Article
Materials Science, Multidisciplinary
Jingjing Gan, Yuxiao Liu, Lingyu Sun, Wenjuan Ma, Guopu Chen, Cheng Zhao, Lihui Wen, Yuanjin Zhao, Lingyun Sun
Summary: This study presents a pH-sensitive drug delivery system for oral treatment of inflammatory bowel disease, which can significantly decrease the production of TNF-alpha in colitis animal models and alleviate colitis symptoms in mice after oral administration. The designed system shows promising potential in treating colon-associated diseases.
APPLIED MATERIALS TODAY
(2021)
Review
Biotechnology & Applied Microbiology
Wunan Zhang, Cecilia Bohns Michalowski, Ana Beloqui
Summary: Inflammatory bowel disease (IBD) poses a global health threat with limited treatment options and poor therapeutic outcomes. Although biologics demonstrate more effective therapeutic mechanisms, their application is restricted due to stability and toxicity issues.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jongyoon Shinn, Juyeon Lee, Seon Ah Lee, Seon Ju Lee, Ah Hyun Choi, Jung Seo Kim, Su Jin Kim, Hyo Jin Kim, Cherin Lee, Yejin Kim, Joohyeon Kim, Jonghee Choi, Byungchae Jung, Taeho Kim, HyeonTaek Nam, Hyungjun Kim, Yonghyun Lee
Summary: This review discusses the potential of RNA interference (RNAi) therapy for treating inflammatory bowel diseases (IBD) and the barriers in the gastrointestinal tract. It also presents the progress and challenges of oral siRNA delivery strategies.
Review
Chemistry, Multidisciplinary
Andreea Nedelcu, Ofelia Mosteanu, Teodora Pop, Teodora Mocan, Lucian Mocan
Summary: Since the beginning of the 21st century, there have been continuous advances in nanoscience in areas such as computational nanomedicine, nanomaterial-based sensors, and biomedical engineering applications. A significant increase in incidence rates of inflammatory bowel disease (IBD) has been observed, including diseases like Crohn's disease (CD) and ulcerative colitis (UC). Nanoparticle-based approaches show promise in targeting therapy for IBD patients, regulating immune responses and acting as anti-inflammatory agents.
APPLIED SCIENCES-BASEL
(2021)
Review
Pharmacology & Pharmacy
Ningcen Li, Meijuan Wang, Zhongxi Lyu, Kai Shan, Zelin Chen, Bo Chen, Yong Chen, Xiyou Hu, Baomin Dou, Jingyu Zhang, Lifen Wang, Tianyi Zhao, Hongjiao Li
Summary: Inflammatory bowel disease (IBD) is a growing concern for global health due to its increasing incidence rate. Medicinal plants and nanoparticles have shown potential in IBD treatment, but their limitations hinder clinical application. Nanoparticles and extracellular vehicles (EVs) offer advantages in drug delivery to the colon, promoting anti-inflammation and improving intestinal health. Clinical trials evaluating the safety and effectiveness of EVs-loaded drugs in IBD are underway. This review discusses the role of synthetic nanoparticles and medicinal plants derived EVs in IBD treatment and highlights limitations and future research needs.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Dinakar Swastha, Nambolan Varsha, Suresh Aravind, Kavassery Balasubramanian Samyuktha, Muruganandam Mohaneswari Yokesh, Akshad Balde, Bakthavatchalam Loganathan Ayilya, Soottawat Benjakul, Se -Kwon Kim, Rasool Abdul Nazeer
Summary: Inflammatory bowel disease (IBD) is a common inflammatory disorder affecting the gastrointestinal tract. Alginate (AG), as a marine-derived polysaccharide, has been extensively studied for its properties in drug delivery systems for IBD treatment. AG-based carrier systems, including nanotechnology-based systems and hydrogels, have shown potential in targeted drug delivery and tissue regeneration. This review focuses on the pathogenesis of IBD, currently studied medications, AG-based drug delivery systems, and their properties for alleviating IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Multidisciplinary
Chi-Pin James Wang, Min Ji Byun, Se-Na Kim, Wooram Park, Hee Ho Park, Tae-Hyung Kim, Jung Seung Lee, Chun Gwon Park
Summary: Inflammatory bowel diseases (IBDs) are gastrointestinal inflammatory disorders featuring chronic intestinal inflammation. Novel biomaterial-based platforms have been developed to deliver drugs to damaged sites with increased efficacy and reduced side effects in IBD treatments.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Multidisciplinary
Yuji Pu, Xi Fan, Zhuangzhuang Zhang, Zhaoyuan Guo, Qingqing Pan, Wenxia Gao, Kui Luo, Bin He
Summary: The current clinical treatments for inflammatory bowel disease (IBD) suffer from severe side effects, low long-term treatment efficacy, and increased risks of infection and malignancy. However, naturally bioactive small molecules, reactive oxygen species scavengers, and gut microbiota modulators have emerged as promising candidates for IBD treatment. Polymeric systems have been engineered as delivery vehicles to improve the bioavailability and efficacy of these therapeutic agents, while reducing their systemic toxicity. This article surveys polymer-derived drug delivery systems for combating IBD.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Biomedical
Niranjan G. Kotla, Rajbir Singh, Becca Baby, Swetha Rasala, Jawad Rasool, Sean O. Hynes, Darrell Martin, Laurence J. Egan, Praveen K. Vemula, Venkatakrishna R. Jala, Yury Rochev, Abhay Pandit
Summary: Delivering drugs directly to inflamed intestinal sites to treat inflammatory bowel disease (IBD) is a challenge, but the development of targeted carrier systems such as IT-NCs shows promising therapeutic potential in improving treatment efficacy.
Article
Immunology
Liucan Wang, Min Yu, Hua Yang
Summary: Effective colon drug delivery using nanocarrier-based nanomedicine is an international frontier research in IBD therapy, offering new opportunities for treatment and diagnoses. Functional nanocarriers with varying characteristics can improve target therapy and bioavailability, enhancing therapeutic efficacy in the treatment of IBD.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Engineering, Biomedical
Neha Shrestha, Yining Xu, Julien R. C. Prevost, Fiona McCartney, David Brayden, Raphael Frederick, Ana Beloqui, Veronique Preat
Summary: Nanoparticle-based oral drug delivery systems have the potential to target inflamed regions in the gastrointestinal tract. This study developed mucus-penetrating nanoparticles to encapsulate monoclonal antibodies for the treatment of inflammatory bowel disease. The results showed that the length of the PEG chain had a significant impact on the efficacy of the nanoparticles in vivo.
ACTA BIOMATERIALIA
(2022)
Review
Pharmacology & Pharmacy
Hicheme Hadji, Kawthar Bouchemal
Summary: The complex pathogenesis of inflammatory bowel disease (IBD) presents challenges for finding an effective cure. Current therapeutic protocols focus on reducing inflammation or maintaining remission, but drugs often have severe side effects or limited bioavailability in the inflamed regions. Researchers have explored the use of nanoparticulate drug delivery systems and polysaccharides for targeted treatment of inflamed tissues, but challenges such as high costs and primary nonresponse remain. This critical review discusses the advances in IBD treatment and reviews the use of polysaccharide nanoparticulate drug delivery systems for IBD treatment.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Gastroenterology & Hepatology
Farah Yasmin, Hala Najeeb, Shehryar Shaikh, Muhammad Hasanain, Unaiza Naeem, Abdul Moeed, Thoyaja Koritala, Syedadeel Hasan, Salim Surani
Summary: Inflammatory bowel disease (IBD) is a chronic illness with complex pathogenesis. The current treatment methods have limitations, so novel drug delivery systems are introduced to overcome these limitations.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Immunology
Stefano Bruscoli, Marta Febo, Carlo Riccardi, Graziella Migliorati
Summary: Inflammatory bowel disease (IBD) comprises ulcerative colitis (UC) and Crohn's disease (CD) and involves immune cell alteration and chronic inflammatory cascade activation against unknown environmental triggers. Therapy focuses on supporting measures and use of anti-inflammatory and immunosuppressive drugs, with glucocorticoids (GCs) being a cornerstone treatment for moderate-to-severe IBD. However, their use is limited by important adverse drug effects, leading researchers to explore newer, safer alternatives.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Biomedical
Chong Zhang, Fen Zeng, Zhengyang Fan, Zhen He, Liang Tai, Qiang Peng, Yixin Zhang, Zhenhua Chao, Wenning Jiang, Lingyun Jia, Lulu Han
Summary: Inflammatory bowel disease (IBD) is a global public health challenge. Current medical treatments are not fully effective and may cause side effects. Researchers have developed a nanoparticle-based treatment strategy for IBD, which can target inflamed colon tissues and reduce systemic exposure of the drug. The nanoparticles also possess reactive oxygen species (ROS)-scavenging ability, which can alleviate inflammation and improve IBD symptoms.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Shogo Sasaki, Hiroto Izumi, Yasuo Morimoto, Kazuo Sakurai, Shinichi Mochizuki
BIOORGANIC & MEDICINAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Nobuaki Fujiwara, Hiroto Izumi, Ryoma Kira, Yasuo Morimoto, Shinichi Mochizuki, Kazuo Sakurai
Summary: The study revealed the presence of multiple isoforms of human Dectin-1, compared to only two forms in mice. Transfecting the Dectin-1 gene into non-expressing cells showed effective suppression of the target gene expression through beta-glucan/Dectin-1-mediated uptake. This suggests that the beta-glucan complex can be a useful tool for delivering antisense oligonucleotides to Dectin-1-expressing cells in both mice and humans.
CARBOHYDRATE RESEARCH
(2021)
Article
Biochemical Research Methods
Mari Takahara, Shinichi Mochizuki, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Kazuo Sakurai, Noriho Kamiya
Summary: This study utilized microbial transglutaminase (MTG) to efficiently conjugate lipids with proteins, designing water-soluble amphiphilic lipopeptides and protein conjugates. The successful lipid-protein conjugates demonstrated high cell adhesion efficiency and prolonged half-life, showing the potential for drug delivery systems.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Kazuki Sumiya, Hiroto Izumi, Shinichi Mochizuki, Kazuo Sakurai
Summary: The study investigates the relationship between antisense oligonucleotides (AS-ODNs) and protein expression, showing that a macromolecular complex formed by beta-1,3-glucan schizophyllan (SPG) and AS-ODNs can be taken up by cells. A new complex containing only one AS-ODN molecule has been isolated and its delivery efficacy will be evaluated in comparison with the previous complex.
Review
Pharmacology & Pharmacy
Shinichi Mochizuki, Noriko Miyamoto, Kazuo Sakurai
Summary: Schizophyllan (SPG) can form complexes with homo-polynucleotides and deliver functional oligonucleotides to antigen presenting cells through specific receptor Dectin-1, leading to therapeutic effects and immune responses.
DRUG METABOLISM AND PHARMACOKINETICS
(2022)
Article
Gastroenterology & Hepatology
So Imakiire, Hidetoshi Takedatsu, Keiichi Mitsuyama, Hideto Sakisaka, Kozo Tsuruta, Masaru Morita, Nobuaki Kuno, Koichi Abe, Sadahiro Funakoshi, Hideki Ishibashi, Shinichiro Yoshioka, Takuji Torimura, Fumihito Hirai
Summary: This study found that PR3-ANCA measurement is useful for diagnosing UC, evaluating disease severity and extension, and predicting the clinical course.
Article
Toxicology
Chinatsu Nishida, Taisuke Tomonaga, Hiroto Izumi, Ke-Yong Wang, Toru Ishidao, Jun-ichi Takeshita, Ryohei Ono, Kazuki Sumiya, Shota Fujii, Shinichi Mochizuki, Kazuo Sakurai, Kei Yamasaki, Kazuhiro Yatera, Yasuo Morimoto, Hidenori Higashi
Summary: Our study suggests that cross-linked polyacrylic acid (CL-PAA) potentially induces strong neutrophil inflammation and pulmonary fibrosis in rat and human lungs.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Reika Tsuji, Soichi Ogata, Shinichi Mochizuki
Summary: Proteins and nucleic acids derived from bioresources have shown potential as a new medical modality. In this study, conjugates of bovine serum albumin (BSA) and hyaluronic acid (HA) were prepared to deliver proteins to cancer cells. The conjugates, with a highly condensed structure and crosslinking through BSA, induced a larger decrease in frequency change and showed high fluorescence intensity in CT26 cells. These conjugates and nanoparticles with densely packed HA structures could serve as an effective platform for delivering proteins to cancer tissues.
BIOORGANIC CHEMISTRY
(2022)
Article
Medicine, General & Internal
Masaru Morita, Hidetoshi Takedatsu, Shinichiro Yoshioka, Keiichi Mitsuyama, Kozo Tsuruta, Kotaro Kuwaki, Ken Kato, Ryosuke Yasuda, Tatsuki Mizuochi, Yushiro Yamashita, Takumi Kawaguchi
Summary: The roles and methods of diagnostic colonoscopy in pediatric patients have evolved and adapted in recent years, as demonstrated by a retrospective analysis. The increasing prevalence of inflammatory bowel disease and eosinophilic gastrointestinal disorder emphasizes the importance of colonoscopy in infants and children.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemical Research Methods
Hitomi Irie, Koji Morita, Miyu Matsuda, Makoto Koizumi, Shinichi Mochizuki
Summary: Recent studies have demonstrated the strong efficacy of peptide-based vaccines for cancer immunotherapy. Co-delivering adjuvant and antigenic peptide molecules to antigen-presenting cells simultaneously can optimize immunological performance. However, the conjugate consisting of 30-mer CpG-DNA and a cancer antigenic peptide of TRP2(180-188) did not induce efficient TRP2(180-188)-specific immune responses in mice.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Kazuki Sumiya, Hiroto Izumi, Yoshiyuki Adachi, Shinichi Mochizuki, Kazuo Sakurai
Summary: This study investigates the structure and nature of different variants of human Dectin-1 expressed on the cellular surface. It reveals the presence of a new N-linked glycosylation site and the important role of glycosylation in the fate and localization of Dectin-1 in cells. The glycosylation is also found to be related to the ingestion of the complex, suggesting additional targets for the complex other than V-1 and V-2.
CARBOHYDRATE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Miyu Matsuda, Shinichi Mochizuki
Summary: This study investigates the aggregation behavior of A/D-type CpG-ODNs and their relationship with immune responses. The results suggest that controlling the formation of CpG ODN aggregates can effectively induce innate immune responses.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Kazuki Sumiya, Takuya Matsunaga, Motoko Tanaka, Shinichi Mochizuki, Kazuo Sakurai
Article
Biochemical Research Methods
Hitomi Irie, Koji Morita, Makoto Koizumi, Shinichi Mochizuki
BIOCONJUGATE CHEMISTRY
(2020)
