Interactions between Atorvastatin and the Farnesoid X Receptor Impair Insulinotropic Effects of Bile Acids and Modulate Diabetogenic Risk

Atorvastatin but Not Pravastatin Impairs Mitochondrial Function in Human Pancreatic Islets and Rat β-Cells. Direct Effect of Oxidative Stress

(2017) Francesca Urbano et al.   Scientific Reports

Toxicity of Atorvastatin on Pancreas Mitochondria: A Justification for Increased Risk of Diabetes Mellitus

(2016) Melina Sadighara et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Statin-Associated Side Effects

(2016) Paul D. Thompson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Role of FXR in β-Cells of Lean and Obese Mice

(2015) Björn Schittenhelm et al.   ENDOCRINOLOGY

Different effects of statins on induction of diabetes mellitus: an experimental study

(2015) Shui-Ping Zhao et al.   Drug Design Development and Therapy

Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells

(2015) Nagendra Yaluri et al.   PLoS One

Atorvastatin induces bile acid-synthetic enzyme Cyp7a1 by suppressing FXR signaling in both liver and intestine in mice

(2014) Zidong Donna Fu et al.   JOURNAL OF LIPID RESEARCH

Bile Acids Acutely Stimulate Insulin Secretion of Mouse  -Cells via Farnesoid X Receptor Activation and KATP Channel Inhibition

(2012) M. Dufer et al.   DIABETES

The significance of the nuclear farnesoid X receptor (FXR) in β cell function

(2012) Martina Düfer et al.   Islets

The statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes

(2011) Katharine Howe et al.   XENOBIOTICA

The nuclear receptor FXR is expressed in pancreatic β-cells and protects human islets from lipotoxicity

(2010) Iuliana Ristea Popescu et al.   FEBS LETTERS

Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials

(2010) Naveed Sattar et al.   LANCET

Postprandial plasma bile acid responses in normal weight and obese subjects

(2010) C. Glicksman et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders

(2009) Stefano Fiorucci et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity

(2008) Oded Shaham et al.   Molecular Systems Biology