Unravelling the adiponectin paradox: novel roles of adiponectin in the regulation of cardiovascular disease

Leptin dose-dependently decreases atherosclerosis by attenuation of hypercholesterolemia and induction of adiponectin

(2016) Annett Hoffmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-γ/Adiponectin SignallingNovelty and Significance

(2016) Alexios S. Antonopoulos et al.   CIRCULATION RESEARCH

Effect of Dipeptidyl Peptidase-4 Inhibitors on Plasma Adiponectin: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2016) Amirhossein Sahebkar et al.   CURRENT MEDICINAL CHEMISTRY

Characterization and comparison of sodium-glucose cotransporter 2 inhibitors: Part 2. Antidiabetic effects in type 2 diabetic mice

(2016) Atsuo Tahara et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Circulating adiponectin and carotid intima-media thickness: A systematic review and meta-analysis

(2016) Karina Gasbarrino et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Adiponectin signaling and function in insulin target tissues

(2016) Hong Ruan et al.   Journal of Molecular Cell Biology

Adiponectin Attenuates Angiotensin II-Induced Vascular Smooth Muscle Cell Remodeling through Nitric Oxide and the RhoA/ROCK Pathway

(2016) Wared Nour-Eldine et al.   Frontiers in Pharmacology

Could changes in adiponectin drive the effect of statins on the risk of new-onset diabetes? The case of pitavastatin

(2015) Lorenzo Arnaboldi et al.   ATHEROSCLEROSIS SUPPLEMENTS

The Concise Guide to PHARMACOLOGY 2015/16: Nuclear hormone receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Overview

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Omentin attenuates atherosclerotic lesion formation in apolipoprotein E-deficient mice

(2015) Mizuho Hiramatsu-Ito et al.   CARDIOVASCULAR RESEARCH

LCZ696: The Next Step in Improving RAS Inhibition?

(2015) Alan H. Gradman   CURRENT HYPERTENSION REPORTS

Clinical Utility of Measuring Epicardial Adipose Tissue Thickness with Echocardiography Using a High-Frequency Linear Probe in Patients with Coronary Artery Disease

(2015) Yukina Hirata et al.   JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

Local and systemic effects of the multifaceted epicardial adipose tissue depot

(2015) Gianluca Iacobellis   Nature Reviews Endocrinology

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

(2015) Christopher Southan et al.   NUCLEIC ACIDS RESEARCH

Interleukin-10 protects against atherosclerosis by modulating multiple atherogenic macrophage function

(2015) Xinbing Han et al.   THROMBOSIS AND HAEMOSTASIS

Switching the Sphingolipid Rheostat in the Treatment of Diabetes and Cancer Comorbidity from a Problem to an Advantage

(2015) Nikolas K. Haass et al.   Biomed Research International

Perspective of Small-Molecule AdipoR Agonist for Type 2 Diabetes and Short Life in Obesity

(2015) Miki Okada-Iwabu et al.   Diabetes & Metabolism Journal

Adiponectin as a Link Between Type 2 Diabetes and Vascular NADPH Oxidase Activity in the Human Arterial Wall: The Regulatory Role of Perivascular Adipose Tissue

(2015) Alexios S. Antonopoulos et al.   DIABETES

Association between Resistin Levels and All-Cause and Cardiovascular Mortality: A New Study and a Systematic Review and Meta-Analysis

(2015) Andrea Fontana et al.   PLoS One

Reciprocal Effects of Systemic Inflammation and Brain Natriuretic Peptide on Adiponectin Biosynthesis in Adipose Tissue of Patients With Ischemic Heart Disease

(2014) Alexios S. Antonopoulos et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Circulating cytokines in relation to the extent and composition of coronary atherosclerosis: Results from the ATHEROREMO-IVUS study

(2014) Linda C. Battes et al.   ATHEROSCLEROSIS

Visceral adipose tissue as a source of inflammation and promoter of atherosclerosis

(2014) Nikolaos Alexopoulos et al.   ATHEROSCLEROSIS

Apelin

(2014) Ying Zhou et al.   International Heart Journal

The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis

(2014) Guo-Xiao Wang et al.   NATURE MEDICINE

Advances in our understanding of adipose tissue homeostasis

(2014) Jennifer H. Stern et al.   Nature Reviews Endocrinology

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

State of the art paper Biochemistry of adipose tissue: an endocrine organ

(2013) Marisa Coelho et al.   Archives of Medical Science

Serum total adiponectin level and the risk of cardiovascular disease in general population: A meta-analysis of 17 prospective studies

(2013) Guang Hao et al.   ATHEROSCLEROSIS

Adiponectin and Leptin: New Targets in Inflammation

(2013) Morena Scotece et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing to increased vulnerability in diabetic heart

(2013) Wenjun Yan et al.   BASIC RESEARCH IN CARDIOLOGY

Adiponectin receptors: A review of their structure, function and how they work

(2013) Toshimasa Yamauchi et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

The Origins and Drivers of Insulin Resistance

(2013) Andrew M.F. Johnson et al.   CELL

Adiponectin Receptor as a Key Player in Healthy Longevity and Obesity-Related Diseases

(2013) Toshimasa Yamauchi et al.   Cell Metabolism

Interactions Between Vascular Wall and Perivascular Adipose Tissue Reveal Novel Roles for Adiponectin in the Regulation of Endothelial Nitric Oxide Synthase Function in Human Vessels

(2013) Marios Margaritis et al.   CIRCULATION

Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines

(2013) Nicolas Venteclef et al.   EUROPEAN HEART JOURNAL

TNF-α signalling and inflammation: interactions between old acquaintances

(2013) Hana Zelová et al.   INFLAMMATION RESEARCH

Association between adiponectin levels and coronary heart disease and mortality: a systematic review and meta-analysis

(2013) Eon Sook Lee et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Apelin Attenuates Oxidative Stress in Human Adipocytes

(2013) Aung Than et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

(2013) Miki Okada-Iwabu et al.   NATURE

Effects of C-reactive protein on adipokines genes expression in 3T3-L1 adipocytes

(2012) Guoyue Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Impact of age on leptin and adiponectin independent of adiposity

(2012) Britta Schautz et al.   BRITISH JOURNAL OF NUTRITION

Role of leptin and adiponectin in insulin resistance

(2012) Amita Yadav et al.   CLINICA CHIMICA ACTA

The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: Oxidative stress and the seesaw of cell survival and death

(2012) James R. Van Brocklyn et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Adiponectin: mechanistic insights and clinical implications

(2012) A. T. Turer et al.   DIABETOLOGIA

Omentin plays an anti-inflammatory role through inhibition of TNF-α-induced superoxide production in vascular smooth muscle cells

(2012) Kyosuke Kazama et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Genetic variability on adiponectin gene affects myocardial infarction risk: The role of endothelial dysfunction

(2012) Alexios S. Antonopoulos et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications

(2012) Mi-Jeong Lee et al.   MOLECULAR ASPECTS OF MEDICINE

Recombinant Adiponectin Does Not Lower Plasma Glucose in Animal Models of Type 2 Diabetes

(2012) Søren Tullin et al.   PLoS One

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

(2012) Zari Dastani et al.   PLoS Genetics

Adiponectin mediates cardioprotection in oxidative stress-induced cardiac myocyte remodeling

(2011) Eric E. Essick et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease

(2011) Wenjun Ouyang et al.   Annual Review of Immunology

Circulating Interleukin-10 and Risk of Cardiovascular Events

(2011) Paul Welsh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Circulating omentin is associated with coronary artery disease in men

(2011) Rei Shibata et al.   ATHEROSCLEROSIS

Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells

(2011) Hideyuki Yamawaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Genome-Wide Association Study Reveals a Quantitative Trait Locus of Adiponectin on CDH13 That Predicts Cardiometabolic Outcomes

(2011) C.-M. Chung et al.   DIABETES

Association of Circulating Levels of Leptin and Adiponectin With Metabolic Syndrome and Coronary Heart Disease in Patients With Various Coronary Risk Factors

(2011) Yutaka Kajikawa et al.   International Heart Journal

Coronary Atherosclerosis Is Associated With Macrophage Polarization in Epicardial Adipose Tissue

(2011) Yoichiro Hirata et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

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(2011) Ling Li et al.   MOLECULAR MEDICINE

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells

(2010) Changyi Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Plasma adiponectin levels are associated with left ventricular hypertrophy in a random sample of middle-aged subjects

(2010) Tero Pääkkö et al.   ANNALS OF MEDICINE

High adiponectin and increased risk of cardiovascular disease and mortality in asymptomatic older men: does NT-proBNP help to explain this association?

(2010) Sasiwarang Goya Wannamethee et al.   EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION

T-cadherin is critical for adiponectin-mediated cardioprotection in mice

(2010) Martin S. Denzel et al.   JOURNAL OF CLINICAL INVESTIGATION

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

Serum levels of apelin and ghrelin in patients with acute coronary syndromes and established coronary artery disease—KOZANI STUDY

(2010) Nikolaos P.E. Kadoglou et al.   Translational Research

Apelin is necessary for the maintenance of insulin sensitivity

(2009) Patrick Yue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation

(2009) Nicholas J. Leeper et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression

(2009) Le Thi Kim Chung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting Redox Signaling in the Vascular Wall: From Basic Science to Clinical Practice

(2009) Charalambos Antoniades et al.   CURRENT PHARMACEUTICAL DESIGN

Systemic Fate of the Adipocyte-Derived Factor Adiponectin

(2009) N. Halberg et al.   DIABETES

Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle

(2009) E.-G. Hong et al.   DIABETES

Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial

(2009) D. K. Coletta et al.   DIABETOLOGIA

Association of the +45T>G and +276G>T polymorphisms in the adiponectin gene with insulin resistance in nondiabetic Greek women

(2009) Labros Melistas et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases

(2009) T Yamauchi et al.   INTERNATIONAL JOURNAL OF OBESITY

Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype

(2009) Koji Ohashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Natriuretic Peptides Enhance the Production of Adiponectin in Human Adipocytes and in Patients With Chronic Heart Failure

(2009) Osamu Tsukamoto et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Subcutaneous and visceral adipose tissue: structural and functional differences

(2009) M. Mohsen Ibrahim   Obesity Reviews

Relation of Epicardial Adipose Tissue to Coronary Atherosclerosis

(2008) Roxana Djaberi et al.   AMERICAN JOURNAL OF CARDIOLOGY

Adipocytes and adipose tissue

(2008) Wieland Kiess et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Leptin: Linking obesity, the metabolic syndrome, and cardiovascular disease

(2008) Sanjeev B. Patel et al.   CURRENT HYPERTENSION REPORTS

Induction of hyperadiponectinemia following long-term treatment of patients with rheumatoid arthritis with infliximab (IFX), an anti-TNF-alpha antibody

(2008) Keiko NISHIDA et al.   ENDOCRINE JOURNAL

Circulating adiponectin levels associate with inflammatory markers, insulin resistance and metabolic syndrome independent of obesity

(2008) J Hung et al.   INTERNATIONAL JOURNAL OF OBESITY

Endothelial dysfunction in adiponectin deficiency and its mechanisms involved

(2008) Yu Cao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Adiponectin receptors: expression in Zucker diabetic rats and effects of fenofibrate and metformin

(2008) Coralie Metais et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Adiponectin Improves Cardiomyocyte Contractile Function indb/dbDiabetic Obese Mice

(2008) Feng Dong et al.   Obesity

The Development of INT131 as a Selective PPAR Modulator: Approach to a Safer Insulin Sensitizer

(2008) Linda S. Higgins et al.   PPAR Research

Leptin deficiency suppresses progression of atherosclerosis in apoE-deficient mice

(2007) Tsuyoshi Chiba et al.   ATHEROSCLEROSIS