CG200745, a Novel HDAC Inhibitor, Attenuates Kidney Fibrosis in a Murine Model of Alport Syndrome

HDAC Inhibitors: Therapeutic Potential in Fibrosis-Associated Human Diseases

(2019) Somy Yoon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Renoprotective Effect of the Histone Deacetylase Inhibitor CG200745 in DOCA-Salt Hypertensive Rats

(2019) Eun Bae et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut microbiota regulates lacteal integrity by inducing VEGF‐C in intestinal villus macrophages

(2019) Sang Heon Suh et al.   EMBO REPORTS

Peroxiredoxin V (PrdxV) negatively regulates EGFR/Stat3-mediated fibrogenesis via a Cys48-dependent interaction between PrdxV and Stat3

(2019) Hoon-In Choi et al.   Scientific Reports

Olmesartan Attenuates Kidney Fibrosis in a Murine Model of Alport Syndrome by Suppressing Tubular Expression of TGFβ

(2019) Suh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RON Receptor Tyrosine Kinase Regulates Epithelial Mesenchymal Transition and the Expression of Pro-Fibrotic Markers via Src/Smad Signaling in HK-2 and NRK49F Cells

(2019) Jung Sun Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Update on Diabetic Nephropathy: Core Curriculum 2018

(2018) Kausik Umanath et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Trichostatin A inhibits the activation of Hepatic stellate cells by Increasing C/EBP-α Acetylation in vivo and in vitro

(2018) Di Ding et al.   Scientific Reports

Histone deacetylase inhibitor, CG200745 attenuates renal fibrosis in obstructive kidney disease

(2018) Hong Sang Choi et al.   Scientific Reports

Small heterodimer partner attenuates hydrogen peroxide-induced expression of cyclooxygenase-2 and inducible nitric oxide synthase by suppression of activator protein-1 and nuclear factor-κB in renal proximal tubule epithelial cells

(2017) Jung Sun Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Inflammatory responses and inflammation-associated diseases in organs

(2017) Linlin Chen et al.   Oncotarget

Histone deacetylase inhibitor, CG200745, attenuates cardiac hypertrophy and fibrosis in DOCA-induced hypertensive rats

(2016) Eunjo Lee et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Peroxiredoxin 5 Protects TGF-β Induced Fibrosis by Inhibiting Stat3 Activation in Rat Kidney Interstitial Fibroblast Cells

(2016) Hoon-In Choi et al.   PLoS One

First-in-human study of the toxicity, pharmacokinetics, and pharmacodynamics of CG200745, a pan-HDAC inhibitor, in patients with refractory solid malignancies

(2015) Kyu-pyo Kim et al.   INVESTIGATIONAL NEW DRUGS

Alpha-lipoic acid attenuates lipopolysaccharide-induced kidney injury

(2014) Sang Heon Suh et al.   Clinical and Experimental Nephrology

Angiotensin-(1-7) attenuates damage to podocytes induced by preeclamptic serum through MAPK pathways

(2014) JIMEI TIAN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: A positive feedback mechanism in the RAS

(2013) Vaibhav B. Patel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Expert Guidelines for the Management of Alport Syndrome and Thin Basement Membrane Nephropathy

(2013) J. Savige et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats

(2012) Tatsuya Usui et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Losartan and enalapril are comparable in reducing proteinuria in children with Alport syndrome

(2012) Nicholas J. A. Webb et al.   PEDIATRIC NEPHROLOGY

A novel histone deacetylase inhibitor, CG200745, potentiates anticancer effect of docetaxel in prostate cancer via decreasing Mcl-1 and Bcl-XL

(2011) Jung Jin Hwang et al.   INVESTIGATIONAL NEW DRUGS

Vasoprotective and Atheroprotective Effects of Angiotensin (1-7) in Apolipoprotein E–Deficient Mice

(2010) Sonja Tesanovic et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Protein Acetylation in the Cardiorenal Axis

(2010) Erik W. Bush et al.   CIRCULATION RESEARCH

Novel histone deacetylase inhibitor CG200745 induces clonogenic cell death by modulating acetylation of p53 in cancer cells

(2010) Eun-Taex Oh et al.   INVESTIGATIONAL NEW DRUGS

Intrarenal Renin Angiotensin System Revisited

(2010) Marcus Pohl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial-Myofibroblast Transition Contributes to the Early Development of Diabetic Renal Interstitial Fibrosis in Streptozotocin-Induced Diabetic Mice

(2009) Jinhua Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Introducing the acetylome

(2009) Karen T Smith et al.   NATURE BIOTECHNOLOGY

Acetylation Goes Global: The Emergence of Acetylation Biology

(2009) K. L. Norris et al.   Science Signaling

Histone deacetylase inhibitors: Anticancer compounds

(2008) Karen T. Smith et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY