Limitations of recellularized biological scaffolds for human transplantation

iPS-Cell Technology and the Problem of Genetic Instability—Can It Ever Be Safe for Clinical Use?

(2019) Stephen Attwood et al.   Journal of Clinical Medicine

Reversal of Surfactant Protein B Deficiency in Patient Specific Human Induced Pluripotent Stem Cell Derived Lung Organoids by Gene Therapy

(2019) Sandra Lawrynowicz Leibel et al.   Scientific Reports

Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms

(2018) Thomas A. Forbes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Extracellular matrix in lung development, homeostasis and disease

(2018) Yong Zhou et al.   MATRIX BIOLOGY

Bone marrow laminins influence hematopoietic stem and progenitor cell cycling and homing to the bone marrow

(2018) Katharina Helene Susek et al.   MATRIX BIOLOGY

Effective regeneration of dystrophic muscle using autologous iPSC-derived progenitors with CRISPR-Cas9 mediated precise correction

(2018) Mackenzie Hagan et al.   MEDICAL HYPOTHESES

HLA in transplantation

(2018) Robert A. Montgomery et al.   Nature Reviews Nephrology

The role of Th1/Th2 cytokines played in regulation of specific CD4 + Th1 cell conversion and activation during inflammatory reaction of chronic obstructive pulmonary disease

(2018) J. Sun et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

In Vitro Detection System to Evaluate the Immunogenic Potential of Xenografts

(2018) Aila Daugs et al.   TISSUE ENGINEERING PART C-METHODS

Graft-specific immune tolerance is determined by residual antigenicity of xenogeneic extracellular matrix scaffolds

(2018) Ailsa J. Dalgliesh et al.   Acta Biomaterialia

3-D physiomimetic extracellular matrix hydrogels provide a supportive microenvironment for rodent and human islet culture

(2018) K. Jiang et al.   BIOMATERIALS

Evaluation of the host immune response to decellularized lung scaffolds derived from α-Gal knockout pigs in a non-human primate model

(2018) Elizabeth C. Stahl et al.   BIOMATERIALS

Development of a novel hybrid bioactive hydrogel for future clinical applications

(2018) Lydia Francis et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Prospective isolation of NKX2-1–expressing human lung progenitors derived from pluripotent stem cells

(2017) Finn Hawkins et al.   JOURNAL OF CLINICAL INVESTIGATION

In vivo implantation of a tissue engineered stem cell seeded hemi-laryngeal replacement maintains airway, phonation, and swallowing in pigs

(2017) P. Herrmann et al.   Journal of Tissue Engineering and Regenerative Medicine

A comparison of tracheal scaffold strategies for pediatric transplantation in a rabbit model

(2017) Elizabeth F. Maughan et al.   LARYNGOSCOPE

HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

(2017) Germán G Gornalusse et al.   NATURE BIOTECHNOLOGY

Long-term expansion of alveolar stem cells derived from human iPS cells in organoids

(2017) Yuki Yamamoto et al.   NATURE METHODS

Cord Blood Banking for Potential Future Transplantation

(2017) William T. Shearer et al.   PEDIATRICS

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

(2017) Dong Niu et al.   SCIENCE

Acellular Mouse Kidney ECM can be Used as a Three-Dimensional Substrate to Test the Differentiation Potential of Embryonic Stem Cell Derived Renal Progenitors

(2017) Manpreet Sambi et al.   Stem Cell Reviews and Reports

Xenogeneic Decellularized Scaffold: A Novel Platform for Ovary Regeneration

(2017) Wen-Yue Liu et al.   TISSUE ENGINEERING PART C-METHODS

Studies of innate immune systems against human cells

(2017) Rieko Sakai et al.   TRANSPLANT IMMUNOLOGY

Natural Scaffolds for Regenerative Medicine: Direct Determination of Detergents Entrapped in Decellularized Heart Valves

(2017) Monica Dettin et al.   Biomed Research International

Acellular Mouse Kidney ECM can be Used as a Three-Dimensional Substrate to Test the Differentiation Potential of Embryonic Stem Cell Derived Renal Progenitors

(2017) Manpreet Sambi et al.   Stem Cell Reviews and Reports

Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications

(2017) Peter W. Andrews et al.   Stem Cell Reports

An Overview of the Top Ten Detergents Used for Membrane Protein Crystallization

(2017) et al.   Crystals

Repopulation of porcine kidney scaffold using porcine primary renal cells

(2016) Mehran Abolbashari et al.   Acta Biomaterialia

The effect of terminal sterilization on the material properties and in vivo remodeling of a porcine dermal biologic scaffold

(2016) Christopher L. Dearth et al.   Acta Biomaterialia

The quantity and quality of α-gal-specific antibodies differ in individuals with and without delayed red meat allergy

(2016) D. Kollmann et al.   ALLERGY

Alveolar-like Stem Cell–derivedMyb−Macrophages Promote Recovery and Survival in Airway Disease

(2016) Michael L. Litvack et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rapid Expansion of Human Epithelial Stem Cells Suitable for Airway Tissue Engineering

(2016) Colin R. Butler et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

In vivo xenogeneic scaffold fate is determined by residual antigenicity and extracellular matrix preservation

(2016) Maelene L. Wong et al.   BIOMATERIALS

Proteomic analysis of naturally-sourced biological scaffolds

(2016) Qiyao Li et al.   BIOMATERIALS

Characterization of a biologically derived rabbit tracheal scaffold

(2016) P. Lange et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Bioengineered human acellular vessels for dialysis access in patients with end-stage renal disease: two phase 2 single-arm trials

(2016) Jeffrey H Lawson et al.   LANCET

A 3D bioprinting system to produce human-scale tissue constructs with structural integrity

(2016) Hyun-Wook Kang et al.   NATURE BIOTECHNOLOGY

Tumourigenicity and Immunogenicity of Induced Neural Stem Cell Grafts Versus Induced Pluripotent Stem Cell Grafts in Syngeneic Mouse Brain

(2016) Mou Gao et al.   Scientific Reports

Human Skin 3D Bioprinting Using Scaffold-Free Approach

(2016) Léa J. Pourchet et al.   Advanced Healthcare Materials

Decellularization of porcine carotid by the recipient’s serum and evaluation of its biocompatibility using a rat autograft model

(2015) Naoaki Ishino et al.   JOURNAL OF ARTIFICIAL ORGANS

Differences in Immunogenicity of HLA Antigens and the Impact of Cross-Reactivity on the Humoral Response

(2015) Donna P. Lucas et al.   TRANSPLANTATION

Acellular Lung Scaffolds Direct Differentiation of Endoderm to Functional Airway Epithelial Cells: Requirement of Matrix-Bound HS Proteoglycans

(2015) Sharareh Shojaie et al.   Stem Cell Reports

The promotion of a constructive macrophage phenotype by solubilized extracellular matrix

(2014) Brian M. Sicari et al.   BIOMATERIALS

The current state of xenotransplantation

(2014) J. Zeyland et al.   JOURNAL OF APPLIED GENETICS

Fibrotic extracellular matrix activates a profibrotic positive feedback loop

(2014) Matthew W. Parker et al.   JOURNAL OF CLINICAL INVESTIGATION

Laminins affect T cell trafficking and allograft fate

(2014) Kristi J. Warren et al.   JOURNAL OF CLINICAL INVESTIGATION

De Novo Production of K- 1 Tubulin-Specific Antibodies: Role in Chronic Lung Allograft Rejection

(2014) T. A. Goers et al.   JOURNAL OF IMMUNOLOGY

Anti-Type V Collagen Humoral Immunity in Lung Transplant Primary Graft Dysfunction

(2014) T. Iwata et al.   JOURNAL OF IMMUNOLOGY

Receptor-Interacting Protein Homotypic Interaction Motif-Dependent Control of NF- B Activation via the DNA-Dependent Activator of IFN Regulatory Factors

(2014) W. J. Kaiser et al.   JOURNAL OF IMMUNOLOGY

Proteoglycans, key regulators of cell–matrix dynamics

(2014) Liliana Schaefer   MATRIX BIOLOGY

Optimizing Recellularization of Whole Decellularized Heart Extracellular Matrix

(2014) Matthew J. Robertson et al.   PLoS One

Immunogenicity of Intensively Decellularized Equine Carotid Arteries Is Conferred by the Extracellular Matrix Protein Collagen Type VI

(2014) Ulrike Boeer et al.   PLoS One

Tissue Engineering of Rat Bladder Using Marrow-Derived Mesenchymal Stem Cells and Bladder Acellular Matrix

(2014) Daniel L. Coutu et al.   PLoS One

Immunogenicity of Decellularized Porcine Liver for Bioengineered Hepatic Tissue

(2013) Sayed-Hadi Mirmalek-Sani et al.   AMERICAN JOURNAL OF PATHOLOGY

Discarded human kidneys as a source of ECM scaffold for kidney regeneration technologies

(2013) Giuseppe Orlando et al.   BIOMATERIALS

Autologous skin reconstruction by combining epidermis and acellular dermal matrix tissue derived from the skin of giant congenital melanocytic nevi

(2013) Pham Hieu Liem et al.   JOURNAL OF ARTIFICIAL ORGANS

Human iPS cell–derived alveolar epithelium repopulates lung extracellular matrix

(2013) Mahboobe Ghaedi et al.   JOURNAL OF CLINICAL INVESTIGATION

Early pseudoaneurysm degeneration in biologic extracellular matrix patch for carotid repair

(2013) Steven S. Weber et al.   JOURNAL OF VASCULAR SURGERY

Synthesis, Characterization, and Antibacterial Activity of Cross-Linked Chitosan-Glutaraldehyde

(2013) Bin Li et al.   Marine Drugs

HLA Engineering of Human Pluripotent Stem Cells

(2013) Laura Riolobos et al.   MOLECULAR THERAPY

Regeneration and experimental orthotopic transplantation of a bioengineered kidney

(2013) Jeremy J Song et al.   NATURE MEDICINE

Immunomodulatory effect of a decellularized skeletal muscle scaffold in a discordant xenotransplantation model

(2013) J. M. Fishman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plant-Derived Human Collagen Scaffolds for Skin Tissue Engineering

(2013) James J. Willard et al.   TISSUE ENGINEERING PART A

Production and Assessment of Decellularized Pig and Human Lung Scaffolds

(2013) Joan E. Nichols et al.   TISSUE ENGINEERING PART A

Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation

(2013) Andrew J. Lutz et al.   XENOTRANSPLANTATION

Acellular Normal and Fibrotic Human Lung Matrices as a Culture System forIn VitroInvestigation

(2012) Adam J. Booth et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Efficient Derivation of Purified Lung and Thyroid Progenitors from Embryonic Stem Cells

(2012) Tyler A. Longmire et al.   Cell Stem Cell

Development of an artificial dermis composed of hyaluronic acid and collagen

(2012) Akina Mineo et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Matrix stiffness reverses the effect of actomyosin tension on cell proliferation

(2012) J. D. Mih et al.   JOURNAL OF CELL SCIENCE

Stem-cell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up study

(2012) Martin J Elliott et al.   LANCET

Human Embryonic Stem Cells Differentiated to Lung Lineage-Specific Cells Ameliorate Pulmonary Fibrosis in a Xenograft Transplant Mouse Model

(2012) Ena Ray Banerjee et al.   PLoS One

Evaluation of humoral immune response to donor HLA after implantation of cellularized versus decellularized human heart valve allografts

(2012) C. Kneib et al.   TISSUE ANTIGENS

The effect of detergent-based decellularization procedures on cellular proteins and immunogenicity in equine carotid artery grafts

(2011) Ulrike Böer et al.   BIOMATERIALS

An overview of tissue and whole organ decellularization processes

(2011) Peter M. Crapo et al.   BIOMATERIALS

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

Use of Fresh Decellularized Allografts for Pulmonary Valve Replacement May Reduce the Reoperation Rate in Children and Young Adults: Early Report

(2011) S. Cebotari et al.   CIRCULATION

Microbial safety in xenotransplantation

(2011) Nicolas J Mueller et al.   Current Opinion in Organ Transplantation

Cytosolic DNA Triggers Mitochondrial Apoptosis via DNA Damage Signaling Proteins Independently of AIM2 and RNA Polymerase III

(2011) M. Wenzel et al.   JOURNAL OF IMMUNOLOGY

Immunogenicity of induced pluripotent stem cells

(2011) Tongbiao Zhao et al.   NATURE

Induction of autoantibodies against lung matrix proteins and smoke-induced inflammation in mice

(2011) Corry-Anke Brandsma et al.   BMC Pulmonary Medicine

Detergent Decellularization of Heart Valves for Tissue Engineering: Toxicological Effects of Residual Detergents on Human Endothelial Cells

(2010) Serghei Cebotari et al.   ARTIFICIAL ORGANS

The effects of processing methods upon mechanical and biologic properties of porcine dermal extracellular matrix scaffolds

(2010) Janet E. Reing et al.   BIOMATERIALS

Human immune responses to porcine xenogeneic matrices and their extracellular matrix constituents in vitro

(2010) Alexandra Bayrak et al.   BIOMATERIALS

Early obstruction of decellularized xenogenic valves in pediatric patients: involvement of inflammatory and fibroproliferative processes

(2010) Iwona Cicha et al.   CARDIOVASCULAR PATHOLOGY

Identification and Classification of Chromosomal Aberrations in Human Induced Pluripotent Stem Cells

(2010) Yoav Mayshar et al.   Cell Stem Cell

Early failure of xenogenous de-cellularised pulmonary valve conduits — a word of caution!☆

(2010) André Rüffer et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix

(2010) Basak E Uygun et al.   NATURE MEDICINE

Regeneration and orthotopic transplantation of a bioartificial lung

(2010) Harald C Ott et al.   NATURE MEDICINE

Characteristics of the Early Immune Response Following Transplantation of Mouse ES Cell Derived Insulin-Producing Cell Clusters

(2010) Ashleigh S. Boyd et al.   PLoS One

Tissue-Engineered Lungs for in Vivo Implantation

(2010) T. H. Petersen et al.   SCIENCE

The Epidemiology and Prevention of Donor-Derived Infections

(2009) Michael G. Ison   ADVANCES IN CHRONIC KIDNEY DISEASE

Simple Agarose−Chitosan Gel Composite System for Enhanced Neuronal Growth in Three Dimensions

(2009) Zheng Cao et al.   BIOMACROMOLECULES

Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component

(2009) Bryan N. Brown et al.   BIOMATERIALS

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-κB

(2009) Manuele Rebsamen et al.   EMBO REPORTS

Embryonic Stem Cells Proliferate and Differentiate when Seeded into Kidney Scaffolds

(2009) E. A. Ross et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Calorimetric study of extracellular tissue matrix degradation and instability after gamma irradiation

(2008) Wendell Q. Sun et al.   Acta Biomaterialia

IgG deposition and activation of the classical complement pathway involvement in the activation of human granulocytes by decellularized porcine heart valve tissue

(2008) Fabienne Bastian et al.   BIOMATERIALS

Incomplete cellular depopulation may explain the high failure rate of bovine ureteric grafts

(2008) J. I. Spark et al.   BRITISH JOURNAL OF SURGERY

In vitrocell culture models for the assessment of pulmonary drug disposition

(2008) Jennifer L Sporty et al.   Expert Opinion on Drug Metabolism & Toxicology

Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-α-1,3-galactose

(2008) Scott P. Commins et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Quantification of DNA in Biologic Scaffold Materials

(2008) Thomas W. Gilbert et al.   JOURNAL OF SURGICAL RESEARCH

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart

(2008) Harald C Ott et al.   NATURE MEDICINE

Immune response to biologic scaffold materials

(2008) Stephen F. Badylak et al.   SEMINARS IN IMMUNOLOGY

Embryonic Stem Cells and Their Differentiated Derivatives Have a Fragile Immune Privilege but Still Represent Novel Targets of Immune Attack

(2008) Douglas C. Wu et al.   STEM CELLS

Host Response to Human Acellular Dermal Matrix Transplantation in a Primate Model of Abdominal Wall Repair

(2008) Hui Xu et al.   TISSUE ENGINEERING PART A

Uniaxial and biaxial properties of terminally sterilized porcine urinary bladder matrix scaffolds

(2007) Donald O. Freytes et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS