Knee loading repairs osteoporotic osteoarthritis by relieving abnormal remodeling of subchondral bone via Wnt/β‐catenin signaling

Osteoporosis

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Muramyl Dipeptide, a Shared Structural Motif of Peptidoglycans, Is a Novel Inducer of Bone Formation Through Induction of Runx2

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Wnt3a involved in the mechanical loading on improvement of bone remodeling and angiogenesis in a postmenopausal osteoporosis mouse model

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Ankle loading ameliorates bone loss from breast cancer–associated bone metastasis

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Cathepsin K–deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression

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Effects of knee loading on obesity-related non-alcoholic fatty liver disease in an ovariectomized mouse model with high-fat diet

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Downregulation of Heat Shock Protein 70 Impairs Osteogenic and Chondrogenic Differentiation in Human Mesenchymal Stem Cells

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Mechanical loading mitigates osteoarthritis symptoms by regulating endoplasmic reticulum stress and autophagy

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Postmenopausal Osteoporosis

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Subchondral plate porosity colocalizes with the point of mechanical load during ambulation in a rat knee model of post-traumatic osteoarthritis

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Knee loading inhibits osteoclast lineage in a mouse model of osteoarthritis

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Comparison of microstructural and mechanical properties of trabeculae in femoral head from osteoporosis patients with and without cartilage lesions: a case–control study

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In vivo mechanical loading rapidly activates β-catenin signaling in osteocytes through a prostaglandin mediated mechanism

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Knee loading protects against osteonecrosis of the femoral head by enhancing vessel remodeling and bone healing

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Targeting subchondral bone in osteoporotic osteoarthritis

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Knee loading reduces MMP13 activity in the mouse cartilage

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Deletion of a Single β-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading

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WNT signaling in bone homeostasis and disease: from human mutations to treatments

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Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

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Osteoporotic OA: a reasonable target for bone-acting agents

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Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes

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Osteoarthritis and Osteoporosis: What Is the Overlap?

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Critical Role of Filamin-binding LIM Protein 1 (FBLP-1)/Migfilin in Regulation of Bone Remodeling

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Wntless functions in mature osteoblasts to regulate bone mass

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Knee loading stimulates healing of mouse bone wounds in a femur neck

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Elbow loading promotes longitudinal bone growth of the ulna and the humerus

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The Haploinsufficient Hematopoietic Microenvironment Is Critical to the Pathological Fracture Repair in Murine Models of Neurofibromatosis Type 1

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Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis

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Subchondral bone attrition may be a reflection of compartment-specific mechanical load: the MOST Study

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Joint loading-driven bone formation and signaling pathways predicted from genome-wide expression profiles

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Changes in subchondral bone mineral density and collagen matrix organization in growing horses☆☆Sources of funding: Financial support was received from the Ministry of Education in Finland (projects 25/627/2006 and 61/627/2005), Academy of Finland (projects 113112, 213548, and 216231), the National Graduate School of Musculo-Skeletal Diseases in Finland and the North-Savo Fund of the Finnish Cultural Foundation. The GEXA study is a project by the Global Equine Research Alliance for which the financial support was granted by the Marilyn Simpson Trust (USA), Horserace Betting Levy Board (UK), Utrecht University (The Netherlands) and the New Zealand Racing Board.

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