Differential turnover of Nup188 controls its levels at centrosomes and role in centriole duplication

PCNT is critical for the association and conversion of centrioles to centrosomes during mitosis

(2019) Jaeyoun Kim et al.   JOURNAL OF CELL SCIENCE

Biallelic Variants in the Nuclear Pore Complex Protein NUP93 Are Associated with Non-progressive Congenital Ataxia

(2019) Ginevra Zanni et al.   CEREBELLUM

Structure and Assembly of the Nuclear Pore Complex

(2019) Bernhard Hampoelz et al.   Annual Review of Biophysics

Phase Separation and the Centrosome: A Fait Accompli?

(2019) Jordan W. Raff   TRENDS IN CELL BIOLOGY

PLK4 promotes centriole duplication by phosphorylating STIL to link the procentriole cartwheel to the microtubule wall

(2019) Tyler Chistopher Moyer et al.   eLife

Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites

(2018) Takuya Yoshizawa et al.   CELL

Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation

(2018) Mario Hofweber et al.   CELL

NUP98 Sets the Size-Exclusion Diffusion Limit through the Ciliary Base

(2018) S. Joseph Endicott et al.   CURRENT BIOLOGY

FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration

(2018) Ella Fung et al.   EMBO REPORTS

Robust identification of mosaic variants in congenital heart disease

(2018) Kathryn B. Manheimer et al.   HUMAN GENETICS

Once and only once: mechanisms of centriole duplication and their deregulation in disease

(2018) Erich A. Nigg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number

(2018) Christian Arquint et al.   Open Biology

Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import

(2018) Veronica Rodriguez-Bravo et al.   CELL

Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome

(2018) Daniela A. Braun et al.   JOURNAL OF CLINICAL INVESTIGATION

PPP1R35 ensures centriole homeostasis by promoting centriole to centrosome conversion

(2018) Chii Shyang Fong et al.   MOLECULAR BIOLOGY OF THE CELL

Integrative structure and functional anatomy of a nuclear pore complex

(2018) Seung Joong Kim et al.   NATURE

A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies

(2017) Li-En Jao et al.   MOLECULAR BIOLOGY OF THE CELL

Mitotic spindle assembly in animal cells: a fine balancing act

(2017) Suzanna L. Prosser et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The eukaryotic linear motif resource – 2018 update

(2017) Marc Gouw et al.   NUCLEIC ACIDS RESEARCH

The roles of the nuclear pore complex in cellular dysfunction, aging and disease

(2017) Stephen Sakuma et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation

(2017) Nikola S. Dzhindzhev et al.   Open Biology

Nucleoplasmic Nup98 controls gene expression by regulating a DExH/D-box protein

(2017) Juliana S. Capitanio et al.   Nucleus

Nucleoplasmic Nup98 controls gene expression by regulating a DExH/D-box protein

(2017) Juliana S. Capitanio et al.   Nucleus

The PLK4–STIL–SAS-6 module at the core of centriole duplication

(2016) Christian Arquint et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nup62, associated with spindle microtubule rather than spindle matrix, is involved in chromosome alignment and spindle assembly during mitosis

(2016) Zhige Wu et al.   CELL BIOLOGY INTERNATIONAL

Regulation of centriolar satellite integrity and its physiology

(2016) Akiko Hori et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Congenital Heart Disease Genetics Uncovers Context-Dependent Organization and Function of Nucleoporins at Cilia

(2016) Florencia del Viso et al.   DEVELOPMENTAL CELL

The Multiple Faces of Disordered Nucleoporins

(2016) Edward A. Lemke   JOURNAL OF MOLECULAR BIOLOGY

Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome

(2016) Daniela A Braun et al.   NATURE GENETICS

Molecular architecture of the inner ring scaffold of the human nuclear pore complex

(2016) J. Kosinski et al.   SCIENCE

Transport Selectivity of Nuclear Pores, Phase Separation, and Membraneless Organelles

(2016) H. Broder Schmidt et al.   TRENDS IN BIOCHEMICAL SCIENCES

Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome

(2015) Noriko Miyake et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface

(2015) Gagan D. Gupta et al.   CELL

The NIMA-like kinase Nek2 is a key switch balancing cilia biogenesis and resorption in the development of left-right asymmetry

(2015) S. J. Endicott et al.   DEVELOPMENT

Binding of STIL to Plk4 activates kinase activity to promote centriole assembly

(2015) Tyler C. Moyer et al.   JOURNAL OF CELL BIOLOGY

The E3 ubiquitin ligase Mib1 regulates Plk4 and centriole biogenesis

(2015) L.  ajanek et al.   JOURNAL OF CELL SCIENCE

Nup2 requires a highly divergent partner, NupA, to fulfill functions at nuclear pore complexes and the mitotic chromatin region

(2015) Sarine Markossian et al.   MOLECULAR BIOLOGY OF THE CELL

In situ structural analysis of the human nuclear pore complex

(2015) Alexander von Appen et al.   NATURE

Conserved molecular interactions in centriole-to-centrosome conversion

(2015) Jingyan Fu et al.   NATURE CELL BIOLOGY

Linker Nups connect the nuclear pore complex inner ring with the outer ring and transport channel

(2015) Jessica Fischer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Architecture of the fungal nuclear pore inner ring complex

(2015) T. Stuwe et al.   SCIENCE

Linker Nups connect the nuclear pore complex inner ring with the outer ring and transport channel

(2015) Jessica Fischer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Plk4-dependent phosphorylation of STIL is required for centriole duplication

(2015) A.-S. Kratz et al.   Biology Open

The diverse roles of the Nup93/Nic96 complex proteins – structural scaffolds of the nuclear pore complex with additional cellular functions

(2014) Benjamin Vollmer et al.   BIOLOGICAL CHEMISTRY

Nuclear Pores Protect Genome Integrity by Assembling a Premitotic and Mad1-Dependent Anaphase Inhibitor

(2014) Veronica Rodriguez-Bravo et al.   CELL

Centriolar satellites: key mediators of centrosome functions

(2014) Maxim A. X. Tollenaere et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

RanBP1 Governs Spindle Assembly by Defining Mitotic Ran-GTP Production

(2014) Michael Shaofei Zhang et al.   DEVELOPMENTAL CELL

Deleterious mutations in the essential mRNA metabolism factor, hGle1, in amyotrophic lateral sclerosis

(2014) Hannah M. Kaneb et al.   HUMAN MOLECULAR GENETICS

The Cep192-Organized Aurora A-Plk1 Cascade Is Essential for Centrosome Cycle and Bipolar Spindle Assembly

(2014) Vladimir Joukov et al.   MOLECULAR CELL

Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis

(2014) Suk-Youl Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pericentriolar material structure and dynamics

(2014) J. B. Woodruff et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Cep192 Controls the Balance of Centrosome and Non-Centrosomal Microtubules during Interphase

(2014) Brian P. O’Rourke et al.   PLoS One

Evidence for an evolutionary relationship between the large adaptor nucleoporin Nup192 and karyopherins

(2014) T. Stuwe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APC/C is an essential regulator of centrosome clustering

(2014) Konstantinos Drosopoulos et al.   Nature Communications

Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole

(2014) Midori Ohta et al.   Nature Communications

Stabilization of Cartwheel-less Centrioles for Duplication Requires CEP295-Mediated Centriole-to-Centrosome Conversion

(2014) Denisse Izquierdo et al.   Cell Reports

The nucleoporin Nup153 affects spindle checkpoint activity due to an association with Mad1

(2014) Yvonne C. Lussi et al.   Nucleus

Nucleoporin Nup188 is required for chromosome alignment in mitosis

(2013) Go Itoh et al.   CANCER SCIENCE

Integrated Structural Analysis of the Human Nuclear Pore Complex Scaffold

(2013) Khanh Huy Bui et al.   CELL

Nucleoporin Nup62 maintains centrosome homeostasis

(2013) Chieko Hashizume et al.   CELL CYCLE

Selective Chemical Crosslinking Reveals a Cep57-Cep63-Cep152 Centrosomal Complex

(2013) Gražvydas Lukinavičius et al.   CURRENT BIOLOGY

Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis

(2013) Nina Schweizer et al.   JOURNAL OF CELL BIOLOGY

An in vitro assay for entry into cilia reveals unique properties of the soluble diffusion barrier

(2013) David K. Breslow et al.   JOURNAL OF CELL BIOLOGY

Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication

(2013) K. F. Sonnen et al.   JOURNAL OF CELL SCIENCE

Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152

(2013) T.-S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure, Dynamics, Evolution, and Function of a Major Scaffold Component in the Nuclear Pore Complex

(2013) Parthasarathy Sampathkumar et al.   STRUCTURE

Dynamic Association of NUP98 with the Human Genome

(2013) Yun Liang et al.   PLoS Genetics

Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors

(2013) Kasper R Andersen et al.   eLife

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

(2012) Kyle J. Roux et al.   JOURNAL OF CELL BIOLOGY

Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification

(2012) Suzanna L. Prosser et al.   JOURNAL OF CELL SCIENCE

Dissection of the NUP107 nuclear pore subcomplex reveals a novel interaction with spindle assembly checkpoint protein MAD1 in Caenorhabditis elegans

(2012) Eduardo Ródenas et al.   MOLECULAR BIOLOGY OF THE CELL

Subdiffraction-resolution fluorescence microscopy reveals a domain of the centrosome critical for pericentriolar material organization

(2012) V. Mennella et al.   NATURE CELL BIOLOGY

Subdiffraction imaging of centrosomes reveals higher-order organizational features of pericentriolar material

(2012) Steffen Lawo et al.   NATURE CELL BIOLOGY

A size-exclusion permeability barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia

(2012) Hooi Lynn Kee et al.   NATURE CELL BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Towards a molecular architecture of centriole assembly

(2012) Pierre Gönczy   NATURE REVIEWS MOLECULAR CELL BIOLOGY

3D-structured illumination microscopy provides novel insight into architecture of human centrosomes

(2012) Katharina F. Sonnen et al.   Biology Open

Insight into Structure and Assembly of the Nuclear Pore Complex by Utilizing the Genome of a Eukaryotic Thermophile

(2011) Stefan Amlacher et al.   CELL

The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation

(2011) Chieh-Ju C Tang et al.   EMBO JOURNAL

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods

(2011) Lis Jakobsen et al.   EMBO JOURNAL

PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis

(2011) Kwanwoo Lee et al.   JOURNAL OF CELL BIOLOGY

Analysis of the yeast nucleoporin Nup188 reveals a conserved S-like structure with similarity to karyopherins

(2011) Dirk Flemming et al.   JOURNAL OF STRUCTURAL BIOLOGY

Nup98 regulates bipolar spindle assembly through association with microtubules and opposition of MCAK

(2011) Marie K. Cross et al.   MOLECULAR BIOLOGY OF THE CELL

The SCF–FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication

(2011) Anja Puklowski et al.   NATURE CELL BIOLOGY

A primary microcephaly protein complex forms a ring around parental centrioles

(2011) Joo-Hee Sir et al.   NATURE GENETICS

Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterning

(2011) K. A. Fakhro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin-Bound Nuclear Pore Components Regulate Gene Expression in Higher Eukaryotes

(2010) Maya Capelson et al.   CELL

Nucleoporins Directly Stimulate Expression of Developmental and Cell-Cycle Genes Inside the Nucleoplasm

(2010) Bernike Kalverda et al.   CELL

Nuclear transport and the mitotic apparatus: an evolving relationship

(2010) Richard Wozniak et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Building the Centriole

(2010) Juliette Azimzadeh et al.   CURRENT BIOLOGY

Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome

(2010) Onur Cizmecioglu et al.   JOURNAL OF CELL BIOLOGY

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability

(2010) Andrew J. Holland et al.   JOURNAL OF CELL BIOLOGY

The nucleoporin Nup188 controls passage of membrane proteins across the nuclear pore complex

(2010) Gandhi Theerthagiri et al.   JOURNAL OF CELL BIOLOGY

DrosophilaAna2 is a conserved centriole duplication factor

(2010) Naomi R. Stevens et al.   JOURNAL OF CELL BIOLOGY

Cep152 interacts with Plk4 and is required for centriole duplication

(2010) Emily M. Hatch et al.   JOURNAL OF CELL BIOLOGY

Gene Regulation by Nucleoporins and Links to Cancer

(2010) Alwin Köhler et al.   MOLECULAR CELL

SCFCyclin F controls centrosome homeostasis and mitotic fidelity through CP110 degradation

(2010) Vincenzo D’Angiolella et al.   NATURE

The Nup107-160 complex and γ-TuRC regulate microtubule polymerization at kinetochores

(2010) Ram Kumar Mishra et al.   NATURE CELL BIOLOGY

The Nuclear Pore Complex and Nuclear Transport

(2010) S. R. Wente et al.   Cold Spring Harbor Perspectives in Biology

Nuclear Pore Proteins Nup153 and Megator Define Transcriptionally Active Regions in the Drosophila Genome

(2010) Juan M. Vaquerizas et al.   PLoS Genetics

Disorders of left-right asymmetry: Heterotaxy and situs inversus

(2009) Mardi J. Sutherland et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Plk1-Dependent Recruitment of γ-Tubulin Complexes to Mitotic Centrosomes Involves Multiple PCM Components

(2009) Laurence Haren et al.   PLoS One

Centriole maturation and transformation to basal body

(2009) Sigrid Hoyer-Fender   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Mammalian SPD-2 Ortholog Cep192 Regulates Centrosome Biogenesis

(2008) Fei Zhu et al.   CURRENT BIOLOGY

The SCF/Slimb Ubiquitin Ligase Limits Centrosome Amplification through Degradation of SAK/PLK4

(2008) Inês Cunha-Ferreira et al.   CURRENT BIOLOGY

Nucleoporin Levels Regulate Cell Cycle Progression and Phase-Specific Gene Expression

(2008) Papia Chakraborty et al.   DEVELOPMENTAL CELL

Spatial and temporal coordination of mitosis by Ran GTPase

(2008) Paul R. Clarke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY