What makes bacterial pathogens so sticky?

Pseudomonas aeruginosa orchestrates twitching motility by sequential control of type IV pili movements

(2019) Lorenzo Talà et al.   Nature Microbiology

Fluidic Force Microscopy Demonstrates That Homophilic Adhesion by Candida albicans Als Proteins Is Mediated by Amyloid Bonds between Cells

(2019) Jérôme Dehullu et al.   NANO LETTERS

Binding of Staphylococcus aureus Protein A to von Willebrand Factor Is Regulated by Mechanical Force

(2019) Felipe Viela et al.   mBio

Pilus-1 Backbone Protein RrgB of Streptococcus pneumoniae Binds Collagen I in a Force-Dependent Way

(2019) Tanja D. Becke et al.   ACS Nano

Mechanostability of the Fibrinogen Bridge between Staphylococcal Surface Protein ClfA and Endothelial Cell Integrin αVβ3

(2019) Felipe Viela et al.   NANO LETTERS

Fibrinogen binding is affected by amino acid substitutions in C-terminal repeat region of fibronectin binding protein A

(2019) Nadia N. Casillas-Ituarte et al.   Scientific Reports

Single Molecule Force Spectroscopy Reveals Two-Domain Binding Mode of Pilus-1 Tip Protein RrgA of Streptococcus pneumoniae to Fibronectin

(2018) Tanja D. Becke et al.   ACS Nano

Mechanical Forces Guiding Staphylococcus aureus Cellular Invasion

(2018) Valeria Prystopiuk et al.   ACS Nano

Staphylococcus aureusclumping factor A is a force-sensitive molecular switch that activates bacterial adhesion

(2018) Philippe Herman-Bausier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force matters in hospital-acquired infections

(2018) Philippe Herman-Bausier et al.   SCIENCE

Molecular mechanism of extreme mechanostability in a pathogen adhesin

(2018) Lukas F. Milles et al.   SCIENCE

Mechanical architecture and folding of E. coli type 1 pilus domains

(2018) Alvaro Alonso-Caballero et al.   Nature Communications

Molecular strategy for blocking isopeptide bond formation in nascent pilin proteins

(2018) Jaime Andrés Rivas-Pardo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium stabilizes the strongest protein fold

(2018) Lukas F. Milles et al.   Nature Communications

Amino acid polymorphisms in the fibronectin-binding repeats of fibronectin-binding protein A affect bond strength and fibronectin conformation

(2017) Nadia N. Casillas-Ituarte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanosensing of shear byPseudomonas aeruginosaleads to increased levels of the cyclic-di-GMP signal initiating biofilm development

(2017) Christopher A. Rodesney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obstruction of pilus retraction stimulates bacterial surface sensing

(2017) Courtney K. Ellison et al.   SCIENCE

Force-Induced Strengthening of the Interaction between Staphylococcus aureus Clumping Factor B and Loricrin

(2017) Pauline Vitry et al.   mBio

N-glycan mediated adhesion strengthening during pathogen-receptor binding revealed by cell-cell force spectroscopy

(2017) Joost te Riet et al.   Scientific Reports

Force Nanoscopy as a Versatile Platform for Quantifying the Activity of Antiadhesion Compounds Targeting Bacterial Pathogens

(2016) Audrey Beaussart et al.   NANO LETTERS

CnaA domains in bacterial pili are efficient dissipaters of large mechanical shocks

(2016) Daniel J. Echelman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical Strength and Inhibition of the Staphylococcus aureus Collagen-Binding Protein Cna

(2016) Philippe Herman-Bausier et al.   mBio

Optical and force nanoscopy in microbiology

(2016) Jie Xiao et al.   Nature Microbiology

Force Sensitivity in Saccharomyces cerevisiae Flocculins

(2016) Cho X. J. Chan et al.   mSphere

Nanoscale adhesion forces between the fungal pathogen Candida albicans and macrophages

(2016) Sofiane El-Kirat-Chatel et al.   Nanoscale Horizons

Nanoscale Pulling of Type IV Pili Reveals Their Flexibility and Adhesion to Surfaces over Extended Lengths of the Pili

(2015) Shun Lu et al.   BIOPHYSICAL JOURNAL

The Mechanical World of Bacteria

(2015) Alexandre Persat et al.   CELL

Forces in yeast flocculation

(2015) Sofiane El-Kirat-Chatel et al.   Nanoscale

Type IV pili mechanochemically regulate virulence factors inPseudomonas aeruginosa

(2015) Alexandre Persat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc-dependent mechanical properties ofStaphylococcus aureusbiofilm-forming surface protein SasG

(2015) Cécile Formosa-Dague et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Staphylococcus aureus Fibronectin-Binding Protein A Mediates Cell-Cell Adhesion through Low-Affinity Homophilic Bonds

(2015) Philippe Herman-Bausier et al.   mBio

Cooperative folding of intrinsically disordered domains drives assembly of a strong elongated protein

(2015) Dominika T. Gruszka et al.   Nature Communications

Nanoscale Adhesion Forces of Pseudomonas aeruginosa Type IV Pili

(2014) Audrey Beaussart et al.   ACS Nano

Dynamic coupling of ALCAM to the actin cortex strengthens cell adhesion to CD6

(2014) J. te Riet et al.   JOURNAL OF CELL SCIENCE

The binding force of the staphylococcal adhesin SdrG is remarkably strong

(2014) Philippe Herman et al.   MOLECULAR MICROBIOLOGY

Adhesion and Nanomechanics of Pili from the Probiotic Lactobacillus rhamnosus GG

(2013) Prachi Tripathi et al.   ACS Nano

Isopeptide Bonds Mechanically Stabilize Spy0128 in Bacterial Pili

(2013) Bo Wang et al.   BIOPHYSICAL JOURNAL

Single-cell force spectroscopy of pili-mediated adhesion

(2013) Ruby May A. Sullan et al.   Nanoscale

Dissociation Rate Constants of Human Fibronectin Binding to Fibronectin-binding Proteins on LivingStaphylococcus aureusIsolated from Clinical Patients

(2012) Nadia N. Casillas-Ituarte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Analysis of Lactobacillus rhamnosus GG Pili in Relation to Adhesion and Immunomodulatory Interactions with Intestinal Epithelial Cells

(2011) Sarah Lebeer et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A Role for Septins in the Interaction between the Listeria monocytogenes Invasion Protein InlB and the Met Receptor

(2011) Serge Mostowy et al.   BIOPHYSICAL JOURNAL

A Role for Amyloid in Cell Aggregation and Biofilm Formation

(2011) Melissa C. Garcia et al.   PLoS One

Polymorphisms in fibronectin binding protein A of Staphylococcus aureus are associated with infection of cardiovascular devices

(2011) S. K. Lower et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isopeptide Bonds Block the Mechanical Extension of Pili in PathogenicStreptococcus pyogenes

(2010) Jorge Alegre-Cebollada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bonds between Fibronectin and Fibronectin-Binding Proteins on Staphylococcus aureus and Lactococcus lactis

(2010) Andrew W. Buck et al.   LANGMUIR

Direct adhesion force measurements between E. coli and human uroepithelial cells in cranberry juice cocktail

(2010) Yatao Liu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Force-induced formation and propagation of adhesion nanodomains in living fungal cells

(2010) D. Alsteens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force-dependent polymorphism in type IV pili reveals hidden epitopes

(2010) N. Biais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Force Generation Is a Conserved Property of Type IV Pilus Systems

(2009) M. Clausen et al.   JOURNAL OF BACTERIOLOGY

Role of Cranberry on Bacterial Adhesion Forces and Implications for Escherichia coli–Uroepithelial Cell Attachment

(2009) Paola A. Pinzón-Arango et al.   JOURNAL OF MEDICINAL FOOD

Force probing surfaces of living cells to molecular resolution

(2009) Daniel J Müller et al.   Nature Chemical Biology

Staphylococcus aureus-Fibronectin Interactions with and without Fibronectin-Binding Proteins and Their Role in Adhesion and Desorption

(2008) C.-P. Xu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Catch-Bond Mechanism of Force-Enhanced Adhesion: Counterintuitive, Elusive, but … Widespread?

(2008) Evgeni V. Sokurenko et al.   Cell Host & Microbe

FimH Forms Catch Bonds That Are Enhanced by Mechanical Force Due to Allosteric Regulation

(2008) Olga Yakovenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperative Retraction of Bundled Type IV Pili Enables Nanonewton Force Generation

(2008) Nicolas Biais et al.   PLOS BIOLOGY