Review
Chemistry, Medicinal
Christian Oktavianus Manginstar, Trina Ekawati Tallei, Nurdjannah Jane Niode, Christina Leta Salaki, Sofia Safitri Hessel
Summary: This literature review provides an overview of propolis' mechanisms of action, wound-healing properties, and its application in treating skin burns. Propolis contains bioactive compounds with antimicrobial, antioxidant, and anti-inflammatory properties, making it a promising candidate for managing skin burn injuries. Further research is needed to fully understand propolis' mechanisms, determine optimal formulations, and establish suitable clinical dosages.
PHYTOTHERAPY RESEARCH
(2023)
Review
Immunology
S. A. El-Sherbeni, W. A. Negm
Summary: The process of wound repair involves the coordination of different cell types and the formation of collagen to promote wound contraction, epithelial cell proliferation, and healing. The use of traditional medicinal plants in wound healing has been practiced for centuries, and recent scientific research supports their efficacy. This review focuses on the wound-healing effects of plant extracts and natural substances in animal models over the past 5 years, showing promising results in various phases of wound healing. Incorporating bioactive natural products into wound dressings has shown positive effects in hemostasis, inflammation, growth, re-epithelialization, and remodeling.
INFLAMMOPHARMACOLOGY
(2023)
Article
Critical Care Medicine
Carly M. Knuth, Sarah Rehou, Dalia Barayan, Marc G. Jeschke
Summary: Sepsis has become the leading cause of death in burn patients, leading to significant morbidity and longer hospitalization. However, sepsis in burn patients is poorly understood. This study compared clinical, metabolic, and inflammatory markers in septic and nonseptic burn patients using different sepsis definitions, and identified temporal biomarker alterations that could improve sepsis diagnosis accuracy in burn patients.
Article
Immunology
Mile Stanojcic, Roohi Vinaik, Abdikarim Abdullahi, Peter Chen, Marc G. Jeschke
Summary: The activation of NLRP3 inflammasome enhances tissue-specific inflammatory responsiveness in burn sepsis, leading to improved bacterial clearance and survival rates in animal models. However, Nlrp3 genetic ablation paradoxically increases acute immune infiltration and inflammation, potentially impacting patient outcomes in septic burn patients.
Article
Engineering, Biomedical
Fei Gong, Nailin Yang, Jiachen Xu, Xiaoyuan Yang, Kailu Wei, Linqian Hou, Bo Liu, He Zhao, Zhuang Liu, Liang Cheng
Summary: This study developed calcium hydride (CaH2)-based dressings with anti-oxidation and anti-inflammation properties for accelerated wound healing. By releasing hydrogen molecules (H-2) and scavenging excess reactive oxygen species (ROS), the CaH2 dressings were able to reduce inflammation levels, promote tissue regeneration and angiogenesis, offering a potential therapeutic option for inflammatory diseases.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Judith C. J. Holzer-Geissler, Simon Schwingenschuh, Martin Zacharias, Johanna Einsiedler, Sonja Kainz, Peter Reisenegger, Christian Holecek, Elisabeth Hofmann, Barbara Wolff-Winiski, Hermann Fahrngruber, Thomas Birngruber, Lars-Peter Kamolz, Petra Kotzbeck
Summary: The treatment of chronic wounds poses a challenge for modern medicine due to the complex pathophysiology involved. Previous wound models used for studying chronic wounds lack translatability to patients and often overlook the impact of exaggerated inflammation. This study aims to investigate the role of prolonged inflammation in a porcine wound model using the TLR7 and TLR8 agonist resiquimod. The results demonstrate that prolonged inflammation delays wound healing, a common observation in chronic wounds. This model highlights the importance of inflammation in wound healing and provides insights into the progression of chronic wounds.
Article
Biochemistry & Molecular Biology
Madhav Bhatia, Ravinder Reddy Gaddam
Summary: Recent research has highlighted the important role of endogenously synthesized hydrogen sulfide (H2S) in inflammation, with promising results in clinical studies. However, defining the precise mechanism by which H2S contributes to inflammation remains a complex challenge, and translating research findings to clinical practice is another hurdle in the field of H2S research.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Engineering, Biomedical
Thamyres Maria Silva Simoes, Jose de Alencar Fernandes Neto, Cassiano Francisco Weege Nonaka, Maria Helena Chaves de Vasconcelos Catao
Summary: This study evaluated the effects of red light emitting diode (LED) photobiomodulation therapy on inflammatory cells during the healing of third-degree skin burns. The results showed that red LED could modulate the number of inflammatory cells in the early stages of healing, but may not be effective in reducing the number of inflammatory cells in the advanced stages of the repair process.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yapeng Lu, Xiaopeng Zhu, Chao Hu, Peng Li, Meihui Zhao, Jinfeng Lu, Guanghua Xia
Summary: A tilapia fish skin gelatin-fucose gum-tannic acid hydrogel wound dressing was designed to promote wound healing. The hydrogel showed excellent properties and could effectively accelerate wound healing while reducing inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Immunology
Annika Heuer, Carolin Stiel, Julia Elrod, Ingo Koenigs, Deirdre Vincent, Patrick Schlegel, Magdalena Trochimiuk, Birgit Appl, Konrad Reinshagen, Laia Pagerols Raluy, Michael Boettcher
Summary: The study found that targeting NETs through DNase1 treatment or genetic knockout can improve both primary and secondary intention wound healing, reduce healing time, and improve scar appearance. DNase1 treatment also decreases neutrophil activation and NETs formation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Alireza Hassanshahi, Mohammad Moradzad, Saman Ghalamkari, Moosa Fadaei, Allison J. Cowin, Mohammadhossein Hassanshahi
Summary: This review discusses the role and mechanisms of macrophages in skin wound healing, including cellular and molecular aspects such as subtypes, metabolism, plasticity, and epigenetics. The interactions between macrophages and factors important for wound healing are also highlighted.
Article
Dermatology
Jennifer Lynn Schiefer, Genoveva Friederike Aretz, Paul Christian Fuchs, Mahsa Bagheri, Martin Funk, Alexandra Schulz, Marc Daniels
Summary: epicite(hydro) showed similar efficacy to SUPRATHEL in treating partial-thickness burn wounds, both dressings provided good pain reduction, wound healing, and scar evaluation. Therefore, epicite(hydro) can be considered as an alternative to SUPRATHEL for the treatment of partial-thickness burn wounds.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Andre G. Buret, Thibault Allain, Jean-Paul Motta, John L. Wallace
Summary: This article reviews the interaction between hydrogen sulfide (H2S), gut microbiota, and health, highlighting the toxic or therapeutic effects of H2S depending on its concentration and source. Low levels of H2S directly stabilize mucus layers, prevent microbiota biofilm fragmentation, and help resolve inflammation and tissue injury. Additionally, dietary H2S may also modulate the abundance and function of microbiota.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Biochemistry & Molecular Biology
Ewa A. Burian, Lubna Sabah, Tonny Karlsmark, Klaus Kirketerp-Moller, Christine J. Moffatt, Jacob P. Thyssen, Magnus S. Agren
Summary: This systematic review investigated the association between cytokine levels and the healing of venous leg ulcers (VLUs). The findings suggest that non-healing VLUs may be associated with elevated pro-inflammatory cytokine levels, which decline with healing. TGF-beta 1 levels tended to increase with VLU healing. Further research is needed to explore other cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Luisa A. DiPietro, Traci A. Wilgus, Timothy J. Koh
Summary: Macrophages play a prominent role in skin wound healing, with functions including host defense and support of new tissue growth. However, the exact role of macrophages in wound healing remains elusive, as some wounds can heal well even with limited or no functional macrophages. Recent advances in understanding macrophage phenotypes and cellular plasticity in wounds may provide new insights and paradigms on macrophage function in wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
