Profiling the Structural Determinants of Aryl Benzamide Derivatives as Negative Allosteric Modulators of mGluR5 by In Silico Study

Computational Drug Design Applied to the Study of Metabotropic Glutamate Receptors

(2019) Claudia Llinas del Torrent et al.   MOLECULES

Exploring the Binding Mechanism of Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators in Clinical Trials by Molecular Dynamics Simulations

(2018) Tingting Fu et al.   ACS Chemical Neuroscience

Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures

(2018) John A. Christopher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core

(2017) Katrina A. Bollinger et al.   ACS Medicinal Chemistry Letters

Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists

(2016) Hoang Nam Vu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Computational Study Exploring the Interaction Mechanism of Benzimidazole Derivatives as Potent Cattle Bovine Viral Diarrhea Virus Inhibitors

(2016) Jinghui Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Safety, Tolerability and Risks Associated with the Use of Newer Generation Antidepressant Drugs: A Critical Review of the Literature

(2016) André F. Carvalho et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Allosteric Binding Site and Activation Mechanism of Class C G-Protein Coupled Receptors: Metabotropic Glutamate Receptor Family

(2015) Zhiwei Feng et al.   AAPS Journal

Integrating the monoamine, neurotrophin and cytokine hypotheses of depression — A central role for the serotonin transporter?

(2015) Jana Haase et al.   PHARMACOLOGY & THERAPEUTICS

Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants

(2015) Kasper Harpsøe et al.   Scientific Reports

The role of metabotropic glutamate receptor 5 in the pathogenesis of mood disorders and addiction: combining preclinical evidence with human Positron Emission Tomography (PET) studies

(2015) Sylvia Terbeck et al.   Frontiers in Neuroscience

Insights into the influence of 5-HT2c aminoacidic variants with the inhibitory action of serotonin inverse agonists and antagonists

(2014) Roberta Galeazzi et al.   JOURNAL OF MOLECULAR MODELING

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain

(2014) Andrew S. Doré et al.   NATURE

mGluR5: Exploration of Orthosteric and Allosteric Ligand Binding Pockets and Their Applications to Drug Discovery

(2014) Christina Mølck et al.   NEUROCHEMICAL RESEARCH

Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety

(2013) Andrew S. Felts et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

CoMFA and CoMSIA analysis of tetrahydroquinolines as potential antimalarial agents

(2011) S. Deshpande et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu5: Identification of easily prepared tool compounds with CNS exposure in rats

(2010) Andrew S. Felts et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

QSAR in the Pharmaceutical Research Setting: QSAR Models for Broad, Large Problems

(2010) D.G. Sprous et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Depression and antidepressants: Insights from knockout of dopamine, serotonin or noradrenaline re-uptake transporters

(2010) Britta Haenisch et al.   PHARMACOLOGY & THERAPEUTICS

3D-QSAR studies of boron-containing dipeptides as proteasome inhibitors with CoMFA and CoMSIA methods

(2008) Yong-Qiang Zhu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY