Article
Cell Biology
Yang-Zhi Hu, Zhi-Li Hu, Tian-You Liao, Yuan Li, Yun-Long Pan
Summary: This study aimed to investigate the effects of lncRNA SND1-IT1, miR-124, and COL4A1 gene on TGF-beta 1-induced EMT in gastric cancer (GC). Through the analysis of tissue samples and experiments on HGC-27 cells, the results demonstrated that TGF-beta 1 can regulate cancer cell migration, invasion, and stimulate EMT through the SND1-IT1/miR-124/COL4A1 axis in GC.
CELL DEATH DISCOVERY
(2022)
Review
Cell Biology
Ji-Ung Jung, Ankita B. Jaykumar, Melanie H. Cobb
Summary: In this review, the role of WNK1 in tumor malignancy, metastasis, angiogenesis, and mesenchymal transition is discussed, providing evidence for its unique association with a subset of invasive cancers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Heng Shi, Jinbo Xie, Keyi Wang, Weiyi Li, Lei Yin, Guangchun Wang, Zonglin Wu, Jinliang Ni, Weipu Mao, Changcheng Guo, Bo Peng
Summary: This study identified LINC01451 as a functional lncRNA with significantly higher expression in BLCa tissues compared to normal tissues. LINC01451 was found to directly interact with LIN28A and LIN28B, promoting proliferation, invasion, and metastasis of BLCa. Mechanistically, LINC01451 was shown to facilitate epithelial-mesenchymal transition through activating the TGF-beta/Smad signaling pathway, leading to the progression of BLCa.
CELLULAR SIGNALLING
(2021)
Review
Medicine, General & Internal
Masao Saitoh
Summary: Epithelial-mesenchymal transition (EMT) plays a crucial role in cancer progression, associated with invasion, metastasis, generation of tumor stem cells, and resistance to therapy. Transforming growth factor (TGF)-beta acts as a key mediator in the EMT process, initiating and maintaining EMT through signaling pathways and transcription factors.
Review
Oncology
Valeria Ramundo, Giuliana Giribaldi, Elisabetta Aldieri
Summary: Metabolic changes in the tumor microenvironment play a critical role in cancer by affecting signaling pathways that control cellular metabolism. The deregulation of cancer metabolism is closely related to oxidative stress control and the involvement of cytokines like transforming growth factor beta (TGF-beta) in tumorigenesis and cancer progression. The crosstalk between TGF-beta and oxidative stress contributes significantly to tumorigenesis and cancer invasiveness by affecting redox imbalance and cellular metabolism.
Article
Oncology
Xuecong Wang, Pieter Johan Adam Eichhorn, Jean Paul Thiery
Summary: TGF-beta signaling regulates embryonic development, wound-healing, and immune homeostasis, but it is altered during tumor progression, leading to enhanced epithelial cell plasticity and a reprogramming of epithelial cells into mesenchymal lineages through EMT. This contributes to increased carcinoma cell invasion, metastasis, and immune evasion.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cheng-Yi Huang, Jenq-Lin Yang, Jih-Jung Chen, Shun-Ban Tai, Yu-Hsuan Yeh, Pei-Feng Liu, Ming-Wei Lin, Chih-Ling Chung, Chun-Lin Chen
Summary: The study showed that FQs inhibit MMP-9 expression in cancer cells, leading to a decrease in cell migration and invasion, demonstrating their potential value in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Meng Lin, Jinmeng Liu, Fengping Zhang, Gaoxiu Qi, Shuqi Tao, Wenyuan Fan, Min Chen, Kang Ding, Fenghua Zhou
Summary: LRG1 plays a critical role in the proliferation, migration, and invasion of tumor cells and can serve as an early tumor and prognostic biomarker. Through the TGF-beta signaling pathway and other independent pathways, LRG1 regulates processes such as angiogenesis, epithelial-mesenchymal transition, and apoptosis, impacting the occurrence and development of tumors.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jiewen Su, Dawei Chen, Yi Ruan, Yuan Tian, Kaiji Lv, Xinhua Zhou, Dongjian Ying, Yeting Lu
Summary: Studies have shown that lncRNA MBNL1-AS1 participates in the progression of gastric cancer by regulating the miR-424-5p/Smad7 axis, thus activating the TGF-beta/EMT pathways. This finding may provide a potential marker for gastric cancer patients.
Article
Cell Biology
Naoto Hori, Yuki Takakura, Ayumi Sugino, Shuto Iwasawa, Kota Nomizo, Naoto Yamaguchi, Hiroyuki Takano, Noritaka Yamaguchi
Summary: In this study, the researchers found that VGLL3 promotes epithelial-to-mesenchymal transition (EMT)-like cell motility by inducing HMGA2 expression and accelerates cancer progression. High levels of VGLL3 expression were shown to have a positive correlation with poor prognosis in various human cancers.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Jian Sun, Weiwei Sheng, Yuteng Ma, Ming Dong
Summary: In the aggressive progression of malignant tumors, MSI2 plays a crucial role in regulating EMT and is closely associated with the EGF, TGF-beta, Notch, and Wnt pathways.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Qingjie Kang, Xudong Peng, Xiangshu Li, Denghua Hu, Guangxu Wen, Zhengqiang Wei, Baohong Yuan
Summary: The study reveals that ORAI1 mediates TGF-beta-induced EMT in colorectal cancer cells by promoting Ca2+ entry and calpain activity.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Caijiao Wang, Luyao Dong, Ziqi Zhao, Zeqing Zhang, Yutong Sun, Chonglong Li, Guoqing Li, Xuefu You, Xinyi Yang, Hao Wang, Wei Hong
Summary: Protein arginine methyltransferase 1 (PRMT1) is an enzyme that catalyzes protein arginine methylation and is involved in various biological processes such as EMT and cancer cell migration. This study designed and synthesized a series of compounds targeting the substrate binding site of PRMT1, and identified compound 1r (WCJ-394) as the most potent inhibitor. WCJ-394 affected the expression of PRMT1-related proteins and inhibited TGF-beta 1-induced EMT and cancer cell migration.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jisu Jeong, Jiyeon Kim
Summary: EMT plays a crucial role in the development of lung cancer, and targeting EMT could inhibit cancer cell invasion and metastasis. This study found that combination treatment with erlotinib and cilengitide showed enhanced inhibitory effects on EMT in lung cancer cells, suggesting that cilengitide could improve the efficacy of anticancer drugs and contribute to improved treatment strategies for inhibiting EMT-based cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Jiang Zhu, Yuming Luo, Yue Zhao, Yao Kong, Hanhao Zheng, Yuting Li, Bowen Gao, Le Ai, Hao Huang, Jian Huang, Zhihua Li, Changhao Chen
Summary: The study identified a novel circRNA circEHBP1 that promotes lymphangiogenesis and lymphatic metastasis in bladder cancer by regulating the TGF beta R1/VEGF-D pathway, highlighting a potential biomarker and therapeutic target for bladder cancer patients with poor prognosis.