☆ 4.6 Article

Heart failure with preserved ejection fraction: Similarities and differences between women and men

INTERNATIONAL JOURNAL OF CARDIOLOGY (2020)

Journal

INTERNATIONAL JOURNAL OF CARDIOLOGY

Volume 304, Issue -, Pages 101-108

Publisher

ELSEVIER IRELAND LTD

DOI: 10.1016/j.ijcard.2020.01.003

Keywords

Heart failure with preserved ejection fraction; Sex differences; Older women

Categories

Cardiac & Cardiovascular Systems

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Abstract

The syndrome of heart failure (HF) with preserved ejection fraction (HFpEF) is now recognized to account for up to half of HF cases and is the dominant form of HF in older adults, especially women. Multiple factors conspire in this predilection of HFpEF for older women. This review will discuss the epidemiology, pathophysiology, prognosis, and treatment of HFpEF with emphasis on the similarities and differences in cardiovascular aging changes, and the differential impact of comorbidities in women versus men. Responses to pharmacologic and lifestyle interventions are also reviewed. We conclude by suggesting future directions for both prevention and treatment of this common and highly morbid cardiovascular disorder. (C) 2020 Elsevier B.V. All rights reserved.

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