Antitumor Potential of Marine and Freshwater Lectins

Oncolytic Vaccinia Virus Expressing Aphrocallistes vastus Lectin as a Cancer Therapeutic Agent

(2019) Tao Wu et al.   Marine Drugs

Plant lectins in cancer therapeutics: Targeting apoptosis and autophagy-dependent cell death

(2019) Sujit K. Bhutia et al.   PHARMACOLOGICAL RESEARCH

Halilectin-3, a Lectin from the Marine Sponge Haliclona caerulea, Induces Apoptosis and Autophagy in Human Breast Cancer MCF7 Cells Through Caspase-9 Pathway and LC3-II Protein Expression

(2018) Luiz G. do Nascimento-Neto et al.   Anti-Cancer Agents in Medicinal Chemistry

Structural characterization of two isolectins from the marine red alga Solieria filiformis (Kützing) P.W. Gabrielson and their anticancer effect on MCF-7 breast cancer cells

(2018) Renata Pinheiro Chaves et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Expression of Lectins in Heterologous Systems

(2018) Dania Martínez-Alarcón et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Marine Compounds and Cancer: 2017 Updates

(2018) Sergey Dyshlovoy et al.   Marine Drugs

Tachypleus tridentatus Lectin Enhances Oncolytic Vaccinia Virus Replication to Suppress In Vivo Hepatocellular Carcinoma Growth

(2018) Gongchu Li et al.   Marine Drugs

Harnessing Oxidative Stress as an Innovative Target for Cancer Therapy

(2018) Lynne Postovit et al.   Oxidative Medicine and Cellular Longevity

Sialic acid-binding lectin from bullfrog eggs inhibits human malignant mesothelioma cell growth in vitro and in vivo

(2018) Takeo Tatsuta et al.   PLoS One

In vitro biomimetic engineering of a human hematopoietic niche with functional properties

(2018) Paul E. Bourgine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vitro Study of the Cytotoxic, Cytostatic, and Antigenotoxic Profile of Hemidesmus indicus (L.) R.Br. (Apocynaceae) Crude Drug Extract on T Lymphoblastic Cells

(2018) Eleonora Turrini et al.   Toxins

Progress in gene therapy using oncolytic vaccinia virus as vectors

(2018) Xue Yang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Sialic Acid-Binding Lectin from Bullfrog Eggs Exhibits an Anti-Tumor Effect Against Breast Cancer Cells Including Triple-Negative Phenotype Cells

(2018) Takeo Tatsuta et al.   MOLECULES

Protein arginine methyltransferase 5 (PRMT5) dysregulation in cancer

(2018) Harshita Shailesh et al.   Oncotarget

Histochemical localization of N-acetylhexosamine-binding lectin HOL-18 in Halichondria okadai (Japanese black sponge), and its antimicrobial and cytotoxic anticancer effects

(2018) Imtiaj Hasan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Ulva pertusa lectin 1 delivery through adenovirus vector affects multiple signaling pathways in cancer cells

(2017) Gongchu Li et al.   GLYCOCONJUGATE JOURNAL

Lectin CGL from the sea mussel Crenomytilus grayanus induces Burkitt’s lymphoma cells death via interaction with surface glycan

(2017) Oleg Chernikov et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Marine Sponge Natural Products with Anticancer Potential: An Updated Review

(2017) Cinzia Calcabrini et al.   Marine Drugs

Marine Lectins DlFBL and HddSBL Fused with Soluble Coxsackie-Adenovirus Receptor Facilitate Adenovirus Infection in Cancer Cells BUT Have Different Effects on Cell Survival

(2017) Bingbing Wu et al.   Marine Drugs

Synergistic anti-tumor effect of bullfrog sialic acid-binding lectin and pemetrexed in malignant mesothelioma

(2017) Toshiyuki Satoh et al.   Oncotarget

Combination therapy in combating cancer

(2017) Reza Bayat Mokhtari et al.   Oncotarget

Noncanonical cell death program independent of caspase activation cascade and necroptotic modules is elicited by loss of TGFβ-activated kinase 1

(2017) September R. Mihaly et al.   Scientific Reports

Cancer therapy in the necroptosis era

(2016) Z Su et al.   CELL DEATH AND DIFFERENTIATION

Catfish rhamnose-binding lectin induces G0/1 cell cycle arrest in Burkitt’s lymphoma cells via membrane surface Gb3

(2016) Shigeki Sugawara et al.   GLYCOCONJUGATE JOURNAL

Internalization of a novel, huge lectin from Ibacus novemdentatus (slipper lobster) induces apoptosis of mammalian cancer cells

(2016) Y. Fujii et al.   GLYCOCONJUGATE JOURNAL

Glycosylation: a hallmark of cancer?

(2016) Bhairavi N. Vajaria et al.   GLYCOCONJUGATE JOURNAL

Galectins: their network and roles in immunity/tumor growth control

(2016) Herbert Kaltner et al.   HISTOCHEMISTRY AND CELL BIOLOGY

RNase activity of sialic acid-binding lectin from bullfrog eggs drives antitumor effect via the activation of p38 MAPK to caspase-3/7 signaling pathway in human breast cancer cells

(2016) Yukiko Kariya et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Anguilla japonicalectin 1 delivery through adenovirus vector induces apoptotic cancer cell death through interaction with PRMT5

(2016) Gongchu Li et al.   JOURNAL OF GENE MEDICINE

A Multivalent Marine Lectin from Crenomytilus grayanus Possesses Anti-cancer Activity through Recognizing Globotriose Gb3

(2016) Jiahn-Haur Liao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hallmarks of glycosylation in cancer

(2016) Jennifer Munkley et al.   Oncotarget

MytiLec, a Mussel R-Type Lectin, Interacts with Surface Glycan Gb3 on Burkitt’s Lymphoma Cells to Trigger Apoptosis through Multiple Pathways

(2015) Imtiaj Hasan et al.   Marine Drugs

Lectins with Potential for Anti-Cancer Therapy

(2015) Tammy Yau et al.   MOLECULES

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

(2015) Mark A. Feitelson et al.   SEMINARS IN CANCER BIOLOGY

RIP1 and RIP3 complex regulates radiation-induced programmed necrosis in glioblastoma

(2015) Arabinda Das et al.   TUMOR BIOLOGY

Rana catesbeiana ribonuclease induces cell apoptosis via the caspase-9/-3 signaling pathway in human glioblastoma DBTRG, GBM8901 and GBM8401 cell lines

(2015) JEN-NI CHEN et al.   Oncology Letters

Adenovirus Carrying Gene Encoding Haliotis discus discus Sialic Acid Binding Lectin Induces Cancer Cell Apoptosis

(2014) Xinyan Yang et al.   Marine Drugs

Exogenous expression of marine lectins DlFBL and SpRBL induces cancer cell apoptosis possibly through PRMT5-E2F-1 pathway

(2014) Liqin Wu et al.   Scientific Reports

Apoptosis and Molecular Targeting Therapy in Cancer

(2014) Mohamed Hassan et al.   Biomed Research International

Altered Tumor-Cell Glycosylation Promotes Metastasis

(2014) Irina Häuselmann et al.   Frontiers in Oncology

cDNA cloning and structural characterization of a lectin from the mussel Crenomytilus grayanus with a unique amino acid sequence and antibacterial activity

(2013) Svetlana N. Kovalchuk et al.   FISH & SHELLFISH IMMUNOLOGY

Sialyl-glycoconjugates in cholesterol-rich microdomains of P388 cells are the triggers for apoptosis induced by Rana catesbeiana oocyte ribonuclease

(2013) Y. Ogawa et al.   GLYCOCONJUGATE JOURNAL

H-3, a new lectin from the marine sponge Haliclona caerulea: Purification and mass spectrometric characterization

(2013) Rômulo Farias Carneiro et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sialic acid-binding lectin (leczyme) induces apoptosis to malignant mesothelioma and exerts synergistic antitumor effects with TRAIL

(2013) TAKEO TATSUTA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Involvement of ER stress in apoptosis induced by sialic acid-binding lectin (leczyme) from bullfrog eggs

(2013) TAKEO TATSUTA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Sialic acid-binding lectin (leczyme) induces caspase-dependent apoptosis-mediated mitochondrial perturbation in Jurkat cells

(2013) TAKEO TATSUTA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Chlorinated Didemnins from the Tunicate Trididemnum solidum

(2013) Sridevi Ankisetty et al.   Marine Drugs

Downregulation of Hsp70 inhibits apoptosis induced by sialic acid-binding lectin (leczyme)

(2013) TAKEO TATSUTA et al.   ONCOLOGY REPORTS

From Darwin to the Census of Marine Life: Marine Biology as Big Science

(2013) Niki Vermeulen   PLoS One

Recombinant hHscFv-RC-RNase protein derived from transgenic tobacco acts as a bifunctional molecular complex against hepatocellular carcinoma

(2012) Lijie Cui et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Structural characterization and antitumor and mitogenic activity of a lectin from the gill of bighead carp (Aristichthys nobilis)

(2012) Dongrui Yao et al.   FISH PHYSIOLOGY AND BIOCHEMISTRY

A Lectin from the MusselMytilus galloprovincialisHas a Highly Novel Primary Structure and Induces Glycan-mediated Cytotoxicity of Globotriaosylceramide-expressing Lymphoma Cells

(2012) Yuki Fujii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An overview of lectins purification strategies

(2012) Kelany S. Nascimento et al.   JOURNAL OF MOLECULAR RECOGNITION

A Lactose-Binding Lectin from the Marine Sponge Cinachyrella Apion (Cal) Induces Cell Death in Human Cervical Adenocarcinoma Cells

(2012) Luciana Rabelo et al.   Marine Drugs

Didemnins, tamandarins and related natural products

(2012) Jisun Lee et al.   NATURAL PRODUCT REPORTS

MAP Kinase Pathways

(2012) D. K. Morrison   Cold Spring Harbor Perspectives in Biology

Cytotoxicity and Glycan-Binding Properties of an 18 kDa Lectin Isolated from the Marine Sponge Halichondria okadai

(2012) Ryo Matsumoto et al.   Toxins

Rana catesbeiana ribonuclease inhibits Japanese encephalitis virus (JEV) replication and enhances apoptosis of JEV-infected BHK-21 cells

(2011) Yu-Hsiu Lee et al.   ANTIVIRAL RESEARCH

The cytotoxic activity of two D-galactose-binding lectins purified from marine invertebrates

(2011) Sarkar Kawsar et al.   Archives of Biological Sciences

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Mechanisms and principles of N-linked protein glycosylation

(2011) Flavio Schwarz et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Purification of a new fungal mannose-specific lectin from Penicillium chrysogenum and its aphicidal properties

(2011) Frédéric Francis et al.   Fungal Biology

Purification and Characterization of a Rhamnose-Binding Chinook Salmon Roe Lectin with Antiproliferative Activity toward Tumor Cells and Nitric Oxide-Inducing Activity toward Murine Macrophages

(2011) Clara Shui Fern Bah et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Crataeva tapia bark lectin is an affinity adsorbent and insecticidal agent

(2011) Regina Maria Sousa de Araújo et al.   PLANT SCIENCE

Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells

(2011) Y.-C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Agents from amphibians with anticancer properties

(2010) Chuang-Xin Lu et al.   ANTI-CANCER DRUGS

Lectins: production and practical applications

(2010) Sze Kwan Lam et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Control of cell cycle progression by phosphorylation of cyclin-dependent kinase (CDK) substrates

(2010) Randy Suryadinata et al.   BIOSCIENCE REPORTS

The pharmaceutical value of marine biodiversity for anti-cancer drug discovery

(2010) Patrick M. Erwin et al.   ECOLOGICAL ECONOMICS

In vitro and in vivo anti-tumor effects of novel Span 80 vesicles containing immobilized Eucheuma serra agglutinin

(2010) Yousuke Omokawa et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Therapeutic properties and uses of marine invertebrates in the ancient Greek world and early Byzantium

(2010) Eleni Voultsiadou   JOURNAL OF ETHNOPHARMACOLOGY

Selective Killing of Cancer Cells by Ashwagandha Leaf Extract and Its Component Withanone Involves ROS Signaling

(2010) Nashi Widodo et al.   PLoS One

Verotoxin-1 Treatment or Manipulation of its Receptor Globotriaosylceramide (Gb3) for Reversal of Multidrug Resistance to Cancer Chemotherapy

(2010) Parviz Behnam-Motlagh et al.   Toxins

A lactose specific lectin from the sponge Cinachyrella apion: Purification, characterization, N-terminal sequences alignment and agglutinating activity on Leishmania promastigotes

(2009) Danielle S. Medeiros et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Anticancer Drugs Discovery and Development from Marine Organisms

(2009) Chiranjib Chakraborty et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Structure of Rhamnose-binding Lectin CSL3: Unique Pseudo-tetrameric Architecture of a Pattern Recognition Protein

(2009) Tsuyoshi Shirai et al.   JOURNAL OF MOLECULAR BIOLOGY

Isolation and characterization of a novel fucose-binding lectin from the gill of bighead carp (Aristichthys nobilis)

(2009) Saikun Pan et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Growth inhibitory activity of a novel lectin from Cliona varians against K562 human erythroleukemia cells

(2008) Alexandre F. S. Queiroz et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A novel C-type lectin from abalone, Haliotis discus discus, agglutinates Vibrio alginolyticus

(2008) Ning Wang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY