Article
Allergy
Maria Sokolova, Georg Schett, Ulrike Steffen
Summary: Autoantibodies such as rheumatoid factor (RF) and antibodies against citrullinated proteins (ACPA) are key markers of rheumatoid arthritis (RA) and can impact disease course and progression. The identification of new autoantibodies and advancements in diagnostic techniques have led to a decrease in the seronegative patient population. Autoantibodies not only play a role in the pathogenesis of RA but also directly influence disease progression and radiographic outcomes.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2022)
Article
Rheumatology
Maria Sokolova, Melanie Hagen, Holger Bang, Georg Schett, Juergen Rech, Ulrike Steffen
Summary: This study suggests that IgA ACPA, combined with IgG ACPA, is a risk factor for flare in RA. In patients who remain in remission, levels of IgA2 ACPA and the proportion of IgA2 in ACPA significantly decline, and this is associated with flare severity.
Review
Cell Biology
Odilia B. J. Corneth, Stefan F. H. Neys, Rudi W. Hendriks
Summary: This review discusses the importance of abnormal B cell signaling in autoimmune diseases, focusing on aberrant B cell receptor (BCR) signaling and other signal transduction pathways. Therapeutic strategies for interfering with B cell signal transduction are also briefly discussed.
Review
Biochemistry & Molecular Biology
Tsvetelina Batsalova, Balik Dzhambazov
Summary: Collagen type II (COL2) is significantly affected by autoimmune responses in rheumatoid arthritis (RA), and posttranslational modifications (PTMs) of COL2 have been implicated in RA autoimmunity. The discovery of anti-citrullinated protein response in RA has led to improved diagnostic assays and classification criteria for the disease. Immunological tolerance induced by modified COL2 peptides is considered as a potential strategy for RA therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Zhen-Yi Long, Yi-Feng Zhou, Hao Yuan, Ya-Meng Peng, Si-Xian Wu, Fang Peng
Summary: The study revealed that the levels of IgG4 and IL-21 in the serum increased with disease progression in collagen-induced arthritis (CIA) rats, and the expression of IgG4 and IL-21 receptors in the ankle joint was significantly higher in the CIA model group. These proteins were closely related to the pathological score, indicating that IL-21 may promote rheumatoid arthritis development by regulating IgG4 content.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Immunology
Masanori A. Murayama, Jun Shimizu, Chie Miyabe, Kazuo Yudo, Yoshishige Miyabe
Summary: Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and bone destruction in multiple joints. Inflammatory cytokines, such as IL-6 and TNF-alpha, play crucial roles in RA development. Biological therapies targeting these cytokines have revolutionized RA treatment, but non-responsiveness is still a challenge. This review focuses on the pathogenic roles of chemokines and their receptors in RA and discusses their potential as therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
G. Halpert, I. Katz, O. Shovman, S. Tarasov, K. K. Ganina, N. Petrova, M. Tocut, A. Volkov, I. Barshack, M. Blank, H. Amital
Summary: Treatment with IVIG significantly reduced clinical arthritis score in DBA/1j mice with collagen-induced arthritis. IVIG showed a mode of action by decreasing circulating levels of inflammatory cytokines and inhibiting anti-collagen antibodies. Histopathological examination revealed that IVIG treatment prevented inflammatory immune cells from migrating into cartilage and synovium, reducing joint damage and preserving joint architecture. These results suggest the valuable anti-inflammatory treatment of IVIG in experimental RA.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiang Gao, Qingyun Wu, Xinle Zhang, Jia Tian, Dahong Liang, Yalin Min, Jiaqi Lu, Xuemei Zhang, Liao Cui, Bilian Xu, Yanzhi Liu
Summary: This study investigated the potential of salvianolate treatment in ameliorating osteopenia in prednisone-treated RA rats. The results showed that Salvianolate significantly improved bone density and bone quality.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Kayo Masuko
Summary: Glucose metabolism may be altered in rheumatoid arthritis and other autoimmune diseases, impacting the pathophysiology of these diseases. Research on glucose and its metabolism contributes to a better understanding of the role of carbohydrates in the occurrence and duration of these diseases.
Article
Plant Sciences
Jun Takeuchi, Kosuke Fukui, Yoshiya Seto, Yousuke Takaoka, Masanori Okamoto
Summary: Small-molecule plant hormones play a crucial role in controlling plant growth, development, differentiation, and environmental responses. Through genomic decoding of model plants with genetic mutants, scientists have elucidated the molecular mechanisms of nine types of plant hormones and identified the structure of hormone receptors. Studies on the three-dimensional structure of ligand-receptor complexes have revealed the details of ligand perception mechanisms.
Article
Pharmacology & Pharmacy
Kai Qian, Xue-Xia Zheng, Chen Wang, Wen-Guang Huang, Xiao-Bao Liu, Shu-Di Xu, Dan-Kai Liu, Min-Ying Liu, Chang-Song Lin
Summary: The study found that beta-sitosterol (BSS) has potential as a treatment for rheumatoid arthritis (RA) by suppressing the proliferation and migration of endothelial cells, thereby alleviating joint swelling and bone destruction. BSS also prevents synovial angiogenesis by inhibiting VEGFR2 and p-VEGFR2 expression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Rheumatology
Achilleas Floudas, Conor M. Smith, Orla Tynan, Nuno Neto, Vinod Krishna, Sarah M. Wade, Megan Hanlon, Clare Cunningham, Viviana Marzaioli, Mary Canavan, Jean M. Fletcher, Ronan H. Mullan, Suzanne Cole, Ling-Yang Hao, Michael G. Monaghan, Sunil Nagpal, Douglas J. Veale, Ursula Fearon
Summary: This study provides a global transcriptomic analysis of the synovial joints in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), revealing the immune-stromal cell interactions in synovial inflammation. The findings highlight the differential transcription profiles and interactions between cell subsets in RA and PsA, suggesting potential targets for targeted therapeutic intervention in these diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Dzhemal Moten, Ivanka Teneva, Desislava Apostolova, Tsvetelina Batsalova, Balik Dzhambazov
Summary: This study investigated the pathogenesis of rheumatoid arthritis (RA) by exploring the molecular mimicry mechanism. It found that the bacterial peptide L-ASNase67-81 can mimic the immunodominant T-cell epitope CII259-273, activate specific T cells, and induce cytokine production in cells from RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Thi Kim Chung Le, Xuan Dat Dao, Dang Vung Nguyen, Duc Huy Luu, Thi Minh Hanh Bui, Thi Huong Le, Huu Thang Nguyen, Tran Ngoan Le, Toshio Hosaka, Thi Thu Thao Nguyen
Summary: The discovery of insulin in 1921 sparked research on insulin activity and insulin resistance. This mini-review synthesizes updated discoveries in this field to uncover related mechanisms and inform the development of novel applications.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Takashi Nawata, Hiroki Sakai, Takeshi Honda, Marina Otsuka, Hina Fujita, Hitoshi Uchinoumi, Shigeki Kobayashi, Takeshi Yamamoto, Masataka Asagiri, Masafumi Yano
Summary: Dantrolene inhibits Ca2+ leakage from destabilized ryanodine receptors and shows potential as a therapeutic agent against endoplasmic reticulum stress-associated diseases. In a mouse model of collagen-induced arthritis, oral administration of dantrolene significantly reduces arthritic scores, suppresses bone and chondral destruction, and inhibits the production of serum anti-type II collagen IgG. These findings suggest that dantrolene may be a potential anti-rheumatic drug.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Immunology
Damian Maseda, Elizabeth M. Johnson, Lindsay E. Nyhoff, Bridgette Baron, Fumiaki Kojima, Ashley J. Wilhelm, Martin R. Ward, Jerold G. Woodward, David D. Brand, Leslie J. Crofford
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Jeoung-Eun Park, Sirshendu Majumdar, David D. Brand, Edward F. Rosloniec, Ae-Kyung Yi, John M. Stuart, Andrew H. Kang, Linda K. Myers
CLINICAL IMMUNOLOGY
(2018)
Review
Immunology
Sujuan Yang, Julie Wang, David Douglass Brand, Song Guo Zheng
FRONTIERS IN IMMUNOLOGY
(2018)
Review
Medicine, General & Internal
Zhiyi Huang, Yu Liu, Guangying Qi, David Brand, Song Guo Zheng
JOURNAL OF CLINICAL MEDICINE
(2018)
Article
Oncology
Weidong Pan, Wen Li, Jun Zhao, Zhiyi Huang, Jingyuan Zhao, Shuxian Chen, Chusi Wang, Youqiu Xue, Feng Huang, Qiannan Fang, Julie Wang, David Brand, Song Guo Zheng
MOLECULAR ONCOLOGY
(2019)
Article
Multidisciplinary Sciences
Tae Won Yoon, Young-In Kim, Hongsik Cho, David D. Brand, Edward F. Rosloniec, Linda K. Myers, Arnold E. Postlethwaite, Karen A. Hasty, John M. Stuart, Ae-Kyung Yi
Article
Multidisciplinary Sciences
Anastasios Karydis, Indra Sandal, Jiwen Luo, Amanda Prislovsky, Amanda Gamboa, Edward F. Rosloniec, David D. Brand
Summary: The study found that carrying the shared epitope and inoculation with Porphyromonas gingivalis increased the percentage of Th17 cells, significantly increased bone loss, and allowed for the generation of CCP2 ACPAs not found in C57BL/6 or DBA/1 arthritic mouse serum.
Article
Immunology
Arnold E. Postlethwaite, Robert C. Tuckey, Tae-Kang Kim, Wei Li, Syamal K. Bhattacharya, Linda K. Myers, David D. Brand, Andrzej T. Slominski
Summary: 20S(OH)D3 significantly suppresses clinical signs and joint damage in a mouse model of rheumatoid arthritis by reducing lymphocyte subsets, inflammatory cytokines, and critical complement-fixing antibodies against type II collagen. These results provide a basis for further consideration of 20S(OH)D3 as a potential treatment for RA and other autoimmune disorders.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Linda K. Myers, Michael Winstead, John D. Kee, Jeoungeun J. Park, Sicheng Zhang, Wei Li, Ae-Kyung Yi, John M. Stuart, Edward F. Rosloniec, David D. Brand, Robert C. Tuckey, Andrzej T. Slominski, Arnold E. Postlethwaite, Andrew H. Kang
Summary: Vitamin D plays a role in regulating inflammation, with the non-calcemic form 20S(OH)D3 showing promise as a potential therapeutic agent for autoimmune diseases like Rheumatoid Arthritis. These effects on inflammation are at least partly mediated by the natural inhibitory receptor LAIR-1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Fazal-Ur-Rehman Bhatti, Yong-Hoon Jeong, Do-Gyoon Kim, Ae-Kyung Yi, David D. Brand, Karen A. Hasty, Hongsik Cho
Summary: The pathophysiology of post-traumatic arthritis (PTOA) was investigated using mouse models. The study found significant biochemical, biomechanical, and pain-related behavioral changes in loaded knee joints compared to non-loaded control joints. These findings provide important insights for studying PTOA.
Article
Oncology
An-Ping Yang, Leyna G. Liu, Min-Min Chen, Fang Liu, Hua You, Lian Liu, Hua Yang, Yang Xun, Jing Liu, Rui-Xue Wang, David D. Brand, Dahai Liu, Song Guo Zheng, Wen-Xing Li
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2019)
Review
Biochemistry & Molecular Biology
Congxiu Ye, David Brand, Song G. Zheng
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2018)
Letter
Immunology
Weiqian Chen, Zhenjian Xu, Yongjiang Zheng, Julie Wang, Wenbin Qian, Nancy Olsen, David Brand, Jin Lin, Song Guo Zheng
CELLULAR & MOLECULAR IMMUNOLOGY
(2017)
Article
Engineering, Biomedical
Narjes Rashidi, Maryam Tamaddon, Chaozong Liu, David D. Brand, Jan Czernuszka
Summary: The study developed a bilayer scaffold that improves production precision through a biomimetic bottom-up approach and guides tissue-specific responses in mesenchymal stem cells, showing great potential as a treatment for osteochondral injuries.
ADVANCED NANOBIOMED RESEARCH
(2022)