Article
Public, Environmental & Occupational Health
Kaitlyn K. Stanhope, Jeff R. Temple, Carla Bann, Corette B. Parker, Donald Dudley, Carol J. R. Hogue
Summary: The majority of health research uses a deductive approach to measure stressful life events, but this study used an inductive process to identify the self-identified most stressful life events in women who experienced perinatal loss. Stillbirth was most commonly identified as the most stressful event, followed by loss by death of someone other than a child. Childhood maltreatment was associated with a lower risk of identifying perinatal loss as the most stressful event.
SOCIAL SCIENCE & MEDICINE
(2021)
Article
Obstetrics & Gynecology
Sukainah Al Khalaf, Karolina Kublickiene, Marius Kublickas, Ali S. Khashan, Alexander E. P. Heazell
Summary: The study found that women with a history of stillbirth in the first two pregnancies have an increased risk of stillbirth or other adverse outcomes in the third pregnancy. Additional surveillance is recommended for these women.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
H. Valgeirsdottir, T. Kunovac Kallak, I. Sundstrom Poromaa, M. Jonsson, N. Roos, L. Lindstrom, A-K Wikstrom
Summary: A nationwide register-based cohort study in Sweden found that women with polycystic ovary syndrome (PCOS) have an increased risk of stillbirth, particularly in late pregnancy. Compared to women without PCOS, women with PCOS had a 50% higher risk of stillbirth. However, women with PCOS and a severe hyperandrogenic profile did not show a stronger association with stillbirth compared to those without this profile.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
Nicole Graham, Louise Stephens, Edward D. Johnstone, Alexander E. P. Heazell
Summary: Placental examination at the time of stillbirth is crucial for predicting the risk of adverse outcomes in subsequent pregnancies, while information about maternal characteristics and classification of the cause of stillbirth does not provide significant prognostic information.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Obstetrics & Gynecology
Miriam L. Estin, Alexa I. K. Campbell, Virginia Y. Watkins, Sarah K. Dotters-Katz, Carla W. Brady, Jerome J. Federspiel
Summary: This study, using a national database, found that patients with intrahepatic cholestasis of pregnancy delivered earlier but had lower stillbirth rates, which were not affected by gestational age at birth.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Endocrinology & Metabolism
Maheswaran Dhanasekaran, Sneha Mohan, Dana Erickson, Pankaj Shah, Linda Szymanski, Vella Adrian, Aoife M. Egan
Summary: This study evaluated the occurrence of diabetic ketoacidosis (DKA) in pregnant women at our hospital and identified the associated clinical risk factors. The study found that DKA was associated with a high rate of maternofetal morbidity and fetal loss. Maternal social stressors and suboptimal glycemic control were commonly found. Prenatal education strategies for women with diabetes mellitus should prioritize the prevention of DKA.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
P. Triggianese, R. Senter, A. Petraroli, A. Zoli, M. Lo Pizzo, D. Bignardi, E. Di Agosta, S. Agolini, F. Arcoleo, O. Rossi, S. Modica, E. Greco, M. S. Chimenti, G. Spadaro, C. De Carolis, M. Cancian
Summary: Most C1INH-HAE women can undergo successful pregnancy and delivery, with reassuring outcomes for those being treated with pdC1INH during pregnancy.
FRONTIERS IN MEDICINE
(2022)
Review
Obstetrics & Gynecology
Danya Bakhbakhi, Dimitrios Siassakos, Anna Davies, Abi Merriel, Katie Barnard, Emma Stead, Clare Shakespeare, James M. N. Duffy, Lisa Hinton, Karolina McDowell, Anna Lyons, Abigail Fraser, Christy Burden, iCHOOSE Collaborat Grp
Summary: The research on interventions after stillbirth diagnosis lacks consistent outcome reporting and evidence improvement. The establishment of a core outcome set is necessary for standardizing outcome collection and reporting in stillbirth care research.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Peripheral Vascular Disease
Brooke Armistead, Leena Kadam, Emily Siegwald, Fergus P. McCarthy, John C. Kingdom, Hamid-Reza Kohan-Ghadr, Sascha Drewlo
Summary: Preeclampsia is a severe hypertensive disorder of pregnancy caused by placental villi pathology leading to widespread maternal endothelial dysfunction. Modulating trophoblast differentiation pathway through PPAR gamma-GCM1 axis may reduce excessive sFLT1 production and improve clinical outcomes. Pharmacological manipulation of PPAR gamma activity shows potential to rescue the antiangiogenic state of preeclampsia.
Article
Public, Environmental & Occupational Health
Sha Huang, Jia Yi Hee, Yuxun Oswald Zhang, Ruofan Gongye, Siyu Zou, Kun Tang
Summary: This study found that pregnancy loss, especially spontaneous and induced abortions, is associated with an increased risk of COPD among Chinese women. However, a single pregnancy has a protective effect.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Obstetrics & Gynecology
Periyasamy Kuppusamy, Ranjan K. Prusty, Itta K. Chaaithanya, Rahul K. Gajbhiye, Geetanjali Sachdeva
Summary: This study examines the trends in pregnancy outcomes among Indian women from 2015 to 2021. The findings indicate a decrease in livebirth and an increase in miscarriage and stillbirth. It highlights the need for region-specific, comprehensive, and high-quality maternal healthcare programs for Indian women.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Multidisciplinary Sciences
Rebecca Stone, Kirsten Palmer, Euan M. Wallace, Mary-Ann Davey, Ryan Hodges, Miranda Davies-Tuck
Summary: Early monitoring of South Asian pregnancies from 39 weeks' gestation with AFI and CTG can help identify potential fetal compromise earlier and trigger intervention to prevent perinatal issues.
SCIENTIFIC REPORTS
(2021)
Article
Obstetrics & Gynecology
Ulla Sovio, Francesca Gaccioli, Emma Cook, D. Stephen Charnock-Jones, Gordon C. S. Smith
Summary: This study aimed to determine the inter-relationships between five first-trimester biomarkers and a range of adverse pregnancy outcomes. The results showed that these biomarkers were associated with fetal growth restriction, preterm birth, and preeclampsia, indicating heterogeneity in the underlying pathophysiological pathways for different types of adverse pregnancy outcomes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
J. Fleminger, P. T. Seed, A. Smith, E. Juszczak, P. H. Dixon, J. Chambers, J. Dorling, C. Williamson, J. G. Thornton, L. C. Chappell
Summary: The study found that there was no specific group of women with intrahepatic cholestasis of pregnancy who would benefit from treatment with ursodeoxycholic acid, indicating that its routine use for improvement of bile acid concentration or itch score should be reconsidered.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Medicine, General & Internal
Emma Rasmark Roepke, Ole Bjarne Christiansen, Karin Kallen, Stefan R. Hansson
Summary: Recurrent pregnancy loss (RPL) is associated with placental dysfunctional disorders, with women with RPL having a higher risk during pregnancy and requiring improved antenatal surveillance.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Vedran Stefanovic
Summary: Approximately 800 women die each day from pregnancy or childbirth-related complications, with 99% of these deaths occurring in developing countries. New IAPM guidelines aim to reduce preventable deaths by using affordable medications to control hypertension, prevent pre-eclampsia, and treat severe cases in remote rural areas.
JOURNAL OF PERINATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Theophilus K. Adu-Bredu, Marcus J. Rijken, Albaro Jose Nieto-Calvache, Vedran Stefanovic, Rozi Aditya Aryananda, Karin Anneliese Fox, Sally L. Collins
Summary: This article provides a simple three-step approach to guide clinicians and sonographers with minimal experience in placenta accreta spectrum through risk stratification and basic prenatal screening for this condition.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Psychiatry
Ida Ringbom, Jaana Suvisaari, Antti Kaariala, Andre Sourander, Mika Gissler, Ian Kelleher, David Gyllenberg
Summary: This study demonstrates that individuals with psychotic disorders are more likely to be NEET, with a higher percentage of long-term NEET. Family-related risk factors have weaker predictive ability for long-term NEET in individuals with psychotic disorders. Among individuals with psychotic disorders, educational problems are associated with adverse labor market outcomes.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Clinical Neurology
Aino Korhonen, Liisa Verho, Karoliina Aarnio, Kirsi Rantanen, Anna Saaros, Hannele Laivuori, Mika Gissler, Minna Tikkanen, Petra Ijas
Summary: This nationwide population-based cohort study in Finland found that pregnancy-related subarachnoid hemorrhage (pSAH) is rare but has high mortality and morbidity. The study showed that the incidence of pSAH has not significantly changed over time, but the age of the mother has an impact on the incidence. Most pSAH cases were aneurysmal and these patients had higher mortality and morbidity rates.
Article
Medicine, General & Internal
Martta Kerkela, Mika Gissler, Tanja Nordstrom, Olavi Ukkola, Juha Veijola
Summary: This study examined the association between participation in the longitudinal follow-up study and cardiometabolic disorders. The results showed that participation in the study may have a weak positive health effect among men.
ANNALS OF MEDICINE
(2023)
Article
Respiratory System
Anna Pulakka, Kari Risnes, Johanna Metsala, Suvi Alenius, Katriina Heikkila, Sara Marie Nilsen, Pieta Nasanen-Gilmore, Peija Haaramo, Mika Gissler, Signe Opdahl, Eero Kajantie
Summary: This study investigated the association between gestational age and obstructive airway disease in adulthood. The results showed that the odds of developing obstructive airway disease were higher for individuals born preterm compared to those born full term. The association was consistent across different gestational age groups and in both Finnish and Norwegian data.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Editorial Material
Clinical Neurology
Marte-Helene Bjork, Torbjoern Tomson, Julie Werenberg Dreier, Silje Alvestad, Nils Erik Gilhus, Mika Gissler, Jannicke Igland, Maarit K. Leinonen, Yuelian Sun, Hakon Magne Vegrim, Helga Zoega, Jakob Christensen
Summary: Women taking antiseizure medication during pregnancy are often advised to take high doses of folic acid supplements (1mg to 5mg) to minimize the risk of birth defects. However, a recent report has shown a link between high dose folic acid intake and an increased risk of childhood cancer in the offspring. This has sparked a debate regarding the recommended dose of folic acid for pregnant women on antiseizure medication. In this Commentary, the authors explain their findings, the methodology used, and address emerging questions.
Article
Clinical Neurology
Teresa Vest, Kirsi Rantanen, Liisa Verho, Karoliina Aarnio, Aino Korhonen, Anna Richardt, Daniel Strbian, Mika Gissler, Hannele Laivuori, Minna Tikkanen, Petra Ijas
Summary: Intracerebral hemorrhage during pregnancy or puerperium (pICH) is a major cause of maternal death globally, but limited epidemiological data exist on its etiology and outcomes. This study found that hypertensive disorders of pregnancy (HDPs) were the main risk factor for pICH, with high maternal mortality and a significant proportion of surviving women experiencing severe disabilities three months later. Therefore, early recognition and treatment of HDPs are crucial in preventing this serious pregnancy complication.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Zahra Roustaei, Anna Heino, Sonja Kiuru-Kuhlefelt, Joan K. Morris, Svetlana Glinianaia, Ester Garne, Maria Loane, Judith Rankin, Mika Gissler
Summary: A study in Finland found that children with major congenital anomalies are less likely to apply for further education compared to children without anomalies. However, most non-chromosomal congenital anomalies did not have a significant impact on educational achievement. Factors such as male sex, lower maternal education levels, and younger maternal age were associated with lower educational achievement in children with congenital anomalies.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Obstetrics & Gynecology
A. Tuominen, L. Saavalainen, M. Niinimaki, M. Gissler, A. But, P. Harkki, O. Heikinheimo
Summary: This study found that the incidence of first live birth was lower in women before surgical verification of endometriosis, regardless of the type of endometriosis.
HUMAN REPRODUCTION
(2023)
Article
Psychology, Clinical
Judit Ozsvar, Mika Gissler, Catharina Lavebratt, Ida A. K. Nilsson
Summary: This study identified various prenatal and at birth exposures associated with offspring eating disorders, some of which are specific to certain types of eating disorders and show sex-specific associations. Confounding by maternal BMI cannot be excluded, however, highlighting the importance of subtype- and sex-stratified analyses.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2023)
Article
Pediatrics
Joanne Given, Joan K. Morris, Ester Garne, Elisa Ballardini, Laia Barrachina-Bonet, Clara Cavero-Carbonell, Mika Gissler, Francesca Gorini, Anna Heino, Sue Jordan, Amanda J. Neville, Anna Pierini, Ieuan Scanlon, Joachim Tan, Stine K. Urhoj, Maria Loane
Summary: This study aimed to evaluate the prescription rates of insulin/insulin analogues in children aged 0-9 years with and without major congenital anomalies. The results showed that children with chromosomal anomalies had an increased risk of developing diabetes requiring insulin therapy, while children with non-chromosomal anomalies had a similar risk to the reference group. Female children had a reduced risk, and preterm births without congenital anomalies were more likely to be prescribed insulin/insulin analogues.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Obstetrics & Gynecology
Kaukonen Sesilia, Pajula Susanna, Koljonen Virve, Gissler Mika, Ulander Veli-Matti, Kaijomaa Marja
Summary: This study evaluates the outcomes of pregnancies and deliveries after bariatric surgery (BS). It found that women who underwent BS had higher risks for pregnancy-induced hypertension, gestational diabetes, pre-term delivery, labor induction, and caesarean sections. However, BS can still be considered a safe and advisable treatment for obesity among fertile-aged women.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Endocrinology & Metabolism
Lotta S. Holopainen, Hanna H. Taehtinen, Mika Gissler, Paeivi E. Korhonen, Mikael O. Ekblad
Summary: This study found that compared to women with a higher body surface area (BSA), underweight and normal weight pregnant women with a smaller BSA may be more susceptible to gestational diabetes mellitus (GDM) and have a pathological oral glucose tolerance test (OGTT). In overweight pregnant women, a higher BSA may increase the risk of GDM and pathological OGTT. Additionally, maternal smoking may increase the risk of diabetes and pathological OGTTs in almost all body mass index groups.
ACTA DIABETOLOGICA
(2023)
Article
Obstetrics & Gynecology
Maiju Kekki, Topias Koukkula, Anne Salonen, Mika Gissler, Hannele Laivuori, Tuomas T. Huttunen, Kati Tihtonen
Summary: This study retrospectively analyzed the occurrence of birth injuries in different modes of delivery, focusing on vaginal breech deliveries. The study found that birth injuries were rare in vaginal breech deliveries, with brachial plexus palsy being the most common type of injury. The incidence of severe birth injury in vaginal breech deliveries was twice as high as in cephalic vaginal deliveries.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)