Evodiamine reduced peripheral hypersensitivity on the mouse with nerve injury or inflammation

Human pharmacological approaches to TRP-ion-channel-based analgesic drug development

(2018) Iris Weyer-Menkhoff et al.   DRUG DISCOVERY TODAY

Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults — United States, 2016

(2018) James Dahlhamer et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Time for nonaddictive relief of pain

(2017) Tilo Grosser et al.   SCIENCE

Cingulate Alpha-2A Adrenoceptors Mediate the Effects of Clonidine on Spontaneous Pain Induced by Peripheral Nerve Injury

(2017) Yong-Jie Wang et al.   Frontiers in Molecular Neuroscience

Partial Activation and Inhibition of TRPV1 Channels by Evodiamine and Rutaecarpine, Two Major Components of the Fruits of Evodia rutaecarpa

(2016) Shenglan Wang et al.   JOURNAL OF NATURAL PRODUCTS

Rutaecarpine attenuates hypoxia-induced right ventricular remodeling in rats

(2016) Wen-Qun Li et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

(2015) Nanna B Finnerup et al.   LANCET NEUROLOGY

Huperzine A Alleviates Mechanical Allodynia but Not Spontaneous Pain via Muscarinic Acetylcholine Receptors in Mice

(2015) Zhen-Xing Zuo et al.   NEURAL PLASTICITY

The pharmacology of TRP channels

(2014) Peter Holzer et al.   BRITISH JOURNAL OF PHARMACOLOGY

CB1 augments mGluR5 function in medial prefrontal cortical neurons to inhibit amygdala hyperactivity in an arthritis pain model

(2014) Guangchen Ji et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Evodiamine and rutaecarpine alkaloids as highly selective transient receptor potential vanilloid 1 agonists

(2014) Bojidarka Ivanova et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Central Terminal Sensitization of TRPV1 by Descending Serotonergic Facilitation Modulates Chronic Pain

(2014) Yu Shin Kim et al.   NEURON

Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease

(2013) Yan He et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Object recognition test in mice

(2013) Marianne Leger et al.   Nature Protocols

Phα1β toxin prevents capsaicin-induced nociceptive behavior and mechanical hypersensitivity without acting on TRPV1 channels

(2013) Celio J. Castro-Junior et al.   NEUROPHARMACOLOGY

Binding Mode Prediction of Evodiamine within Vanilloid Receptor TRPV1

(2012) Zhanli Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TRPV1 in GABAergic Interneurons Mediates Neuropathic Mechanical Allodynia and Disinhibition of the Nociceptive Circuitry in the Spinal Cord

(2012) Yong Ho Kim et al.   NEURON

Evodiamine improves congnitive abilities in SAMP8 and APPswe/PS1ΔE9 transgenic mouse models of Alzheimer's disease

(2011) Shu-min Yuan et al.   ACTA PHARMACOLOGICA SINICA

Transient receptor potential vanilloid type 1 and pain development

(2011) Enza Palazzo et al.   CURRENT OPINION IN PHARMACOLOGY

Lateralized amygdala activation: Importance in the regulation of anxiety and pain behavior

(2011) Lee Tran et al.   PHYSIOLOGY & BEHAVIOR

Alleviating Neuropathic Pain Hypersensitivity by Inhibiting PKM  in the Anterior Cingulate Cortex

(2010) X.-Y. Li et al.   SCIENCE

Rutecarpine ameliorates bodyweight gain through the inhibition of orexigenic neuropeptides NPY and AgRP in mice

(2009) Su-Jin Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis and vasodilator effects of rutaecarpine analogues which might be involved transient receptor potential vanilloid subfamily, member 1 (TRPV1)

(2009) Zhuo Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Unmasking the tonic-aversive state in neuropathic pain

(2009) Tamara King et al.   NATURE NEUROSCIENCE