αβ and γδ T cell receptors: Similar but different

Structural basis of assembly of the human T cell receptor–CD3 complex

(2019) De Dong et al.   NATURE

γδ T cell responses: How many ligands will it take till we know?

(2018) David Vermijlen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Anti-CD3 Fab Fragments Enhance Tumor Killing by Human γδ T Cells Independent of Nck Recruitment to the γδ T Cell Antigen Receptor

(2018) Claudia Juraske et al.   Frontiers in Immunology

The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness

(2018) Daisy Melandri et al.   NATURE IMMUNOLOGY

The butyrophilin 3A1 intracellular domain undergoes a conformational change involving the juxtamembrane region

(2017) Khiem Nguyen et al.   FASEB JOURNAL

Concomitant Disruption ofCD4andCD8Genes Facilitates the Development of Double Negative αβ TCR+Peripheral T Cells That Respond Robustly to Staphylococcal Superantigen

(2017) Vaidehi R. Chowdhary et al.   JOURNAL OF IMMUNOLOGY

γδTCR immunoglobulin constant region domain exchange in human αβTCRs improves TCR pairing without altering TCR gene-modified T cell function

(2017) Changli Tao et al.   Molecular Medicine Reports

A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation

(2016) Mahima Swamy et al.   IMMUNITY

TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets

(2016) Miguel Muñoz-Ruiz et al.   NATURE IMMUNOLOGY

Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol

(2016) Feng Wang et al.   NATURE IMMUNOLOGY

Nck Binds to the T Cell Antigen Receptor Using Its SH3.1 and SH2 Domains in a Cooperative Manner, Promoting TCR Functioning

(2015) Pussadee Paensuwan et al.   JOURNAL OF IMMUNOLOGY

Phosphoantigen Presentation to TCR γδ Cells, a Conundrum Getting Less Gray Zones

(2015) Gennaro De Libero et al.   Frontiers in Immunology

The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human Vγ9Vδ2 T Cells

(2014) Andrew Sandstrom et al.   IMMUNITY

Conformational changes in the T cell receptor differentially determine T cell subset development in mice

(2014) R. Blanco et al.   Science Signaling

The CD3 Conformational Change in the γδ T Cell Receptor Is Not Triggered by Antigens but Can Be Enforced to Enhance Tumor Killing

(2014) Elaine P. Dopfer et al.   Cell Reports

The Vγ9Vδ2 T Cell Antigen Receptor and Butyrophilin-3 A1: Models of Interaction, the Possibility of Co-Evolution, and the Case of Dendritic Epidermal T Cells

(2014) Mohindar M. Karunakaran et al.   Frontiers in Immunology

Functional development of γδ T cells

(2013) Immo Prinz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells

(2013) Stefano Vavassori et al.   NATURE IMMUNOLOGY

Increased Cholesterol Content in Gammadelta (γδ) T Lymphocytes Differentially Regulates Their Activation

(2013) Hsin-Yuan Cheng et al.   PLoS One

NSOM/QD-Based Visualization of GM1 Serving as Platforms for TCR/CD3 Mediated T-Cell Activation

(2013) Liyun Zhong et al.   Biomed Research International

Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human    T-cell subset

(2012) C. Harly et al.   BLOOD

Diversity of γδ T-cell antigens

(2012) Willi K Born et al.   Cellular & Molecular Immunology

Innate NKTγδ and NKTαβ cells exert similar functions and compete for a thymic niche

(2012) Pablo Pereira et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Organization of the resting TCR in nanoscale oligomers

(2012) Wolfgang W. A. Schamel et al.   IMMUNOLOGICAL REVIEWS

Cholesterol and Sphingomyelin Drive Ligand-independent T-cell Antigen Receptor Nanoclustering

(2012) Eszter Molnár et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain

(2012) Etienne Gagnon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nck Recruitment to the TCR Required for ZAP70 Activation during Thymic Development

(2012) A. Borroto et al.   JOURNAL OF IMMUNOLOGY

Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids

(2012) Xiaoshan Shi et al.   NATURE

T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

(2011) Jarrett J. Adams et al.   IMMUNITY

Increased Sensitivity of Antigen-Experienced T Cells through the Enrichment of Oligomeric T Cell Receptor Complexes

(2011) Rashmi Kumar et al.   IMMUNITY

Formation and Aggregation of Lipid Rafts in γδ T Cells Following Stimulation with Mycobacterium tuberculosis Antigens

(2011) He-Zuo Lü et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Fine Tuning of the Threshold of T Cell Selection by the Nck Adapters

(2010) E. Roy et al.   JOURNAL OF IMMUNOLOGY

Unexpected Role for the B Cell-Specific Src Family Kinase B Lymphoid Kinase in the Development of IL-17-Producing    T Cells

(2010) R. M. Laird et al.   JOURNAL OF IMMUNOLOGY

Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire

(2010) E. Roy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profiling of the early transcriptional response of murine γδ T cells following TCR stimulation

(2009) Renee M. Laird et al.   MOLECULAR IMMUNOLOGY

The molecular basis of TCR germline bias for MHC is surprisingly simple

(2009) K Christopher Garcia et al.   NATURE IMMUNOLOGY

Highly Active Microbial Phosphoantigen Induces Rapid yet Sustained MEK/Erk- and PI-3K/Akt-Mediated Signal Transduction in Anti-Tumor Human γδ T-Cells

(2009) Daniel V. Correia et al.   PLoS One

Cooperativity Between T Cell Receptor Complexes Revealed by Conformational Mutants of CD3 

(2009) N. Martinez-Martin et al.   Science Signaling

Evolutionarily Conserved Amino Acids That Control TCR-MHC Interaction

(2008) Philippa Marrack et al.   Annual Review of Immunology

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

(2008) Chenqi Xu et al.   CELL

Brokering the peace: the origin of intestinal T cells

(2008) A Hayday et al.   Mucosal Immunology

Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells

(2008) Lynn M Boyden et al.   NATURE GENETICS

NSOM/QD-based nanoscale immunofluorescence imaging of antigen-specific T-cell receptor responses during an in vivo clonal V 2V 2 T-cell expansion

(2007) Y. Chen et al.   BLOOD