Review
Cell Biology
Linda Studer, Annika Blank, John-Melle Bokhorst, Iris D. Nagtegaal, Inti Zlobec, Alessandro Lugli, Andreas Fischer, Heather Dawson
Summary: Tumour budding in colorectal cancer serves as a robust and independent biomarker of aggressive tumor biology, with evidence strongly supporting its reporting in routine practice. Establishing a standardized and evidence-based scoring method is crucial for implementing tumour budding assessment, while the development of automated methods for assessment is a key focus for further research and validation to ensure accuracy and standardization.
Article
Pathology
Philipp Lohneis, Julia Rohmann, Florian Gebauer, Lena Hieggelke, Christiane Bruns, Wolfgang Schroeder, Reinhard Buettner, Heike Loeser, Alexander Quaas
Summary: This study investigated the role of tumor budding as an additional prognostic factor in esophageal adenocarcinomas with poor response to neoadjuvant therapy, finding a strong positive correlation between high numbers of tumor buds and poor prognosis.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Pathology
Han-Na Kim, Soo Yeon Lee, Baek-Hui Kim, Chung-Yeul Kim, Aeree Kim, Hayeon Kim
Summary: Tumor budding in gallbladder cancer has clinical and pathological implications, with high TB grades correlating with poorer survival outcomes, but not significantly associated with death or recurrence risk in multivariate analysis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Patrick Veit-Haibach, Hakan Ahlstrom, Ronald Boellaard, Roberto C. Delgado Bolton, Swen Hesse, Thomas Hope, Martin W. Huellner, Andrei Iagaru, Geoffrey B. Johnson, Andreas Kjaer, Ian Law, Ur Metser, Harald H. Quick, Bernhard Sattler, Lale Umutlu, Greg Zaharchuk, Ken Herrmann
Summary: The Society of Nuclear Medicine and Molecular Imaging (SNMMI), the European Association of Nuclear Medicine (EANM), and the International Society for Magnetic Resonance in Medicine (ISMRM) are professional organizations that aim to promote the science and practice of nuclear medicine and magnetic resonance imaging. These organizations periodically define guidelines to improve the quality of service and ensure safe and effective use of diagnostic imaging techniques. The guidelines are educational tools designed to assist practitioners, but adherence to them does not guarantee accurate diagnosis or successful outcomes.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Pathology
Philipp Lohneis, Lena Hieggelke, Florian Gebauer, Markus Ball, Christiane Bruns, Reinhard Buettner, Heike Loeser, Alexander Quaas
Summary: Tumor budding in esophageal adenocarcinomas, evaluated according to the ITBCC criteria, is an independent prognostic factor associated with reduced overall survival. Regardless of the quantification approach used, an increased number of tumor buds is significantly correlated with worse overall survival. Prospective studies using ITBCC criteria are needed to confirm these findings in the future.
Article
Immunology
Ilke Evrim Secinti, Tumay Ozgur, Didar Gursoy, Isa Dede
Summary: This study aimed to investigate the relationship between tumor budding and clinicopathologic prognostic criteria in colorectal adenocarcinomas, and discuss the inclusion of a fourth group in the scoring system. The results showed that tumor budding was associated with various pathological features and overall survival. H&E staining was sufficient for assessment, but additional staining methods may be needed in certain conditions.
Review
Surgery
Aryeh Shander, Howard L. Corwin, Jens Meier, Michael Auerbach, Elvira Bisbe, Jeanna Blitz, Jochen Erhard, David Faraoni, Shannon L. Farmer, Steven M. Frank, Domenico Girelli, Tiffany Hall, Jean-Francois Hardy, Axel Hofmann, Cheuk-Kwong Lee, Tsin W. Leung, Sherri Ozawa, Jameela Sathar, Donat R. Spahn, Rosalio Torres, Matthew A. Warner, Manuel Munoz
Summary: Perioperative anemia has been linked to increased risk of red blood cell transfusion, morbidity, and mortality after surgery. However, the optimal approach for diagnosing and managing perioperative anemia is not fully established. Therefore, an international expert panel developed consensus recommendations through evidence review using modified RAND Delphi methodology.
Article
Genetics & Heredity
Eric Legius, Ludwine Messiaen, Pierre Wolkenstein, Patrice Pancza, Robert A. Avery, Yemima Berman, Jaishri Blakeley, Dusica Babovic-Vuksanovic, Karin Soares Cunha, Rosalie Ferner, Michael J. Fisher, Jan M. Friedman, David H. Gutmann, Hildegard Kehrer-Sawatzki, Bruce R. Korf, Victor-Felix Mautner, Sirkku Peltonen, Katherine A. Rauen, Vincent Riccardi, Elizabeth Schorry, Anat Stemmer-Rachamimov, David A. Stevenson, Gianluca Tadini, Nicole J. Ullrich, David Viskochil, Katharina Wimmer, Kaleb Yohay, Susan M. Huson, D. Gareth Evans, Scott R. Plotkin
Summary: The study revised the diagnostic criteria for neurofibromatosis type 1 (NF1) and established criteria for Legius syndrome (LGSS) by combining major developments in genetics, ophthalmology, dermatology, and neuroimaging. Consensus on minimal clinical and genetic criteria for diagnosing and differentiating NF1 and LGSS was reached, with recommendations for mosaic forms of these conditions. Continued refinement of these new criteria will be necessary to study their diagnostic properties, reconsider criteria not included, and identify new features of the conditions, hence proposing an initiative to periodically update the diagnostic criteria for NF1 and LGSS.
GENETICS IN MEDICINE
(2021)
Article
Surgery
Fabio Santanelli di Pompeo, Mark W. Clemens, Michael Atlan, Giovanni Botti, Peter G. Cordeiro, Daphne De Jong, Arianna Di Napoli, Dennis Hammond, Cara L. Haymaker, Steven M. Horwitz, Kelly Hunt, Peter Lennox, Patrick Mallucci, Roberto N. Miranda, Alexandre M. Munhoz, Eric Swanson, Suzanne D. Turner, Guido Firmani, Michail Sorotos
Summary: This study provides practice recommendations for breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) based on a literature review and expert consensus. A total of 218 manuscripts were included in the review, and 36 statements were prepared. The study highlights the need for further research and actions to better understand and address this disease.
AESTHETIC SURGERY JOURNAL
(2022)
Article
Genetics & Heredity
Scott R. Plotkin, Ludwine Messiaen, Eric Legius, Patrice Pancza, Robert A. Avery, Jaishri O. Blakeley, Dusica Babovic-Vuksanovic, Rosalie Ferner, Michael J. Fisher, Jan M. Friedman, Marco Giovannini, David H. Gutmann, Clemens Oliver Hanemann, Michel Kalamarides, Hildegard Kehrer-Sawatzki, Bruce R. Korf, Victor-Felix Mautner, Mia MacCollin, Laura Papi, Katherine A. Rauen, Vincent Riccardi, Elizabeth Schorry, Miriam J. Smith, Anat Stemmer-Rachamimov, David A. Stevenson, Nicole J. Ullrich, David Viskochil, Katharina Wimmer, Kaleb Yohay, Susan M. Huson, Pierre Wolkenstein, D. Gareth Evans
Summary: The study aims to update the diagnostic criteria for neurofibromatosis type 2 (NF2) and schwannomatosis (SWN) by incorporating recent advances in genetics, ophthalmology, neuropathology, and neuroimaging. The updated criteria include clinical features and genetic testing, emphasizing the phenotypic overlap between the two conditions.
GENETICS IN MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Loris Riccardo Lopetuso, Sara Deleu, Lihi Godny, Valentina Petito, Pierluigi Puca, Federica Facciotti, Harry Sokol, Gianluca Ianiro, Luca Masucci, Maria Abreu, Iris Dotan, Samuel Paul Costello, Ailsa Hart, Tariq H. Iqbal, Sudarshan Paramsothy, Maurizio Sanguinetti, Silvio Danese, Herbert Tilg, Fabio Cominelli, Theresa T. Pizarro, Alessandro Armuzzi, Giovanni Cammarota, Antonio Gasbarrini, Severine Vermeire, Franco Scaldaferri
Summary: An international panel of experts has generated evidence-based guidelines for the evaluation and management of inflammatory bowel disease (IBD) using faecal microbiota transplantation (FMT). The guidelines provide specific statements and recommendations to promote FMT as a recognized strategy for the treatment of IBD.
Review
Gastroenterology & Hepatology
Joerg M. Pollok, Pascale Tinguely, Marina Berenguer, Claus U. Niemann, Dimitri A. Raptis, Michael Spiro
Summary: Enhanced recovery for liver transplant recipients has been controversial. This review aims to summarize current knowledge, identify key components, and establish internationally accepted guidelines. Expert statements were prepared based on systematic literature reviews and a consensus conference, resulting in 80 final recommendations.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Joerg M. Pollok, Pascale Tinguely, Marina Berenguer, Claus U. Niemann, Dimitri A. Raptis, Michael Spiro
Summary: There is significant controversy surrounding enhanced recovery for liver-transplant recipients, and this review aimed to summarize current knowledge, identify key components, and create internationally accepted guidelines. A collaborative effort by the ERAS4OLT.org partnership and specialists from around the world resulted in 80 final recommendations covering various aspects of enhanced recovery for liver transplantation. These guidelines provide a comprehensive overview and can guide the development of enhanced recovery programs globally.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Clinical Neurology
Randall M. Chesnut, Sergio Aguilera, Andras Buki, Eileen M. Bulger, Giuseppe Citerio, D. Jamie Cooper, Ramon Diaz Arrastia, Michael Diringer, Anthony Figaji, Guoyi Gao, Romergryko G. Geocadin, Jamshid Ghajar, Odette Harris, Gregory W. J. Hawryluk, Alan Hoffer, Peter Hutchinson, Mathew Joseph, Ryan Kitagawa, Geoffrey Manley, Stephan Mayer, David K. Menon, Geert Meyfroidt, Daniel B. Michael, Mauro Oddo, David O. Okonkwo, Mayur B. Patel, Claudia Robertson, Jeffrey V. Rosenfeld, Andres M. Rubiano, Juain Sahuquillo, Franco Servadei, Lori Shutter, Deborah M. Stein, Nino Stocchetti, Fabio Silvio Taccone, Shelly D. Timmons, Eve C. Tsai, Jamie S. Ullman, Walter Videtta, David W. Wright, Christopher Zammit
Summary: The study found that the practice of ICP monitoring exceeds existing guidelines, with clinical examination (GCS) being the most important characteristic in the decision-making process. The research provides the main clinical determinants representing 80% consensus on ICP monitor insertion.
Article
Surgery
Martin D. Haug, Garyfalia Lekakis, Mario Bussi, Nazim Cerkes, Jay Calvert, Charles East, Olivier Gerbault, Wolfgang Gubisch, Werner Heppt, Haldun Kamburoglu, Sam Most, Carlo M. Oranges, Josef Vavrina, Rod J. Rohrich, Enrico Robotti
Summary: International leading experts in rhinosurgery conducted discussions and developed consensus recommendations on how to safely perform rhinoplasty, improving surgical safety and minimizing infection risks.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Multidisciplinary Sciences
Jeremy Di Domizio, Muhammet F. Gulen, Fanny Saidoune, Vivek V. Thacker, Ahmad Yatim, Kunal Sharma, Theo Nass, Emmanuella Guenova, Martin Schaller, Curdin Conrad, Christine Goepfert, Laurence de Leval, Christophe von Garnier, Sabina Berezowska, Anaelle Dubois, Michel Gilliet, Andrea Ablasser
Summary: This study reveals the mechanism behind aberrant type I interferon responses in COVID-19 through the cGAS-STING pathway and demonstrates its importance in severe cases. By using animal and lung-on-chip models, the study provides insights into host-directed therapeutic strategies for COVID-19.
Article
Medicine, Research & Experimental
Haitang Yang, Sabina Berezowska, Patrick Dorn, Philipp Zens, Peiru Chen, Ren-Wang Peng, Thomas M. Marti, Gregor J. Kocher, Ralph A. Schmid, Sean R. R. Hall
Summary: This study investigates the relationship between the tumor microenvironment (TME) and tumor-infiltrating lymphocytes (TILs) in malignant pleural mesothelioma (MPM). The results suggest that targeting the TME can potentially redirect the fate of TILs and restore anti-tumor immunity in MPM.
Article
Oncology
Jian Shen, Na Sun, Philipp Zens, Thomas Kunzke, Achim Buck, Verena M. Prade, Jun Wang, Qian Wang, Ronggui Hu, Annette Feuchtinger, Sabina Berezowska, Axel Walch
Summary: Metabolic classifiers developed using mass spectrometry imaging combined with machine learning can assess the response to neoadjuvant chemotherapy in patients with non-small cell lung cancer (NSCLC) and predict prognosis with high accuracy.
CANCER COMMUNICATIONS
(2022)
Article
Oncology
Ruiwen Ding, Prateek Prasanna, German Corredor, Cristian Barrera, Philipp Zens, Cheng Lu, Priya Velu, Patrick Leo, Niha Beig, Haojia Li, Paula Toro, Sabina Berezowska, Vipul Baxi, David Balli, Merzu Belete, David L. Rimm, Vamsidhar Velcheti, Kurt Schalper, Anant Madabhushi
Summary: This study reveals the spatial differences in tumor-infiltrating lymphocytes (TILs) between lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC). TIL density is prognostic of overall survival in LUAD, while spatial arrangement is more prognostically relevant in LUSC. The TIL signature specific to LUAD is associated with overall survival and response to therapy. In both subtypes, TIL features are associated with immune scores and biological pathways related to immune recognition, response, and evasion.
NPJ PRECISION ONCOLOGY
(2022)
Article
Pathology
Philipp Zens, Corina Bello, Amina Scherz, Michael von Gunten, Adrian Ochsenbein, Ralph A. Schmid, Sabina Berezowska
Summary: This study investigated the effect of chemotherapy on PD-L1 expression and tumor infiltrating lymphocytes (TILs) in non-small cell lung cancer (NSCLC). The results showed that PD-L1 expression mostly remained unchanged after neoadjuvant chemotherapy. Higher CD8 + TILs density and more tertiary lymphoid structures were associated with longer survival.
Article
Medicine, General & Internal
Simone Benhamou, Evelyne Fournier, Giacomo Puppa, Thomas McKee, Frederic Ris, Laura Rubbia-Brandt, Valeria Viassolo, Thomas Zilli, Inti Zlobec, Pierre Olivier Chappuis, Elisabetta Rapiti
Summary: This study established a large cohort of colorectal cancer (CRC) patients and their relatives to investigate the impact of family history and tumor biomarkers on patient outcomes. The cohort includes 5499 patients and provides detailed clinical and molecular data. Future plans involve further research and correlation analysis with the latest follow-up data.
Article
Pathology
Magdalena Skoworonska, Annika Blank, Irene Centeno, Caroline Hammer, Aurel Perren, Inti Zlobec, Tilman T. Rau
Summary: The standardized preanalytical code (SPREC) is a precise format for aggregating warm ischemia (WIT), cold ischemia (CIT), and fixation times (FIT). Through empirical research, the Tissue Bank Bern has developed a fully informative SPREC code and identified its dual role as a sample characteristic and a traceable process parameter. The study also reveals specific differences in WIT, CIT, and FIT values in various organs, as well as the potential to optimize the SPREC fixation and adapt its categories based on real-life data.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2023)
Article
Cell Biology
Angel F. Alvarez-Prado, Roeltje R. Maas, Klara Soukup, Florian Klemm, Mara Kornete, Fanny S. Krebs, Vincent Zoete, Sabina Berezowska, Jean-Philippe Brouland, Andreas F. Hottinger, Roy T. Daniel, Monika E. Hegi, Johanna A. Joyce
Summary: Brain metastases (BrMs) are a common type of brain tumor in adults, usually originating from lung and breast primary cancers. Effective therapies are needed due to the high mortality rate associated with BrMs. Genetic profiling of primary tumors is used to guide targeted therapies against BrMs, and immune-based strategies for metastatic cancer treatment are gaining momentum. However, the tumor immune microenvironment (TIME) of BrMs is heterogeneous and it is unknown whether specific genetic profiles are associated with distinct immune states. In this study, the immunogenomic landscape of human BrMs was extensively characterized, revealing unique TIME phenotypes in genetically distinct lung- and breast-BrMs, which allows for the development of personalized immunotherapies based on the genetic makeup of the tumors.
CELL REPORTS MEDICINE
(2023)
Article
Pathology
Nicole Schaad, Sabina Berezowska, Aurel Perren, Ekkehard Hewer
Summary: Synoptic reporting improves the completeness and standardization of surgical pathology reports, enhancing the quality of clinical cancer care. Implementing this reporting system, however, poses challenges due to the required effort for database setup and maintenance. A template-based, database-free approach was found to significantly increase the completeness of surgical pathology reports compared to narrative reports, making it a viable alternative during the implementation of synoptic reporting.
Article
Cell Biology
Haitang Yang, Yanyun Gao, Duo Xu, Ke Xu, Shun-Qing Liang, Zhang Yang, Amina Scherz, Sean R. R. Hall, Stefan Forster, Sabina Berezowska, Feng Yao, Adrian F. F. Ochsenbein, Thomas M. M. Marti, Gregor J. J. Kocher, Ralph A. A. Schmid, Patrick Dorn, Ren-Wang Peng
Summary: Malignant pleural mesothelioma (MPM) is a lethal malignancy caused by asbestos exposure. In this study, we found that the hyperactive MAPK pathway is a molecular driver of MPM, and blocking this pathway induces cell apoptosis. Additionally, the MAPK pathway cooperates with PARP1 to regulate ROS levels, and combining MEK inhibitors with PARP inhibitors enhances cell apoptosis.
CELL DEATH DISCOVERY
(2023)
Article
Biochemistry & Molecular Biology
Oxana (Sachenkova) Lundstrom, Max Adriaan Verbiest, Feifei Xia, Helyaneh Ziaei Jam, Inti Zlobec, Maria Anisimova, Melissa Gymrek
Summary: Short tandem repeats (STRs), consisting of repeated one to six nucleotide motifs, have been shown to influence various traits in humans. However, the study of STRs has been limited due to technical challenges. Recent advancements in genome-wide analysis tools have enabled large-scale analysis of STR variations in populations.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Oncology
Jun Wang, Na Sun, Thomas Kunzke, Jian Shen, Philipp Zens, Verena M. Prade, Annette Feuchtinger, Sabina Berezowska, Axel Walch
Summary: Molecular subtyping of lung squamous cell carcinoma (LUSC) has been performed, but stratification based on tissue metabolomics is lacking. In this study, different tumor and stroma subtypes with distinct metabolite patterns were identified in LUSC patients. The subtypes were associated with specific immunological features and metabolic pathways, and may contribute to personalized therapy.
NPJ PRECISION ONCOLOGY
(2023)
Article
Pathology
Andrew Janowczyk, Inti Zlobec, Cedric Walker, Sabina Berezowska, Viola Huschauer, Marianne Tinguely, Joel Kupferschmid, Thomas Mallet, Doron Merkler, Mario Kreutzfeldt, Radivoje Gasic, Tilman T. Rau, Luca Mazzucchelli, Isgard Eyberg, Gieri Cathomas, Kirsten D. Mertz, Viktor H. Koelzer, Davide Soldini, Wolfram Jochum, Matthias Roessle, Maurice Henkel, Rainer Grobholz
Summary: The integration of digital pathology (DP) into clinical diagnostic workflows is being emphasized as new hardware and software become available. To facilitate DP adoption, the Swiss Digital Pathology Consortium (SDiPath) organized a Delphi process and generated a series of recommendations for DP integration. Through the collaboration of four working groups, the process produced 83 consensus statements, providing up-to-date resources and best practices to ensure safe and efficient DP usage for national and international hospitals, researchers, and device manufacturers.
Review
Cell Biology
Sabina Berezowska, Marie Maillard, Mark Keyter, Bettina Bisig
Summary: Squamous cell carcinoma (SCC) is a type of lung cancer that can be divided into keratinising, non-keratinising, and basaloid SCC. Histomorphology alone can be used to diagnose keratinising SCC, but immunohistochemical analyses should be used for non-keratinising and basaloid tumors to confirm the diagnosis and exclude other possibilities. In cases where the morphology is ambiguous, a diagnosis of SCC can be made based on squamous immunophenotype. Most SCCs are associated with smoking and have specific molecular characteristics, but there are rare cases in younger and non-smoking patients. Lymphoepithelial carcinoma (LEC) is a poorly differentiated SCC with lymphoplasmacytic infiltrate and often associated with Epstein-Barr virus (EBV). This article describes the morphological and molecular characteristics of SCC and LEC and discusses the important differential diagnoses.
Article
Pathology
Ana Leni Frei, Raphael Oberson, Elias Baumann, Aurel Perren, Rainer Grobholz, Alessandro Lugli, Heather Dawson, Christian Abbet, Ibai Lertxundi, Stefan Reinhard, Aart Mookhoek, Johann Feichtinger, Rossella Sarro, Gallus Gadient, Corina Dommann-Scherrer, Jessica Barizzi, Sabina Berezowska, Katharina Glatz, Susanne Dertinger, Yara Banz, Rene Schoenegg, Laura Rubbia-Brandt, Achim Fleischmann, Guenter Saile, Pierre Mainil-Varlet, Ruggero Biral, Luca Giudici, Alex Soltermann, Audrey Baur Chaubert, Sylvia Stadlmann, Joachim Diebold, Kristof Egervaril, Charles Beniere, Francesca Saro, Andrew Janowczyk, Inti Zlobec
Summary: Estimating tumor cell fraction (TCF) is a common clinical task with high variability among pathologists. This study evaluated the impact of using a tumor cell fraction computer-aided diagnostic (TCFCAD) tool to support pathologists' evaluation. The results showed that with the assistance of TCFCAD, interobserver variability decreased and estimates were closer to the ground truth. Pathologists also reported increased confidence in their assessments when aided by the TCFCAD tool.
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.