.   CLINICAL NUTRITION

Inflammatory bowel disease increases the risk of Parkinson’s disease: a Danish nationwide cohort study 1977–2014

(2018) Marie Villumsen et al.   GUT

Inflammatory Bowel Disease and Parkinson’s Disease: A Nationwide Swedish Cohort Study

(2018) Petra Weimers et al.   INFLAMMATORY BOWEL DISEASES

Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve

(2018) Norihito Uemura et al.   Molecular Neurodegeneration

The fecal microbiome of ALS patients

(2018) David Brenner et al.   NEUROBIOLOGY OF AGING

Internalization, axonal transport and release of fibrillar forms of alpha-synuclein

(2018) Gregor Bieri et al.   NEUROBIOLOGY OF DISEASE

Fecal markers of intestinal inflammation and intestinal permeability are elevated in Parkinson's disease

(2018) Andreas Schwiertz et al.   PARKINSONISM & RELATED DISORDERS

Helicobacter pylori infection is associated with an increased risk of Parkinson's disease: A population-based retrospective cohort study

(2018) Huei-Kai Huang et al.   PARKINSONISM & RELATED DISORDERS

Anti–Tumor Necrosis Factor Therapy and Incidence of Parkinson Disease Among Patients With Inflammatory Bowel Disease

(2018) Inga Peter et al.   JAMA Neurology

The risk of Parkinson’s disease in inflammatory bowel disease: A systematic review and meta-analysis

(2018) Feng zhu et al.   DIGESTIVE AND LIVER DISEASE

Intestinal Pathology and Gut Microbiota Alterations in a Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Mouse Model of Parkinson’s Disease

(2018) Feng Lai et al.   NEUROCHEMICAL RESEARCH

The impact of Helicobacter pylori infection, eradication therapy and probiotic supplementation on gut microenvironment homeostasis: An open-label, randomized clinical trial

(2018) Luyi Chen et al.   EBioMedicine

Immune system responses in Parkinson's disease: Early and dynamic

(2018) Malú G. Tansey et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease

(2018) Nicholas M. Vogt et al.   Alzheimers Research & Therapy

The Microbiome-Gut-Brain Axis in Health and Disease

(2017) Timothy G. Dinan et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

American Association of Neuropathologists, Inc. Abstracts of the 93rd Annual Meeting June 8–11, 2017 Garden Grove, CA

(2017)   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Assessment of neuroinflammation in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study

(2017) Morten Gersel Stokholm et al.   LANCET NEUROLOGY

Assessments of plasma ghrelin levels in the early stages of parkinson's disease

(2017) Ning Song et al.   MOVEMENT DISORDERS

Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome

(2017) Erin M. Hill-Burns et al.   MOVEMENT DISORDERS

The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder

(2017) Anna Heintz-Buschart et al.   MOVEMENT DISORDERS

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Vagotomy and Parkinson disease

(2017) Bojing Liu et al.   NEUROLOGY

Gut microbiota: Implications in Parkinson's disease

(2017) Arun Parashar et al.   PARKINSONISM & RELATED DISORDERS

Structural changes of gut microbiota in Parkinson’s disease and its correlation with clinical features

(2017) Wei Li et al.   Science China-Life Sciences

Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson’s disease patients

(2017) J. R. Bedarf et al.   Genome Medicine

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation

(2016) Diana Matheoud et al.   CELL

Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes

(2016) Saïda Abounit et al.   EMBO JOURNAL

Association Between Parkinsonʼs Disease and Inflammatory Bowel Disease

(2016) Jung-Chun Lin et al.   INFLAMMATORY BOWEL DISEASES

Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson's Disease

(2016) J. A. Bayliss et al.   JOURNAL OF NEUROSCIENCE

Appendectomy in mid and later life and risk of Parkinson's disease: A population-based study

(2016) Connie Marras et al.   MOVEMENT DISORDERS

Appendectomy and risk of Parkinson's disease: A nationwide cohort study with more than 10 years of follow-up

(2016) Elisabeth Svensson et al.   MOVEMENT DISORDERS

Neuropathological basis of nonmotor manifestations of Parkinson's disease

(2016) Charles H. Adler et al.   MOVEMENT DISORDERS

Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls

(2016) Marcus M. Unger et al.   PARKINSONISM & RELATED DISORDERS

Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases

(2016) Shivani Ghaisas et al.   PHARMACOLOGY & THERAPEUTICS

Evaluation of the Microbial Diversity in Amyotrophic Lateral Sclerosis Using High-Throughput Sequencing

(2016) Xin Fang et al.   Frontiers in Microbiology

Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health

(2016) David Ríos-Covián et al.   Frontiers in Microbiology

Augmentation of Autoantibodies by Helicobacter pylori in Parkinson’s Disease Patients May Be Linked to Greater Severity

(2016) Gunasekaran Suwarnalata et al.   PLoS One

Protective effect of vagotomy suggests source organ for Parkinson disease

(2015) Madison T. Gray et al.   ANNALS OF NEUROLOGY

Does vagotomy reduce the risk of Parkinson's disease: The authors reply

(2015) Elisabeth Svensson et al.   ANNALS OF NEUROLOGY

Does vagotomy reduce the risk of Parkinson's disease?

(2015) Ole-Bjørn Tysnes et al.   ANNALS OF NEUROLOGY

Vagotomy and subsequent risk of Parkinson's disease

(2015) Elisabeth Svensson et al.   ANNALS OF NEUROLOGY

Gut Microbiota: The Conductor in the Orchestra of Immune–Neuroendocrine Communication

(2015) Sahar El Aidy et al.   CLINICAL THERAPEUTICS

Can Parkinson's Disease Come From the Gut?

(2015) Ronald B. Postuma   MOVEMENT DISORDERS

Appendectomy may delay Parkinson's disease Onset

(2015) Alexandre Mendes et al.   MOVEMENT DISORDERS

Colonic bacterial composition in Parkinson's disease

(2015) Ali Keshavarzian et al.   MOVEMENT DISORDERS

MDS research criteria for prodromal Parkinson's disease

(2015) Daniela Berg et al.   MOVEMENT DISORDERS

Commensal bacteria direct selective cargo sorting to promote symbiosis

(2015) Qin Zhang et al.   NATURE IMMUNOLOGY

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

The association between infectious burden and Parkinson's disease: A case-control study

(2015) Xian-Le Bu et al.   PARKINSONISM & RELATED DISORDERS

Helicobacter pylori infection is associated with worse severity of Parkinson's disease

(2015) Ai Huey Tan et al.   PARKINSONISM & RELATED DISORDERS

Intestinal Dysbiosis and Lowered Serum Lipopolysaccharide-Binding Protein in Parkinson’s Disease

(2015) Satoru Hasegawa et al.   PLoS One

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Increased Intestinal Permeability and Parkinson Disease Patients: Chicken or Egg?

(2014) D. Salat-Foix et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Cytokine Gene Polymorphisms and Parkinson's Disease: A Meta-Analysis

(2014) Chu Ketan et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Six Persistent Research Misconceptions

(2014) Kenneth J. Rothman   JOURNAL OF GENERAL INTERNAL MEDICINE

The Gut Microbiome and the Brain

(2014) Leo Galland   JOURNAL OF MEDICINAL FOOD

ATP13A2/PARK9 Regulates Secretion of Exosomes and  -Synuclein

(2014) T. Tsunemi et al.   JOURNAL OF NEUROSCIENCE

Neuro-humoral signalling by bile acids and the TGR5 receptor in the gastrointestinal tract

(2014) Nigel W. Bunnett   JOURNAL OF PHYSIOLOGY-LONDON

The prevalence of Parkinson's disease: A systematic review and meta-analysis

(2014) Tamara Pringsheim et al.   MOVEMENT DISORDERS

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

Small intestinal bacterial overgrowth in Parkinson's disease

(2014) Ai Huey Tan et al.   PARKINSONISM & RELATED DISORDERS

Ghrelin as a Neuroprotective and Palliative Agent in Alzheimer's and Parkinson's Disease

(2013) Vanessa V. dos Santos et al.   CURRENT PHARMACEUTICAL DESIGN

Antimicrobial Surveillance in Idiopathic Parkinsonism: Indication-Specific Improvement in Hypokinesia FollowingHelicobacter pyloriEradication and Non-Specific Effect of Antimicrobials for Other Indications in Worsening Rigidity

(2013) Sylvia M. Dobbs et al.   HELICOBACTER

Motor fluctuations and Helicobacter pylori in Parkinson’s disease

(2013) Karl-Erik Rahne et al.   JOURNAL OF NEUROLOGY

Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study

(2013) Alex Iranzo et al.   LANCET NEUROLOGY

Alpha-synuclein in the appendiceal mucosa of neurologically intact subjects

(2013) Madison T. Gray et al.   MOVEMENT DISORDERS

The role of small intestinal bacterial overgrowth in Parkinson's disease

(2013) Alfonso Fasano et al.   MOVEMENT DISORDERS

Sodium butyrate improves locomotor impairment and early mortality in a rotenone-induced Drosophila model of Parkinson’s disease

(2013) R. St. Laurent et al.   NEUROSCIENCE

Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series

(2013) Carlos H. Schenck et al.   SLEEP MEDICINE

Inflammation and Adaptive Immunity in Parkinson's Disease

(2013) R. L. Mosley et al.   Cold Spring Harbor Perspectives in Medicine

Voices from within: gut microbes and the CNS

(2012) Paul Forsythe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Human milk oligosaccharide consumption by intestinal microbiota

(2012) A. Marcobal et al.   CLINICAL MICROBIOLOGY AND INFECTION

Treatment for Helicobacter pylori infection and risk of parkinson’s disease in Denmark

(2012) H. H. Nielsen et al.   EUROPEAN JOURNAL OF NEUROLOGY

The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders

(2012) Raymond H Thomas et al.   Journal of Neuroinflammation

Prospective outcome of rapid eye movement sleep behaviour disorder: psychiatric disorders as a potential early marker of Parkinson's disease: Figure 1

(2012) Yun Kwok Wing et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Blue-green algae or cyanobacteria in the intestinal micro-flora may produce neurotoxins such as Beta-N-Methylamino-l-Alanine (BMAA) which may be related to development of amyotrophic lateral sclerosis, Alzheimer’s disease and Parkinson-Dementia-Complex in humans and Equine Motor Neuron Disease in Horses

(2012) Steven R. Brenner   MEDICAL HYPOTHESES

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

Colonic inflammation in Parkinson's disease

(2012) David Devos et al.   NEUROBIOLOGY OF DISEASE

Leukocyte-subset counts in idiopathic parkinsonism provide clues to a pathogenic pathway involving small intestinal bacterial overgrowth. A surveillance study

(2012) R Dobbs et al.   Gut Pathogens

Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

(2012) Francisco Pan-Montojo et al.   Scientific Reports

Local infusion of ghrelin enhanced hippocampal synaptic plasticity and spatial memory through activation of phosphoinositide 3-kinase in the dentate gyrus of adult rats

(2011) Liang Chen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Prevalence of Small Intestinal Bacterial Overgrowth in Parkinson's Disease

(2011) Maurizio Gabrielli et al.   MOVEMENT DISORDERS

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

Role of ghrelin system in neuroprotection and cognitive functions: Implications in Alzheimer's disease

(2011) Manuel D. Gahete et al.   PEPTIDES

Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease

(2011) Christopher B. Forsyth et al.   PLoS One

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress and animal models of inflammatory bowel disease—An update on the role of the hypothalamo–pituitary–adrenal axis

(2011) S.O. Reber   PSYCHONEUROENDOCRINOLOGY

Brain?Gut?Microbe Communication in Health and Disease

(2011) Sue Grenham et al.   Frontiers in Physiology

Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

(2010) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

Protection of dopaminergic cells from MPP+-mediated toxicity by histone deacetylase inhibition

(2010) Sarah K. Kidd et al.   BRAIN RESEARCH

Proteasome inhibition in medaka brain induces the features of Parkinson’s disease

(2010) Hideaki Matsui et al.   JOURNAL OF NEUROCHEMISTRY

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

IBS: an epigenetic perspective

(2010) Timothy G. Dinan et al.   Nature Reviews Gastroenterology & Hepatology

Cyanobacterial neurotoxin BMAA in ALS and Alzheimer’s disease

(2009) J. Pablo et al.   ACTA NEUROLOGICA SCANDINAVICA

Innate and Adaptive Immunity for the Pathobiology of Parkinson's Disease

(2009) David K. Stone et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular Pathology of Lewy Body Diseases

(2009) Katrin Beyer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ghrelin Promotes and Protects Nigrostriatal Dopamine Function via a UCP2-Dependent Mitochondrial Mechanism

(2009) Z. B. Andrews et al.   JOURNAL OF NEUROSCIENCE

Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

(2009) Dennis W Dickson et al.   LANCET NEUROLOGY

The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease

(2009) Paolo Barone et al.   MOVEMENT DISORDERS

Medical records documentation of constipation preceding Parkinson disease: A case-control study

(2009) R. Savica et al.   NEUROLOGY

Neuroprotective Effect of Ghrelin in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson’s Disease by Blocking Microglial Activation

(2009) Minho Moon et al.   NEUROTOXICITY RESEARCH

A timeline for Parkinson's disease

(2009) Christopher H. Hawkes et al.   PARKINSONISM & RELATED DISORDERS

Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra

(2008) Hong Jiang et al.   EXPERIMENTAL NEUROLOGY

HelicobacterHypothesis for Idiopathic Parkinsonism: Before and Beyond

(2008) R. John Dobbs et al.   HELICOBACTER

Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons

(2008) Xuefei Wu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Ghrelin Antagonized 1-Methyl-4-Phenylpyridinium (MPP+)-Induced Apoptosis in MES23.5 Cells

(2008) Juanjuan Dong et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Helicobacter pyloriinfection and motor fluctuations in patients with Parkinson's disease

(2008) Won Yong Lee et al.   MOVEMENT DISORDERS

Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder

(2008) R. B. Postuma et al.   NEUROLOGY

The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease: a critical analysis of α-synuclein staging

(2008) M. E. Kalaitzakis et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons

(2008) Eric J. Benner et al.   PLoS One