Personalization of dexamethasone therapy in childhood acute lymphoblastic leukaemia

Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia

(2015) S. E. Karol et al.   BLOOD

Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re-sensitization by JNK inhibition

(2015) Lindsay Nicholson et al.   BRITISH JOURNAL OF HAEMATOLOGY

NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells

(2015) Steven W Paugh et al.   NATURE GENETICS

Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia

(2015) J Gregers et al.   PHARMACOGENOMICS JOURNAL

Infection-related mortality in children with acute lymphoblastic leukemia: an analysis of infectious deaths on UKALL2003

(2014) D. O'Connor et al.   BLOOD

Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells

(2014) D. Jing et al.   BLOOD

Loss of TBL1XR1 Disrupts Glucocorticoid Receptor Recruitment to Chromatin and Results in Glucocorticoid Resistance in a B-Lymphoblastic Leukemia Model

(2014) Courtney L. Jones et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The BCL2-938 C > A promoter polymorphism is associated with risk group classification in children with acute lymphoblastic leukemia

(2013) Annette Künkele et al.   BMC CANCER

Direct Reversal of Glucocorticoid Resistance by AKT Inhibition in Acute Lymphoblastic Leukemia

(2013) Erich Piovan et al.   CANCER CELL

Bim Polymorphisms: Influence on Function and Response to Treatment in Children with Acute Lymphoblastic Leukemia

(2013) V. Gagne et al.   CLINICAL CANCER RESEARCH

Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing: 2013 Update

(2013) M V Relling et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Impact of promoter polymorphisms in key regulators of the intrinsic apoptosis pathway on the outcome of childhood acute lymphoblastic leukemia

(2013) R. Sanchez et al.   HAEMATOLOGICA

Copy number genome alterations are associated with treatment response and outcome in relapsed childhood ETV6/RUNX1-positive acute lymphoblastic leukemia

(2013) A. Bokemeyer et al.   HAEMATOLOGICA

Treatment reduction for children and young adults with low-risk acute lymphoblastic leukaemia defined by minimal residual disease (UKALL 2003): a randomised controlled trial

(2013) Ajay Vora et al.   LANCET ONCOLOGY

The right dose for the right patient

(2012) B. L. Asselin   BLOOD

Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?

(2012) C.-H. Pui et al.   BLOOD

The primary role of hepatic metabolism in idiosyncratic drug-induced liver injury

(2012) David E Amacher   Expert Opinion on Drug Metabolism & Toxicology

Outcomes after Induction Failure in Childhood Acute Lymphoblastic Leukemia

(2012) Martin Schrappe et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dexamethasone exposure and asparaginase antibodies affect relapse risk in acute lymphoblastic leukemia

(2011) J. D. Kawedia et al.   BLOOD

ETV6/RUNX1-positive relapses evolve from an ancestral clone and frequently acquire deletions of genes implicated in glucocorticoid signaling

(2011) L. Kuster et al.   BLOOD

Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies

(2011) L. E. Hogan et al.   BLOOD

Pharmacokinetics, Pharmacodynamics, and Comparative Bioavailability of Single, Oral 2-mg Doses of Dexamethasone Liquid and Tablet Formulations: A Randomized, Controlled, Crossover Study in Healthy Adult Volunteers

(2011) Christian Queckenberg et al.   CLINICAL THERAPEUTICS

Dexamethasone versus prednisone for induction therapy in childhood acute lymphoblastic leukemia: a systematic review and meta-analysis

(2011) O Teuffel et al.   LEUKEMIA

Synergistic activity of rapamycin and dexamethasone in vitro and in vivo in acute lymphoblastic leukemia via cell-cycle arrest and apoptosis

(2011) Chong Zhang et al.   LEUKEMIA RESEARCH

BTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia

(2010) J. C. van Galen et al.   BLOOD

Pharmacokinetic, pharmacodynamic, and pharmacogenetic determinants of osteonecrosis in children with acute lymphoblastic leukemia

(2010) J. D. Kawedia et al.   BLOOD

Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia

(2009) R. W. Stam et al.   BLOOD

Genetic Predictors of Interindividual Variability in Hepatic CYP3A4 Expression

(2009) V. Lamba et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Low doses of 2-deoxy-glucose sensitize acute lymphoblastic leukemia cells to glucocorticoid-induced apoptosis

(2009) K Eberhart et al.   LEUKEMIA

Levels of glucocorticoid receptor and its ligand determine sensitivity and kinetics of glucocorticoid-induced leukemia apoptosis

(2009) G Gruber et al.   LEUKEMIA

CD20 up-regulation in pediatric B-cell precursor acute lymphoblastic leukemia during induction treatment: setting the stage for anti-CD20 directed immunotherapy

(2008) M. N. Dworzak et al.   BLOOD

Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells

(2008) E. Hulleman et al.   BLOOD

Influence of ABCB1 and ABCG2 polymorphisms on doxorubicin disposition in Asian breast cancer patients

(2008) Suman Lal et al.   CANCER SCIENCE

Asparaginase May Influence Dexamethasone Pharmacokinetics in Acute Lymphoblastic Leukemia

(2008) Lei Yang et al.   JOURNAL OF CLINICAL ONCOLOGY

Acute lymphoblastic leukaemia

(2008) Ching-Hon Pui et al.   LANCET

Converting cell lines representing hematological malignancies from glucocorticoid-resistant to glucocorticoid-sensitive: Signaling pathway interactions

(2008) Anna S. Garza et al.   LEUKEMIA RESEARCH

γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

(2008) Pedro J Real et al.   NATURE MEDICINE