A novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration

Noradrenergic dysfunction accelerates LPS-elicited inflammation-related ascending sequential neurodegeneration and deficits in non-motor/motor functions

(2019) Sheng Song et al.   BRAIN BEHAVIOR AND IMMUNITY

Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells

(2018) Margherita Norelli et al.   NATURE MEDICINE

CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade

(2018) Theodoros Giavridis et al.   NATURE MEDICINE

Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson’s disease

(2018) Gregory P. Williams et al.   Journal of Neuroinflammation

α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes

(2018) Taraneh Ebrahimi et al.   Journal of Neuroinflammation

Loss of Brain Norepinephrine Elicits Neuroinflammation-Mediated Oxidative Injury and Selective Caudo-Rostral Neurodegeneration

(2018) Sheng Song et al.   MOLECULAR NEUROBIOLOGY

Innate immune memory in the brain shapes neurological disease hallmarks

(2018) Ann-Christin Wendeln et al.   NATURE

Microglia in neurodegeneration

(2018) Suzanne Hickman et al.   NATURE NEUROSCIENCE

Microglial Implication in Parkinson’s Disease: Loss of Beneficial Physiological Roles or Gain of Inflammatory Functions?

(2018) Cynthia Lecours et al.   Frontiers in Cellular Neuroscience

PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

(2018) Jueqi Chen et al.   NATURE

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

(2018) Richard Gordon et al.   Science Translational Medicine

NLRP3 Inflammasome Contributes to Lipopolysaccharide-induced Depressive-Like Behaviors via Indoleamine 2,3-dioxygenase Induction

(2017) Seon-A Jeon et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity

(2017) Eva Czirr et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Markers of microglia in post-mortem brain samples from patients with Alzheimer’s disease: a systematic review

(2017) K E Hopperton et al.   MOLECULAR PSYCHIATRY

T cells from patients with Parkinson’s disease recognize α-synuclein peptides

(2017) David Sulzer et al.   NATURE

The NLRP3 Inflammasome is Involved in the Pathogenesis of Parkinson’s Disease in Rats

(2017) Zhijuan Mao et al.   NEUROCHEMICAL RESEARCH

NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide

(2017) Wei Zhu et al.   NEUROSCIENCE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microglial phenotypes in Parkinson’s disease and animal models of the disease

(2017) Valerie Joers et al.   PROGRESS IN NEUROBIOLOGY

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

Clash of the Cytokine Titans: counter-regulation of interleukin-1 and type I interferon-mediated inflammatory responses

(2016) Katrin D Mayer-Barber et al.   Cellular & Molecular Immunology

Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration

(2016) Shih-Heng Chen et al.   CURRENT OPINION IN PHARMACOLOGY

Cell death and inflammation: the case for IL-1 family cytokines as the canonical DAMPs of the immune system

(2016) Seamus J. Martin   FEBS Journal

Lipopolysaccharide-Induced Behavioral Alterations Are Alleviated by Sodium Phenylbutyrate via Attenuation of Oxidative Stress and Neuroinflammatory Cascade

(2016) Ashok Jangra et al.   INFLAMMATION

Acute neuroinflammation provokes intracellular acidification in mouse hippocampus

(2016) Anna A. Tyrtyshnaia et al.   Journal of Neuroinflammation

Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein

(2016) Wei Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson’s disease models

(2015) Qingshan Wang et al.   BRAIN

NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients

(2015) Sonja Johann et al.   GLIA

Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage

(2015) Denise N. Bronner et al.   IMMUNITY

Systemic inflammation and microglial activation: systematic review of animal experiments

(2015) Inge C.M. Hoogland et al.   Journal of Neuroinflammation

Stress Induces the Danger-Associated Molecular Pattern HMGB-1 in the Hippocampus of Male Sprague Dawley Rats: A Priming Stimulus of Microglia and the NLRP3 Inflammasome

(2015) M. D. Weber et al.   JOURNAL OF NEUROSCIENCE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis

(2015) Sean P. Cullen et al.   Cell Reports

Microglial cell dysregulation in brain aging and neurodegeneration

(2015) Rommy von Bernhardi et al.   Frontiers in Aging Neuroscience

Cognitive decline after sepsis

(2015) Djillali Annane et al.   Lancet Respiratory Medicine

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

(2015) Amna Abderrazak et al.   Redox Biology

NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes

(2015) Audrey Gustin et al.   PLoS One

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Microglial regulation of immunological and neuroprotective functions of astroglia

(2014) Shih-Heng Chen et al.   GLIA

Macrophage Antigen Complex-1 Mediates Reactive Microgliosis and Progressive Dopaminergic Neurodegeneration in the MPTP Model of Parkinson's Disease

(2014) X. Hu et al.   JOURNAL OF IMMUNOLOGY

Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases

(2014) Hugo González et al.   JOURNAL OF NEUROIMMUNOLOGY

Involvement of Inflammasome Activation in Lipopolysaccharide-induced Mice Depressive-like Behaviors

(2013) Yi Zhang et al.   CNS Neuroscience & Therapeutics

NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration

(2013) Liya Qin et al.   GLIA

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

MHCII Is Required for  -Synuclein-Induced Activation of Microglia, CD4 T Cell Proliferation, and Dopaminergic Neurodegeneration

(2013) A. S. Harms et al.   JOURNAL OF NEUROSCIENCE

Aberrant Protein S-Nitrosylation in Neurodegenerative Diseases

(2013) Tomohiro Nakamura et al.   NEURON

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

(2013) Gaia Codolo et al.   PLoS One

Understanding brain dysfunction in sepsis

(2013) Romain Sonneville et al.   Annals of Intensive Care

Further characterisation of the LPS model of Parkinson’s disease: A comparison of intra-nigral and intra-striatal lipopolysaccharide administration on motor function, microgliosis and nigrostriatal neurodegeneration in the rat

(2012) Deirdre B. Hoban et al.   BRAIN BEHAVIOR AND IMMUNITY

Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury

(2012) Atsushi Sato et al.   Journal of Neuroinflammation

The Central Theme of Parkinson’s Disease: α-Synuclein

(2012) Mehmet Ozansoy et al.   MOLECULAR NEUROBIOLOGY

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Sepsis-induced morbidity in mice: Effects on body temperature, body weight, cage activity, social behavior and cytokines in brain

(2012) Jill I. Granger et al.   PSYCHONEUROENDOCRINOLOGY

Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics and neuronal synaptic damage in neurodegenerative diseases

(2011) T Nakamura et al.   CELL DEATH AND DIFFERENTIATION

β2-Adrenergic Receptor Activation Prevents Rodent Dopaminergic Neurotoxicity by Inhibiting Microglia via a Novel Signaling Pathway

(2011) Li Qian et al.   JOURNAL OF IMMUNOLOGY

Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity

(2011) Dan Zhang et al.   Journal of Neuroinflammation

HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration

(2011) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cytokine, Sickness Behavior, and Depression

(2009) Robert Dantzer   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Does neuroinflammation fan the flame in neurodegenerative diseases?

(2009) Tamy C Frank-Cannon et al.   Molecular Neurodegeneration

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration

(2009) H. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endotoxin induces a delayed loss of TH-IR neurons in substantia nigra and motor behavioral deficits

(2008) Yuxin Liu et al.   NEUROTOXICOLOGY

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

(2008) Hui-Ming Gao et al.   TRENDS IN IMMUNOLOGY

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

(2008) Claire Henchcliffe et al.   Nature clinical practice. Neurology