Article
Computer Science, Information Systems
Damianos P. Sakas, Dimitrios P. Reklitis, Marina C. Terzi
Summary: To gain a competitive edge, logistics companies should adopt innovative strategies, such as redesigning their marketing plan based on customer activity on social media and websites. This study aims to help logistics firms enhance their digital marketing effectiveness through marketing re-engineering and change management. The methodology involved collecting behavioral big data, conducting regression and correlation analyses, and creating a fuzzy cognitive map simulation to optimize strategies. The findings indicate that redesigning marketing strategies and utilizing customer behavioral big data can significantly impact digital marketing performance. Social media big data can also influence change management and re-engineering processes by reducing costs and increasing visibility.
Review
Green & Sustainable Science & Technology
Natanael Karjanto
Summary: Sustainability in education is crucial for raising awareness among students and cultivating their mindset towards adopting sustainable lifestyles. This article focuses on sustainability in chemical engineering education and explores how potential engineers can pursue sustainable careers.
Article
Oncology
Xingyun Liu, Jia Yang, Chengwei Yang, Xiang Huang, Mingming Han, Fang Kang, Juan Li
Summary: The study revealed that morphine promotes the malignant biological behavior of non-small cell lung cancer H460 cells by enhancing cell growth, migration, and invasion, as well as through modifying cell cycle progression and exerting an antiapoptotic effect. This effect is mediated through the activation of the MOR and Src/mTOR signaling pathways.
CANCER CELL INTERNATIONAL
(2021)
Article
Behavioral Sciences
Marjan Nikbakhtzadeh, Ehsan Raeis-Abdollahi, Esmail Riahi, Reza Arezoomandan
Summary: Natural rewards and abused drugs affect brain reward systems, with sexual experience prolonging morphine-seeking behavior while sex deprivation blocking maintenance. Interaction between sex and drug rewards influences preference for morphine, indicating the impact of natural rewarding stimuli on drug-seeking behaviors.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Masaya Harada, Vincent Pascoli, Agnes Hiver, Jerome Flakowski, Christian Luescher
Summary: The study reveals that compulsive individuals exhibit stronger neuronal activity in the DS during the cue predicting reward availability, even at the risk of punishment. An increased AMPA/NMDA ratio was observed selectively at orbitofrontal cortex to DS synapses, and spiny projection neurons in the DS showed an activity peak at the moment of signaled reward availability.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Gastroenterology & Hepatology
Bridget Truitt, Greeshma Venigalla, Praveen Singh, Salma Singh, Junyi Tao, Irina Chupikova, Sabita Roy
Summary: The opioid epidemic has led to millions of people suffering from opioid use disorder due to over-prescription of addictive substances. This study explores the potential of the microbiome as a therapeutic target for morphine withdrawal, as gut dysbiosis caused by morphine use has been linked to tolerance. The results suggest that the microbiome plays a role in the severity of somatic withdrawal symptoms through a gram-positive, TLR2 mediated mechanism.
Article
Biochemistry & Molecular Biology
Roberta Teixeira Polez, Maria Morits, Christopher Jonkergouw, Josphat Phiri, Juan Jose Valle-Delgado, Markus B. Linder, Thaddeus Maloney, Orlando J. Rojas, Monika Osterberg
Summary: This study explores the potential of plant-based hydrogels in tissue engineering, combining polysaccharide tragacanth gum, antioxidant lignin nanoparticles, and TEMPO-oxidized cellulose nanofibrils. The hydrogels exhibited adjustable rheological properties and swelling capacity, with Young's moduli comparable to soft tissues. In vitro experiments also demonstrated their ability to promote cell proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Infectious Diseases
Joana P. Costa, Teresa Pinheiro, Maria S. Martins, M. Fernanda N. N. Carvalho, Joana R. Feliciano, Jorge H. Leitao, Rafaela A. L. Silva, Joana F. Guerreiro, Luis M. C. Alves, Ines Custodio, Joao Cruz, Fernanda Marques
Summary: This study assessed the cytotoxic activity of camphorimine complexes based on Cu(I), Cu(II), Ag(I), and Au(I) metal sites against ovarian cancer cells. The results showed that the gold complexes exhibited the highest activity, followed by the silver complexes, and then the copper complexes. It was also found that the Ag(I) and Au(I) camphorimine complexes had higher cytotoxic activity than cisplatin. Furthermore, the camphorimine complexes had minimal interaction with DNA compared to cisplatin. The cytotoxic activity of the complexes was directly related to cellular uptake and inversely related to ROS formation.
Review
Biotechnology & Applied Microbiology
Yanxia Wang, Yao Chen, Ling Jiang, He Huang
Summary: The contamination of food and feed by mycotoxins poses a serious threat to global food safety and public health. Enzymes have emerged as a promising approach for biological detoxification, but their low efficiency and stability limit their application. This review summarizes recent trends in structure-based engineering to improve the efficiency, selectivity, and stability of enzymes in detoxifying mycotoxins, providing insights into obtaining innovative and effective biocatalysts for mycotoxin degradation.
BIOTECHNOLOGY ADVANCES
(2022)
Article
Computer Science, Information Systems
George Nokas, Theodore Kotsilieris
Summary: Keratoconus is a common non-inflammatory disease of the eyes that affects vision. Eye rubbing has been identified as a risk factor for its development. This study aims to use hand motion data and machine learning techniques to detect potential problems early and prevent complications.
Article
Neurosciences
Clara I. C. Wolfe, Eun-Kyung Hwang, Elfrieda C. Ijomor, Agustin Zapata, Alexander F. Hoffman, Carl R. Lupica
Summary: The lateral habenula (LHb) balances reward and aversion by opposing activation of brain reward nuclei and is involved in the inhibition of responding for cocaine in a model of impulsive behavior. Activation of cholinergic signal to LHb and M(2)Rs is critical for the inhibition of responding for cocaine, and the cellular mechanisms underlying this effect have been defined.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Business
Kane Smith, Gurpreet Dhillon
Summary: Cyberstalking is a growing threat to society, and policymakers should address it utilizing the input of constituents. The process should be guided by the constituent's values to develop actionable objectives and means of implementation that maximize potential benefits.
Article
Biotechnology & Applied Microbiology
Xiaoli Zhou, Zhiqiang Xu, Yueqiu Li, Jia He, Honghui Zhu
Summary: In this study, the chitin-active CjLPMO10A from Cellvibrio japonicus was engineered to improve its thermal and chemical stability by introducing disulfide bonds, while maintaining its catalytic activity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Green & Sustainable Science & Technology
Shamila Janakiraman, Sunnie Lee Watson, William R. Watson, Zui Cheng
Summary: Environmental responsibilities have expanded beyond controlling industrial emissions and waste, now including logistics, products, and processes. Companies are increasingly environmentally conscious, leading to a demand for environmental engineering professionals. Engineering education should focus on cultivating critical thinkers who can create sustainable solutions, while addressing interdisciplinary challenges in sustainability projects.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Laura Fernandez-Lopez, Sergi Roda, Ana Robles-Martin, Ruben Munoz-Tafalla, David Almendral, Manuel Ferrer, Victor Guallar
Summary: Lipases have valuable potential for industrial use, but often require engineering modifications for optimal performance. This study improved the lipase activity by mutating its lid domain and swapping it with another lipase's lid domain, demonstrating the importance of lid domains in determining substrate specificity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Yasmeen Abouelhassan, Aaron T. Garrison, Fang Bai, Verrill M. Norwood, Minh Thu Nguyen, Shouguang Jin, Robert W. Huigens
Article
Chemistry, Multidisciplinary
Akash Basak, Yasmeen Abouelhassan, Verrill M. Norwood, Fang Bai, Minh Thu Nguyen, Shouguang Jin, Robert W. Huigens
CHEMISTRY-A EUROPEAN JOURNAL
(2016)
Article
Chemistry, Medicinal
Aaron T. Garrison, Yasmeen Abouelhassan, Verrill M. Norwood, Dimitris Kallifidas, Fang Bai, Minh Thu Nguyen, Melanie Rolfe, Gena M. Burch, Shouguang Jin, Hendrik Luesch, Robert W. Huigens
JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Chemistry, Medicinal
Akash Basak, Yasmeen Abouelhassan, Young S. Kim, Verrill M. Norwood, Shouguang Jin, Robert W. Huigens
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Review
Biochemistry & Molecular Biology
Verrill M. Norwood, Robert W. Huigens
Article
Chemistry, Organic
Nicholas G. Paciaroni, Verrill M. Norwood, Daniel E. Garcia, Robert W. Huigens
TETRAHEDRON LETTERS
(2019)
Article
Chemistry, Medicinal
Nicholas G. Paciaroni, David L. Perry, Verrill M. Norwood, Claribel Murillo-Solano, Jennifer Collins, Srinivasarao Tenneti, Debopam Chakrabarti, Robert W. Huigens
ACS INFECTIOUS DISEASES
(2020)
Article
Biochemistry & Molecular Biology
Michael J. Ferracane, Ariana C. Brice-Tutt, Jeremy S. Coleman, Grant G. Simpson, Lisa L. Wilson, Shainnel O. Eans, Heather M. Stacy, Thomas F. Murray, Jay P. McLaughlin, Jane Aldrich
ACS CHEMICAL NEUROSCIENCE
(2020)
Article
Pharmacology & Pharmacy
Ariana C. Brice-Tutt, Lisa L. Wilson, Shainnel O. Eans, Heather M. Stacy, Chloe A. Simons, Grant G. Simpson, Jeremy S. Coleman, Michael J. Ferracane, Jane V. Aldrich, Jay P. McLaughlin
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Ariana C. Brice-Tutt, Sanjeewa N. Senadheera, Michelle L. Ganno, Shainnel O. Eans, Tanvir Khaliq, Thomas F. Murray, Jay P. McLaughlin, Jane Aldrich
Article
Chemistry, Medicinal
Ke Liu, Massimiliano Brivio, Tao Xiao, Verrill M. Norwood, Young S. Kim, Shouguang Jin, Antonio Papagni, Luca Vaghi, Robert W. I. I. I. I. I. I. Huigens
Summary: This study reports synthetic routes to fluorine-containing halogenated phenazine and halogenated acridine agents and investigates their effects against Gram-positive pathogens and biofilms. The results demonstrate significant antibacterial and biofilm-killing activities of these compounds, possibly through iron starvation.
ACS INFECTIOUS DISEASES
(2022)
Review
Chemistry, Multidisciplinary
Hashim F. Motiwala, Ahlam M. Armaly, Jackson G. Cacioppo, Thomas C. Coombs, Kimberly R. K. Koehn, Verrill M. Norwood IV, Jeffrey Aube
Summary: HFIP is a polar solvent that is widely used in organic synthesis for stabilizing ionic species, transferring protons, and engaging in various intermolecular interactions.
Article
Chemistry, Multidisciplinary
Nicholas G. Paciaroni, Ranjala Ratnayake, James H. Matthews, Verrill M. Norwood, Austin C. Arnold, Long H. Dang, Hendrik Luesch, Robert W. Huigens
CHEMISTRY-A EUROPEAN JOURNAL
(2017)