Article
Polymer Science
Sakchai Laksee, Chamaiporn Supachettapun, Nongnuj Muangsin, Pattra Lertsarawut, Thitirat Rattanawongwiboon, Phitchan Sricharoen, Nunticha Limchoowong, Threeraphat Chutimasakul, Tanagorn Kwamman, Kasinee Hemvichian
Summary: This study introduces a new method for delivering hydrophobic camptothecin using targeted gold nanohybrids, which enhances the efficacy and selectivity of the system while reducing toxicity to normal cells.
Article
Chemistry, Medicinal
Sivarasan Ganesan, Jagadeesh Kumar Alagarasan, Mohandoss Sonaimuthu, Kanakaraj Aruchamy, Fatemah Homoud Alkallas, Amira Ben Gouider Trabelsi, Fedor Vasilievich Kusmartsev, Veerababu Polisetti, Moonyong Lee, Huang-Mu Lo
Summary: This study formulated and characterized salsalate-loaded chitosan nanoparticles prepared using the ionic gelation method and investigated their release behavior, antibacterial activity, and ability to inhibit biofilm production. The optimized nanoparticles showed sustained drug release and exhibited excellent antibacterial and antibiofilm activities. CSNPs could be a promising dosage form for sustained drug delivery and enhanced therapeutic effects.
Article
Agricultural Engineering
Fuyuan Lu, Shuzhen Ni, Xiangxi Meng, Chuanling Si, Menghua Qin, Yan Wang, Yingjuan Fu, Xiaoqian Chen
Summary: The majority of current oral drugs are hydrophobic and have gastrointestinal toxic side effects, limiting their therapeutic efficacy. Lignin nanoparticles (LNPs) with antimicrobial and antioxidant properties show great potential for application in pharmaceuticals. This study prepared LNPs by modifying and self-assembling alkali lignin, and evaluated their application in a hydrophobic oral drug delivery system using Ibuprofen. The IBU-loaded LNPs showed controlled release in the intestine rather than the stomach and improved the bioavailability of Ibuprofen drugs. The research proposes a method for preparing smart lignin nanoparticles and demonstrates their promising application in pharmaceuticals industry.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Engineering, Biomedical
A. S. Soubhagya, K. Balagangadharan, N. Selvamurugan, D. Sathya Seeli, M. Prabaharan
Summary: A novel type of porous three-dimensional film CCMPBG was fabricated using the freeze-drying method, showing improved biocompatibility, antimicrobial activity and wound closure ability, making it an effective dressing material for wound therapy.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2022)
Article
Pharmacology & Pharmacy
Zhiyao Qi, Yuening Qiu, Zilong Zhong, Junyou Wang, Wei Bian, Martien A. Cohen Stuart, Mingwei Wang
Summary: Active components in Chinese medicine have shown great potential in treating various diseases, but their poor solubility and toxicity limit their practical applications. Flash Nanoprecipitation (FNP) provides a promising method to construct drug-loaded nanoparticles with high loading content and tunable release. These nanoparticles display efficient inhibition of cancer cells while reducing cytotoxicity to normal cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yan Xu, Zheng Zhang, Hehui Wang, Wu Zhong, Chengmei Sun, Wei Sun, Hongwei Wu
Summary: The study developed an organic-inorganic hybrid nanoparticle as a carrier for zoledronic acid, achieving high drug loading efficiency, sustained drug release, and good biocompatibility. In vitro and in vivo experiments showed low cytotoxicity and acceptable immune response under low-dose nanoparticle treatment, suggesting its potential application for future osteosarcoma therapeutic strategies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Food Science & Technology
Shushan Gao, Chonghao Zhu, Liangfei Ma, Chenghai Liu, Hongqiong Zhang, Shengming Zhang
Summary: In order to reduce the usage of petroleum-based plastic products, a lignin-based film material called aminated lignin/Fe(III)/PVA was developed. This film demonstrated hydrophobicity, UV-blocking function, and good slow-release performance. The aminated lignin/Fe(III)/PVA film showed higher tensile strength, elongation at break, and fracture resistance compared to pure PVA film due to the hydrogen bonding between lignin and PVA. It has the potential to be used as a food packaging material with UV-blocking function and can also be developed for other packaging applications such as seedling bowls, pots, and coating films during transport.
Article
Engineering, Chemical
Eunjoo Koh, Yong Taek Lee
Summary: In this study, a superhydrophobic and omniphobic nanofiber membrane was prepared using polyamide 6, with surface modification to enhance anti-fouling and anti-wetting properties. The hydrophobicity of the membrane surface was improved by altering the contact angle between the feed solution and the membrane surface.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
N. Zakeri, H. R. Rezaie, J. Javadpour, M. Kharaziha
Summary: The study successfully developed pH-sensitive zeolite Y nanoparticles for cisplatin delivery, with good cytocompatibility and sustained drug release properties.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Chemistry, Medicinal
Md. Khalid Anwer, Mohammed Muqtader Ahmed, Mohammed F. Aldawsari, Muzaffar Iqbal, Vinay Kumar
Summary: In this study, DSM-loaded beta-CD-based nanosponges were prepared using DPC as a cross-linker. The optimized NSPs (D-NSP3) showed improved free radical scavenging activity and dissolution efficiency compared to pure DSM. Additionally, D-NSP3 exhibited cytotoxic activity against MCF-7 breast cancer cells. These findings suggest that DSM-loaded NSPs might be a promising therapy option for breast cancer.
Article
Polymer Science
Farzaneh Sabbagh, Nadia Mahmoudi Khatir, Khadijeh Kiarostami
Summary: Nanocomposites were prepared by combining k-carrageenan, polyvinyl alcohol (PVA), and doped nanoparticles (MgO and MgZnO). The structure of the composites was analyzed, and active ingredient catechin was loaded. SEM and texture analysis revealed that MgZnO composites had increased entrapment efficiency and drug release. ZnO played an effective role in the structure and performance of the composites.
Article
Biochemistry & Molecular Biology
Boyuan Li, Guozhu Chang, Qifeng Dang, Chengsheng Liu, Hao Song, Aoqing Chen, Meng Yang, Lufei Shi, Bonian Zhang, Dongsu Cha
Summary: This study developed multifunctional nanoparticles based on a chitosan derivative, which demonstrated high antibacterial activity, good antioxidation, and low cytotoxicity. These nanoparticles have potential as new biomedical materials for promoting skin wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Muhammad Suhail, Jia-Yu Liu, Ming-Chia Hung, I-Hui Chiu, Muhammad Usman Minhas, Pao-Chu Wu
Summary: The aim of this study was to develop pH-responsive hydrogels for controlled drug delivery. The hydrogels showed good swelling and drug release properties, with higher concentrations of hydrogel contents leading to increased porosity and drug loading. These hydrogels had a slow degradation rate and exhibited no toxic effects on human colon cancer cells.
Article
Chemistry, Physical
Jiling Liang, Tingting Han, Wenwu Wang, Lunqiu Zhang, Yan Zhang
Summary: To design more environmentally friendly, economical, and efficient demulsifiers for oily wastewater treatment, Fe3O4@ODPA nanoparticles were prepared and characterized. The Fe3O4@ODPA nanoparticles showed hydrophobic nature with water contact angles of more than 120 degrees and had a diameter of 12-15 nm. The demulsification efficiency (R-O) of Fe3O4@ODPA samples was higher than that of bare Fe3O4 samples, and it maintained high R-O even after being reused for demulsification 11 times.
Article
Chemistry, Multidisciplinary
Anju Tyagi, Abhijit Mishra
Summary: Excessive use of antibiotics globally has led to increased resistance among disease-causing microorganisms, prompting the exploration of antimicrobial polymers as a promising solution. The molecular weight of these polymers plays a crucial role in their antibacterial efficacy and cytotoxicity, with higher molecular weight polymers exhibiting greater antibacterial activity but also higher cytotoxicity. Overall, the polymers show potential in combating drug-resistant pathogens with varying levels of efficacy and biocompatibility depending on their molecular weight.
Article
Biophysics
Ping Zhou, Feifei Mao, Fei He, Yu Han, Hongjiao Li, Jing Chen, Shicheng Wei
COLLOIDS AND SURFACES B-BIOINTERFACES
(2019)
Article
Biochemistry & Molecular Biology
Ping Zhou, Yu Han, Jiamin Shi, Rui Zhang, Xiaolin Ren, Hongjiao Li, Feng Lan
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Review
Engineering, Biomedical
Rui Zhang, Tianwei Guo, Yu Han, Hongxin Huang, Jiamin Shi, Jiaxuan Hu, Hongjiao Li, Jianlin Wang, Amina Saleem, Ping Zhou, Feng Lan
Summary: Various approaches, including genetic manipulation, biochemical factors supplement, mechanical stress, electrical stimulation, and three-dimensional culture, have been developed to promote the maturation of cardiomyocyte like cells derived from human pluripotent stem cells. Establishing synthetic artificial microenvironments based on the in vivo development program of cardiomyocytes has gained attention for their potential to accelerate maturation.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Article
Engineering, Multidisciplinary
Ping Zhou, Hongjiao Li, Feifei Mao, Hongxin Huang, Siqi Long, Fei He, Jing Chen, Shicheng Wei
Summary: The study focused on the effects of hierarchical micron/nano scale patterns, created by micro-pillars and nanotubes, on the behaviors of different cells and bacteria on titanium surfaces. The synergistic effect of these patterns was observed on MG63 osteoblasts, L929 fibroblasts, SCC epithelial cells, and P. gingivalis functions, highlighting their importance in biomedical implant surface design.
JOURNAL OF BIONIC ENGINEERING
(2021)
Review
Biotechnology & Applied Microbiology
Yu-Qi Liu, Li-Ying Qin, Hong-Jiao Li, Yi-Xi Wang, Rui Zhang, Jia-Min Shi, Jin-Hua Wu, Gen-Xi Dong, Ping Zhou
Summary: UCNP, with the ability to convert near-infrared light to visible or UV light, are promising nanomaterials for effective and safe cancer treatment. They have been widely used in chemotherapy drug delivery, photodynamic therapy, and photothermal therapy. UCNP can also be applied in tumor monitoring and precise targeted therapy.
Review
Engineering, Biomedical
Ping Zhou, Liying Qin, Zhangjie Ge, Biyao Xie, Hongxin Huang, Fei He, Shengqin Ma, Lina Ren, Jiamin Shi, Suying Pei, Genxi Dong, Yongmei Qi, Feng Lan
Summary: This review summarizes the design and limitations of reported synthetic substrates for cell culture, focusing on the development of promising peptide displaying surfaces and the biophysical regulation of synthetic substrate surfaces as well as three-dimensional culture systems.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Xiuping Gao, Weisheng Liu, Gang Han, Xiaohui Jiang, Lingyi Li, Ping Zhou, Shasha Wang, Tao Liu, Jinyuan Zhou, Haodong Zhang, Kai Huang, Yang Li, Min Wang, Zhiwen Jin, Erqing Xie
Summary: In this study, persistent luminescence nanoparticle scintillators (PLNS) were developed for X-ray-induced photodynamic therapy (X-PDT). The PLNS of SiO2@Zn2SiO4:Mn2+, Yb3+, Li+ exhibited excellent X-ray and UV-excited persistent luminescence, as well as tunable emission spectra. By loading a photosensitizer, effective energy transfer was observed even after removing X-ray irradiation. The dose of X-ray for X-PDT was significantly reduced using the PLNS, indicating their great potential for X-PDT applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Biotechnology & Applied Microbiology
Jing Li, Rongshuang Tan, Xueru Bian, Zhangjie Ge, Jiamin Li, Zhihui Li, Lingzi Liao, Ling Yang, Rui Zhang, Ping Zhou
Summary: This review comprehensively summarizes the research on carbon dots in terms of synthesis methods, optical properties, and biotoxicity. It focuses on the application of carbon dots in stem cell imaging and differentiation, aiming to stimulate the design of future related carbon dots.
Article
Engineering, Biomedical
Yixi Wang, Chuanyang Ding, Zhangjie Ge, Zhipeng Li, Lixin Chen, Xiaolong Guo, Genxi Dong, Ping Zhou
Summary: In this study, blue fluorescent carbon dots (HCDs) were synthesized using honokiol, a traditional Chinese medicinal herb, which exhibited irreversible killing effects on both gram-positive and gram-negative bacteria. The bracket surface was modified with polydopamine and HCDs, resulting in a coating with stable antibacterial properties and good biocompatibility. This study provides a new solution and strategy for addressing the hazards caused by bacterial adhesion on orthodontic brackets.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Shaoli Ding, Rongzhi Zhang, Pengxia Zhang, Jiamin Shi, Lu Liu, Jiamin Li, Rui Zhang, Fujian Wu, Ping Zhou
Summary: This study established a quantitative, dynamic, and simple monitoring index to investigate the in vitro differentiation process of hiPSCs. The relationship between telomerase activity and the expression of marker genes/proteins as well as cell types at each time point was analyzed.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Biotechnology & Applied Microbiology
Chenggang Wang, Lixin Chen, Rongshuang Tan, Yuchen Li, Yiqing Zhao, Lingzi Liao, Zhangjie Ge, Chuanyang Ding, Zhankui Xing, Ping Zhou
Summary: This paper reviews the research progress of carbon dots (CDs) and their composites in targeted tumor imaging, detection, diagnosis, drug delivery, and tumor killing, and discusses the challenges and perspectives of their future applications in these fields.
Article
Engineering, Biomedical
Ping Zhou, Siqi Long, Feifei Mao, Hongxin Huang, Hongjiao Li, Fei He, Rui Zhang, Liling Ren, Jing Chen, Shicheng Wei
BIOMEDICAL MATERIALS
(2020)