Journal
MATERIALS LETTERS
Volume 256, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.matlet.2019.126616
Keywords
Nanoparticles; Gelatin; Pol-epsilon-caprolactone; Electrospun hybrid mats; Gymnema sylvestre; Biomaterials
Funding
- UGC-DAE Consortium for Scientific Research, Kalpakkam, India [CSR-KN/CRS-70/2015-16/811]
- Lee Kong Chian School of Medicine, Nanyang Technological University Singapore Start-Up Grant [L0412290]
- Strategic Academic Initiative (SAI) Grant [L0494003]
- Wound Care Innovation for the Tropics (WCIT) Programme under the Industry Alignment Fund Pre-Positioning (IAF-PP) Grant Singapore [H17/01/a0/0K9]
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Bacterial infection followed by biofilm formation at the site of injury presents an extensive and tenacious challenge to wound care management as it leads to delayed wound healing. Recently nanoparticles and nanofibers have been widely investigated for their superior physical and biological supportive properties. This study presents the green synthesis of nickel oxide nanoparticles using Gymnema sylvestre extracts. The synthesized nanoparticles were infused into electrospun poly-epsilon-caprolactone/Gelatin hybrid nanofibrous mats. As synthesized nanofibrous mats exhibited good wettability, enhanced mechanical properties, biocompatibility and potent antibacterial activity. Overall, the bio functionalized nickel oxide nanoparticles infused electrospun nanofibrous mats can serve as an effective anti-infective wound dressing. (C) 2019 Elsevier B.V. All rights reserved.
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