Article
Endocrinology & Metabolism
Christian A. Unger, Ahmed K. Aladhami, Marion C. Hope, William E. Cotham, Kendall W. Nettles, Deborah J. Clegg, Kandy T. Velazquez, Reilly T. Enos
Summary: This study indicates that enhanced skeletal muscle aromatase activity in male mice can mitigate the negative effects of a high-fat diet on obesity-associated metabolic impairments. Skeletal muscle estrogen can improve metabolic and inflammatory outcomes while promoting skeletal muscle hypertrophy, thus improving metabolic abnormalities and inflammation caused by a high-fat diet.
Article
Biochemistry & Molecular Biology
Ao Sun, Xiaoqin Hu, Huijian Chen, Yulan Ma, Xiyue Yan, Dangsheng Peng, Jie Ping, Youe Yan
Summary: Research has shown that ursolic acid acts as an anti-obesity agent by increasing irisin secretion and promoting the beiging of white adipose tissue (WAT).
Article
Food Science & Technology
Yanan Sun, Ning Liu, Huihui Wang, Taiqi Qu, Fazheng Ren, Yixuan Li
Summary: Modern technological lifestyles promote allergic diseases, especially food allergies. This study found that a high-fat diet increases the risk of allergies and uncovered the underlying molecular mechanisms, mainly involving energy metabolism and mitochondrial function.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Nutrition & Dietetics
Heather C. Spooner, Stefani A. Derrick, Magdalena Maj, Rodrigo Manjarin, Gabriella V. Hernandez, Deepali S. Tailor, Parisa S. Bastani, Rob K. Fanter, Marta L. Fiorotto, Douglas G. Burrin, Michael R. La Frano, Angelos K. Sikalidis, Jason M. Blank
Summary: The study found that high-fructose, high-fat diets may lead to an increase in total triacylglycerol content in muscle tissue, but a decrease in intramyocellular lipid content and the number of type I (slow oxidative) muscle fibers. Additionally, high-fructose, high-fat diets also induced autophagy and inflammation responses.
Article
Nutrition & Dietetics
Song Huang, Xinyue Zheng, Xinyu Zhang, Zhe Jin, Sujuan Liu, Li Fu, Yanmei Niu
Summary: This study investigates the regulatory relationship between AMPK alpha 2 and HDAC4/5 expression during exercise. The findings suggest that exercise can enhance skeletal muscle oxidative capacity and promote HDAC5 degradation through MuRF1-mediated ubiquitination.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2022)
Article
Nutrition & Dietetics
Jiaqi Cui, Lin Song, Rui Wang, Shuyuan Hu, Zhao Yang, Zengtie Zhang, Bo Sun, Wei Cui
Summary: This study suggests that maternal metformin during gestation and lactation has the potential to overcome the negative effects of perinatal exposure to a high-fat diet in offspring. This is achieved by altering myogenesis, mitochondrial biogenesis, and dynamics through the AMPK/mTOR pathways in skeletal muscle.
Article
Agriculture, Dairy & Animal Science
Huimei Fan, Yanhong Li, Jie Wang, Jiahao Shao, Tao Tang, Mauricio A. Elzo, Li Wang, Tianfu Lai, Yuan Ma, Mingchuan Gan, Xianbo Jia, Songjia Lai
Summary: Untargeted metabolomic analysis of rabbit skeletal muscle revealed that a high-fat diet altered the metabolism of phospholipids, carnitine, amino acids, and steroids. Specifically, phospholipids, LCACs, histidine, carnosine, and tetrahydrocorticosteroids were identified as potential biomarkers for type 2 diabetes and metabolic syndrome, indicating their importance in related diseases.
Article
Medicine, Research & Experimental
Melissa L. Erickson, Zachary W. Patinkin, Allison M. Duensing, Dana Dabelea, Leanne M. Redman, Kristen E. Boyle
Summary: Exposure to maternal obesity can lead to metabolic dysfunction in offspring. The study found that MSCs from infants of mothers with obesity had variations in metabolic efficiency related to fatty acid oxidation, influenced by maternal metabolic environment and infant fat mass.
Article
Biochemistry & Molecular Biology
Matteo Serano, Cecilia Paolini, Antonio Michelucci, Laura Pietrangelo, Flavia A. Guarnier, Feliciano Protasi
Summary: A high-fat diet may increase the susceptibility of wild type mice to heat stress, resulting in increased heat production and oxidative stress in skeletal muscles, as well as enhanced sensitivity to temperature and caffeine in isolated muscles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Robert A. Jacobs, Carsten Lundby
Summary: This study aimed to compare measures of mitochondrial function obtained from ex vivo and in vivo assessments, finding that ex vivo measures are generally lower but become more similar after correcting for respiratory data. The results support the idea that maximal skeletal muscle respiratory rates exceed those achieved during maximal whole-body exercise.
Article
Biology
Allison C. Stone, Robert C. Noland, Randall L. Mynatt, Samuel E. Velasquez, David S. Bayless, Eric Ravussin, Jaycob D. Warfel
Summary: The study examines the sexually dimorphic metabolic phenotype in mice lacking HuR in skeletal muscle, revealing an increase in adiposity regardless of sex, but only male animals develop insulin resistance as a result. The detrimental metabolic effects associated with HuR inhibition can be corrected by feeding a diet rich in lipids or carbohydrates, especially for male mice. The capacity for lipid oxidation in skeletal muscle without HuR may be linked to decreased glucose clearance in male but not female mice.
Article
Medicine, Research & Experimental
Lei Xu, Jie Jia, Shudan Miao, Lijing Gong, Jin Wang, Shiyi He, Ying Zhang
Summary: The study aimed to investigate the effects of aerobic exercise on the CHRONO-BMAL1 pathway and glucose metabolism in high-fat diet-fed mice. The results showed that aerobic exercise prevented weight gain, dyslipidemia, and systemic insulin resistance in the high-fat diet-fed mice. It also decreased the amount of CHRONO bound to BMAL1 and increased glucose uptake, oxidation, and glycogenesis in skeletal muscle.
Article
Nutrition & Dietetics
Chutimon Termkwancharoen, Wachirawadee Malakul, Amnat Phetrungnapha, Sakara Tunsophon
Summary: This study investigated the effects of naringin on skeletal muscle metabolism in obese rats. The results showed that naringin reduced body weight, improved biochemical parameters, increased antioxidant enzymes, glucose uptake, and protein synthesis, leading to improved muscle mass.
Article
Cell Biology
Jiuzhou Huo, Vikram Prasad, Kelly M. Grimes, Davy Vanhoutte, N. Scott Blair, Suh-Chin Lin, Michael J. Bround, Donald M. Bers, Jeffery D. Molkentin
Summary: MCUb is an inducible control point that regulates skeletal muscle mitochondrial Ca2+ levels and substrate utilization, impacting overall metabolic balance.
Review
Pharmacology & Pharmacy
Shengnan Shen, Qiwen Liao, Xiuping Chen, Cheng Peng, Ligen Lin
Summary: This review summarizes the roles of irisin in regulating glucose metabolism, neuroplasticity, satiety, cell function, bone remodeling, and adipose tissue function. Irisin acts as a key communicator between skeletal muscle and other organs, and manipulating its levels could be a promising therapeutic strategy for treating obesity and related metabolic disorders.
DRUG DISCOVERY TODAY
(2022)
Article
Oncology
Laura E. Griffin, Sarah E. Kohrt, Atul Rathore, Colin D. Kay, Magdalena M. Grabowska, Andrew P. Neilson
Summary: Flavanols are metabolized by gut microbiota to bioavailable metabolites, which can inhibit bladder cancer proliferation. The use of individual genetics and microbial metabotyping to design personalized dietary interventions can reduce bladder cancer incidence and improve treatment outcomes.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Peripheral Vascular Disease
Vienna E. Brunt, Abigail G. Casso, Rachel A. Gioscia-Ryan, Zachary J. Sapinsley, Brian P. Ziemba, Zachary S. Clayton, Amy E. Bazzoni, Nicholas S. VanDongen, James J. Richey, David A. Hutton, Melanie C. Zigler, Andrew P. Neilson, Kevin P. Davy, Douglas R. Seals
Summary: The study reveals that elevated levels of TMAO with aging contribute to aortic stiffening and increased SBP in both humans and mice, potentially increasing the risk for cardiovascular disease. This effect is mediated by the formation of advanced glycation end-products and superoxide-stimulated oxidative stress, highlighting TMAO as a novel therapeutic target for reducing the risk of aortic stiffening-related clinical disorders.
Article
Biochemistry & Molecular Biology
Lisard Iglesias-Carres, Michael D. Hughes, Cortney N. Steele, Monica A. Ponder, Kevin P. Davy, Andrew P. Neilson
Summary: This review summarizes the role of TMAO as a risk factor for CVD and discusses the potential of phytochemicals in reducing TMAO formation by modulating gut microbiota and inhibiting host metabolism. The article also provides insights for future studies on phytochemicals as TMAO-reducing agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Review
Neurosciences
Carol L. Cheatham, David C. Nieman, Andrew P. Neilson, Mary Ann Lila
Summary: Age-related cognitive changes may be an early indication of dementia progression, and these changes are driven by complex interactions among factors such as diet, activity levels, genetics, and environment. Recent studies have found that flavonoid-rich foods can inhibit neuroinflammation and enhance cognitive performance. Improved cognition is also correlated with a physically active lifestyle and a diverse gut microbiome. This article suggests that a combination of flavonoid intake and physical exertion may have potential impacts on cognitive function, mediated by the gut microbiome. Further research is needed to explore this hypothesis through animal studies and clinical interventions.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Agriculture, Multidisciplinary
Lisard Iglesias-Carres, Emily S. Krueger, Jacob A. Herring, Jeffery S. Tessem, Andrew P. Neilson
Summary: In this study, it was found that phenolic compounds such as caffeic acid, catechin, and epicatechin could effectively inhibit the production of TMA, suggesting their potential as lead bioactives for in vivo testing.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Kathryn C. Racine, Lisard Iglesias-Carres, Jacob A. Herring, Mario G. Ferruzzi, Colin D. Kay, Jeffery S. Tessem, Andrew P. Neilson
Summary: This study found that cocoa supplementation may have different gender responses in the development and progression of type 2 diabetes. Acute cocoa reduced fasting hyperglycemia in females, while chronic supplementation improved hyperinsulinemia in males but worsened hyperlipidemia and hyperinsulinemia in females.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Physiology
Vienna E. Brunt, Nathan T. Greenberg, Zachary J. Sapinsley, Abigail G. Casso, James J. Richey, Nicholas S. VanDongen, Rachel A. Gioscia-Ryan, Brian P. Ziemba, Andrew P. Neilson, Kevin P. Davy, Douglas R. Seals
Summary: Consumption of a Western-style diet is associated with impaired vascular function and cardiovascular disease risk, which may be partly mediated by increased levels of the gut microbiome-derived metabolite TMAO. In a mouse study, suppression of TMAO with DMB prevented diet-induced vascular dysfunction, aortic stiffening, decreased endurance exercise tolerance, and increased frailty.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daphne K. Weikart, Vijaya V. Indukuri, Kathryn C. Racine, Kiana M. Coleman, Jasna Kovac, Darrell W. Cockburn, Helene Hopfer, Andrew P. Neilson, Joshua D. Lambert
Summary: Fermentation and roasting protocols do not affect the anti-obesity and anti-inflammatory efficacy of cocoa in obese mice. Cocoa supplementation reduces body weight gain, increases colonic length, and decreases gut permeability in both male and female mice. There are significant sex differences in the effects of both high-fat diet and cocoa supplementation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Neurosciences
Abigail G. Casso, Nicholas S. VanDongen, Rachel A. Gioscia-Ryan, Zachary S. Clayton, Nathan T. Greenberg, Brian P. Ziemba, David A. Hutton, Andrew P. Neilson, Kevin P. Davy, Douglas R. Seals, Vienna E. Brunt
Summary: Vascular dysfunction develops progressively with aging, increasing the risk of cardiovascular diseases. Gut microbiome-derived TMAO induces this dysfunction, but it can be prevented or attenuated by DMB supplementation.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Food Science & Technology
Lisard Iglesias-Carres, Kathryn C. Racine, Sydney Chadwick, Candace Nunn, Sathya B. Kalambur, Andrew P. Neilson, Mario G. Ferruzzi
Summary: The use of alternative, green antioxidant (AOX) systems is required by consumers, but natural AOX systems have challenges in maintaining desirable color in fried potato chips. Ascorbic acid solubilization in oil and migration to the chip surface play crucial roles in the observed off-color formation. Multiple complex reactions, including Maillard reactions and food matrix components, may contribute to color development. Factors such as AOX concentration, free amino acid concentration, temperature, and moisture are critical for controlling undesirable color formation during frying.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Lisard Iglesias-Carres, Angelica Bruno, Isabella 'Antuono, Vito Linsalata, Angela Cardinali, Andrew P. Neilson
Summary: This study investigated the chemical composition and in vitro biological activities of two globe artichoke varieties, RS and SS, and found that they have potential antioxidant and cardioprotective effects, as well as neuroprotective effects.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Food Science & Technology
Adhini Kuppuswamy Satheesh Babu, Chrissa Petersen, Henry A. Paz, Lisard Iglesias-Carres, Ying Li, Ying Zhong, Andrew P. Neilson, Umesh D. Wankhade, Pon Velayutham Anandh Babu
Summary: This study develops an efficient strategy to deplete gut microbes and suppress the production of microbial metabolites in mice without affecting their metabolic health.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Lisard Iglesias-Carres, Kathryn C. Racine, Andrew P. Neilson
Summary: This study suggests that regular consumption of cocoa and coffee could be a nutritional strategy to reduce TMAO levels by inhibiting TMA production. Digestion is required to unlock the TMA inhibition potential of coffee and cocoa beverages, while teas do not possess strong inhibition potential either digested or undigested. Fractions rich in chlorogenic acid were found to be the most bioactive in inhibiting TMA production.
Article
Biochemistry & Molecular Biology
Micaela Hayes, Zulfiqar Mohamedshah, Sydney Chadwick-Corbin, Roberta Hoskin, Massimo Iorizzo, Mary Ann Lila, Andrew P. Neilson, Mario G. Ferruzzi
Summary: Insights into the impact of food matrix factors on the bioavailability of bioactive carotenoids and chlorophylls from fruits and vegetables are crucial. In vitro models were used to assess the stability, bioaccessibility, and intestinal absorption of carotenoids and chlorophylls in different forms of spinach. The results showed that spinach forms created by various drying technologies deliver similar levels of bioaccessible bioactives, and the lower gastrointestinal tract may play a significant role in the absorption of these compounds.
Article
Biochemistry & Molecular Biology
Zulfiqar Mohamedshah, Micaela Hayes, Sydney Chadwick-Corbin, Andrew P. Neilson, Mario G. Ferruzzi
Summary: The study compared the bioavailability and metabolism of phenolics between grapes and grape juice. It found that phenolics in grape juice were more easily absorbed compared to whole grapes. However, overall, the absorbable phenolics from 100% grape juice were similar to those from whole grapes, suggesting that consuming whole fruit and juice may have similar health benefits.
Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
Summary: This study reveals the important role of KDM2B in triple-negative breast cancer (TNBC). KDM2B affects cellular resistance to oxidative stress by regulating a network of genes and metabolic enzymes, in collaboration with ATF4 and MYC. Additionally, high expression of KDM2B is associated with poor prognosis in patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Joongmin Kim, Hyeongsoo Kim, Sang Hyun Park, Yura Kang, Kyungdo Han, Sang-Hak Lee
Summary: This study aimed to investigate the optimal LDL-C level after statin therapy in individuals with intermediate cardiovascular risk. The results showed that achieving LDL-C levels <120 mg/dL after statin therapy could lower the event risk.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Ze Chen, Li -Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang
Summary: Accumulating evidence suggests that NAFLD has an intrauterine origin, with adverse prenatal environments and glucocorticoid exposure playing a crucial role in the developmental programming of fetal hepatic lipid metabolism. The offspring's glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis is programmed in utero, leading to postnatal catch-up growth and disrupted glucose and lipid metabolism, increasing susceptibility to NAFLD. Mismatch between intrauterine and postnatal environments can further disturb the programmed endocrine axes and accelerate the onset of NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
Summary: This study investigates the role of CCDC92 in the pathogenesis of diabetic kidney disease (DKD). The expression of CCDC92 was found to increase in kidney biopsies from patients with DKD and was correlated with glomerular lipid accumulation. Animal studies further confirmed the induction of CCDC92 in the kidney, particularly in podocytes, and the podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and lipid deposition. CCDC92 was shown to promote podocyte lipotoxicity through ABCA1 signaling-mediated lipid homeostasis. Therefore, CCDC92 may serve as a potential biomarker of podocyte injury in DKD and targeting CCDC92 could be an innovative therapeutic strategy for DKD patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
Summary: The discovery and revival of brown adipose tissue (BAT) in adult humans have opened up new possibilities for treating obesity and metabolic diseases. BAT not only plays a role in generating heat, but also secretes signaling molecules known as batokines, which regulate overall metabolism. This review highlights the importance of BAT-derived metabolites in controlling thermogenesis, substrate metabolism, and other biological processes, as well as their potential to alleviate obesity and related metabolic complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)