Article
Medicine, Research & Experimental
Zhaohai Pan, Jiaojiao Fan, Qi Xie, Xin Zhang, Wen Zhang, Qing Ren, Minjing Li, Qiusheng Zheng, Jun Lu, Defang Li
Summary: TBPoS-2OH exhibits significant photocytoxicity and can effectively increase apoptotic rates in melanoma cells. By elevating intracellular ROS levels and activating the mitochondrial apoptosis pathway, TBPoS-2OH shows anticancer effects on A375 and B16 cells.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Fengyun Shen, Lele Sun, Lihua Wang, Rui Peng, Chunhai Fan, Zhuang Liu
Summary: This study reported a novel immune adjuvant that can transdermally deliver chemotherapy drugs into melanoma, induce immunogenic death of tumor cells, and trigger systemic tumor-specific immune responses.
Article
Biophysics
Xiang Wang, Kang Song, Yan Fan, Jun Du, Jinliang Liu, Jiayu Xu, Lulu Zheng, Ruizhuo Ouyang, Yuhao Li, Yuqing Miao, Dawei Zhang
Summary: The study constructed an ultrasound-triggered ROS damage nanoamplifier using a synergistic strategy of ROS damage and decreased tumor self-protection capability, enhancing the treatment efficacy for mutant p53 tumors.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Cheol Park, Hee-Jae Cha, Hyun Hwangbo, Seon Yeong Ji, Da Hye Kim, Min Yeong Kim, EunJin Bang, Su Hyun Hong, Sung Ok Kim, Soon-Jeong Jeong, Hyesook Lee, Sung-Kwon Moon, Jung-Hyun Shim, Gi-Young Kim, Suengmok Cho, Yung Hyun Choi
Summary: Phloroglucinol, a polyphenolic compound, has potent antioxidant activity in mouse myoblasts and may have therapeutic benefits for oxidative-stress-mediated muscle disease by activating Nrf2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Simeon Santourlidis, Wolfgang A. Schulz, Marcos J. Arauzo-Bravo, Daniela Gerovska, Pauline Ott, Marcelo L. Bendhack, Mohamed Hassan, Lars Erichsen
Summary: Epigenetic mechanisms play a fundamental role in the initiation and development of melanoma, but research in this area is relatively limited compared to other cancers. This review provides a brief summary of the epigenetic aspects relevant to melanoma pathogenesis and introduces new perspectives from epigenetic research in other cancers that may have potential for melanoma diagnosis and therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Cell Biology
Christopher J. Carnie, Stephen P. Jackson
Summary: Transcription-coupled repair of DNA lesions occurs in all domains of life, with a highly conserved transcription-elongation factor ELOF1 playing a key role in the process in eukaryotes. Additionally, evidence of a second transcription-coupled repair pathway has been found in mammalian cells.
NATURE CELL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Tong-Fei Li, Hua-Zhen Xu, Yong-Hong Xu, Ting-Ting Yu, Jun-Ming Tang, Ke Li, Chao Wang, Xing-Chun Peng, Qi-Rui Li, Xue-Yu Sang, Mei-Yan Zheng, Yan Liu, Li Zhao, Xiao Chen
Summary: This study successfully addressed the limitations of Chlorin e6 (Ce6) in tumor photodynamic therapy by using functionalized superparamagnetic iron oxide nanoparticles as carriers. The nanoparticles significantly increased Ce6 uptake in melanoma cells, leading to enhanced therapeutic effects.
MOLECULAR PHARMACEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Marta Osrodek, Michal Wozniak
Summary: Despite recent advances in the treatment of cutaneous melanoma, challenges remain, including resistance to conventional chemotherapy and limited efficacy of immune checkpoint inhibitors in only a small subset of patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Oncology
Oliver H. Kraemer, Gunter Schneider
Summary: In this commentary, we summarize and discuss recent evidence on the regulation and relevance of the transcription factor c-FOS in diffuse large B cell lymphoma cells treated with epigenetic erasers of the histone deacetylase inhibitor family.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Physical
Yao Huang, Tingting Peng, Yangyan Chen, Fapeng Zhang, Wanshan Hu, XinYi Gao, Hongyu Chen, Ping Tang, Chuanbin Wu, Xin Pan
Summary: This study developed an oxygen reservoir-irrigated photodynamic therapy (PDT) that integrates oxygen supply, oxygen economizing, and oxygen infiltration. By modulating tumor oxygenation and permeability, it achieves complete eradication of primary melanoma and stimulates immunogenic cell death.
Article
Chemistry, Physical
Yao Huang, Tingting Peng, Yangyan Chen, Fapeng Zhang, Wanshan Hu, XinYi Gao, Hongyu Chen, Ping Tang, Chuanbin Wu, Xin Pan
Summary: An oxygen reservoir-irrigated photodynamic therapy has been developed to improve the efficacy of tumor treatment by considering oxygen supply, economizing, and infiltration. This therapy effectively reduces tumor hypoxia, promotes immunogenic cell death, and enhances the antitumor effects when combined with checkpoint-blockade inhibitors.
Article
Biochemistry & Molecular Biology
Xiaotong Zhao, Manman Zhang, Jinhan Wang, Kaihua Ji, Yan Wang, Xiaohui Sun, Chang Xu, Qin Wang, Ningning He, Huijuan Song, Liqing Du, Feng Wang, Hao Huang, Yang Liu, Qiang Liu
Summary: The risk of cancer increases with age, and radiotherapy often causes intestinal damage. NRF2, a key protective factor, decreases with aging. NRF2 deficiency worsens cellular DNA damage and intestinal pathological damage. SIRT6 or SIRT7 overexpression improves cell proliferation and protects against radiation damage in NRF2 KO cells. Supplementation of NMN increases SIRT6 and SIRT7 levels, reduces cellular ROS, and ameliorates DNA damage in NRF2 KO cells. Long-term oral NMN administration attenuates radiation-induced jejunum injury, increases the number of intestinal stem cells, and promotes intestinal proliferation in NRF2-/- mice.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Mengyao Chen, Jingxian Yang, Lulu Zhou, Xiaochun Hu, Chunhui Wang, Keke Chai, Ruihao Li, Lei Feng, Yanting Sun, Chunyan Dong, Shuo Shi
Summary: The study presents a smart pH/ROS-responsive nanoplatform Fe2+@UCM-BBD for tumor combination therapy, which exhibits excellent capability of inducing tumor apoptosis through DNA damage, promoting H2O2 production for CDT, and achieving CDT through ROS-responsive mechanism.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Oncology
Hongbo Chen, Kai Hou, Jing Yu, Le Wang, Xue Chen
Summary: Melanoma, an increasingly common form of skin cancer, poses challenges due to complications and drug resistance associated with traditional treatments. Combining nanoparticles with conventional methods offers a promising approach by efficiently targeting melanoma cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Medicinal
Izabela Nawrot-Hadzik, Adam Matkowski, Magdalena Fast, Anna Choromanska
Summary: Vanicosides A and B isolated from Reynoutria sachalinensis rhizomes are disaccharide phenylpropanoid esters with proven antioxidant activity. They can induce cell death by generating reactive oxygen species (ROS) into melanoma cells. The glucose molecule in their structure can affect glucose transporters (GLUTs), which are upregulated in cancer cells.
Article
Engineering, Biomedical
Nianzhou Yu, Xi Luo, Tianhong Wei, Qian Zhang, Jing Yu, Lisha Wu, Juan Su, Mingliang Chen, Kai Huang, Fangfang Li, Yang Xie, Fang Fang, Liang Zhang, Renliang He, Xiang Chen, Shuang Zhao, WenBo Bu
Summary: Dermabrasion combined with photodynamic therapy (D-PDT) is a safe and effective treatment for non-melanoma skin cancer, showing significant improvement in patients' quality of life and overall cosmetic outcomes.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Dermatology
Zuotao Zhao, Chong Zhang, Yu Jiang, Cong Peng, Wu Zhu, Shuang Zhao, Xiang Chen, Jie Li
Summary: The study developed and validated the Chinese version of the chronic urticaria quality of life questionnaire (CU-Q2oL), showing it to be a valid, reliable, and sensitive instrument. The Chinese CU-Q2oL was able to distinguish well between patients with different levels of urticaria activity and was sensitive to changes in treatment outcomes.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Article
Dermatology
Runqiu Liu, Cong Peng, Danrong Jing, Yangjian Xiao, Wu Zhu, Shuang Zhao, Jianglin Zhang, Xiang Chen, Jie Li
Summary: This study investigated the relationship between gut microbiota and the efficacy of antihistamines in patients with Chronic Spontaneous Urticaria (CSU), finding that Lachnospira is a signature for predicting the efficacy of antihistamine in these patients.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Biology
Jiancun Zhou, Zheng Wu, Zixi Jiang, Kai Huang, Kehua Guo, Shuang Zhao
Summary: This study investigates the impact of color backgrounds on the classification of skin diseases using deep learning models, demonstrating that background color significantly affects the classification of skin diseases, with classifiers trained on the green subset achieving the best performance for black and red skin lesions.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Yi-Fei Li, Qiong-Qiong Hou, Shuang Zhao, Xiaoyan Chen, Min Tang, Lin Li
Summary: This study aimed to screen effective neoantigens for liver cancer patients and construct immune clusters to select patients who might benefit from vaccination. Through analyzing RNA-seq data and clinical information, neoantigens related to prognosis and immune infiltrating cells were identified. Additionally, three immune clusters with different features were found in the liver cancer cohorts. Overall, this study is of great importance for the development of LIHC mRNA vaccines.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Jiapeng Miao, Yujie Wang, Xiaoyu Gu, Wenrui Lin, Zhen Ouyang, Mi Wang, Mingliang Chen, Shuang Zhao, Xianggui Wang, Juan Su
Summary: The risk of cardiovascular disease (CVD) death is significantly increased in older malignant melanoma (MM) patients, signaling the importance of preventing and treating CVD in these patients. CVD is a leading cause of death, surpassing primary cancer, in older patients diagnosed with MM.
Article
Oncology
Pian Yu, Hui Wei, Kaixuan Li, Shiguo Zhu, Jie Li, Chao Chen, Detian Zhang, Yayun Li, Lei Zhu, Xiaoqing Yi, Nian Liu, Panpan Liu, Shuang Zhao, Xiang Chen, Cong Peng
Summary: This study identified Ailanthone (AIL) as a novel c-Jun inhibitor that can inhibit melanoma cell growth by directly targeting c-Jun and promoting its degradation. AIL also enhances the therapeutic efficacy of anti-PD-L1 by reducing Treg infiltration in the tumor microenvironment (TME).
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Computer Science, Artificial Intelligence
Xiaoyu He, Yong Wang, Shuang Zhao, Xiang Chen
Summary: This study proposes a co-attention fusion network (CAFNet) for skin cancer diagnosis, which extracts features and fuses multimodal images to enhance representation ability and achieve high accuracy.
PATTERN RECOGNITION
(2023)
Article
Chemistry, Multidisciplinary
Han Shan, Xin Sun, Xin Liu, Qi Sun, Yao He, Ziyan Chen, Qibo Lin, Zixi Jiang, Xiang Chen, Zeyu Chen, Shuang Zhao
Summary: This study developed a facile and scalable strategy for one-step construction of targeted liposomes using a versatile microfluidic mixing device (MMD). The method was validated by successfully constructing a programmed death-ligand 1 (PD-L1)-targeting indocyanine green (ICG)-liposome. The technique showed versatility and efficiency in preparing multifunctional targeted liposomal nanoplatforms for molecular imaging and disease theranostics.
Article
Environmental Sciences
Xinchen Ke, Tianhao Wu, Guiyun Gao, Songchun Yang, Wenrui Lin, Yi Xiao, Minxue Shen, Mingliang Chen, Xiang Chen, Shuang Zhao, Juan Su
Summary: Through a web-based questionnaire, we found that delay in seeking medical attention (DSMA) and delay in diagnosis (DD) of melanoma are related to factors such as age, education, income, and patients' histories.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biotechnology & Applied Microbiology
Biao Quan, Xiangdong Liu, Shuang Zhao, Xiang Chen, Xuan Zhang, Zeyu Chen
Summary: Ocular choroidal melanoma (OCM) is the most common primary malignant tumor in adult eyes, and early detection and treatment have become increasingly important worldwide. The main challenge in early detection is the similarity of clinical features with benign choroidal nevus. To address this, ultrasound localization microscopy (ULM) using image deconvolution algorithm and ultrasound plane wave imaging based on three-frame difference algorithm were proposed. Experiments using Verasonics Vantage system and a linear array transducer showed improved microbubble localization, finer microvasculature network reconstruction, and more precise flow velocity estimation. The effectiveness of ultrasound plane wave imaging was demonstrated on flow phantom and in an in vivo OCM model. The super-resolution ULM can provide doctors with conclusive suggestions for early diagnosis of OCM, which is significant for patient treatment and prognosis.
BIOENGINEERING-BASEL
(2023)
Article
Medicine, Research & Experimental
Xin Li, Shuang Zhao, Xiaohui Bian, Lining Zhang, Lixia Lu, Shiyao Pei, Liang Dong, Wensheng Shi, Lingjuan Huang, Xiyuan Zhang, Mingliang Chen, Xiang Chen, Mingzhu Yin
Summary: Our study investigates the changes in tumor microenvironment (TME) between primary and recurrent cutaneous squamous cell carcinoma (cSCC) using single-cell RNA sequencing (scRNA-seq). We identified an immunosuppressed microenvironment in recurrent cSCC, with T cell exclusion and enrichment of SPP1+ tumor-associated macrophages (TAMs). CD8+ T cells showed exhaustion and low inflammatory features, while SPP1+ TAMs displayed pro-tumor characteristics. Different subgroups of SPP1+ TAMs exhibited distinct functions. A subset of tumor-specific keratinocytes (TSKs) showed significant epithelial-mesenchymal transition (EMT) features, possibly due to their interaction with IL7R+ cancer-associated fibroblasts (CAFs). We also found that the growth factor/cytokine Midkine (MDK) played a role in different cell-cell interactions in cSCC with different staging.
Proceedings Paper
Neuroimaging
Jing Xu, Yuan Gao, Wei Liu, Kai Huang, Shuang Zhao, Le Lu, Xiaosong Wang, Xian-Sheng Hua, Yu Wang, Xiang Chen
Summary: Skin tumor is a common disease worldwide, and early identification is crucial for survival rate. However, the visual ambiguities in multi-modal imaging data pose challenges for accurate diagnosis. In this study, a cross-modality fusion module and a transformer-based deep classification framework were proposed to effectively fuse multi-source data for skin tumors. The experimental results demonstrated significant improvements in classification accuracy.
MEDICAL IMAGE COMPUTING AND COMPUTER ASSISTED INTERVENTION, MICCAI 2022, PT III
(2022)
Article
Immunology
Poyee Lau, Guanxiong Zhang, Shuang Zhao, Long Liang, Hailun Zhang, Guowei Zhou, Mien-Chie Hung, Xiang Chen, Hong Liu
Summary: This study reveals the important role of SPHK1 in tumor immunity and shows that its inhibition can suppress tumor growth and promote antitumor immunity. Additionally, SPHK1 and MTA3 are identified as biological markers for predicting the efficacy of anti-PD-1 mAb therapy in melanoma patients.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Wenbo Bu, Shuang Zhao, Qian Zhang, Fang Fang, Liu Yang
Summary: This study describes the clinical features of refractory hidradenitis suppurativa (HS) patients and evaluates the efficacy of combined treatment with modified excision and bidirectional photodynamic therapy (PDT). The results show that the combined treatment is effective in treating HS, with good efficacy and cosmetic outcomes.
LASERS IN MEDICAL SCIENCE
(2022)