Article
Multidisciplinary Sciences
Man Wu, Guang Xu, Chong Han, Peng-Fei Luan, Yu-Hang Xing, Fang Nan, Liang-Zhong Yang, Youkui Huang, Zheng-Hu Yang, Lin Shan, Li Yang, Jiaquan Liu, Ling-Ling Chen
Summary: In this study, it was found that individual spherical FC/DFC units in human cells are coated by DDX21, and the long noncoding RNA SLERT promotes DDX21 to adopt a closed conformation and form loose clusters, impacting ribosomal RNA production.
Article
Biochemistry & Molecular Biology
Arpita Ghosh, Satya Prakash Pandey, Dheeraj Chandra Joshi, Priya Rana, Asgar Hussain Ansari, Jennifer Seematti Sundar, Praveen Singh, Yasmeen Khan, Mary Krishna Ekka, Debojyoti Chakraborty, Souvik Maiti
Summary: This study discovered the presence of three stable RNA G-quadruplexes (rG4s) in the 3' region of MALAT1 and demonstrated their specific binding with nucleolar proteins Nucleolin and Nucleophosmin. Imaging showed that the rG4s in MALAT1 facilitate the localization of these proteins to nuclear speckles, and mutations disrupting the rG4s compromised their localization. Biophysical studies revealed that a truncated version of Nucleolin tightly binds to all three rG4s.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Martina Zafferani, Justin G. Martyr, Dhanasheel Muralidharan, Nadeska I. Montalvan, Zhengguo Cai, Amanda E. Hargrove
Summary: The characterization of RNA tertiary structures in human diseases has shown their pervasiveness and potential therapeutic value. This study focuses on small molecule-mediated modulation of RNA tertiary structures, specifically targeting the triple helix of the noncoding RNA MALAT1. Through a series of assays, the researchers identified small molecules that can bind to and impact the stability of the MALAT1 triple helix. They also developed predictive models for evaluating small molecule affinity and stability-based assays. This work establishes a powerful tool for studying and targeting disease-associated RNA triple helices.
ACS CHEMICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Liping Zhang, Junyi Hu, Bahar I. Meshkat, Kenneth W. Liechty, Junwang Xu
Summary: In diabetic wounds, MALAT1 and TGF-β1 expression are significantly up-regulated, and knockdown of MALAT1 attenuates TGF-β1-induced EMT in HaCaT cells by inducing the expression of the critical transcription factor ZEB1, providing new insights into the pathogenesis of diabetic wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Junhui Hou, Gong Zhang, Xia Wang, Yuan Wang, Kefeng Wang
Summary: Chemotherapy is a crucial treatment for cancer, but the emergence of resistance poses a major challenge. Recent studies have identified a link between long non-coding RNA MALAT1 and chemotherapy resistance, suggesting its potential as a target for overcoming resistance. This review explores the mechanisms underlying MALAT1-mediated resistance and presents new possibilities for cancer treatment.
BIOMARKER RESEARCH
(2023)
Article
Immunology
Imran Ahmad, Raza Ali Naqvi, Araceli Valverde, Afsar R. Naqvi
Summary: This study unraveled the important role of MALAT1 in macrophage polarization and immune functions, and delineated its antagonistic relationship with miR-30b, providing critical insights into the regulation of macrophage polarization and immune responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Minmin Xiong, Mengshi Wu, Dan Peng, Weijun Huang, Zehong Chen, Haoxian Ke, Zewen Chen, Wu Song, Yonghua Zhao, Andy P. Xiang, Xiaomin Zhong
Summary: DANCR plays a critical role in Doxorubicin-induced apoptosis by interacting with QK to enhance the expression of MALAT1 in colorectal cancer cells. Through modulation of RNA stability, DANCR and QK jointly suppress the process of apoptosis.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Yinli Zheng, Jinjun Wu, Ru Deng, Censhan Lin, Yuhua Huang, Xia Yang, Chunhua Wang, Mingming Yang, Yangfan He, Jiabin Lu, Xiaodong Su, Qian Yan, Yinghui Zhu, Xinyuan Guan, Yan Li, Jingping Yun
Summary: The study revealed that upregulation of G3BP2 in ESCC is significantly correlated with lymph node metastasis, depth of tumor invasion, and unfavorable outcomes. G3BP2 enhances ESCC cell migration and invasion through interactions with LINC01554 and HDGF.
Article
Oncology
An-Chih Wu, Wen-Bin Yang, Kwang-Yu Chang, Jung-Shun Lee, Jing-Ping Liou, Ruei-Yuan Su, Siao Muk Cheng, Daw-Yang Hwang, Ushio Kikkawa, Tsung- Hsu, Chih-Yang Wang, Wen-Chang Chang, Pin-Yuan Chen, Jian-Ying Chuang
Summary: This study identifies LINC00461 as a significantly increased lncRNA in stem-like/treatment-resistant GBM cells, and demonstrates that targeting the HDAC6/RBP axis through LINC00461 can suppress GBM cell proliferation and prolong patient survival.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Longhui Hao, Wenzheng Wu, Yankun Xu, Yufan Chen, Chengzhen Meng, Jingyi Yun, Xiaoyu Wang
Summary: LncRNAs are non-coding RNA transcripts that interact with DNA, RNA, and proteins to regulate gene expression in human tissues. The lncRNA MALAT1 plays a significant role in various cancers and is considered a biomarker and therapeutic target. This article provides a comprehensive review of the structure and functions of lncRNAs, focusing on the discoveries and mechanisms of lncRNA-MALAT1 in different cancers, as well as ongoing research on drug development. The findings present a promising potential for the understanding and treatment of cancer.
Review
Cell Biology
Mary Catherine Bridges, Amanda C. Daulagala, Antonis Kourtidis
Summary: This review summarizes the current knowledge of subcellular localization of long noncoding RNAs (lncRNAs), factors controlling their localization, emerging themes, and discusses the implications of lncRNA localization on their function and cellular behavior, as well as opportunities for future research.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hui Miao, Fan Wu, Yu Li, Chenyu Qin, Yongyun Zhao, Mingfeng Xie, Hongyuan Dai, Hong Yao, Haoyang Cai, Qianhong Wang, Xu Song, Ling Li
Summary: This study investigates how lncRNA MALAT1 cooperates with splicing factors in alternative splicing regulation. It is found that MALAT1 stabilizes the interaction between PTBP1 and PSF, forming a functional module that affects alternative splicing events. The functional module has more significance in hepatocellular carcinoma. Additionally, MALAT1 also stabilizes the interaction between PSF and other heterogeneous nuclear ribonucleoparticle proteins.
Article
Cell Biology
Xinzhu Li, Wenan Xu, Xiaoyu Lin, Jingyi Wu, Buling Wu
Summary: In this study, it was found that MALAT1 is mainly expressed in the cytoplasm of dental pulp cells and is involved in the regulation of mineralization process in a high-glucose microenvironment. Specifically, MALAT1 participates in dental pulp cell mineralization by regulating multiple factors (TGF beta-1, BMP2, MSX2, SP7, ALP, and DSPP).
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Manting Ma, Bolin Cai, Zhen Zhou, Shaofen Kong, Jing Zhang, Haiping Xu, Xiquan Zhang, Qinghua Nie
Summary: This study discovered a novel LncRNA-TBP that is specifically enriched in slow-twitch muscle fibers. Functional studies revealed that LncRNA-TBP inhibits myoblast proliferation and promotes myogenic differentiation in vitro. In vivo, LncRNA-TBP reduces fat deposition, activates slow-twitch muscle phenotype, and induces muscle hypertrophy.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Xun-Xi Lu, Wen-Xiao Yang, Yu -Chen Pei, Hong Luo, Xiao-Guang Li, Yun-Jin Wang, Guo-Liang Zhang, Hong Ling, Zhi-Ming Shao, Xin Hu
Summary: Dysregulation of RNA-binding proteins (RBPs) is a characteristic of cancer. Investigating the functions and mechanisms of abnormal RBPs can help identify new cancer biomarkers and treatment strategies. In this study, SNRPC was identified as an oncogenic modulator in triple-negative breast cancer (TNBC). SNRPC upregulation was associated with poor prognosis, and its inhibition impaired TNBC cell proliferation, migration, and invasion. SNRPC also contributed to the stability of U1 snRNP and the transcriptional program controlled by RNA Pol II. Knockdown of SNRPC reduced the expression of oncogenes and inhibited TNBC progression via the TNFAIP2-Rac1-β-catenin signaling pathway.
