Potent USP10/13 antagonist spautin‐1 suppresses melanoma growth via ROS‐mediated DNA damage and exhibits synergy with cisplatin

Cisplatin: The first metal based anticancer drug

(2019) Sumit Ghosh   BIOORGANIC CHEMISTRY

The methyl-triclosan induced caspase-dependent mitochondrial apoptosis in HepG2 cells mediated through oxidative stress

(2019) Xiaoqian Li et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models

(2018) Jia Liu et al.   Autophagy

Macrovipecetin, a C-type lectin from Macrovipera lebetina venom, inhibits proliferation migration and invasion of SK-MEL-28 human melanoma cells and enhances their sensitivity to cisplatin

(2018) Manel B. Hammouda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

PARP inhibitor veliparib and HDAC inhibitor SAHA synergistically co-target the UHRF1/BRCA1 DNA damage repair complex in prostate cancer cells

(2018) Linglong Yin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors

(2018) Shengzhe Zhang et al.   Nature Communications

The role of cellular reactive oxygen species in cancer chemotherapy

(2018) Haotian Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Vitexin compound 1, a novel extraction from a Chinese herb, suppresses melanoma cell growth through DNA damage by increasing ROS levels

(2018) Nian Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

ROS and the DNA damage response in cancer

(2018) Upadhyayula Sai Srinivas et al.   Redox Biology

Flavone protects HBE cells from DNA double-strand breaks caused by PM2.5

(2017) Xing Ren et al.   Human Cell

A review of redox signaling and the control of MAP kinase pathway in plants

(2017) Yukun Liu et al.   Redox Biology

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(2015) Shiyao Zhu et al.   ARCHIVES OF TOXICOLOGY

GADD45A inhibits autophagy by regulating the interaction between BECN1 and PIK3C3

(2015) Dongdong Zhang et al.   Autophagy

Reactive oxygen species in redox cancer therapy

(2015) Lingying Tong et al.   CANCER LETTERS

Strategy to enhance the anticancer efficacy of X-ray radiotherapy in melanoma cells by platinum complexes, the role of ROS-mediated signaling pathways

(2014) Qiang Xie et al.   CANCER LETTERS

What Is the Role of Chemotherapy in the Treatment of Melanoma?

(2014) Ahmed I. Megahed et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Cisplatin in cancer therapy: Molecular mechanisms of action

(2014) Shaloam Dasari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia

(2014) SHAN SHAO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Southwest Oncology Group S0008: A Phase III Trial of High-Dose Interferon Alfa-2b Versus Cisplatin, Vinblastine, and Dacarbazine, Plus Interleukin-2 and Interferon in Patients With High-Risk Melanoma—An Intergroup Study of Cancer and Leukemia Group B, Children's Oncology Group, Eastern Cooperative Oncology Group, and Southwest Oncology Group

(2014) Lawrence E. Flaherty et al.   JOURNAL OF CLINICAL ONCOLOGY

Systems biology of cisplatin resistance: past, present and future

(2014) L Galluzzi et al.   Cell Death & Disease

The number of excised lymph nodes is associated with survival of melanoma patients with lymph node metastasis

(2013) C. R. Rossi et al.   ANNALS OF ONCOLOGY

Deubiquitinating Enzymes as Therapeutic Targets in Cancer

(2013) Key-Hwan Lim et al.   CURRENT PHARMACEUTICAL DESIGN

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(2013) Alexander MM Eggermont et al.   LANCET

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations

(2012) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

Deubiquitinases in cancer: new functions and therapeutic options

(2011) J M Fraile et al.   ONCOGENE

Molecular mechanisms of cisplatin resistance

(2011) L Galluzzi et al.   ONCOGENE

Systematic Review of Medical Treatment in Melanoma: Current Status and Future Prospects

(2011) C. Garbe et al.   ONCOLOGIST

Estrogen receptor β causes a G2 cell cycle arrest by inhibiting CDK1 activity through the regulation of cyclin B1, GADD45A, and BTG2

(2010) Sreenivasan Paruthiyil et al.   BREAST CANCER RESEARCH AND TREATMENT

Biological Activity of 4-Substituted Methoxybenzoyl- Aryl-Thiazole: An Active Microtubule Inhibitor

(2010) C.-M. Li et al.   CANCER RESEARCH

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

USP10 Regulates p53 Localization and Stability by Deubiquitinating p53

(2010) Jian Yuan et al.   CELL

Ubiquitin: Same Molecule, Different Degradation Pathways

(2010) Michael J. Clague et al.   CELL

The role of deubiquitinating enzymes in chromatin regulation

(2010) Boyko S. Atanassov et al.   FEBS LETTERS

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

(2010) Cory M. Johannessen et al.   NATURE

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY