Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes

Metabolic reorganization in winter: Regulation of pyruvate dehydrogenase (PDH) during long-term freezing and anoxia

(2019) Rasha Al-attar et al.   CRYOBIOLOGY

Frontline Science: Monocytes sequentially rewire metabolism and bioenergetics during an acute inflammatory response

(2019) Xuewei Zhu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

PDH-mediated metabolic flow is critical for skeletal muscle stem cell differentiation and myotube formation during regeneration in mice

(2019) Shimpei Hori et al.   FASEB JOURNAL

Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation

(2019) Jade D. Bailey et al.   Cell Reports

Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair

(2019) Markus Ruetz et al.   SCIENCE

Exploring the cellular network of metabolic flexibility in the adipose tissue

(2018) Samar H. K. Tareen et al.   Genes and Nutrition

Branched Chain Amino Acids: Beyond Nutrition Metabolism

(2018) Cunxi Nie et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of Immune-Responsive Gene 1 (IRG1) as a Target of A20

(2018) Emmy Van Quickelberghe et al.   JOURNAL OF PROTEOME RESEARCH

Role of SLC7A5 in Metabolic Reprogramming of Human Monocyte/Macrophage Immune Responses

(2018) Bo Ruem Yoon et al.   Frontiers in Immunology

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation

(2018) Niamh C. Williams et al.   Frontiers in Immunology

Exploring the cellular network of metabolic flexibility in the adipose tissue

(2018) Samar H. K. Tareen et al.   Genes and Nutrition

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

(2018) Michael P. Murphy et al.   CELL

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism

(2018) Sungmi Park et al.   Diabetes & Metabolism Journal

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

(2018) Jorge Domínguez-Andrés et al.   Cell Metabolism

Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complex

(2018) Alla Klyuyeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic regulation of macrophage phenotype and function

(2017) Shilpi Saha et al.   IMMUNOLOGICAL REVIEWS

Mitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock

(2017) Kumar Subramani et al.   Scientific Reports

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Pyruvate dehydrogenase kinase 2 and 4 gene deficiency attenuates nociceptive behaviors in a mouse model of acute inflammatory pain

(2016) Mithilesh Kumar Jha et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

(2016) Shih-Chin Cheng et al.   NATURE IMMUNOLOGY

Metabolic reprogramming by the pyruvate dehydrogenase kinase–lactic acid axis: Linking metabolism and diverse neuropathophysiologies

(2016) Mithilesh Kumar Jha et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Dichloroacetate treatment improves mitochondrial metabolism and reduces brain injury in neonatal mice

(2016) Yanyan Sun et al.   Oncotarget

Human Monocytes Undergo Functional Re-programming during Sepsis Mediated by Hypoxia-Inducible Factor-1α

(2015) Irina N. Shalova et al.   IMMUNITY

The role of Pyruvate Dehydrogenase Complex in cardiovascular diseases

(2015) Wanqing Sun et al.   LIFE SCIENCES

Metabolic–epigenetic crosstalk in macrophage activation

(2015) Jeroen Baardman et al.   Epigenomics

The Pyruvate Dehydrogenase Complexes: Structure-based Function and Regulation

(2014) Mulchand S. Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

(2014) Valerie A. Gerriets et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Nutrient deprivation induces the Warburg effect through ROS/AMPK-dependent activation of pyruvate dehydrogenase kinase

(2013) Ching-An Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of pyruvate metabolism and human disease

(2013) Lawrence R. Gray et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of pyruvate metabolism in metabolic-related diseases

(2013) Nam Ho Jeoung et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases

(2012) Peter W. Stacpoole   AGING CELL

NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response

(2012) Tie Fu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The spectrum of pyruvate dehydrogenase complex deficiency: Clinical, biochemical and genetic features in 371 patients

(2012) Kavi P. Patel et al.   MOLECULAR GENETICS AND METABOLISM

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase

(2012) Ji Yun Jeong et al.   Diabetes & Metabolism Journal

Heme Oxygenase-1 Couples Activation of Mitochondrial Biogenesis to Anti-inflammatory Cytokine Expression

(2011) Claude A. Piantadosi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changes in Temperature Preferences and Energy Homeostasis in Dystroglycan Mutants

(2009) K.-i. Takeuchi et al.   SCIENCE