Cdk5 Inhibitory Peptide Prevents Loss of Neurons and Alleviates Behavioral Changes in p25 Transgenic Mice

AAV9-Mediated Cdk5 Inhibitory Peptide Reduces Hyperphosphorylated Tau and Inflammation and Ameliorates Behavioral Changes Caused by Overexpression of p25 in the Brain

(2019) Miaojing Xu et al.   JOURNAL OF ALZHEIMERS DISEASE

Current Status on Clinical Development of Adeno-Associated Virus-Mediated Liver-Directed Gene Therapy for Inborn Errors of Metabolism

(2019) Virginia Maria Ginocchio et al.   HUMAN GENE THERAPY

Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1

(2019) Shilpa Prabhakar et al.   Molecular Therapy-Methods & Clinical Development

Gene therapy comes of age

(2018) Cynthia E. Dunbar et al.   SCIENCE

Cdk5 Inhibitory Peptide Prevents Loss of Dopaminergic Neurons and Alleviates Behavioral Changes in an MPTP Induced Parkinson’s Disease Mouse Model

(2018) Rongni He et al.   Frontiers in Aging Neuroscience

Adeno-associated virus 9–mediated Cdk5 inhibitory peptide reverses pathologic changes and behavioral deficits in the Alzheimer’s disease mouse model

(2017) Yong He et al.   FASEB JOURNAL

Cold Inducible RNA Binding Protein Is Involved in Chronic Hypoxia Induced Neuron Apoptosis by Down-Regulating HIF-1α Expression and Regulated By microRNA-23a

(2017) Xiaoming Chen et al.   International Journal of Biological Sciences

TFP5, a Peptide Inhibitor of Aberrant and Hyperactive Cdk5/p25, Attenuates Pathological Phenotypes and Restores Synaptic Function in CK-p25Tg Mice

(2017) Varsha Shukla et al.   JOURNAL OF ALZHEIMERS DISEASE

Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy

(2017) Jerry R. Mendell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant

(2017) Lindsey A. George et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neurodegeneration-Like Pathological and Behavioral Changes in an AAV9-Mediated p25 Overexpression Mouse Model

(2016) Xiao Zhou et al.   JOURNAL OF ALZHEIMERS DISEASE

Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial

(2016) Jean Bennett et al.   LANCET

The interaction of Munc 18 (p67) with the p10 domain of p35 protects in vivo Cdk5/p35 activity from inhibition by TFP5, a peptide derived from p35

(2016) Niranjana D. Amin et al.   MOLECULAR BIOLOGY OF THE CELL

Adeno-associated viral vectors for the treatment of hemophilia

(2015) Katherine A. High et al.   HUMAN MOLECULAR GENETICS

Alzheimer’s Disease: Mechanism and Approach to Cell Therapy

(2015) Takashi Amemori et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Peptide TFP5/TP5 derived from Cdk5 activator P35 provides neuroprotection in the MPTP model of Parkinson’s disease

(2015) BK. Binukumar et al.   MOLECULAR BIOLOGY OF THE CELL

CDK5 activator protein p25 preferentially binds and activates GSK3β

(2014) Hei-Man Chow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific Inhibition of p25/Cdk5 Activity by the Cdk5 Inhibitory Peptide Reduces Neurodegeneration In Vivo

(2013) J. R. Sundaram et al.   JOURNAL OF NEUROSCIENCE

A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice

(2012) Varsha Shukla et al.   FASEB JOURNAL

Cdk5/p25-Induced Cytosolic PLA2-Mediated Lysophosphatidylcholine Production Regulates Neuroinflammation and Triggers Neurodegeneration

(2012) J. R. Sundaram et al.   JOURNAL OF NEUROSCIENCE

AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial

(2011) Peter A LeWitt et al.   LANCET NEUROLOGY

Cdk5: Multitasking between physiological and pathological conditions

(2011) Joao P. Lopes et al.   PROGRESS IN NEUROBIOLOGY

Cdk5, the multifunctional surveyor

(2010) Vassiliki Lalioti et al.   CELL CYCLE

A 24-Residue Peptide (p5), Derived from p35, the Cdk5 Neuronal Activator, Specifically Inhibits Cdk5-p25 Hyperactivity and Tau Hyperphosphorylation

(2010) Ya-Li Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Dynamic Determinants of Ligand Binding and Regulation of Cyclin-Dependent Kinase 5 by Pathological Activator p25 and Inhibitory Peptide CIP

(2010) A. Cardone et al.   JOURNAL OF MOLECULAR BIOLOGY

O4-01-08: Neurodegeneration and neuroinflammation in cdk5/p25 inducible mice: A model for hippocampal sclerosis and neocortical degeneration

(2008) David Muyllaert et al.   Alzheimers & Dementia