4.6 Article

Effect of chemical composition and sulfated modification of alginate in the development of delivery systems based on electrostatic interactions for small molecule drugs

Journal

MATERIALS LETTERS
Volume 263, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.matlet.2019.127235

Keywords

Polymer; Biomaterials; Chemical composition; Sulfated modification; Ionic complex

Funding

  1. Iran National Science Foundation [96008314]
  2. Royan Institute, Tehran, Iran

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The ionic complexation of different chemical compositions of alginate and its sulfated derivative with tetracycline hydrochloride (TCH), as a cationic drug model, was investigated. The complexes of TCH with mannuronate-enriched alginate entrapped the highest amount of the drug. However, the ability of all unmodified alginates for ionic complexation was very weak. Interestingly, the chemical modification of alginate with sulfate groups resulted in drug-polymer complexes with remarkable entrapment efficiency of TCH. The results of this study suggested alginate sulfate as a promising biomaterial in designing delivery systems for cationic small molecule drugs. (C) 2019 Elsevier B.V. All rights reserved.

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