Article
Oncology
Tong Liu, Peilong Li, Juan Li, Qiuchen Qi, Zhaowei Sun, Shuang Shi, Yan Xie, Shibiao Liu, Yunshan Wang, Lutao Du, Chuanxin Wang
Summary: Cancer-cell-released exosomal miRNAs play a significant role in tumor microenvironment communication, with miR-320b identified as closely associated with lymphangiogenesis and lymphatic metastasis in ESCC patients. Through transfer by exosomes, miR-320b activates the AKT pathway in HLECs independently of VEGF-C, affecting tube formation, migration, and EMT progression in ESCC cells. Furthermore, METTL3 positively regulates pri-miR-320b maturation through an m6A-dependent mechanism.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Oncology
Sen Liu, Xu Chen, Tianxin Lin
Summary: The article summarizes the molecular mechanisms of lymphatic metastasis in bladder cancer, including lymphangiogenesis, noncoding RNAs, and microenvironment-associated molecules. Newly discovered radiomics and genomics approaches have improved the preoperative diagnostic accuracy of lymph node metastasis, potentially leading to promising therapeutic strategies.
Article
Multidisciplinary Sciences
Zhenyuan Li, Tailiang Lu, Zhian Chen, Xiang Yu, Lingzhi Wang, Guodong Shen, Huilin Huang, Zhenhao Li, Yingxin Ren, Weihong Guo, Yanfeng Hu
Summary: Most early stage gastric cancer patients do not have lymph node metastases, but metastases appear in the advanced stage. However, some patients have lymph node metastases in the early stage and none in the advanced stage. To explore the molecular mechanisms involved, clinical samples were collected from patients with early and advanced stage gastric cancer with and without lymph node metastases, as well as metastatic lymph nodes. HOXA11 was identified as a key target that is upregulated in gastric cancer tissues and closely associated with lymphatic metastases. HOXA11 transcriptionally regulates TGF beta 1 expression, activates the TGF beta 1/Smad2 pathway, promotes EMT development, induces VEGF-C secretion, and lymphangiogenesis. These findings provide a plausible mechanism for HOXA11-modulated tumor lymphatic metastasis and suggest HOXA11 as a potential therapeutic target for LN-metastatic gastric cancer.
Article
Cell Biology
Qun Lu, Haoli Yin, Yongming Deng, Wei Chen, Wenli Diao, Meng Ding, Wenmin Cao, Yao Fu, Wenjing Mo, Xiaoqing Chen, Qing Zhang, Xiaozhi Zhao, Hongqian Guo
Summary: This study reveals the regulatory mechanism of circDHTKD1 in lymphangiogenesis and lymph node metastasis in bladder cancer. By interacting with miR-149-5p and regulating CXCL5 expression, circDHTKD1 promotes lymphangiogenesis and recruits and activates neutrophils, contributing to lymph node metastasis in bladder cancer.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Xisheng Liu, Xiaole Meng, Xiao Peng, Qianlan Yao, Fangming Zhu, Zhongyi Ding, Hongze Sun, Xueni Liu, Dan Li, Ying Lu, Huamei Tang, Bin Li, Zhihai Peng
Summary: The global downregulation of miRNA expression, potentially due to defects in miRNA processing machinery, is a hallmark of human cancer. In colorectal cancer (CRC), downregulation of the key regulator of miRNA processing, Argonaute 2 (AGO2), has been found to promote epithelial-mesenchymal transition (EMT) and indicate poor prognosis. Knockdown of AGO2 in CRC cells enhanced migration, invasion, and metastasis, while integrated analyses revealed neuropilin 1 (NRP1) as a new substrate of AGO2 via miR-185-3p. Therapeutically targeting the AGO2/miR-185-3p/NRP1 axis may offer a potential treatment approach for CRC.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Chih-Yang Lin, Shih-Wei Wang, Jeng-Hung Guo, Huai-Ching Tai, Wen-Chun Sun, Cheng-Ta Lai, Chen-Yu Yang, Shih-Chia Liu, Yi-Chin Fong, Chih-Hsin Tang
Summary: WISP-3 can promote the production of VEGF-C in chondrosarcoma cells, stimulating lymphatic endothelial cell tube formation and promoting lymphangiogenesis by modulating the ERK, JNK, and p38 signaling pathways. This suggests that the WISP-3/VEGF-C axis may be a valuable target for treating lymphangiogenesis in human chondrosarcoma.
Article
Biochemistry & Molecular Biology
Hiroki Yoshioka, Goo Jun, Akiko Suzuki, Junichi Iwata
Summary: The study identified novel pathogenic microRNAs associated with cleft palate. miR-449 and miR-486b promote cell proliferation, while miR-130a and miR-301a inhibit it. Dexamethasone suppresses miR-130a expression, and a miR-130a mimic can ameliorate the cell proliferation defect induced by dexamethasone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Peripheral Vascular Disease
Anqi Li, Linyu Zhu, Ningjing Lei, Jiajia Wan, Xixi Duan, Shuangqing Liu, Yanru Cheng, Ming Wang, Zhuoyu Gu, Huilei Zhang, Yueyue Bai, Li Zhang, Fazhan Wang, Chen Ni, Zhihai Qin
Summary: The expression of S100A4 in lymphatic endothelial cells promotes lymphatic vessel sprouting in growing tumors by regulating glycolysis. S100A4 plays a crucial role in the position and motility of tip cells, and its expression is upregulated under hypoxic conditions. These findings suggest that S100A4 is a novel regulator of tumor-induced lymphangiogenesis.
Review
Oncology
Yuting Li, Xiaofan Gao, Yibao Huang, Xiaoran Zhu, Yingying Chen, Liru Xue, Qingqing Zhu, Bo Wang, Mingfu Wu
Summary: Although previous studies have revealed the etiology of cervical cancer, metastasis still remains the main cause of poor prognosis and high cancer-related mortality. Close communication between cervical cancer cells and immune cells in the tumor microenvironment (TME) has been shown to promote metastatic dissemination. Understanding the mechanisms of tumor metastasis is crucial for the development of effective therapies. This review interprets various characteristics of the TME that contribute to lymphatic metastasis of cervical cancer, and summarizes the complex interactions between tumor cells and immune cells, as well as potential therapeutic strategies to target the TME.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Bo Wei, Gui-rong Xiao, Cheng-long Wu, Yi-qin Xu
Summary: This study investigated the molecular mechanisms of lncRNA-HAGLR promoting in vitro neuron differentiation by targeting the miR-130a-3p-MeCP2 axis using SH-SY5Y cell model. Results showed that HAGLR played a crucial role in RA-induced SH-SY5Y differentiation, functioning as a ceRNA of miR-130a-3p to target MeCP2, contributing to the understanding of the pathogenesis and progression of PD.
Article
Medicine, Research & Experimental
Yifan Li, Jing Xun, Botao Wang, Yuan Ma, Lanqiu Zhang, Lei Yang, Ruifang Gao, Jun Guan, Tianyu Liu, Hejun Gao, Ximo Wang, Qi Zhang
Summary: The study found that miR-3065-3p is overexpressed in colorectal cancer and associated with poor prognosis. It promotes the stemness and metastasis of colorectal cancer. CRLF1, as a downstream target of miR-3065-3p, inhibits the stemness of colorectal cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Andrology
Qinrong Ping, Yunqiang Shi, Meng Yang, Hui Li, Yiming Zhong, Jian Li, Xiaofang Bi, Chunhui Wang
Summary: The study found that DANCR regulates the proliferation, migration, invasion, and lymphatic metastasis of bladder cancer cells through the miR-335/VEGF-C molecular axis. Inhibition of miR-335 and overexpression of VEGF-C can reverse the inhibitory effect of silencing DANCR on bladder cancer cells.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Article
Gastroenterology & Hepatology
Jie Zhao, Honggang Wang, Jin Zhou, Jun Qian, Haojun Yang, Yan Zhou, Hao Ding, Yu Gong, Xiaoyang Qi, Yuwen Jiao, Pu Ying, Liming Tang, Ye Sun, Weiming Zhu
Summary: The study reveals that miR-130a-3p promotes the progression of Crohn's disease through the ATG16L1/NF-kappa B pathway and serves as a potential preclinical therapeutic target in Crohn's disease.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Chemistry, Multidisciplinary
Zhonghua Wu, Bicheng Qu, Minxian Yuan, Jingjing Liu, Cen Zhou, Mingwei Sun, Zhexu Guo, Yaqing Zhang, Yongxi Song, Zhenning Wang
Summary: The overexpression of cysteine-rich intestinal protein-1 (CRIP1) in gastric cancer promotes lymphangiogenesis and lymphatic vessel permeability, leading to lymphatic metastasis. This study uncovers the role and mechanism of CRIP1 in mediating gastric cancer lymphatic metastasis, providing potential targets for future therapeutics.
Article
Critical Care Medicine
Liang-Shan Peng, Yan Xu, Qiao-Sheng Wang
Summary: SAE is a condition that leads to cognitive dysfunction, and it is associated with neuroinflammation. This study investigated the role of YY1 in SAE and found that it promotes M2 polarization of microglia and reduces neuroinflammation and behavioral deficits. YY1 achieves this by inhibiting the activity of miR-130a-3p, which targets TREM-2.