Base‐Assisted C−H Bond Cleavage in Cross‐Coupling: Recent Insights into Mechanism, Speciation, and Cooperativity

C–H Acidity and Arene Nucleophilicity as Orthogonal Control of Chemoselectivity in Dual C–H Bond Activation

(2019) Ji-Ren Liu et al.   ORGANIC LETTERS

Cooperative Au/Ag Dual-Catalyzed Cross-Dehydrogenative Biaryl Coupling: Reaction Development and Mechanistic Insight

(2019) Weipeng Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Importance of Kinetic and Thermodynamic Control when Assessing Mechanisms of Carboxylate-Assisted C–H Activation

(2019) Raed A. Alharis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evaluation of the Agostic and Syndetic Donations in Aromatic Ring Agostic Interactions Involved in Heteroatom Ligand-Directed C–H Bond Activation

(2019) John A. Harrison et al.   ORGANOMETALLICS

Operando Spectroscopic and Kinetic Characterization of Aerobic Allylic C–H Acetoxylation Catalyzed by Pd(OAc)2/4,5-Diazafluoren-9-one

(2019) Jonathan N. Jaworski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oligothiophene Synthesis by a General C–H Activation Mechanism: Electrophilic Concerted Metalation–Deprotonation (eCMD)

(2019) Long Wang et al.   ACS Catalysis

Di-Palladium Complexes are Active Catalysts for Mono-N-Protected Amino Acid-Accelerated Enantioselective C–H Functionalization

(2019) Joseph J. Gair et al.   ACS Catalysis

Steric Effect of Carboxylate Ligands on Pd-Catalyzed Intramolecular C(sp2 )-H and C(sp3 )-H Arylation Reactions

(2018) Yutaka Tanji et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Understanding Thermal and Photochemical Aryl-Aryl Cross-Coupling by the Au(I)-AuIII) Redox Couple

(2018) Rameswar Bhattacharjee et al.   CHEMISTRY-A EUROPEAN JOURNAL

Palladium Acetate Revisited: Unusual Ring-Current Effects, One-Electron Reduction, and Metal–Metal Bonding

(2018) Ryan J. Pakula et al.   INORGANIC CHEMISTRY

Multiple roles of silver salts in palladium-catalyzed C–H activations

(2018) Katherine L. Bay et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Ag(I)-C–H Activation Enables Near-Room Temperature Direct α-Arylation of Benzo[b]thiophenes

(2018) Chiara Colletto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-Enabled β-C(sp3)–H Olefination of Free Carboxylic Acids

(2018) Zhe Zhuang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Study of Direct Arylation of Indole Using Differential Selectivity Measurements: Shedding Light on the Active Species and Revealing the Key Role of Electrophilic Substitution in the Catalytic Cycle

(2018) Anna A. Kurokhtina et al.   ORGANOMETALLICS

Palladium-Catalyzed γ-C(sp3 )−H Arylation of Thiols by a Detachable Protecting/Directing Group

(2018) Likun Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design of catalysts for site-selective and enantioselective functionalization of non-activated primary C–H bonds

(2018) Kuangbiao Liao et al.   Nature Chemistry

3d Transition Metals for C–H Activation

(2018) Parthasarathy Gandeepan et al.   CHEMICAL REVIEWS

NBO Orbital Interaction Analysis for the Ambiphilic Metal–Ligand Activation/Concerted Metalation Deprotonation (AMLA/CMD) Mechanism Involved in the Cyclopalladation Reaction of N,N-Dimethylbenzylamine with Palladium Acetate

(2018) M. Arif Sajjad et al.   ORGANOMETALLICS

Pd-Catalyzed Aerobic Oxidative Biaryl Coupling: Non-Redox Cocatalysis by Cu(OTf)2 and Discovery of Fe(OTf)3 as a Highly Effective Cocatalyst

(2017) Dian Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Base-Catalyzed Aryl-B(OH)2 Protodeboronation Revisited: From Concerted Proton Transfer to Liberation of a Transient Aryl Anion

(2017) Paul A. Cox et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

C–H Alkenylation of Heteroarenes: Mechanism, Rate, and Selectivity Changes Enabled by Thioether Ligands

(2017) Bradley J. Gorsline et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-selective and stereoselective functionalization of non-activated tertiary C–H bonds

(2017) Kuangbiao Liao et al.   NATURE

Ligand-accelerated non-directed C–H functionalization of arenes

(2017) Peng Wang et al.   NATURE

Mono-N-protected amino acid ligands stabilize dimeric palladium(ii) complexes of importance to C–H functionalization

(2017) Joseph J. Gair et al.   Chemical Science

Bimetallic catalysis for C–C and C–X coupling reactions

(2017) Dominic R. Pye et al.   Chemical Science

S,O-Ligand-Promoted Palladium-Catalyzed C–H Functionalization Reactions of Nondirected Arenes

(2017) Kananat Naksomboon et al.   ACS Catalysis

Ligand-Promoted Direct C–H Arylation of Simple Arenes: Evidence for a Cooperative Bimetallic Mechanism

(2017) Jaewoon Kim et al.   ACS Catalysis

Ag(I)-Catalyzed C–H Activation: The Role of the Ag(I) Salt in Pd/Ag-Mediated C–H Arylation of Electron-Deficient Arenes

(2016) Daniel Whitaker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed, Site-Selective Direct Allylation of Aryl C–H Bonds by Silver-Mediated C–H Activation: A Synthetic and Mechanistic Investigation

(2016) Sarah Yunmi Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-selective and stereoselective functionalization of unactivated C–H bonds

(2016) Kuangbiao Liao et al.   NATURE

Enantioselective amine α-functionalization via palladium-catalysed C–H arylation of thioamides

(2016) Pankaj Jain et al.   Nature Chemistry

Role of Silver Salts in Palladium-Catalyzed Arene and Heteroarene C–H Functionalization Reactions

(2016) Monica D. Lotz et al.   ORGANOMETALLICS

Catalyst Efficacy of Homogeneous and Heterogeneous Palladium Catalysts in the Direct Arylation of Common Heterocycles

(2016) Ian Fairlamb et al.   SYNLETT

Factors Controlling Stability and Reactivity of Dimeric Pd(II) Complexes in C–H Functionalization Catalysis

(2016) Brandon E. Haines et al.   ACS Catalysis

Undirected, Homogeneous C–H Bond Functionalization: Challenges and Opportunities

(2016) John F. Hartwig et al.   ACS Central Science

Catalytic Silylation of Unactivated C–H Bonds

(2015) Chen Cheng et al.   CHEMICAL REVIEWS

Ligand-Promoted Reactivity of Alkenes in Dehydrogenative Heck Reactions of Furans and Thiophenes

(2015) Alexandre Vasseur et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Mechanistic Insights into the Palladium-Catalyzed Aziridination of Aliphatic Amines by C–H Activation

(2015) Adam P. Smalley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism of the Palladium-Catalyzed Arene C–H Acetoxylation: A Comparison of Catalysts and Ligand Effects

(2015) Amanda K. Cook et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Au-Catalyzed Cross-Coupling of Arenes via Double C–H Activation

(2015) Xacobe C. Cambeiro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Insights of a Concerted Metalation–Deprotonation Reaction with [Cp*RhCl2]2

(2015) Aaron P. Walsh et al.   ORGANOMETALLICS

Deactivation in Homogeneous Transition Metal Catalysis: Causes, Avoidance, and Cure

(2014) Robert H. Crabtree   CHEMICAL REVIEWS

Ruthenium(II)-Catalyzed Oxidative CH Alkenylations of Sulfonic Acids, Sulfonyl Chlorides and Sulfonamides

(2014) Wenbo Ma et al.   CHEMISTRY-A EUROPEAN JOURNAL

Pd-Catalyzed Aerobic Oxidative Coupling of Arenes: Evidence for Transmetalation between Two Pd(II)-Aryl Intermediates

(2014) Dian Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-catalysed C–H activation of aliphatic amines to give strained nitrogen heterocycles

(2014) Andrew McNally et al.   NATURE

Regio- and Stereoselective Allylic C–H Arylation with Electron-Deficient Arenes by 1,1′-Bi-2-naphthol–Palladium Cooperation

(2014) Gang-Wei Wang et al.   ORGANIC LETTERS

Organometallics Roundtable 2013–2014

(2014) John A. Gladysz et al.   ORGANOMETALLICS

Rhodium-Catalyzed Intermolecular C-H Silylation of Arenes with High Steric Regiocontrol

(2014) C. Cheng et al.   SCIENCE

Formation and propagation of well-defined Pd nanoparticles (PdNPs) during C–H bond functionalization of heteroarenes: are nanoparticles a moribund form of Pd or an active catalytic species?

(2014) Christoph G. Baumann et al.   TETRAHEDRON

Non-directed allylic C–H acetoxylation in the presence of Lewis basic heterocycles

(2014) Hasnain A. Malik et al.   Chemical Science

A Survey of Sulfide Ligands for Allylic CH Oxidations of Terminal Olefins

(2013) Chi “Chip” Le et al.   CHEMISTRY-A EUROPEAN JOURNAL

Towards Ideal Synthesis: Alkenylation of Aryl CH Bonds by a Fujiwara-Moritani Reaction

(2013) Lihong Zhou et al.   CHEMISTRY-A EUROPEAN JOURNAL

Controllable Mono-/Dialkenylation of Benzyl Thioethers through Rh-Catalyzed Aryl CH Activation

(2013) Xi-Sha Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Gold-Catalyzed Oxidative Coupling of Arylsilanes and Arenes: Origin of Selectivity and Improved Precatalyst

(2013) Liam T. Ball et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Meta-Selective C–H Bond Activation with a Nitrile-Containing Template: Computational Study on Mechanism and Origins of Selectivity

(2013) Yun-Fang Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thioether-Promoted Direct Olefination of Polyfluoroarenes Catalyzed by Palladium

(2013) Cai-Zhi Wu et al.   ORGANIC LETTERS

Aerobic Dehydrogenative Heck Reaction of Ferrocene with a Pd(OAc)2/4,5-Diazafluoren-9-one Catalyst

(2013) Michał Piotrowicz et al.   ORGANOMETALLICS

On the role of anionic ligands in the site-selectivity of oxidative C–H functionalization reactions of arenes

(2013) Italo A. Sanhueza et al.   Chemical Science

Origins of regioselectivity of the palladium-catalyzed (aromatic)CH bond metalation–deprotonation

(2012) Serge I. Gorelsky   COORDINATION CHEMISTRY REVIEWS

Mechanistic Studies on Direct Arylation of Pyridine N-Oxide: Evidence for Cooperative Catalysis between Two Distinct Palladium Centers

(2012) Yichen Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activation of remote meta-C–H bonds assisted by an end-on template

(2012) Dasheng Leow et al.   NATURE

Pyridine Ligands as Promoters in PdII/0-Catalyzed C–H Olefination Reactions

(2012) Asako Kubota et al.   ORGANIC LETTERS

Transition-State Metal Aryl Bond Stability Determines Regioselectivity in Palladium Acetate Mediated C–H Bond Activation of Heteroarenes

(2012) Alban Petit et al.   ORGANIC LETTERS

Palladium-Catalyzed C–H Alkenylation of Arenes Using Thioethers as Directing Groups

(2012) Ming Yu et al.   ORGANIC LETTERS

Reactivity and Regioselectivity of Palladium-Catalyzed Direct Arylation in Noncooperative and Cooperative Processes

(2012) Serge I. Gorelsky   ORGANOMETALLICS

Gold-Catalyzed Direct Arylation

(2012) L. T. Ball et al.   SCIENCE

Bimetallic Redox Synergy in Oxidative Palladium Catalysis

(2011) David C. Powers et al.   ACCOUNTS OF CHEMICAL RESEARCH

Remarkably High Reactivity of Pd(OAc)2/Pyridine Catalysts: Nondirected CH Oxygenation of Arenes

(2011) Marion H. Emmert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regiocontrolled aerobic oxidative coupling of indoles and benzene using Pd catalysts with 4,5-diazafluorene ligands

(2011) Alison N. Campbell et al.   CHEMICAL COMMUNICATIONS

Intermolecular Dehydrogenative Heck Reactions

(2011) Jean Le Bras et al.   CHEMICAL REVIEWS

Catalytic Dehydrogenative Cross-Coupling: Forming Carbon−Carbon Bonds by Oxidizing Two Carbon−Hydrogen Bonds

(2011) Charles S. Yeung et al.   CHEMICAL REVIEWS

Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope

(2011) Lutz Ackermann   CHEMICAL REVIEWS

Recent advances in the transition metal-catalyzed twofold oxidative C–H bond activation strategy for C–C and C–N bond formation

(2011) Seung Hwan Cho et al.   CHEMICAL SOCIETY REVIEWS

A DFT comparison of the neutral and cationic Heck pathways

(2011) Carina Bäcktorp et al.   DALTON TRANSACTIONS

The role of three-center/four-electron bonds in superelectrophilic dirhodium carbene and nitrene catalytic intermediates

(2011) John F. Berry   DALTON TRANSACTIONS

Analysis of the Palladium-Catalyzed (Aromatic)C–H Bond Metalation–Deprotonation Mechanism Spanning the Entire Spectrum of Arenes

(2011) Serge I. Gorelsky et al.   JOURNAL OF ORGANIC CHEMISTRY

Evidence for in Situ Catalyst Modification during the Pd-Catalyzed Conversion of Aryl Triflates to Aryl Fluorides

(2011) Thomas J. Maimone et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Assessment of the Intermediacy of Arylpalladium Carboxylate Complexes in the Direct Arylation of Benzene: Evidence for C−H Bond Cleavage by “Ligandless” Species

(2011) Yichen Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Aerobic Dehydrogenative Cross-Coupling of Polyfluoroarenes with Thiophenes: Facile Access to Polyfluoroarene–Thiophene Structure

(2011) Chun-Yang He et al.   ORGANOMETALLICS

Evaluation of Electron-Deficient Phosphine Ligands for Direct Arylation of Heterocycles

(2010) Olivier René et al.   ADVANCED SYNTHESIS & CATALYSIS

Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions

(2010) Thomas W. Lyons et al.   CHEMICAL REVIEWS

Overview of the Mechanistic Work on the Concerted Metallation–Deprotonation Pathway

(2010) David Lapointe et al.   CHEMISTRY LETTERS

Electronic Structures of PdIIDimers

(2010) John E. Bercaw et al.   INORGANIC CHEMISTRY

Modulating Reactivity and Diverting Selectivity in Palladium-Catalyzed Heteroaromatic Direct Arylation Through the Use of a Chloride Activating/Blocking Group

(2010) Benoît Liégault et al.   JOURNAL OF ORGANIC CHEMISTRY

Mechanistic Analysis of AzineN-Oxide Direct Arylation: Evidence for a Critical Role of Acetate in the Pd(OAc)2Precatalyst

(2010) Ho-Yan Sun et al.   JOURNAL OF ORGANIC CHEMISTRY

Predictable and Site-Selective Functionalization of Poly(hetero)arene Compounds by Palladium Catalysis

(2010) David Lapointe et al.   JOURNAL OF ORGANIC CHEMISTRY

Ligand-Accelerated C−H Activation Reactions: Evidence for a Switch of Mechanism

(2010) Keary M. Engle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Auxiliary-Assisted Palladium-Catalyzed Arylation and Alkylation of sp2and sp3Carbon−Hydrogen Bonds

(2010) Dmitry Shabashov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allylic C−H Acetoxylation with a 4,5-Diazafluorenone-Ligated Palladium Catalyst: A Ligand-Based Strategy To Achieve Aerobic Catalytic Turnover

(2010) Alison N. Campbell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allylic Oxidations of Terminal Olefins Using a Palladium Thioether Catalyst

(2010) William H. Henderson et al.   ORGANIC LETTERS

Electrophilic, Ambiphilic, and Nucleophilic C−H Bond Activation: Understanding the Electronic Continuum of C−H Bond Activation Through Transition-State and Reaction Pathway Interaction Energy Decompositions

(2010) Daniel H. Ess et al.   ORGANOMETALLICS

Cyclometalation Using d-Block Transition Metals: Fundamental Aspects and Recent Trends

(2009) Martin Albrecht   CHEMICAL REVIEWS

C−H Activation for the Construction of C−B Bonds

(2009) Ibraheem A. I. Mkhalid et al.   CHEMICAL REVIEWS

Mechanisms of C–H bond activation: rich synergy between computation and experiment

(2009) Youcef Boutadla et al.   DALTON TRANSACTIONS

Energetics of C−H Bond Activation of Fluorinated Aromatic Hydrocarbons Using a [Tp′Rh(CNneopentyl)] Complex

(2009) Meagan E. Evans et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transition-State Charge Transfer Reveals Electrophilic, Ambiphilic, and Nucleophilic Carbon−Hydrogen Bond Activation

(2009) Daniel H. Ess et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism of Benzoquinone-Promoted Palladium-Catalyzed Oxidative Cross-Coupling Reactions

(2009) Kami L. Hull et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd(II)-Catalyzed Olefination of Electron-Deficient Arenes Using 2,6-Dialkylpyridine Ligands

(2009) Yang-Hui Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

C−H Activation of Phenyl Imines and 2-Phenylpyridines with [Cp*MCl2]2(M = Ir, Rh): Regioselectivity, Kinetics, and Mechanism

(2009) Ling Li et al.   ORGANOMETALLICS

PdII-Catalyzed Enantioselective Activation of C(sp2)H and C(sp3)H Bonds Using Monoprotected Amino Acids as Chiral Ligands

(2008) Bing-Feng Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed C−H Functionalization of PyridineN-Oxides: Highly Selective Alkenylation and Direct Arylation with Unactivated Arenes

(2008) Seung Hwan Cho et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analysis of the Concerted Metalation-Deprotonation Mechanism in Palladium-Catalyzed Direct Arylation Across a Broad Range of Aromatic Substrates

(2008) Serge I. Gorelsky et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Direct Arylation of Nitro-Substituted Aromatics with Aryl Halides

(2008) Laurence Caron et al.   ORGANIC LETTERS

Transition State Energy Decomposition Study of Acetate-Assisted and Internal Electrophilic Substitution C−H Bond Activation by (acac-O,O)2Ir(X) Complexes (X = CH3COO, OH)

(2008) Daniel H. Ess et al.   ORGANOMETALLICS

Rhodium Carbenoid Induced Intermolecular C-H Functionalization at Tertiary C-H Bonds

(2008) Huw Davies et al.   SYNLETT