Effect of heart ischemia and administration route on biodistribution and transduction efficiency of AAV9 vectors

Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

(2019) Emelia J. Benjamin et al.   CIRCULATION

Translational aspects of AAV-mediated cardiac gene therapy

(2018) Tilman Ziegler et al.   HUMAN GENE THERAPY

Characterization of Recombinant Adeno-Associated Viral Transduction and Safety Profiles in Cardiomyocytes

(2018) Jianzhong Ai et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The interstitium in cardiac repair: role of the immune–stromal cell interplay

(2018) Elvira Forte et al.   Nature Reviews Cardiology

Gene transfer to promote cardiac regeneration

(2016) Chiara Collesi et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Gene therapy for cardiovascular disease: advances in vector development, targeting, and delivery for clinical translation

(2015) Melvin Y. Rincon et al.   CARDIOVASCULAR RESEARCH

Efficacy and safety of myocardial gene transfer of adenovirus, adeno-associated virus and lentivirus vectors in the mouse heart

(2015) M Merentie et al.   GENE THERAPY

Genome-wide RNAi screening identifies host restriction factors critical for in vivo AAV transduction

(2015) Miguel Mano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuregulin-1β Induces Mature Ventricular Cardiac Differentiation from Induced Pluripotent Stem Cells Contributing to Cardiac Tissue Repair

(2015) Olalla Iglesias-García et al.   STEM CELLS AND DEVELOPMENT

The Role of SUMO-1 in Cardiac Oxidative Stress and Hypertrophy

(2014) Ahyoung Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing

(2014) Qiurong Ding et al.   CIRCULATION RESEARCH

Functional polymers of gene delivery for treatment of myocardial infarct

(2014) Young-Wook Won et al.   JOURNAL OF CONTROLLED RELEASE

Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction

(2014) Christian Bär et al.   Nature Communications

Drawing a high-resolution functional map of adeno-associated virus capsid by massively parallel sequencing

(2014) Kei Adachi et al.   Nature Communications

MiR-378 Controls Cardiac Hypertrophy by Combined Repression of Mitogen-Activated Protein Kinase Pathway Factors

(2013) Jayavarshni Ganesan et al.   CIRCULATION

Cardiac-Selective Expression of Extracellular Superoxide Dismutase After Systemic Injection of Adeno-Associated Virus 9 Protects the Heart Against Post–Myocardial Infarction Left Ventricular Remodeling

(2013) Prasad R. Konkalmatt et al.   Circulation-Cardiovascular Imaging

Application of Mutated miR-206 Target Sites Enables Skeletal Muscle-specific Silencing of Transgene Expression of Cardiotropic AAV9 Vectors

(2013) Anja Geisler et al.   MOLECULAR THERAPY

AAV9.I-1c Delivered via Direct Coronary Infusion in a Porcine Model of Heart Failure Improves Contractility and Mitigates Adverse Remodeling

(2012) Kenneth M. Fish et al.   Circulation-Heart Failure

Prevalence and pharmacological modulation of humoral immunity to AAV vectors in gene transfer to synovial tissue

(2012) F Mingozzi et al.   GENE THERAPY

Pharmacological Modulation of Humoral Immunity in a Nonhuman Primate Model of AAV Gene Transfer for Hemophilia B

(2012) Federico Mingozzi et al.   MOLECULAR THERAPY

Comparison of Adeno-Associated Virus Serotypes and Delivery Methods for Cardiac Gene Transfer

(2012) Hongfei Fang et al.   Human Gene Therapy Methods

The evolution of heart gene delivery vectors

(2011) Nalinda B. Wasala et al.   JOURNAL OF GENE MEDICINE

A single direct injection into the left ventricular wall of an adeno-associated virus 9 (AAV9) vector expressing extracellular superoxide dismutase from the cardiac troponin-T promoter protects mice against myocardial infarction

(2011) Konkal-Matt R. Prasad et al.   JOURNAL OF GENE MEDICINE

Preclinical Differences of Intravascular AAV9 Delivery to Neurons and Glia: A Comparative Study of Adult Mice and Nonhuman Primates

(2011) Steven J Gray et al.   MOLECULAR THERAPY

Engineering Liver-detargeted AAV9 Vectors for Cardiac and Musculoskeletal Gene Transfer

(2011) Nagesh Pulicherla et al.   MOLECULAR THERAPY

Cardiac AAV9-S100A1 Gene Therapy Rescues Post-Ischemic Heart Failure in a Preclinical Large Animal Model

(2011) S. T. Pleger et al.   Science Translational Medicine

Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution

(2010) K-M R Prasad et al.   GENE THERAPY

SERCA2a Gene Transfer Enhances eNOS Expression and Activity in Endothelial Cells

(2010) Lahouaria Hadri et al.   MOLECULAR THERAPY

Long-Term Cardiac-Targeted RNA Interference for the Treatment of Heart Failure Restores Cardiac Function and Reduces Pathological Hypertrophy

(2009) Lennart Suckau et al.   CIRCULATION

Adeno-Associated Virus (AAV) Serotype 9 Provides Global Cardiac Gene Transfer Superior to AAV1, AAV6, AAV7, and AAV8 in the Mouse and Rat

(2008) Lawrence T. Bish et al.   HUMAN GENE THERAPY

Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damage-response proteins

(2008) T. Cervelli et al.   JOURNAL OF CELL SCIENCE

Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection

(2008) Carmela Zincarelli et al.   MOLECULAR THERAPY