A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L
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Title
A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L
Authors
Keywords
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Journal
MOLECULES
Volume 25, Issue 3, Pages 698
Publisher
MDPI AG
Online
2020-02-08
DOI
10.3390/molecules25030698
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Note: Only part of the references are listed.- Clinical and translational pharmacology of the cathepsin K inhibitor odanacatib studied for osteoporosis
- (2019) Julie A. Stone et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Cell penetrable, clickable and tagless activity-based probe of human cathepsin L
- (2019) Dibyendu Dana et al. BIOORGANIC CHEMISTRY
- Cysteine Cathepsins in Tumor-Associated Immune Cells
- (2019) Tanja Jakoš et al. Frontiers in Immunology
- Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain
- (2019) Paul D. Boudreau et al. JOURNAL OF MEDICINAL CHEMISTRY
- Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors
- (2018) Maude Giroud et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cysteine cathepsins in extracellular matrix remodeling: Extracellular matrix degradation and beyond
- (2018) Matej Vizovišek et al. MATRIX BIOLOGY
- Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes
- (2018) Marcin Poreba et al. Chemical Science
- UniProt: a worldwide hub of protein knowledge
- (2018) NUCLEIC ACIDS RESEARCH
- Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors
- (2017) Bernd Kuhn et al. JOURNAL OF MEDICINAL CHEMISTRY
- Toolbox of Fluorescent Probes for Parallel Imaging Reveals Uneven Location of Serine Proteases in Neutrophils
- (2017) Paulina Kasperkiewicz et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Clinical significance of cathepsin L and cathepsin B in dilated cardiomyopathy
- (2017) Siddharth Mehra et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Optimization of a Protease Activated Probe for Optical Surgical Navigation
- (2017) Joshua J. Yim et al. MOLECULAR PHARMACEUTICS
- The Future of Cysteine Cathepsins in Disease Management
- (2017) Lovro Kramer et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Cathepsin L and B as Potential Markers for Liver Fibrosis: Insights From Patients and Experimental Models
- (2017) Mansi Manchanda et al. Clinical and Translational Gastroenterology
- Preclinical Evaluation of Cathepsin-Based Fluorescent Imaging System for Cytoreductive Surgery
- (2016) Carlos H. F. Chan et al. ANNALS OF SURGICAL ONCOLOGY
- Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94
- (2016) Dhivya R. Sudhan et al. CLINICAL & EXPERIMENTAL METASTASIS
- Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of Cathepsin L
- (2016) Piotr Sosnowski et al. FEBS LETTERS
- Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins
- (2016) Stjepko Cermak et al. PLoS One
- Antimicrobial Peptide LL-37 Is Both a Substrate of Cathepsins S and K and a Selective Inhibitor of Cathepsin L
- (2015) Pierre-Marie Andrault et al. BIOCHEMISTRY
- Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L
- (2015) Erica N. Parker et al. BIOORGANIC & MEDICINAL CHEMISTRY
- 1 The cathepsin-L inhibitor CAA0225 protects against myocardial ischaemia-reperfusion injury
- (2015) W He et al. HEART
- Multiple Cathepsins Promote Pro–IL-1β Synthesis and NLRP3-Mediated IL-1β Activation
- (2015) Gregory M. Orlowski et al. JOURNAL OF IMMUNOLOGY
- Cathepsin L targeting in cancer treatment
- (2015) Dhivya R. Sudhan et al. PHARMACOLOGY & THERAPEUTICS
- Redundancy between Cysteine Cathepsins in Murine Experimental Autoimmune Encephalomyelitis
- (2015) Euan Ramsay Orr Allan et al. PLoS One
- Cysteine cathepsins: their role in tumor progression and recent trends in the development of imaging probes
- (2015) Reik Löser et al. Frontiers in Chemistry
- Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors
- (2015) Marton Siklos et al. Acta Pharmaceutica Sinica B
- Cathepsin Inhibition-Induced Lysosomal Dysfunction Enhances Pancreatic Beta-Cell Apoptosis in High Glucose
- (2015) Minjeong Jung et al. PLoS One
- An Active 32-kDa Cathepsin L Is Secreted Directly from HT 1080 Fibrosarcoma Cells and Not via Lysosomal Exocytosis
- (2015) Yoko Hashimoto et al. PLoS One
- Activity-Based Profiling of Proteases
- (2014) Laura E. Sanman et al. Annual Review of Biochemistry
- A cathepsin L-specific inhibitor preferentially inhibits degradation of autophagosomal LC3 and GABARAP in HeLa and Huh-7 cells
- (2014) Takashi Ueno et al. Autophagy
- Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L–A hybrid design approach
- (2014) Dibyendu Dana et al. CHEMICAL COMMUNICATIONS
- Prodrug-Inspired Probes Selective to Cathepsin B over Other Cysteine Cathepsins
- (2014) Morshed A. Chowdhury et al. JOURNAL OF MEDICINAL CHEMISTRY
- Plasma levels of cathepsins L, K, and V and risks of abdominal aortic aneurysms: A randomized population-based study
- (2013) Bing-Jie Lv et al. ATHEROSCLEROSIS
- Identification of new peptide amides as selective cathepsin L inhibitors: The first step towards selective irreversible inhibitors?
- (2013) Ana Torkar et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Optimization of Triazine Nitriles as Rhodesain Inhibitors: Structure-Activity Relationships, Bioisosteric Imidazopyridine Nitriles, and X-ray Crystal Structure Analysis with Human Cathepsin L
- (2013) Veronika Ehmke et al. ChemMedChem
- The Marine Cyanobacterial Metabolite Gallinamide A Is a Potent and Selective Inhibitor of Human Cathepsin L
- (2013) Bailey Miller et al. JOURNAL OF NATURAL PRODUCTS
- Biogenesis and Proteolytic Processing of Lysosomal DNase II
- (2013) Susumu Ohkouchi et al. PLoS One
- Dynamin Rings: Not Just for Fission
- (2013) Sanja Sever et al. TRAFFIC
- Selective cancer targeting with prodrugs activated by histone deacetylases and a tumour-associated protease
- (2013) Nobuhide Ueki et al. Nature Communications
- Podocyte Biology and Pathogenesis of Kidney Disease
- (2012) Jochen Reiser et al. Annual Review of Medicine
- A Novel Photoaffinity-Based Probe for Selective Detection of Cathepsin L Active Form
- (2012) Ana Torkar et al. CHEMBIOCHEM
- Microarray-guided discovery of two-photon (2P) small molecule probes for live-cell imaging of cysteinyl cathepsin activities
- (2012) Zhenkun Na et al. CHEMICAL COMMUNICATIONS
- Decreased arthritis severity in cathepsin L-deficient mice is attributed to an impaired T helper cell compartment
- (2012) Uta Schurigt et al. INFLAMMATION RESEARCH
- The Tick Salivary Protein Sialostatin L Inhibits the Th9-Derived Production of the Asthma-Promoting Cytokine IL-9 and Is Effective in the Prevention of Experimental Asthma
- (2012) H. Horka et al. JOURNAL OF IMMUNOLOGY
- Protease-Activated Drug Development
- (2012) Ki Young Choi et al. Theranostics
- Cysteine cathepsins: From structure, function and regulation to new frontiers
- (2011) Vito Turk et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Azepanone-based inhibitors of human cathepsin S: Optimization of selectivity via the P2 substituent
- (2011) Jeffrey K. Kerns et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Halogen Bonding at the Active Sites of Human Cathepsin L and MEK1 Kinase: Efficient Interactions in Different Environments
- (2011) Leo A. Hardegger et al. ChemMedChem
- Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes
- (2011) Laura E Edgington et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- The resurgence of covalent drugs
- (2011) Juswinder Singh et al. NATURE REVIEWS DRUG DISCOVERY
- Structural basis for the recognition and cleavage of histone H3 by cathepsin L
- (2011) Melanie A. Adams-Cioaba et al. Nature Communications
- Systematic Investigation of Halogen Bonding in Protein-Ligand Interactions
- (2010) Leo A. Hardegger et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Homing of Progenitor Cells to Ischemic Tissues
- (2010) Emmanouil Chavakis et al. ANTIOXIDANTS & REDOX SIGNALING
- Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors
- (2010) G.D. Kishore Kumar et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L
- (2010) G.D. Kishore Kumar et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Cathepsin-L contributes to cardiac repair and remodelling post-infarction
- (2010) Mei Sun et al. CARDIOVASCULAR RESEARCH
- Novel Peptidyl Aryl Vinyl Sulfones as Highly Potent and Selective Inhibitors of Cathepsins L and B
- (2010) Laura Mendieta et al. ChemMedChem
- Enhancing the Outcome of Cell Therapy for Cardiac Repair
- (2010) Emmanouil Chavakis et al. CIRCULATION
- Regulation of cell proliferation and differentiation in the kidney
- (2010) Neil et al. Frontiers in Bioscience-Landmark
- Strategies for discovering and derisking covalent, irreversible enzyme inhibitors
- (2010) Douglas S Johnson et al. Future Medicinal Chemistry
- Specialized roles for cysteine cathepsins in health and disease
- (2010) Jochen Reiser et al. JOURNAL OF CLINICAL INVESTIGATION
- Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors
- (2010) Rajesh T. Shenoy et al. JOURNAL OF STRUCTURAL BIOLOGY
- A Small-Molecule Oxocarbazate Inhibitor of Human Cathepsin L Blocks Severe Acute Respiratory Syndrome and Ebola Pseudotype Virus Infection into Human Embryonic Kidney 293T cells
- (2010) P. P. Shah et al. MOLECULAR PHARMACOLOGY
- Parkinson's disease involves autophagy and abnormal distribution of cathepsin L
- (2010) Lingyun Li et al. NEUROSCIENCE LETTERS
- Finding enzymes that are actively involved in cancer
- (2010) M. Bogyo PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The proteome of lysosomes
- (2010) Bernd A. Schröder et al. PROTEOMICS
- Dipeptidyl nitrile inhibitors of Cathepsin L
- (2009) Nabil Asaad et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Real-time monitoring of drug release
- (2009) Roy Weinstain et al. CHEMICAL COMMUNICATIONS
- Cathepsin L Inactivates Human Trypsinogen, Whereas Cathepsin L-Deletion Reduces the Severity of Pancreatitis in Mice
- (2009) Thomas Wartmann et al. GASTROENTEROLOGY
- Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse
- (2009) Lianne C. Hsing et al. JOURNAL OF AUTOIMMUNITY
- Acquisition of T Regulatory Function in Cathepsin L-Inhibited T Cells by Eye-Derived CTLA-2 during Inflammatory Conditions
- (2009) S. Sugita et al. JOURNAL OF IMMUNOLOGY
- A Combined Crystallographic and Molecular Dynamics Study of Cathepsin L Retrobinding Inhibitors
- (2009) Rajesh T. Shenoy et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cathepsin L, target in cancer treatment?
- (2009) Jacqueline M. Lankelma et al. LIFE SCIENCES
- Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry
- (2008) Benjamin F. Cravatt et al. Annual Review of Biochemistry
- Cathepsin L expression is up-regulated by hypoxia in human melanoma cells: role of its 5′-untranslated region
- (2008) Didier Jean et al. BIOCHEMICAL JOURNAL
- Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype
- (2008) Michael C. Myers et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K
- (2008) Jacques Yves Gauthier et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB
- (2008) Jeremy P. Mallari et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Crystal structure and silica condensing activities of silicatein α–cathepsin L chimeras
- (2008) Michael Fairhead et al. CHEMICAL COMMUNICATIONS
- Molecular Docking of Cathepsin L Inhibitors in the Binding Site of Papain
- (2008) Mary Pat Beavers et al. Journal of Chemical Information and Modeling
- Exploring Inhibitor Binding at the S′ Subsites of Cathepsin L
- (2008) Shafinaz F. Chowdhury et al. JOURNAL OF MEDICINAL CHEMISTRY
- High glucose reduces cathepsin L activity and impairs invasion of circulating progenitor cells
- (2008) Carmen Urbich et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Homing and engraftment of progenitor cells: A prerequisite for cell therapy
- (2008) Emmanouil Chavakis et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3β signaling
- (2008) Qizhu Tang et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Kinetic Characterization and Molecular Docking of a Novel, Potent, and Selective Slow-Binding Inhibitor of Human Cathepsin L
- (2008) P. P. Shah et al. MOLECULAR PHARMACOLOGY
- The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A
- (2008) Christian Faul et al. NATURE MEDICINE
- Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor
- (2007) Michael C. Myers et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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