Article
Microbiology
Vikram Pareek, Stephanie Devineau, Sathesh K. Sivasankaran, Arpit Bhargava, Jitendra Panwar, Shabarinath Srikumar, Seamus Fanning
Summary: Silver nanoparticles exhibit a triclosan-like antibacterial mechanism and induce oxidative stress against multi-drug resistant Klebsiella pneumoniae. The study sheds light on the potential development of resistance mechanisms by bacteria against silver nanoparticles in therapy.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Seyed M. M. Mousavi, Seyed M. A. Mousavi, Mostafa Moeinizadeh, Mahshad Aghajanidelavar, Sajjad Rajabi, Maryam Mirshekar
Summary: This study aims to investigate the effect of silver nanoparticles (AgNPs) on the expression levels of virulence and biofilm-related genes in multidrug-resistant (MDR) Klebsiella pneumoniae. The results showed that AgNPs can effectively inhibit the growth of MDR K. pneumoniae, and downregulate the expression of virulence and biofilm-related genes.
JOURNAL OF BASIC MICROBIOLOGY
(2023)
Article
Microbiology
M. Ortiz-Padilla, I Portillo-Calderon, B. de Gregorio-Iaria, J. Blazquez, J. Rodriguez-Bano, A. Pascual, J. M. Rodriguez-Martinez, F. Docobo-Perez
Summary: This study aimed to characterize the role of specific genes in fosfomycin resistance in Klebsiella pneumoniae and assess the potential synergistic effect of combining fosfomycin with sodium phosphonoformate. The results showed that inactivation of the fosA gene led to decreased fosfomycin resistance, while the addition of PPF had limited effects and showed decreased activity in the presence of fosfomycin-resistant mutations.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Alessandra Carattoli, Gabriele Arcari, Giulia Bibbolino, Federica Sacco, Dario Tomolillo, Federica Maria Di Lella, Maria Trancassini, Luigi Faino, Mario Venditti, Guido Antonelli, Giammarco Raponi
Summary: A study conducted in a university hospital in Rome, Italy identified multiple CZA-resistant KPC-3 protein variants, including novel variants that had not been reported before. These variants showed different sensitivities and activities to antibiotics, possibly due to mutations caused by amino acid substitutions, insertions, and deletions.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Inglid Fontoura, Thais S. Veriato, Leandro J. Raniero, Maiara L. Castilho
Summary: This study analyzes the synergistic effect of the carbapenem antibiotic Imipenem with silver nanoparticles (AgNPs) against different susceptibility clinical profiles of Klebsiella pneumoniae (K. pneumoniae). The combination of AgNPs and Imipenem showed a reduction in Imipenem concentration in all strains studied, and the synergism was demonstrated through the fractional inhibitory concentration index. The proposed association resulted in inhibitory effects on different K. pneumoniae profiles in both planktonic forms and biofilm, with a peculiar behavior in the Imipenem-resistant profile.
Article
Biochemistry & Molecular Biology
Fuqiang Kang, Zili Chai, Beiping Li, Mingda Hu, Zilong Yang, Xia Wang, Wenting Liu, Hongguang Ren, Yuan Jin, Junjie Yue
Summary: This study identified 15,946 prophages from 1437 fully assembled K. pneumoniae genomes deposited in the NCBI database, with 9755 prophages on chromosomes and 6191 prophages on plasmids. The results showed that prophages in the K. pneumoniae genomes are diverse and widely distributed. The prophages encoded multiple putative virulence factors and antibiotic resistance genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Inorganic & Nuclear
M. Aravind, T. Kumaresubitha, Nafis Ahmed, P. Velusamy
Summary: This study focuses on environmentally friendly synthesis of plasmonic Ag nanoparticles from cinnamon-derived natural materials and discusses their potential applications in biomedicine, water treatment, and catalysis. The research demonstrates that these nanoparticles exhibit high antibacterial and photo degradation efficiency, as well as superior catalytic activity compared to commercial TiO2 nanoparticles.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Microbiology
Mi Nguyen-Tra Le, Thao Huu-Huong Nguyen, Van Minh Trinh, Tam Phuc-Bao Nguyen, Miki Kawada-Matsuo, Shizuo Kayama, Motoyuki Sugai, Hitoshi Komatsuzawa
Summary: This study identified bacteriocin genes in 180 K. pneumoniae species complex genomes and found that 32.8% of isolates carried at least one bacteriocin type. Microcin E492 was the most prevalent bacteriocin with a wide spectrum of antibacterial activity. Other bacteriocins had lower detection rates and limited inhibitory activity. These findings are important for understanding the K. pneumoniae species complex and the potential applications of bacteriocins in treating multidrug-resistant bacteria.
MICROBIOLOGY SPECTRUM
(2023)
Article
Pharmacology & Pharmacy
Jenna M. Kuhn, Yuanpu Peter Di
Summary: The emergence and dissemination of carbapenem-resistant Klebsiella pneumoniae (KP) is causing antibiotic-resistant nosocomial infections with high morbidity and mortality rates. Colistin, the last-resort peptide antibiotic, is increasingly being used to treat multidrug-resistant KP infections. However, resistance to colistin is also on the rise. This study investigates the timing and association of colistin resistance mutations in KP, aiming to advance the development of effective therapeutics to combat these infections.
Article
Food Science & Technology
Nikoletta Argyro Theocharidi, Iliana Balta, Dimitra Houhoula, Andreas G. Tsantes, George P. Lalliotis, Angeliki C. Polydera, Haralambos Stamatis, Panagiotis Halvatsiotis
Summary: The study revealed a high frequency of foodborne Klebsiella pneumoniae in Greece, with most strains carrying both resistance and virulence genes, indicating a significant risk to human health.
Article
Materials Science, Multidisciplinary
Nagwa El-Desouky, Kamel R. Shoueir, Ibrahim El-Mehasseb, Maged El-Kemary
Summary: Plasmonic silver nanoparticles with an absorption peak were fabricated using banana waste peduncles and a nanocomposite sensitive to solar light irradiation was successfully synthesized, showing excellent photocatalytic and antimicrobial activity.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Microbiology
Shewli Mukerji, Shafi Sahibzada, Rebecca Abraham, Marc Stegger, David Jordan, David J. Hampson, Mark O'Dea, Terence Lee, Sam Abraham
Summary: Human population and activities contribute significantly to the spread of antimicrobial resistant bacteria. This study focused on the carriage rates of critically important antimicrobial-resistant (CIA-R) Escherichia coli and Klebsiella pneumoniae by Silver Gulls and their proximity to human populations. The results showed a high prevalence of CIA-R E. coli and K. pneumoniae in Silver Gulls in urban areas compared to remote locations, indicating a strong association between anthropogenic activities and the acquisition of resistant bacteria by gulls.
VETERINARY MICROBIOLOGY
(2023)
Article
Infectious Diseases
Bhuvan Yadav, Srujana Mohanty, Bijayini Behera
Summary: This study aimed to investigate the occurrence of hypervirulent Klebsiella pneumoniae (hvKP) isolates from different clinical specimens in a tertiary care hospital in eastern India, and to study the distribution of virulence factors, capsular serotypes, and antibiogram profile. The distribution of carbapenemase-encoding genes in convergent (hvKP and carbapenem-resistant) isolates was also examined.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Microbiology
Maytham Hussein, Zetao Sun, Jane Hawkey, Rafah Allobawi, Louise M. Judd, Vincenzo Carbone, Rajnikant Sharma, Varsha Thombare, Mark Baker, Gauri G. Rao, Jian Li, Kathryn E. Holt, Tony Velkov
Summary: This study investigated the mechanism of nitrofurantoin action and resistance in Klebsiella pneumoniae. The researchers found that highly resistant mutants showed modified expression of genes related to membrane transport and nitroreductase activity. Metabolomic analysis revealed global perturbations in response to nitrofurantoin exposure. The study also highlighted the key role of efflux pump regulator oqxR in nitrofurantoin resistance.
Article
Medicine, General & Internal
Ying Zhou, Yang Yang, Xiaobin Li, Dongxing Tian, Wenxiu Ai, Weiwen Wang, Bingjie Wang, Barry N. Kreiswirth, Fangyou Yu, Liang Chen, Xiaofei Jiang
Summary: In this study, the native CRISPR system of K. pneumoniae was used to successfully cure multidrug-resistant IncFII plasmids through conjugation-mediated delivery of the CRISPR-Cas3 system. The work demonstrated that CRISPR-mediated plasmid curing could re-sensitize drug-resistant K. pneumoniae to multiple antibiotics.
Article
Microbiology
Shruti Talukdar, Madhumita Talukdar, Manorama Buragohain, Archana Yadav, R. N. S. Yadav, T. C. Bora
Article
Chemistry, Applied
Archana M. Das, Manash P. Hazarika, Monmi Goswami, Archana Yadav, Pradip Khound
CARBOHYDRATE POLYMERS
(2016)
Article
Biotechnology & Applied Microbiology
M. Talukdar, M. Bordoloi, P. P. Dutta, S. Saikia, B. Kolita, S. Talukdar, S. Nath, A. Yadav, R. Saikia, D. K. Jha, T. C. Bora
JOURNAL OF APPLIED MICROBIOLOGY
(2016)
Article
Green & Sustainable Science & Technology
Paranjoli Boruah, Pallavi Dowarah, Rupjyoti Hazarika, Archana Yadav, Pranab Barkakati, Tridip Goswami
JOURNAL OF CLEANER PRODUCTION
(2016)
Article
Plant Sciences
Rajal Debnath, Archana Yadav, Vijai K. Gupta, Bhim P. Singh, Pratap J. Handique, Ratul Saikia
FRONTIERS IN PLANT SCIENCE
(2016)
Article
Chemistry, Applied
N'guadi Blaise Allou, Archana Yadav, Mintu Pal, Rajib Lochan Goswamee
CARBOHYDRATE POLYMERS
(2018)
Article
Biochemistry & Molecular Biology
Debjani Baruah, Monmi Goswami, Raj Narayan Singh Yadav, Archana Yadav, Archana Moni Das
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2018)
Article
Chemistry, Applied
Rumi Kotoky, Manobjyoti Bordoloi, Archana Yadav, Kashyap J. Tamuli, Surovi Saikia, Partha P. Dutta, Prodip P. Khound, Siddhartha P. Saikia
NATURAL PRODUCT RESEARCH
(2019)
Article
Multidisciplinary Sciences
Juthika Saikia, Rupak K. Sarma, Rajashree Dhandia, Archana Yadav, Rupjyoti Bharali, Vijai K. Gupta, Ratul Saikia
SCIENTIFIC REPORTS
(2018)
Article
Pharmacology & Pharmacy
Nguadi Blaise Allou, Jitu Saikia, Polakshi Bordoloi, Archana Yadav, Mintu Pal, Rajib Lochan Goswamee
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2019)
Article
Environmental Sciences
Pooja Talukdar, Palakshi Bordoloi, Priyankush Protim Bora, Archana Yadav, Ratul Saikia, Sachin Rameshrao Geed
Summary: The present study investigated the biodegradability of oily sludge using a bacterial consortium isolated from petroleum-contaminated sites. Lab scale composting experiments showed that a combination of 10% oily sludge exhibited the highest carbon removal of 40.33% within 90 days. To further enhance biodegradation, a slurry bioreactor was used, achieving maximum petroleum hydrocarbon removals of 48.8% and 46.5% on the 78th and 140th days respectively. The results contribute to the development of sustainable and eco-friendly treatment methods for petroleum waste.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Engineering, Environmental
Priyakshree Borthakur, Najrul Hussain, Gitashree Darabdhara, Puma K. Boruah, Bhagyasmeeta Sharma, Prandeep Borthakur, Archana Yadav, Manash R. Das
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2018)
Article
Engineering, Environmental
Bhagyasmeeta Sharma, Puma K. Boruah, Archana Yadav, Manash R. Das
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2018)
Article
Microbiology
Anwesha Gohain, Animesh Gogoi, Rajal Debnath, Archana Yadav, Bhim P. Singh, Vijai K. Gupta, Rajeev Sharma, Ratul Saikia
FEMS MICROBIOLOGY LETTERS
(2015)
Article
Biochemistry & Molecular Biology
Girgis Obaid, Menitte Eroy, Jie Zhao, Shazia Bano, Mari Mino-Kenudson, Tayyaba Hasan
Summary: The presence of desmoplasia in pancreatic ductal adenocarcinoma (PDAC) is associated with poor treatment outcomes and reduced drug delivery. By analyzing collagen subtypes in PDAC tumors following different treatment regimens, immunofluorescence profiling can predict long-term survival and tumor growth inhibition. This information can aid in personalized treatment and improve patient survival.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Fatemeh Malekpour, Rashin Bahrami, Mahshid Hodjat, Neda Hakimiha, Behnam Bolhari, Aidin Sooratgar, Soheil Niavarzi
Summary: This study investigated the effect of photobiomodulation (PBM) therapy using an 808 nm diode laser on cellular modulation mechanisms in regenerative endodontic procedures (REPs). The results showed that PBM treatment significantly increased cell viability and migration, and enhanced the release of TGF-131 from dentin.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Pranathi Tata, Ramakrishnan Ganesan, Jayati Ray Dutta
Summary: Thin film coatings with potent antibacterial properties are widely used in medical devices, frequently touched surfaces, and food packaging. However, achieving antibacterial performance under both light and dark conditions remains a challenge. In this study, we successfully prepared AgBr-coated ZnO nanorod thin film architecture using a unique surfactant-mediated solution-phase spin-coating approach. The resulting structures showed dual functionality as antimicrobial agents and photosensitizers, effectively enhancing the visible-light photodisinfection efficacy of ZnO nanorods. The concentration of the surfactant-based precursor solution could be modulated to control the AgBr content. Additionally, components like urea and lactic acid were found to enhance the photocatalytic efficiency of the structures.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)