Celastrol prevents cadmium-induced neuronal cell death by blocking reactive oxygen species-mediated mammalian target of rapamycin pathway

Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A

(2016) Chong Xu et al.   NEUROPHARMACOLOGY

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

(2016) D. Grahame Hardie et al.   TRENDS IN CELL BIOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Experimental design and analysis and their reporting: new guidance for publication in BJP

(2015) Michael J Curtis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP

(2015) John C McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Celastrol induces cell cycle arrest by MicroRNA-21-mTOR-mediated inhibition p27 protein degradation in gastric cancer

(2015) Min Sha et al.   Cancer Cell International

Treatment of Obesity with Celastrol

(2015) Junli Liu et al.   CELL

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

(2015) Christopher Southan et al.   NUCLEIC ACIDS RESEARCH

Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study

(2015) H-Y Li et al.   Cell Death & Disease

Celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy

(2015) Hyun-Woo Lee et al.   BMB Reports

Cadmium Induces PC12 Cells Apoptosis via an Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase-Mediated Mitochondrial Apoptotic Pathway

(2014) Chenyang Jiang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations

(2014) Yao-Tsung Yeh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rotenone Induction of Hydrogen Peroxide Inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E Pathways, Leading to Neuronal Apoptosis

(2014) Qian Zhou et al.   TOXICOLOGICAL SCIENCES

mTOR in aging, metabolism, and cancer

(2013) Marion Cornu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Mitochondrial Diseases of the Brain

(2013) Rajnish K. Chaturvedi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Induction of apoptosis by antimycin A in differentiated PC12 cell line

(2013) Xu Lanju et al.   JOURNAL OF APPLIED TOXICOLOGY

Celastrol prevents cadmium-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network

(2013) Sujuan Chen et al.   JOURNAL OF NEUROCHEMISTRY

Celastrol from ‘Thunder God Vine’ Protects SH-SY5Y Cells Through the Preservation of Mitochondrial Function and Inhibition of p38 MAPK in a Rotenone Model of Parkinson’s Disease

(2013) Bong-Suk Choi et al.   NEUROCHEMICAL RESEARCH

Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy

(2013) Yong-Ning Deng et al.   NEUROCHEMISTRY INTERNATIONAL

N-acetyl-L-cysteine protects against cadmium-induced neuronal apoptosis by inhibiting ROS-dependent activation of Akt/mTOR pathway in mouse brain

(2013) Sujuan Chen et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Cadmium and Its Neurotoxic Effects

(2013) Bo Wang et al.   Oxidative Medicine and Cellular Longevity

Caspofungin Kills Candida albicans by Causing both Cellular Apoptosis and Necrosis

(2012) Binghua Hao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Celastrol suppresses breast cancer MCF-7 cell viability via the AMP-activated protein kinase (AMPK)-induced p53–polo like kinase 2 (PLK-2) pathway

(2012) Ji Hae Kim et al.   CELLULAR SIGNALLING

Mitochondrion-Specific Antioxidants as Drug Treatments for Alzheimer Disease

(2012) Hector H. Palacios et al.   CNS & Neurological Disorders-Drug Targets

Oral bioavailability and gender-related pharmacokinetics of celastrol following administration of pure celastrol and its related tablets in rats

(2012) Jun Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Adenosine monophosphate-activated protein kinase overactivation leads to accumulation of α-synuclein oligomers and decrease of neurites

(2012) Peizhou Jiang et al.   NEUROBIOLOGY OF AGING

Neurodegeneration as a consequence of failed mitochondrial maintenance

(2011) Mariusz Karbowski et al.   ACTA NEUROPATHOLOGICA

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways

(2011) Radhamani Kannaiyan et al.   APOPTOSIS

Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells

(2011) Guozhu Chen et al.   BMC CANCER

NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action

(2011) Vincent Jaquet et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial Stress Signals Revise an Old Aging Theory

(2011) Dong Kyun Woo et al.   CELL

Purple sweet potato color attenuates domoic acid-induced cognitive deficits by promoting estrogen receptor-α-mediated mitochondrial biogenesis signaling in mice

(2011) Jun Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death

(2011) Sujuan Chen et al.   JOURNAL OF NEUROCHEMISTRY

Calcium Signaling Is Involved in Cadmium-Induced Neuronal Apoptosis via Induction of Reactive Oxygen Species and Activation of MAPK/mTOR Network

(2011) Baoshan Xu et al.   PLoS One

Advances in metal-induced oxidative stress and human disease

(2011) Klaudia Jomova et al.   TOXICOLOGY

Celastrol: Molecular targets of Thunder God Vine

(2010) Antero Salminen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer

(2010) Radhamani Kannaiyan et al.   CANCER LETTERS

Celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway

(2010) X. Pang et al.   CANCER RESEARCH

N-acetylcysteine prevents memory deficits, the decrease in acetylcholinesterase activity and oxidative stress in rats exposed to cadmium

(2010) Jamile F. Gonçalves et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation

(2010) Valérie Vingtdeux et al.   FASEB JOURNAL

Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms

(2010) José M. Matés et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death

(2010) Long Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rapamycin Inhibits Cytoskeleton Reorganization and Cell Motility by Suppressing RhoA Expression and Activity

(2010) Lei Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New insights into the role of mitochondria in aging: mitochondrial dynamics and more

(2010) A. Y. Seo et al.   JOURNAL OF CELL SCIENCE

Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells

(2010) Long Chen et al.   LABORATORY INVESTIGATION

Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin

(2009) J. Renugadevi et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats

(2009) J. Renugadevi et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer’s disease

(2009) Magali Dumont et al.   JOURNAL OF NEUROCHEMISTRY

Role of Free Radicals and Poly(ADP-Ribose)Polymerase-1 in the Development of Spinal Cord Injury: New Potential Therapeutic Targets

(2008) S. Cuzzocrea et al.   CURRENT MEDICINAL CHEMISTRY

Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5

(2008) Long Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis

(2008) Long Chen et al.   JOURNAL OF NEUROCHEMISTRY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins

(2008) L Liu et al.   ONCOGENE

Role of mTOR in physiology and pathology of the nervous system

(2007) Lukasz Swiech et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Adiponectin Activates Adenosine Monophosphate-Activated Protein Kinase and Decreases Luteinizing Hormone Secretion in LβT2 Gonadotropes

(2007) Min Lu et al.   MOLECULAR ENDOCRINOLOGY