DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis

YAP and TAZ limit cytoskeletal and focal adhesion maturation to enable persistent cell motility

(2019) Devon E. Mason et al.   JOURNAL OF CELL BIOLOGY

DLC1 deficiency and YAP signaling drive endothelial cell contact inhibition of growth and tumorigenesis

(2019) Lisa Ritchey et al.   ONCOGENE

YAP/TAZ upstream signals and downstream responses

(2018) Antonio Totaro et al.   NATURE CELL BIOLOGY

Mechanotransduction in talin through the interaction of the R8 domain with DLC1

(2018) Alexander William M. Haining et al.   PLOS BIOLOGY

Control of endothelial cell polarity and sprouting angiogenesis by non-centrosomal microtubules

(2018) Maud Martin et al.   eLife

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

(2018) Filipa Neto et al.   eLife

Filopodia and focal adhesions: An integrated system driving branching morphogenesis in neuronal pathfinding and angiogenesis

(2018) Robert S. Fischer et al.   DEVELOPMENTAL BIOLOGY

Zebrafish mutants and TEAD reporters reveal essential functions for Yap and Taz in posterior cardinal vein development

(2018) Matteo Astone et al.   Scientific Reports

Stiffness-Induced Endothelial DLC-1 Expression Forces Leukocyte Spreading through Stabilization of the ICAM-1 Adhesome

(2018) Lilian Schimmel et al.   Cell Reports

Endothelial cell adaptation in regeneration

(2018) Jesus M. Gomez-Salinero et al.   SCIENCE

Novel insights into endothelial cell malignancies

(2018) Taekyu Ha et al.   Oncotarget

YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation

(2017) Jongshin Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of DLC1 Deficiency on Endothelial Cell Contact Growth Inhibition and Angiosarcoma Progression

(2017) David Sánchez-Martín et al.   JNCI-Journal of the National Cancer Institute

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hold Me, but Not Too Tight—Endothelial Cell–Cell Junctions in Angiogenesis

(2017) Anna Szymborska et al.   Cold Spring Harbor Perspectives in Biology

YAP regulates cell mechanics by controlling focal adhesion assembly

(2017) Giorgia Nardone et al.   Nature Communications

YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis

(2017) Chuwen Lin et al.   eLife

Effects of DLC1 Deficiency on Endothelial Cell Contact Growth Inhibition and Angiosarcoma Progression

(2017) David Sánchez-Martín et al.   JNCI-Journal of the National Cancer Institute

Cell–cell junctional mechanotransduction in endothelial remodeling

(2016) Yvonne L. Dorland et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cell behaviors and dynamics during angiogenesis

(2016) Charles Betz et al.   DEVELOPMENT

Endothelial basement membrane laminin 511 is essential for shear stress response

(2016) Jacopo Di Russo et al.   EMBO JOURNAL

Traction force dynamics predict gap formation in activated endothelium

(2016) Erik T. Valent et al.   EXPERIMENTAL CELL RESEARCH

Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

(2016) Sirio Dupont   EXPERIMENTAL CELL RESEARCH

Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension

(2016) Thomas Bertero et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

(2016) Li Wang et al.   NATURE

Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis

(2016) Kuei-Chun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex

(2016) Thomas Zacharchenko et al.   STRUCTURE

Between Rho(k) and a Hard Place: The Relation Between Vessel Wall Stiffness, Endothelial Contractility, and Cardiovascular Disease

(2015) S. Huveneers et al.   CIRCULATION RESEARCH

Endothelial cell spheroids as a versatile tool to study angiogenesis in vitro

(2015) Maximilian Heiss et al.   FASEB JOURNAL

The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling

(2015) Costanza Giampietro et al.   JOURNAL OF CELL BIOLOGY

The Hippo Pathway Effector YAP Regulates Motility, Invasion, and Castration-Resistant Growth of Prostate Cancer Cells

(2015) Lin Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2

(2015) Hyun-Jung Choi et al.   Nature Communications

Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression

(2015) Claudio A. Franco et al.   PLOS BIOLOGY

Model-based Traction Force Microscopy Reveals Differential Tension in Cellular Actin Bundles

(2015) Jérôme R. D. Soiné et al.   PLoS Computational Biology

F-Actin–Anchored Focal Adhesions Distinguish Endothelial Phenotypes of Human Arteries and Veins

(2014) Daphne van Geemen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Concerted modulation of paxillin dynamics at focal adhesions by deleted in liver cancer-1 and focal adhesion kinase during early cell spreading

(2014) Shelly Kaushik et al.   Cytoskeleton

Malignant vascular tumors—an update

(2014) Cristina Antonescu   MODERN PATHOLOGY

The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis

(2014) Katie Bentley et al.   NATURE CELL BIOLOGY

Rho GAPs and GEFs

(2014) Jaap D van Buul et al.   Cell Adhesion & Migration

GAP-independent functions of DLC1 in metastasis

(2013) David Barras et al.   CANCER AND METASTASIS REVIEWS

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Decoupling Polarization of the Golgi Apparatus and GM1 in the Plasma Membrane

(2013) Blaine Bisel et al.   PLoS One

PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis

(2013) Frankie Chi Fat Ko et al.   Nature Communications

Quantitative mapping of averaged focal adhesion dynamics in migrating cells by shape normalization

(2012) C. Mohl et al.   JOURNAL OF CELL SCIENCE

DLC1 Interaction with  -Catenin Stabilizes Adherens Junctions and Enhances DLC1 Antioncogenic Activity

(2012) V. Tripathi et al.   MOLECULAR AND CELLULAR BIOLOGY

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Silencing of DLC1 Upregulates PAI-1 Expression and Reduces Migration in Normal Prostate Cells

(2011) Y.-P. Shih et al.   MOLECULAR CANCER RESEARCH

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo

(2011) Kristen L. Meerbrey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)

(2011) G. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical regulation of vascular growth and tissue regeneration in vivo

(2011) J. D. Boerckel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration

(2010) Margaret L. Gardel et al.   Annual Review of Cell and Developmental Biology

Dynamics of endothelial cell behavior in sprouting angiogenesis

(2010) Hanna M Eilken et al.   CURRENT OPINION IN CELL BIOLOGY

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration

(2010) Y Lin et al.   ONCOGENE

Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility

(2009) T. Y. Kim et al.   CANCER AND METASTASIS REVIEWS

Simultaneous loss of the DLC1 and PTEN tumor suppressors enhances breast cancer cell migration

(2009) Johanna Heering et al.   EXPERIMENTAL CELL RESEARCH

Focal adhesion-localization of START-GAP1/DLC1 is essential for cell motility and morphology

(2009) Katsuhisa Kawai et al.   GENES TO CELLS

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deleted in liver cancer-1 (DLC-1): A tumor suppressor not just for liver

(2007) Yi-Chun Liao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

(2007) Kevin D. Healy et al.   MOLECULAR CARCINOGENESIS